NOAEL Studies Cosmetic Ingredient

Calcium Pyrophosphate NOAEL Studies

INCI: CALCIUM PYROPHOSPHATE

CAS: 7790-76-3

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 30 mg/kg bw/day rat oral 90 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
ToxValDB_ECHA_IUCLID 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL >30 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf07e4b0a7c65d1cc15e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12520/7/6/2?documentUUID=f954506f-483a-42ef-8698-5060abfca9cd; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=ECHA IUCLID:15844643:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_941ef169ed94b219ece9a14badd7fc45
ToxValDB_PPRTV_(CPHEA) 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_PPRTV_(CPHEA) NOAEL (HED) =240 mg/kg bw/day Rat oral - subchronic LONG_REF=NIER (2007) as cited in OECD (2012); NIER (2009,2010) as cited in OECD (2011a); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b383; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1621; TOXICOLOGICAL_EFFECT=No treatment - related effects; STUDY_GROUP=PPRTV (CPHEA):15654072:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_fceb8b92e3d886a513118ee214286816
ToxValDB_PPRTV_(CPHEA) RfD (provisional) =8 mg/kg bw/day Human oral - Toxicity Value LONG_REF=NIER (2007) as cited in OECD (2012); NIER (2009,2010) as cited in OECD (2011a); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b383; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1621; TOXICOLOGICAL_EFFECT=No treatment related effects in male/female rats; STUDY_GROUP=PPRTV (CPHEA):15653871:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_13875bbd38c148b111e229eebd7982ec
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier X69NU20D19 UNII - - - chemical {"approval_status":null,"molecular_formula":"2Ca.O7P2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"X69NU20D19"}
openFDA substances FDA UNII substance identifier X69NU20D19 UNII - - - chemical {"approval_status":null,"molecular_formula":"2Ca.O7P2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"X69NU20D19"}
openFDA substances FDA UNII substance identifier X69NU20D19 UNII - - - chemical {"approval_status":null,"molecular_formula":"2Ca.O7P2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"X69NU20D19"}
openFDA substances FDA UNII substance identifier X69NU20D19 UNII - - - chemical {"approval_status":null,"molecular_formula":"2Ca.O7P2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"X69NU20D19"}