NOAEL Studies Active Ingredient

Caffeine NOAEL Studies

INCI: CAFFEINE

CAS: 58-08-2

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

Back to parent ingredient page
COSMOS DB 54 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 21 mg/kg bw/day rat oral 90 day Subchronic REACH; NTP TR
COSMOS DB LOAEL 23 mg/kg bw/day mouse oral 90 day Subchronic REACH; NTP report
COSMOS DB LOAEL 29 mg/kg bw/day rat oral 21 day Developmental PAFA; FOOD CHEM TOXICOL 25:647-662
COSMOS DB LOAEL 100 mg/kg bw/day rat oral 6-20 Gestation day Developmental PAFA; FOOD CHEM TOXICOL 25:125-13
COSMOS DB NOAEL 3 mg/kg bw/day rat oral 1 day Neurotoxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 6 mg/kg bw/day rat oral 19 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 10 mg/kg bw/day rat oral 130 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 12.5 mg/kg bw/day monkey oral NA Multigeneration Reproductive US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 13 mg/kg bw/day monkey oral 287 day Reproductive US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 15 mg/kg bw/day rat oral 5 day Neurotoxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 20 mg/kg bw/day rat oral 105 day Neurotoxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 22.5 mg/kg bw/day rat oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 24.7 mg/kg bw/day rat oral 20 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 25 mg/kg bw/day rat oral 13 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 26.4 mg/kg bw/day mouse oral NA Reproductive US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 28 mg/kg bw/day monkey oral 287 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 29 mg/kg bw/day rat oral 20 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 30 mg/kg bw/day rat oral NA Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 32.5 mg/kg bw/day rabbit oral 13 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 35 mg/kg bw/day rat oral 180 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 36 mg/kg bw/day rat oral 21 day Neurotoxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 37 mg/kg bw/day swine oral 56 day Reproductive US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 40 mg/kg bw/day rat oral 77 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 49 mg/kg bw/day rat oral 728 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 49.3 mg/kg bw/day rat oral 819 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 50 mg/kg bw/day rat oral 36 day Reproductive US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 55 mg/kg bw/day mouse oral 560 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 60 mg/kg bw/day rat oral 3 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 65 mg/kg bw/day syrian hamster oral 90 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 68 mg/kg bw/day rat oral 707 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 75 mg/kg bw/day rat oral 56 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 75.1 mg/kg bw/day rat oral 20 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 80 mg/kg bw/day rat oral 22 day Reproductive US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 83 mg/kg bw/day rat oral 21 day Neurotoxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 86.6 mg/kg bw/day rat oral 20 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 92 mg/kg bw/day mouse oral 105 day Neurotoxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 100 mg/kg bw/day cat oral 21 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 115 mg/kg bw/day rat oral 38 day Neurotoxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 116 mg/kg bw/day rat oral 14 day Neurotoxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 120 mg/kg bw/day rat oral 546 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 122 mg/kg bw/day mouse oral 90 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 125 mg/kg bw/day mouse oral 69 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 135 mg/kg bw/day rat oral 728 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 136 mg/kg bw/day rat oral 100 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 150 mg/kg bw/day mouse oral 11 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 159 mg/kg bw/day mouse oral 14 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 177 mg/kg bw/day rat oral 105 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 179 mg/kg bw/day rat oral 84 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 220 mg/kg bw/day mouse oral 14 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 250 mg/kg bw/day rat oral 525 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 279 mg/kg bw/day rat oral 90 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 375 mg/kg bw/day mouse oral 13 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 500 mg/kg bw/day rat oral 28 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 800 mg/kg bw/day rat oral 42 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
ECHA 52 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA NOAEL ca.50.7 mg/kg bw/day rat oral: drinking water - developmental toxicity dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=6f9d841a-b828-458f-a537-7742ae31b66e_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=6f9d841a-b828-458f-a537-7742ae31b66e/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1983; basis=other:; key_result=false; entry_uuid=05d6062d-1f89-4469-afc1-a43a1330ef13
ECHA NOAEL ca.10.1 mg/kg bw/day rat oral: drinking water - developmental toxicity dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=6f9d841a-b828-458f-a537-7742ae31b66e_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=6f9d841a-b828-458f-a537-7742ae31b66e/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1983; basis=other:; key_result=false; entry_uuid=2ede575f-8548-4f4b-abbd-5f2ec4ce9cf4
ECHA NOAEL >204.5 mg/kg bw/day rat oral: drinking water - developmental toxicity dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=6f9d841a-b828-458f-a537-7742ae31b66e_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=6f9d841a-b828-458f-a537-7742ae31b66e/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1983; basis=other:; key_result=false; entry_uuid=ca841f13-5b7a-42ad-94c7-eaf6bd1e9209
ECHA NOAEL 22 mg/kg bw/day mouse oral: drinking water - fertility, other dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=e1a7ca44-4d9a-4210-abd3-06e222d990ad_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=e1a7ca44-4d9a-4210-abd3-06e222d990ad/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1984; ReportDate=1984-08-29; key_result=false; entry_uuid=1203550c-a261-4010-a59c-0b8c97c1efd3
ECHA NOAEL 88 mg/kg bw/day mouse oral: drinking water - fertility, other dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=e1a7ca44-4d9a-4210-abd3-06e222d990ad_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=e1a7ca44-4d9a-4210-abd3-06e222d990ad/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1984; ReportDate=1984-08-29; key_result=false; entry_uuid=3d4404f7-0dd6-4089-913d-8421fb642a5a
ECHA NOAEL >=167.4 mg/kg bw/day mouse oral: drinking water - sub-chronic toxicity: oral dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=0dfb12ce-7930-45bd-ba27-2704d8304851_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=0dfb12ce-7930-45bd-ba27-2704d8304851/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1983; basis=other:; key_result=false; entry_uuid=42da67e7-0c96-4c74-b1c9-6a7d7d9dde97
ECHA NOAEL >=179.4 mg/kg bw/day mouse oral: drinking water - sub-chronic toxicity: oral dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=0dfb12ce-7930-45bd-ba27-2704d8304851_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=0dfb12ce-7930-45bd-ba27-2704d8304851/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1983; basis=other:; key_result=false; entry_uuid=9f4de77d-d0f0-4d3a-a8f5-4d141e5e7b3e
ECHA NOAEL >=245 mg/kg bw/day rat oral: drinking water - short-term repeated dose toxicity: oral dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=ec45ae85-1455-4c89-9a9c-ce9797e26770_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=ec45ae85-1455-4c89-9a9c-ce9797e26770/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1982; basis=other:; key_result=false; entry_uuid=0ed18a86-afcf-40e6-b22c-5cc9724aa93d
ECHA NOAEL >=285 mg/kg bw/day rat oral: drinking water - short-term repeated dose toxicity: oral dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=ec45ae85-1455-4c89-9a9c-ce9797e26770_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=ec45ae85-1455-4c89-9a9c-ce9797e26770/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1982; basis=other:; key_result=false; entry_uuid=fe0354cf-8ddf-45dc-b0ff-3d8cad7f1f1a
ECHA NOAEL <=10 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=b6fc06f0-2ca5-42d4-af90-9c84d66446f8_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=b6fc06f0-2ca5-42d4-af90-9c84d66446f8/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1984; basis=other:; key_result=false; upper_value=10; entry_uuid=24431966-05c5-4a97-ac0e-f10c8fedd194
ECHA NOAEL >40 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=b6fc06f0-2ca5-42d4-af90-9c84d66446f8_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=b6fc06f0-2ca5-42d4-af90-9c84d66446f8/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1984; basis=other:; key_result=false; entry_uuid=01ad21de-5777-4336-aa4c-165d9bb87fd1
ECHA NOAEL <=12.5 mg/kg bw/day rat oral: gavage - two-generation reproductive toxicity dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=2214af21-94a1-4099-8841-0d50ce8b3f8e_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=2214af21-94a1-4099-8841-0d50ce8b3f8e/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1996; basis=other:; key_result=false; upper_value=12.5; entry_uuid=3a489ecf-3c7d-46d1-b329-d6b93917ae99
ECHA NOAEL >80 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=fdac7564-b7c5-428a-a124-ea30d7c1dc10_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=fdac7564-b7c5-428a-a124-ea30d7c1dc10/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1984; basis=other:; key_result=false; entry_uuid=0ab1094b-0577-48c6-b86c-8a5ba732f50c
ECHA NOAEL ca.50.7 mg/kg bw/day rat oral: drinking water - developmental toxicity dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=6f9d841a-b828-458f-a537-7742ae31b66e_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=6f9d841a-b828-458f-a537-7742ae31b66e/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1983; basis=other:; key_result=false; entry_uuid=05d6062d-1f89-4469-afc1-a43a1330ef13
ECHA NOAEL ca.10.1 mg/kg bw/day rat oral: drinking water - developmental toxicity dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=6f9d841a-b828-458f-a537-7742ae31b66e_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=6f9d841a-b828-458f-a537-7742ae31b66e/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1983; basis=other:; key_result=false; entry_uuid=2ede575f-8548-4f4b-abbd-5f2ec4ce9cf4
ECHA NOAEL >204.5 mg/kg bw/day rat oral: drinking water - developmental toxicity dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=6f9d841a-b828-458f-a537-7742ae31b66e_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=6f9d841a-b828-458f-a537-7742ae31b66e/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1983; basis=other:; key_result=false; entry_uuid=ca841f13-5b7a-42ad-94c7-eaf6bd1e9209
ECHA NOAEL 22 mg/kg bw/day mouse oral: drinking water - fertility, other dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=e1a7ca44-4d9a-4210-abd3-06e222d990ad_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=e1a7ca44-4d9a-4210-abd3-06e222d990ad/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1984; ReportDate=1984-08-29; key_result=false; entry_uuid=1203550c-a261-4010-a59c-0b8c97c1efd3
ECHA NOAEL 88 mg/kg bw/day mouse oral: drinking water - fertility, other dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=e1a7ca44-4d9a-4210-abd3-06e222d990ad_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=e1a7ca44-4d9a-4210-abd3-06e222d990ad/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1984; ReportDate=1984-08-29; key_result=false; entry_uuid=3d4404f7-0dd6-4089-913d-8421fb642a5a
ECHA NOAEL >=167.4 mg/kg bw/day mouse oral: drinking water - sub-chronic toxicity: oral dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=0dfb12ce-7930-45bd-ba27-2704d8304851_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=0dfb12ce-7930-45bd-ba27-2704d8304851/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1983; basis=other:; key_result=false; entry_uuid=42da67e7-0c96-4c74-b1c9-6a7d7d9dde97
ECHA NOAEL >=179.4 mg/kg bw/day mouse oral: drinking water - sub-chronic toxicity: oral dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=0dfb12ce-7930-45bd-ba27-2704d8304851_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=0dfb12ce-7930-45bd-ba27-2704d8304851/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1983; basis=other:; key_result=false; entry_uuid=9f4de77d-d0f0-4d3a-a8f5-4d141e5e7b3e
ECHA NOAEL >=245 mg/kg bw/day rat oral: drinking water - short-term repeated dose toxicity: oral dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=ec45ae85-1455-4c89-9a9c-ce9797e26770_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=ec45ae85-1455-4c89-9a9c-ce9797e26770/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1982; basis=other:; key_result=false; entry_uuid=0ed18a86-afcf-40e6-b22c-5cc9724aa93d
ECHA NOAEL >=285 mg/kg bw/day rat oral: drinking water - short-term repeated dose toxicity: oral dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=ec45ae85-1455-4c89-9a9c-ce9797e26770_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=ec45ae85-1455-4c89-9a9c-ce9797e26770/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1982; basis=other:; key_result=false; entry_uuid=fe0354cf-8ddf-45dc-b0ff-3d8cad7f1f1a
ECHA NOAEL <=10 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=b6fc06f0-2ca5-42d4-af90-9c84d66446f8_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=b6fc06f0-2ca5-42d4-af90-9c84d66446f8/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1984; basis=other:; key_result=false; upper_value=10; entry_uuid=24431966-05c5-4a97-ac0e-f10c8fedd194
ECHA NOAEL >40 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=b6fc06f0-2ca5-42d4-af90-9c84d66446f8_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=b6fc06f0-2ca5-42d4-af90-9c84d66446f8/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1984; basis=other:; key_result=false; entry_uuid=01ad21de-5777-4336-aa4c-165d9bb87fd1
ECHA NOAEL <=12.5 mg/kg bw/day rat oral: gavage - two-generation reproductive toxicity dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=2214af21-94a1-4099-8841-0d50ce8b3f8e_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=2214af21-94a1-4099-8841-0d50ce8b3f8e/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1996; basis=other:; key_result=false; upper_value=12.5; entry_uuid=3a489ecf-3c7d-46d1-b329-d6b93917ae99
ECHA NOAEL >80 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=fdac7564-b7c5-428a-a124-ea30d7c1dc10_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=fdac7564-b7c5-428a-a124-ea30d7c1dc10/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1984; basis=other:; key_result=false; entry_uuid=0ab1094b-0577-48c6-b86c-8a5ba732f50c
ECHA NOAEL ca.50.7 mg/kg bw/day rat oral: drinking water - developmental toxicity dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=6f9d841a-b828-458f-a537-7742ae31b66e_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=6f9d841a-b828-458f-a537-7742ae31b66e/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1983; basis=other:; key_result=false; entry_uuid=05d6062d-1f89-4469-afc1-a43a1330ef13
ECHA NOAEL ca.10.1 mg/kg bw/day rat oral: drinking water - developmental toxicity dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=6f9d841a-b828-458f-a537-7742ae31b66e_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=6f9d841a-b828-458f-a537-7742ae31b66e/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1983; basis=other:; key_result=false; entry_uuid=2ede575f-8548-4f4b-abbd-5f2ec4ce9cf4
ECHA NOAEL >204.5 mg/kg bw/day rat oral: drinking water - developmental toxicity dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=6f9d841a-b828-458f-a537-7742ae31b66e_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=6f9d841a-b828-458f-a537-7742ae31b66e/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1983; basis=other:; key_result=false; entry_uuid=ca841f13-5b7a-42ad-94c7-eaf6bd1e9209
ECHA NOAEL 22 mg/kg bw/day mouse oral: drinking water - fertility, other dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=e1a7ca44-4d9a-4210-abd3-06e222d990ad_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=e1a7ca44-4d9a-4210-abd3-06e222d990ad/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1984; ReportDate=1984-08-29; key_result=false; entry_uuid=1203550c-a261-4010-a59c-0b8c97c1efd3
ECHA NOAEL 88 mg/kg bw/day mouse oral: drinking water - fertility, other dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=e1a7ca44-4d9a-4210-abd3-06e222d990ad_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=e1a7ca44-4d9a-4210-abd3-06e222d990ad/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1984; ReportDate=1984-08-29; key_result=false; entry_uuid=3d4404f7-0dd6-4089-913d-8421fb642a5a
ECHA NOAEL >=167.4 mg/kg bw/day mouse oral: drinking water - sub-chronic toxicity: oral dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=0dfb12ce-7930-45bd-ba27-2704d8304851_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=0dfb12ce-7930-45bd-ba27-2704d8304851/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1983; basis=other:; key_result=false; entry_uuid=42da67e7-0c96-4c74-b1c9-6a7d7d9dde97
ECHA NOAEL >=179.4 mg/kg bw/day mouse oral: drinking water - sub-chronic toxicity: oral dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=0dfb12ce-7930-45bd-ba27-2704d8304851_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=0dfb12ce-7930-45bd-ba27-2704d8304851/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1983; basis=other:; key_result=false; entry_uuid=9f4de77d-d0f0-4d3a-a8f5-4d141e5e7b3e
ECHA NOAEL >=245 mg/kg bw/day rat oral: drinking water - short-term repeated dose toxicity: oral dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=ec45ae85-1455-4c89-9a9c-ce9797e26770_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=ec45ae85-1455-4c89-9a9c-ce9797e26770/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1982; basis=other:; key_result=false; entry_uuid=0ed18a86-afcf-40e6-b22c-5cc9724aa93d
ECHA NOAEL >=285 mg/kg bw/day rat oral: drinking water - short-term repeated dose toxicity: oral dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=ec45ae85-1455-4c89-9a9c-ce9797e26770_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=ec45ae85-1455-4c89-9a9c-ce9797e26770/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1982; basis=other:; key_result=false; entry_uuid=fe0354cf-8ddf-45dc-b0ff-3d8cad7f1f1a
ECHA NOAEL <=10 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=b6fc06f0-2ca5-42d4-af90-9c84d66446f8_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=b6fc06f0-2ca5-42d4-af90-9c84d66446f8/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1984; basis=other:; key_result=false; upper_value=10; entry_uuid=24431966-05c5-4a97-ac0e-f10c8fedd194
ECHA NOAEL >40 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=b6fc06f0-2ca5-42d4-af90-9c84d66446f8_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=b6fc06f0-2ca5-42d4-af90-9c84d66446f8/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1984; basis=other:; key_result=false; entry_uuid=01ad21de-5777-4336-aa4c-165d9bb87fd1
ECHA NOAEL <=12.5 mg/kg bw/day rat oral: gavage - two-generation reproductive toxicity dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=2214af21-94a1-4099-8841-0d50ce8b3f8e_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=2214af21-94a1-4099-8841-0d50ce8b3f8e/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1996; basis=other:; key_result=false; upper_value=12.5; entry_uuid=3a489ecf-3c7d-46d1-b329-d6b93917ae99
ECHA NOAEL >80 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=02f8585c-1e28-4a05-9f39-63528aabc93f.i6z; document=fdac7564-b7c5-428a-a124-ea30d7c1dc10_02f8585c-1e28-4a05-9f39-63528aabc93f.i6d; document_key=fdac7564-b7c5-428a-a124-ea30d7c1dc10/02f8585c-1e28-4a05-9f39-63528aabc93f; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1984; basis=other:; key_result=false; entry_uuid=0ab1094b-0577-48c6-b86c-8a5ba732f50c
ECHA LEL =220 mg/kg bw/day Rat oral - acute QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10085/7/3/2?documentUUID=02f8585c-1e28-4a05-9f39-63528aabc93f; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15801532:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d09c16a00ddf870a912b288aa6c8c9c5
ECHA LEL =240 mg/kg bw/day Rat oral - acute QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10085/7/3/2?documentUUID=02f8585c-1e28-4a05-9f39-63528aabc93f; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15801533:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_60f121478e18f25d995cb0ab62066ab1
ECHA LEL ~35 mg/kg bw/day Mouse oral - acute QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10085/7/3/2?documentUUID=02f8585c-1e28-4a05-9f39-63528aabc93f; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15807229:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8c9f2de0ab6430569ad836ca9293e11f
ECHA NOAEL >204.5 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac3ee4b0a7c65d1be197; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10085/7/9/3?documentUUID=02f8585c-1e28-4a05-9f39-63528aabc93f; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15823389:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6a983fb305b4122db6b6a66d854f7b16
ECHA NOAEL >40 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac3ee4b0a7c65d1be19b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10085/7/9/3?documentUUID=02f8585c-1e28-4a05-9f39-63528aabc93f; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15824954:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_73b80892fb4447abc7adb63c7f09c20f
ECHA NOAEL >=179.4 mg/kg bw/day Mouse oral subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae73e4b0a7c65d1c951f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10085/7/6/2?documentUUID=02f8585c-1e28-4a05-9f39-63528aabc93f; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15849582:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a5afd8f60604b96e0efcc41d0c44ba0e
ECHA NOAEL >=167.4 mg/kg bw/day Mouse oral subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae73e4b0a7c65d1c951f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10085/7/6/2?documentUUID=02f8585c-1e28-4a05-9f39-63528aabc93f; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15849583:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8c06f288f0b41eb82a001dbb33a3d5e0
ECHA NOAEL =228 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae73e4b0a7c65d1c9531; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10085/7/6/2?documentUUID=02f8585c-1e28-4a05-9f39-63528aabc93f; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15849584:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5a953a867ae46f4b8a60d929214c93d8
ECHA NOAEL >=245 mg/kg bw/day Rat oral short-term; 14 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb65e4b0a7c65d225e32; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10085/7/6/2?documentUUID=02f8585c-1e28-4a05-9f39-63528aabc93f; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15849585:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_17765dee3fb76b2ee9f39716c643e2ac
ECHA NOAEL >=285 mg/kg bw/day Rat oral short-term; 14 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb65e4b0a7c65d225e32; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10085/7/6/2?documentUUID=02f8585c-1e28-4a05-9f39-63528aabc93f; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15849586:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_004b05b7ad415b3b6a530a74c7c6fed8
ECHA NOAEL =22 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab1ae4b0a7c65d1b8cb0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10085/7/9/2?documentUUID=02f8585c-1e28-4a05-9f39-63528aabc93f; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15860467_15862166:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5c6a6bee87535f587994968145a5344b
ECHA NOAEL <12.5 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab1ae4b0a7c65d1b8cad; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10085/7/9/2?documentUUID=02f8585c-1e28-4a05-9f39-63528aabc93f; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15861087:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_36b6ec3a3c42091ac3d6461a940771cb
ECHA NOAEL =88 mg/kg bw/day Mouse oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab1ae4b0a7c65d1b8cb8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10085/7/9/2?documentUUID=02f8585c-1e28-4a05-9f39-63528aabc93f; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15862048:M/F:F2-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ee49865606612b67d43b7caedec625b9
IARC Monographs 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
IARC Monographs IARC carcinogenicity classification 3 IARC group - - 1990 IARC Monographs {"additional_info":"volume_publication_year=1991","evaluation_year":1990,"source_table":"iarc_classifications","volume":"51"}
NTP ICE acute oral 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 =192 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_7953; row=241; data_type=In Vivo; mixture=Chemical; chemical_name=Caffeine; preferred_name=Caffeine; dtxsid=DTXSID0020232; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020232; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0020232; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =367 mg/kg bw Rat oral acute Rat Acute Oral Toxicity ECHA ChemProp (undated); record_id=acute_oral_7955; row=242; data_type=In Vivo; mixture=Chemical; chemical_name=Caffeine; preferred_name=Caffeine; dtxsid=DTXSID0020232; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020232; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0020232; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =192 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_7953; row=241; data_type=In Vivo; mixture=Chemical; chemical_name=Caffeine; preferred_name=Caffeine; dtxsid=DTXSID0020232; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020232; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0020232; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =367 mg/kg bw Rat oral acute Rat Acute Oral Toxicity ECHA ChemProp (undated); record_id=acute_oral_7955; row=242; data_type=In Vivo; mixture=Chemical; chemical_name=Caffeine; preferred_name=Caffeine; dtxsid=DTXSID0020232; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020232; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0020232; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =192 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_7953; row=241; data_type=In Vivo; mixture=Chemical; chemical_name=Caffeine; preferred_name=Caffeine; dtxsid=DTXSID0020232; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020232; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0020232; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =367 mg/kg bw Rat oral acute Rat Acute Oral Toxicity ECHA ChemProp (undated); record_id=acute_oral_7955; row=242; data_type=In Vivo; mixture=Chemical; chemical_name=Caffeine; preferred_name=Caffeine; dtxsid=DTXSID0020232; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020232; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0020232; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =192 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_7953; row=241; data_type=In Vivo; mixture=Chemical; chemical_name=Caffeine; preferred_name=Caffeine; dtxsid=DTXSID0020232; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020232; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0020232; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =367 mg/kg bw Rat oral acute Rat Acute Oral Toxicity ECHA ChemProp (undated); record_id=acute_oral_7955; row=242; data_type=In Vivo; mixture=Chemical; chemical_name=Caffeine; preferred_name=Caffeine; dtxsid=DTXSID0020232; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020232; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0020232; source_file=acute_oral.xlsx
NTP ICE adme parameters 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE adme parameters Clint 0.2855 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=29; Record_ID=adme_parameters_350; Data_Type=Measured; DTXSID=DTXSID0020232; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=0.2855; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Paini 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020232; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020232
NTP ICE adme parameters Clint 1.458 uL/min/10^6 cells Rat - - Measured; httk, Rat Hepatic Intrinsic Clearance sheet=Data; excel_row=31; Record_ID=adme_parameters_350; Data_Type=Measured; DTXSID=DTXSID0020232; Assay=httk, Rat Hepatic Intrinsic Clearance; Endpoint=Clint; Response=1.458; Response_Unit=ul/min/10^6 cells; Species=Rat; Reference=httk2.3.1, Wood 2017; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020232; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020232
NTP ICE adme parameters Fu 0.7335 fraction Rat - - Measured; httk, Rat Plasma Fraction Unbound sheet=Data; excel_row=28; Record_ID=adme_parameters_350; Data_Type=Measured; DTXSID=DTXSID0020232; Assay=httk, Rat Plasma Fraction Unbound; Endpoint=Fu; Response=0.7335; Response_Unit=Unitless Fraction; Species=Rat; Reference=httk2.3.1, Honda 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020232; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020232
NTP ICE adme parameters Fu 1 fraction Human - - Measured; httk, Human Plasma Fraction Unbound sheet=Data; excel_row=30; Record_ID=adme_parameters_350; Data_Type=Measured; DTXSID=DTXSID0020232; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=1.0; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Paini 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020232; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020232
NTP ICE cancer 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE cancer IARC group 3 unitless - - - WOE; IARC Carcinogenicity sheet=Data; excel_row=44; Record_ID=cancer_2440; Data_Type=WOE; Formulation_Name=Caffeine; Mixture=Chemical; DTXSID=DTXSID0020232; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/69; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020232; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020232
NTP ICE cancer Top dose 1179 mg/kg bw/day Rat Dosed feed - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=47; Record_ID=cancer_5553; Data_Type=In Vivo; Formulation_ID=Cancer_PID_99; Formulation_Name=Aspirin; Phenacetin; Caffeine; Percent_Active_Ingredient=4.0; Mixture=Mixture; DTXSID=DTXSID0020232; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=1179; Response_Unit=mg/kg/day; Species=Rat; Strain=F344/N; Sex=Male; Route=Dosed feed; Reference=TR-067; URL=https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr067/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020232; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020232
NTP ICE cancer Top dose 1.4 % Mouse Dosed feed - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=49; Record_ID=cancer_5556; Data_Type=In Vivo; Formulation_ID=Cancer_PID_99; Formulation_Name=Aspirin; Phenacetin; Caffeine; Percent_Active_Ingredient=4.0; Mixture=Mixture; DTXSID=DTXSID0020232; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=1.4; Response_Unit=%; Species=Mouse; Strain=B6C3F1; Sex=Female; Route=Dosed feed; Reference=TR-067; URL=https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr067/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020232; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020232
NTP ICE endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=6186; RecordID=ARPathway2016_1352; DatasetName=ARPathway2016; DTXSID=DTXSID0020232; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020232; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020232
ToxValDB ECOTOX 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB ECOTOX LOEL =300 mg/L Rat environmental short-term; 2 days short-term LONG_REF=Experientia44(10): 833-840 Cicurel,L., and B.P. Schmid Postimplantation Embryo Culture for the Assessment of the Teratogenic Potential and Potency of Compounds 1988; TITLE=Postimplantation Embryo Culture for the Assessment of the Teratogenic Potential and Potency of Compounds; AUTHOR=Cicurel,L., and B.P. Schmid; DOI=10.1007/BF01941180; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=94518; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=Growth: Length; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594869_15597966:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8485b48f0bcab6b65ddb8094551b4abd
ToxValDB ECOTOX LOEL =30 mg/L Rat environmental short-term; 2 days short-term LONG_REF=Experientia44(10): 833-840 Cicurel,L., and B.P. Schmid Postimplantation Embryo Culture for the Assessment of the Teratogenic Potential and Potency of Compounds 1988; TITLE=Postimplantation Embryo Culture for the Assessment of the Teratogenic Potential and Potency of Compounds; AUTHOR=Cicurel,L., and B.P. Schmid; DOI=10.1007/BF01941180; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=94518; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=Morphology: General morphological changes; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594869_15597966:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4cb913606426a4c787029f9a887818d1
ToxValDB ECOTOX LOEL =20 mg/kg bw/day Rat oral short-term; 22 days short-term LONG_REF=- | Biol. Trace Elem. Res.50(3): 229-236 Rossowska,M.J., P. Ghanaei, and T. Nakamoto Effect of Dietary Caffeine and Zinc on the Activity of Antioxidant Enzymes, Zinc, and Copper Concentration of the Heart and Liver in Fast-Growing Rats 1995; TITLE=Effect of Dietary Caffeine and Zinc on the Activity of Antioxidant Enzymes, Zinc, and Copper Concentration of the Heart and Liver in Fast-Growing Rats; AUTHOR=Rossowska,M.J., P. Ghanaei, and T. Nakamoto; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=85619; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Enzyme(s): Copper zinc superoxide dismutase (Cu,ZnSOD) activity, heart | Enzyme(s): Manganese superoxide dismutase (MnSOD) activity, heart|Enzyme(s): Superoxide dismutase (SOD) activity, heart | Enzyme(s): Copper zinc superoxide dismutase (Cu,ZnSOD) activity, liver; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX:15613011:F:-juvenile; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=ebbe21765aed7b1b421a03284b700abe
ToxValDB ECOTOX NOEL =0.5 mmol/kg Mouse injection short-term; 1.25 days short-term LONG_REF=Mutat. Res.66:33-43 King,M.T., H. Beikirch, K. Eckhardt, E. Gocke, and D. Wild Mutagenicity Studies with X-Ray Contrast Media, Analgesics, Antipyretics, Antirheumatics and Some Other Pharmaceutical Drugs in Bacterial, Drosophila and Mammalian Test Systems 1979; TITLE=Mutagenicity Studies with X-Ray Contrast Media, Analgesics, Antipyretics, Antirheumatics and Some Other Pharmaceutical Drugs in Bacterial, Drosophila and Mammalian Test Systems; AUTHOR=King,M.T., H. Beikirch, K. Eckhardt, E. Gocke, and D. Wild; DOI=10.1016/0165-1218(79)90005-3; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=181059; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=Genetics: Micronuclei; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15606066:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=78b10b3044e0ba9b4ac3dc8149a57d71
ToxValDB ECOTOX NOEL =2.88 mg/kg bw/day Rat oral subchronic; 84 days subchronic LONG_REF=- | Arch. Toxicol.Suppl.4:443-445 Selmeci-Antal,M., M. Barta-Bedo, G. Constantinovits, K. Nagy, and J. Szepvolgyi Nutritional Toxicological Studies with Lannate: Interactions with Caffeine and Ethanol 1980; TITLE=Nutritional Toxicological Studies with Lannate: Interactions with Caffeine and Ethanol; AUTHOR=Selmeci-Antal,M., M. Barta-Bedo, G. Constantinovits, K. Nagy, and J. Szepvolgyi; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75289; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1980; ORIGINAL_YEAR=1980; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX:15613100:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=8a15e2f591566bbd7914cc2295e8cc9f
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =44.37 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630507:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_26c5764a386fdf4f7523cd5e18794809
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 3G6A5W338E UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H10N4O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3G6A5W338E"}
openFDA substances FDA UNII substance identifier 3G6A5W338E UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H10N4O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3G6A5W338E"}
openFDA substances FDA UNII substance identifier 3G6A5W338E UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H10N4O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3G6A5W338E"}
openFDA substances FDA UNII substance identifier 3G6A5W338E UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H10N4O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3G6A5W338E"}