NOAEL Studies Cosmetic Ingredient

CAMELLIA SINENSIS EXTRACT NOAEL Studies

CAS: 84650-60-2

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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CIR_vision_codex 12 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
CIR_vision_codex NOAEL =200 mg/kg body weight - oral - oral toxicity {"citation":"3,600; 200; 2","dose":"g of the high-dose group had decreased growth rates, and there was an increase in pup loss.","effect":"g of the high-dose group had decreased growth rates, and there was an increase in pup loss. Reduced growth rates were observed among pups at 3,600 ppm, but only in the second generation. Both sexes of the F1 generation in the high-dose group showed decreased abso- lute kidney and liver weights. The F1 males had decreased spleen and prostate weights, but the females’ spleens were normal. Histological examination revealed no abnormalities. The lowest dose was considered the overall no observed adverse effects level (NOAEL). The authors derived an NOAEL of 200 mg/kg body weight per day EGCG prepara- tion. Because dams consumed twice the amount of feed during the crucial lactation period, during which effects occurred, twice the lowest dose (ie, 2 \u0006 100 mg/kg/d) was estimated to be the NOAEL.74 Becker et al 57S","page":10,"pdf":"PRS658.pdf","row_type":"noael_study","study_id":"PRS658_noael_001"}
CIR_vision_codex NOAEL =100 mg/kg/d - oral - oral toxicity {"citation":"200; 2; 100","dose":"The lowest dose was considered the overall no observed adverse effects level (NOAEL).","effect":"ney and liver weights. The F1 males had decreased spleen and prostate weights, but the females’ spleens were normal. Histological examination revealed no abnormalities. The lowest dose was considered the overall no observed adverse effects level (NOAEL). The authors derived an NOAEL of 200 mg/kg body weight per day EGCG prepara- tion. Because dams consumed twice the amount of feed during the crucial lactation period, during which effects occurred, twice the lowest dose (ie, 2 \u0006 100 mg/kg/d) was estimated to be the NOAEL.74 Becker et al 57S","page":10,"pdf":"PRS658.pdf","row_type":"noael_study","study_id":"PRS658_noael_002"}
CIR_vision_codex NOAEL =1 % human - - NOAEL study {"citation":"106; 101; (0","dose":"The test substance was administered under occlusion.94,95 A black tea extract (100%;","effect":"observed in any of the 106 to complete the induction phase. No reactions were observed in any of the 101 that completed the challenge phase. An eye cream containing Camellia Sinensis Leaf Extract (0.86%; black tea) was not irritating or sensitizing in an HRIPT (n ¼ 638). The test substance was administered under occlusion.94,95 A black tea extract (100%; 1.0% solids) was negative in an HRIPT (n ¼ 100). No further details were provided.65 Camellia Sinensis Leaf Extract (as tea leaf absolute) was reported to have a no observed effect level of 480 mg/cm2 in an HRIPT.92 Camellia Sinensis Leaf Water. In an HRIPT (n ¼ 110) of a mascara containing Camellia Sinensis Leaf Water (30%), there were no signs of irritation or sensitization.96 Phototoxicity Camellia Sinensis Leaf Extract. There were no signs of erythema on treated sites on the forearms of subjects (n ¼ 6) treated with Camellia Sinensis Leaf Extracts (10%; in the form of green or black tea) and exposed to long-, mid-, and short- wavelength ultraviolet light (UVA, B, and C).97 Freeze- dried green and black tea extracts were used t...","page":16,"pdf":"PRS658.pdf","row_type":"noael_study","study_id":"PRS658_noael_003"}
CIR_vision_codex NOAEL =200 mg/kg body weight - oral - oral toxicity {"citation":"3,600; 200; 2","dose":"g of the high-dose group had decreased growth rates, and there was an increase in pup loss.","effect":"g of the high-dose group had decreased growth rates, and there was an increase in pup loss. Reduced growth rates were observed among pups at 3,600 ppm, but only in the second generation. Both sexes of the F1 generation in the high-dose group showed decreased abso- lute kidney and liver weights. The F1 males had decreased spleen and prostate weights, but the females’ spleens were normal. Histological examination revealed no abnormalities. The lowest dose was considered the overall no observed adverse effects level (NOAEL). The authors derived an NOAEL of 200 mg/kg body weight per day EGCG prepara- tion. Because dams consumed twice the amount of feed during the crucial lactation period, during which effects occurred, twice the lowest dose (ie, 2 \u0006 100 mg/kg/d) was estimated to be the NOAEL.74 Becker et al 57S","page":10,"pdf":"PRS658.pdf","row_type":"noael_study","study_id":"PRS658_noael_001"}
CIR_vision_codex NOAEL =100 mg/kg/d - oral - oral toxicity {"citation":"200; 2; 100","dose":"The lowest dose was considered the overall no observed adverse effects level (NOAEL).","effect":"ney and liver weights. The F1 males had decreased spleen and prostate weights, but the females’ spleens were normal. Histological examination revealed no abnormalities. The lowest dose was considered the overall no observed adverse effects level (NOAEL). The authors derived an NOAEL of 200 mg/kg body weight per day EGCG prepara- tion. Because dams consumed twice the amount of feed during the crucial lactation period, during which effects occurred, twice the lowest dose (ie, 2 \u0006 100 mg/kg/d) was estimated to be the NOAEL.74 Becker et al 57S","page":10,"pdf":"PRS658.pdf","row_type":"noael_study","study_id":"PRS658_noael_002"}
CIR_vision_codex NOAEL =1 % human - - NOAEL study {"citation":"106; 101; (0","dose":"The test substance was administered under occlusion.94,95 A black tea extract (100%;","effect":"observed in any of the 106 to complete the induction phase. No reactions were observed in any of the 101 that completed the challenge phase. An eye cream containing Camellia Sinensis Leaf Extract (0.86%; black tea) was not irritating or sensitizing in an HRIPT (n ¼ 638). The test substance was administered under occlusion.94,95 A black tea extract (100%; 1.0% solids) was negative in an HRIPT (n ¼ 100). No further details were provided.65 Camellia Sinensis Leaf Extract (as tea leaf absolute) was reported to have a no observed effect level of 480 mg/cm2 in an HRIPT.92 Camellia Sinensis Leaf Water. In an HRIPT (n ¼ 110) of a mascara containing Camellia Sinensis Leaf Water (30%), there were no signs of irritation or sensitization.96 Phototoxicity Camellia Sinensis Leaf Extract. There were no signs of erythema on treated sites on the forearms of subjects (n ¼ 6) treated with Camellia Sinensis Leaf Extracts (10%; in the form of green or black tea) and exposed to long-, mid-, and short- wavelength ultraviolet light (UVA, B, and C).97 Freeze- dried green and black tea extracts were used t...","page":16,"pdf":"PRS658.pdf","row_type":"noael_study","study_id":"PRS658_noael_003"}
CIR_vision_codex NOAEL =200 mg/kg body weight - oral - oral toxicity {"citation":"3,600; 200; 2","dose":"g of the high-dose group had decreased growth rates, and there was an increase in pup loss.","effect":"g of the high-dose group had decreased growth rates, and there was an increase in pup loss. Reduced growth rates were observed among pups at 3,600 ppm, but only in the second generation. Both sexes of the F1 generation in the high-dose group showed decreased abso- lute kidney and liver weights. The F1 males had decreased spleen and prostate weights, but the females’ spleens were normal. Histological examination revealed no abnormalities. The lowest dose was considered the overall no observed adverse effects level (NOAEL). The authors derived an NOAEL of 200 mg/kg body weight per day EGCG prepara- tion. Because dams consumed twice the amount of feed during the crucial lactation period, during which effects occurred, twice the lowest dose (ie, 2 \u0006 100 mg/kg/d) was estimated to be the NOAEL.74 Becker et al 57S","page":10,"pdf":"PRS658.pdf","row_type":"noael_study","study_id":"PRS658_noael_001"}
CIR_vision_codex NOAEL =100 mg/kg/d - oral - oral toxicity {"citation":"200; 2; 100","dose":"The lowest dose was considered the overall no observed adverse effects level (NOAEL).","effect":"ney and liver weights. The F1 males had decreased spleen and prostate weights, but the females’ spleens were normal. Histological examination revealed no abnormalities. The lowest dose was considered the overall no observed adverse effects level (NOAEL). The authors derived an NOAEL of 200 mg/kg body weight per day EGCG prepara- tion. Because dams consumed twice the amount of feed during the crucial lactation period, during which effects occurred, twice the lowest dose (ie, 2 \u0006 100 mg/kg/d) was estimated to be the NOAEL.74 Becker et al 57S","page":10,"pdf":"PRS658.pdf","row_type":"noael_study","study_id":"PRS658_noael_002"}
CIR_vision_codex NOAEL =1 % human - - NOAEL study {"citation":"106; 101; (0","dose":"The test substance was administered under occlusion.94,95 A black tea extract (100%;","effect":"observed in any of the 106 to complete the induction phase. No reactions were observed in any of the 101 that completed the challenge phase. An eye cream containing Camellia Sinensis Leaf Extract (0.86%; black tea) was not irritating or sensitizing in an HRIPT (n ¼ 638). The test substance was administered under occlusion.94,95 A black tea extract (100%; 1.0% solids) was negative in an HRIPT (n ¼ 100). No further details were provided.65 Camellia Sinensis Leaf Extract (as tea leaf absolute) was reported to have a no observed effect level of 480 mg/cm2 in an HRIPT.92 Camellia Sinensis Leaf Water. In an HRIPT (n ¼ 110) of a mascara containing Camellia Sinensis Leaf Water (30%), there were no signs of irritation or sensitization.96 Phototoxicity Camellia Sinensis Leaf Extract. There were no signs of erythema on treated sites on the forearms of subjects (n ¼ 6) treated with Camellia Sinensis Leaf Extracts (10%; in the form of green or black tea) and exposed to long-, mid-, and short- wavelength ultraviolet light (UVA, B, and C).97 Freeze- dried green and black tea extracts were used t...","page":16,"pdf":"PRS658.pdf","row_type":"noael_study","study_id":"PRS658_noael_003"}
CIR_vision_codex NOAEL =200 mg/kg body weight - oral - oral toxicity {"citation":"3,600; 200; 2","dose":"g of the high-dose group had decreased growth rates, and there was an increase in pup loss.","effect":"g of the high-dose group had decreased growth rates, and there was an increase in pup loss. Reduced growth rates were observed among pups at 3,600 ppm, but only in the second generation. Both sexes of the F1 generation in the high-dose group showed decreased abso- lute kidney and liver weights. The F1 males had decreased spleen and prostate weights, but the females’ spleens were normal. Histological examination revealed no abnormalities. The lowest dose was considered the overall no observed adverse effects level (NOAEL). The authors derived an NOAEL of 200 mg/kg body weight per day EGCG prepara- tion. Because dams consumed twice the amount of feed during the crucial lactation period, during which effects occurred, twice the lowest dose (ie, 2 \u0006 100 mg/kg/d) was estimated to be the NOAEL.74 Becker et al 57S","page":10,"pdf":"PRS658.pdf","row_type":"noael_study","study_id":"PRS658_noael_001"}
CIR_vision_codex NOAEL =100 mg/kg/d - oral - oral toxicity {"citation":"200; 2; 100","dose":"The lowest dose was considered the overall no observed adverse effects level (NOAEL).","effect":"ney and liver weights. The F1 males had decreased spleen and prostate weights, but the females’ spleens were normal. Histological examination revealed no abnormalities. The lowest dose was considered the overall no observed adverse effects level (NOAEL). The authors derived an NOAEL of 200 mg/kg body weight per day EGCG prepara- tion. Because dams consumed twice the amount of feed during the crucial lactation period, during which effects occurred, twice the lowest dose (ie, 2 \u0006 100 mg/kg/d) was estimated to be the NOAEL.74 Becker et al 57S","page":10,"pdf":"PRS658.pdf","row_type":"noael_study","study_id":"PRS658_noael_002"}
CIR_vision_codex NOAEL =1 % human - - NOAEL study {"citation":"106; 101; (0","dose":"The test substance was administered under occlusion.94,95 A black tea extract (100%;","effect":"observed in any of the 106 to complete the induction phase. No reactions were observed in any of the 101 that completed the challenge phase. An eye cream containing Camellia Sinensis Leaf Extract (0.86%; black tea) was not irritating or sensitizing in an HRIPT (n ¼ 638). The test substance was administered under occlusion.94,95 A black tea extract (100%; 1.0% solids) was negative in an HRIPT (n ¼ 100). No further details were provided.65 Camellia Sinensis Leaf Extract (as tea leaf absolute) was reported to have a no observed effect level of 480 mg/cm2 in an HRIPT.92 Camellia Sinensis Leaf Water. In an HRIPT (n ¼ 110) of a mascara containing Camellia Sinensis Leaf Water (30%), there were no signs of irritation or sensitization.96 Phototoxicity Camellia Sinensis Leaf Extract. There were no signs of erythema on treated sites on the forearms of subjects (n ¼ 6) treated with Camellia Sinensis Leaf Extracts (10%; in the form of green or black tea) and exposed to long-, mid-, and short- wavelength ultraviolet light (UVA, B, and C).97 Freeze- dried green and black tea extracts were used t...","page":16,"pdf":"PRS658.pdf","row_type":"noael_study","study_id":"PRS658_noael_003"}
COSMOS_DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 20000 mg/kg bw/day rat oral 9 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
NTP_ICE_skin_sensitization 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization CD54, EC200 51.9 ug/mL - Dermal - In Vitro; CE_hCLAT2018; h-CLAT sheet=Data_invitro; excel_row=1854; Record_ID=skin_sensitization_invitro_475; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID20894206; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=51.9; Reported_Response_Unit=ug/mL; Response=51.9; Response_Unit=ug/mL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID20894206
NTP_ICE_skin_sensitization CV75 254 ug/mL - Dermal - In Vitro; CE_hCLAT2018; h-CLAT sheet=Data_invitro; excel_row=1856; Record_ID=skin_sensitization_invitro_475; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID20894206; Assay=h-CLAT; Endpoint=CV75; Reported_Response=254; Reported_Response_Unit=ug/mL; Response=254; Response_Unit=ug/mL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID20894206
NTP_ICE_skin_sensitization EC1.5 >200 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=6691; Record_ID=skin_sensitization_invitro_1584; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID20894206; Assay=KeratinoSens; Endpoint=EC1.5; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=200; Reported_Response_Unit=uM; Response=200; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID20894206
NTP_ICE_skin_sensitization EC3 >400 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=6692; Record_ID=skin_sensitization_invitro_1584; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID20894206; Assay=KeratinoSens; Endpoint=EC3; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=400; Reported_Response_Unit=uM; Response=400; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID20894206
NTP_ICE_skin_sensitization Imax 2.13 ratio - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=6694; Record_ID=skin_sensitization_invitro_1584; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID20894206; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=2.13; Reported_Response_Unit=Unitless; Response=2.13; Response_Unit=Ratio; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID20894206
UnifiedCodex:CIR:beta.noael_studies 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
UnifiedCodex:CIR:beta.noael_studies - 1 % human - - - SOURCE_SUBDIR=PRS658; REPORT_TITLE=Safety Assessment of Camellia sinensis– Derived Ingredients As Used in Cosmetics Lillian C. Becker1, Wilma F. Bergfeld2, Donald V. Belsito2, Ronald A. Hill2, Curtis D. Klaassen2, Daniel C. Liebler2, James G. Marks Jr2, Ronald C. Shank2, Tho; OPINION_NUMBER=PRS658; COMMITTEE=Cosmetic Ingredient Review Expert Panel; REPORT_DATE=Suite 1200; VALUE_TEXT=1.0; DOSE=The test substance was administered under occlusion.94,95 A black tea extract (100%;; EFFECT=observed in any of the 106 to complete the induction phase. No reactions were observed in any of the 101 that completed the challenge phase. An eye cream containing Camellia Sinensis Leaf Extract (0.86%; black tea) was not irritating or sensitizing in an HRIPT (n ¼ 638). The test substance was administered under occlusion.94,95 A black tea extract (100%; 1.0% solids) was negative in an HRIPT (n ¼ 100). No further details were provided.65 Camellia Sinensis Leaf Extract (as tea leaf absolute) was reported to have a no observed effect level of 480 mg/cm2 in an HRIPT.92 Camellia Sinensis Leaf Water. In an HRIPT (n ¼ 110) of a mascara containing Camellia Sinensis Leaf Water (30%), there were no signs of irritation or sensitization.96 Phototoxicity Camellia Sinensis Leaf Extract. There were no signs of erythema on treated sites on the forearms of subjects (n ¼ 6) treated with Camellia Sinensis Leaf Extracts (10%; in the form of green or black tea) and exposed to long-, mid-, and short- wavelength ultraviolet light (UVA, B, and C).97 Freeze- dried green and black tea extracts were used t...; CITATION=106; 101; (0; CITATION_NUMBERS=[106,101]; REFERENCE=106; 101; (0; DETAILS_JSON={"cas_number":"84650-60-2","citation":"106; 101; (0","dose":"The test substance was administered under occlusion.94,95 A black tea extract (100%;","duration":"","effect":"observed in any of the 106 to complete the induction phase. No reactions were observed in any of the 101 that completed the challenge phase. An eye cream containing Camellia Sinensis Leaf Extract (0.86%; black tea) was not irritating or sensitizing in an HRIPT (n ¼ 638). The test substance was administered under occlusion.94,95 A black tea extract (100%; 1.0% solids) was negative in an HRIPT (n ¼ 100). No further details were provided.65 Camellia Sinensis Leaf Extract (as tea leaf absolute) was reported to have a no observed effect level of 480 mg/cm2 in an HRIPT.92 Camellia Sinensis Leaf Water. In an HRIPT (n ¼ 110) of a mascara containing Camellia Sinensis Leaf Water (30%), there were no signs of irritation or sensitization.96 Phototoxicity Camellia Sinensis Leaf Extract. There were no signs of erythema on treated sites on the forearms of subjects (n ¼ 6) treated with Camellia Sinensis Leaf Extracts (10%; in the form of green or black tea) and exposed to long-, mid-, and short- wavelength ultraviolet light (UVA, B, and C).97 Freeze- dried green and black tea extracts were used t...","endpoint":"","ingredient":"Camellia sinensis– Derived Ingredients","loael_value":"","noael_unit":"%","noael_value":"1.0","page":16,"route":"","species":"human","study_id":"PRS658_noael_003"}
UnifiedCodex:CIR:beta.noael_studies oral toxicity 200 mg/kg body weight - oral - oral toxicity SOURCE_SUBDIR=PRS658; REPORT_TITLE=Safety Assessment of Camellia sinensis– Derived Ingredients As Used in Cosmetics Lillian C. Becker1, Wilma F. Bergfeld2, Donald V. Belsito2, Ronald A. Hill2, Curtis D. Klaassen2, Daniel C. Liebler2, James G. Marks Jr2, Ronald C. Shank2, Tho; OPINION_NUMBER=PRS658; COMMITTEE=Cosmetic Ingredient Review Expert Panel; REPORT_DATE=Suite 1200; VALUE_TEXT=200; DOSE=g of the high-dose group had decreased growth rates, and there was an increase in pup loss.; EFFECT=g of the high-dose group had decreased growth rates, and there was an increase in pup loss. Reduced growth rates were observed among pups at 3,600 ppm, but only in the second generation. Both sexes of the F1 generation in the high-dose group showed decreased abso- lute kidney and liver weights. The F1 males had decreased spleen and prostate weights, but the females’ spleens were normal. Histological examination revealed no abnormalities. The lowest dose was considered the overall no observed adverse effects level (NOAEL). The authors derived an NOAEL of 200 mg/kg body weight per day EGCG prepara- tion. Because dams consumed twice the amount of feed during the crucial lactation period, during which effects occurred, twice the lowest dose (ie, 2  100 mg/kg/d) was estimated to be the NOAEL.74 Becker et al 57S; CITATION=3,600; 200; 2; CITATION_NUMBERS=[3,600,200,2]; REFERENCE=3,600; 200; 2; DETAILS_JSON={"cas_number":"84650-60-2","citation":"3,600; 200; 2","dose":"g of the high-dose group had decreased growth rates, and there was an increase in pup loss.","duration":"","effect":"g of the high-dose group had decreased growth rates, and there was an increase in pup loss. Reduced growth rates were observed among pups at 3,600 ppm, but only in the second generation. Both sexes of the F1 generation in the high-dose group showed decreased abso- lute kidney and liver weights. The F1 males had decreased spleen and prostate weights, but the females’ spleens were normal. Histological examination revealed no abnormalities. The lowest dose was considered the overall no observed adverse effects level (NOAEL). The authors derived an NOAEL of 200 mg/kg body weight per day EGCG prepara- tion. Because dams consumed twice the amount of feed during the crucial lactation period, during which effects occurred, twice the lowest dose (ie, 2 \u0006 100 mg/kg/d) was estimated to be the NOAEL.74 Becker et al 57S","endpoint":"oral toxicity","ingredient":"Camellia sinensis– Derived Ingredients","loael_value":"","noael_unit":"mg/kg body weight","noael_value":"200","page":10,"route":"oral","species":"","study_id":"PRS658_noael_001"}
UnifiedCodex:CIR:beta.noael_studies oral toxicity 100 mg/kg/d - oral - oral toxicity SOURCE_SUBDIR=PRS658; REPORT_TITLE=Safety Assessment of Camellia sinensis– Derived Ingredients As Used in Cosmetics Lillian C. Becker1, Wilma F. Bergfeld2, Donald V. Belsito2, Ronald A. Hill2, Curtis D. Klaassen2, Daniel C. Liebler2, James G. Marks Jr2, Ronald C. Shank2, Tho; OPINION_NUMBER=PRS658; COMMITTEE=Cosmetic Ingredient Review Expert Panel; REPORT_DATE=Suite 1200; VALUE_TEXT=100; DOSE=The lowest dose was considered the overall no observed adverse effects level (NOAEL).; EFFECT=ney and liver weights. The F1 males had decreased spleen and prostate weights, but the females’ spleens were normal. Histological examination revealed no abnormalities. The lowest dose was considered the overall no observed adverse effects level (NOAEL). The authors derived an NOAEL of 200 mg/kg body weight per day EGCG prepara- tion. Because dams consumed twice the amount of feed during the crucial lactation period, during which effects occurred, twice the lowest dose (ie, 2  100 mg/kg/d) was estimated to be the NOAEL.74 Becker et al 57S; CITATION=200; 2; 100; CITATION_NUMBERS=[200,2,100]; REFERENCE=200; 2; 100; DETAILS_JSON={"cas_number":"84650-60-2","citation":"200; 2; 100","dose":"The lowest dose was considered the overall no observed adverse effects level (NOAEL).","duration":"","effect":"ney and liver weights. The F1 males had decreased spleen and prostate weights, but the females’ spleens were normal. Histological examination revealed no abnormalities. The lowest dose was considered the overall no observed adverse effects level (NOAEL). The authors derived an NOAEL of 200 mg/kg body weight per day EGCG prepara- tion. Because dams consumed twice the amount of feed during the crucial lactation period, during which effects occurred, twice the lowest dose (ie, 2 \u0006 100 mg/kg/d) was estimated to be the NOAEL.74 Becker et al 57S","endpoint":"oral toxicity","ingredient":"Camellia sinensis– Derived Ingredients","loael_value":"","noael_unit":"mg/kg/d","noael_value":"100","page":10,"route":"oral","species":"","study_id":"PRS658_noael_002"}