NOAEL Studies Cosmetic Ingredient

Calcium Disodium EDTA NOAEL Studies

INCI: CALCIUM DISODIUM EDTA

CAS: 62-33-9

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 250 mg/kg bw/day rat oral 728 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 1340 mg/kg bw/day rat oral 8 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ADI =2.5 mg/kg bw/day Consumers - - ADI EFSA ANS - 2010 - OutputID 545 - Consumers - Scientific Opinion on the use of ferric sodium EDTA as a source of iron added for nutritional purposes to foods for the general population (including food supplements) and to foods for particular nutritional uses - doi:10.2903/j.efsa.2010.1414
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ADI =2.5 mg/kg bw/day Consumers - - ADI EFSA ANS - 2010 - OutputID 545 - Consumers - Scientific Opinion on the use of ferric sodium EDTA as a source of iron added for nutritional purposes to foods for the general population (including food supplements) and to foods for particular nutritional uses - doi:10.2903/j.efsa.2010.1414
NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =10000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_8471; row=4689; data_type=In Vivo; mixture=Chemical; chemical_name=Calcium disodium ethylenediaminetetraacetate; preferred_name=Calcium disodium ethylenediaminetetraacetate; dtxsid=DTXSID2036409; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2036409; source_file=acute_oral.xlsx
ToxValDB_ECHA_IUCLID 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LOAEL =2750 mg/kg bw/day Rat oral subchronic; 1 months subchronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae8ce4b0a7c65d1c9bc1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5354/7/6/2?documentUUID=99b0226e-6d09-4673-9ef4-dba6f574876c; YEAR=1984; ORIGINAL_YEAR=1984; STUDY_GROUP=ECHA IUCLID:15849644:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_71d1c2a72024e02c09aa0e4cd2be374c
ToxValDB_ECHA_IUCLID NOAEC >250 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa0ce4b0a7c65d1b4064; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20274/7/8?documentUUID=8eee38b3-52cd-4d80-b0c5-1e4a75700ed4; YEAR=2000; ORIGINAL_YEAR=2000; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15820470_15820471:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6b131d5672c7486f8b45689109331fd0
ToxValDB_ECHA_IUCLID NOAEL >=338 mg/kg bw/day Dog oral chronic; 12 months chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae8ce4b0a7c65d1c9bd3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5354/7/6/2?documentUUID=99b0226e-6d09-4673-9ef4-dba6f574876c; YEAR=1984; ORIGINAL_YEAR=1984; STUDY_GROUP=ECHA IUCLID:15847323:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0b725987f4646987086dfa2de0dd052d
ToxValDB_ECHA_IUCLID NOAEL >=250 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab1ae4b0a7c65d1b8e61; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5354/7/9/2?documentUUID=99b0226e-6d09-4673-9ef4-dba6f574876c; YEAR=1984; ORIGINAL_YEAR=1984; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15860476_15860922_15861618:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a9fd21b65a43e50278ce27d3729f1178
ToxValDB_GESTIS_DNEL 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL local =10 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15630516_15630517:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ac8b8a3dcb052c44cbb7f3b98c95e444
ToxValDB_GESTIS_DNEL DNEL systemic =30 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15630516_15630517:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7df5852baf95397e6cef6a74164d93e6
ToxValDB_WHO_JECFA_ADI 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_WHO_JECFA_ADI ADI <=2.5 mg/kg Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650afb5fe4b0d99f5a87ada0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/3011; YEAR=1973; ORIGINAL_YEAR=1973; STUDY_GROUP=WHO JECFA ADI:15715427:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3c39c7f4553b1965fd8581e68b0a846b
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 8U5D034955 UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H12N2O8.Ca.2Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8U5D034955"}
openFDA substances FDA UNII substance identifier 8U5D034955 UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H12N2O8.Ca.2Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8U5D034955"}
openFDA substances FDA UNII substance identifier 8U5D034955 UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H12N2O8.Ca.2Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8U5D034955"}
openFDA substances FDA UNII substance identifier 8U5D034955 UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H12N2O8.Ca.2Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8U5D034955"}