NOAEL Studies
Cosmetic Ingredient
Butyric Acid NOAEL Studies
INCI: BUTYRIC ACID
CAS: 107-92-6
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS_DB 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS_DB | NOAEL | 4000 | mg/kg bw/day | rat | oral | 7 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 4800 | mg/kg bw/day | syrian hamster | oral | 7 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 6000 | mg/kg bw/day | mouse | oral | 7 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
NTP_ICE_acute_inhalation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_inhalation | LC50 | >5 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=4389; Record_ID=acute_inhalation_2939; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8021515; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=5; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13507/7/3/3/?documentUUID=7c7f6bdc-fa25-48e0-a818-57af0ec2ab42; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021515; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021515 |
NTP_ICE_endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=5826; RecordID=ARPathway2016_501; DatasetName=ARPathway2016; DTXSID=DTXSID8021515; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021515; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021515 |
NTP_ICE_skin_irritation 10 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_irritation | Breakthrough Time | 40.57 | min | - | Dermal | - | In Vitro; Corrositex | sheet=Data_invitro; excel_row=5117; Record_ID=skin_irritation_invitro_47; Data_Type=In Vitro; Concentration=99; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8021515; Assay=Corrositex; Endpoint=Breakthrough Time; Response=40.57; Response_Unit=min; Reference=ICCVAM 1999; Not available; ntp.niehs.nih.gov/iccvam/docs/dermal_docs/corprrep.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021515; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021515 |
| NTP_ICE_skin_irritation | Viability (240 minutes) | 3.4 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=5111; Record_ID=skin_irritation_invitro_1889; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8021515; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=3.4; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021515; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021515 |
| NTP_ICE_skin_irritation | Viability (240 minutes) | 4.6 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=5110; Record_ID=skin_irritation_invitro_1890; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8021515; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=4.60; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021515; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021515 |
| NTP_ICE_skin_irritation | Viability (240 minutes) | 6.3 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=5112; Record_ID=skin_irritation_invitro_1888; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8021515; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=6.3; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021515; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021515 |
| NTP_ICE_skin_irritation | Viability (3 minutes) | 3.8 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=5106; Record_ID=skin_irritation_invitro_1888; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8021515; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=3.8; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021515; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021515 |
| NTP_ICE_skin_irritation | Viability (3 minutes) | 8 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=5107; Record_ID=skin_irritation_invitro_1889; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8021515; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=8; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021515; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021515 |
| NTP_ICE_skin_irritation | Viability (3 minutes) | 14.8 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=5108; Record_ID=skin_irritation_invitro_1890; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8021515; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=14.8; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021515; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021515 |
| NTP_ICE_skin_irritation | Viability (60 minutes) | 2.4 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=5116; Record_ID=skin_irritation_invitro_1888; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8021515; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=2.4; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021515; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021515 |
| NTP_ICE_skin_irritation | Viability (60 minutes) | 2.8 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=5115; Record_ID=skin_irritation_invitro_1889; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8021515; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=2.8; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021515; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021515 |
| NTP_ICE_skin_irritation | Viability (60 minutes) | 4.7 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=5114; Record_ID=skin_irritation_invitro_1890; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8021515; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=4.7; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021515; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021515 |
NTP_ICE_skin_sensitization 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=3334; Record_ID=skin_sensitization_invivo_844; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8021515; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Epstein 1977: report to RIFM|RIFM 1977; https://www.rifm.org/rifm-science-database.php#gsc.tab=0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021515; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021515 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 675 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=3332; Record_ID=skin_sensitization_invivo_844; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8021515; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=675; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Epstein 1977: report to RIFM|RIFM 1977; https://www.rifm.org/rifm-science-database.php#gsc.tab=0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021515; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021515 |
| NTP_ICE_skin_sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=3338; Record_ID=skin_sensitization_invivo_844; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8021515; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Epstein 1977: report to RIFM|RIFM 1977; https://www.rifm.org/rifm-science-database.php#gsc.tab=0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021515; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8021515 |
ToxValDB_DOE_Protective_Action_Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_DOE_Protective_Action_Criteria | LEL | =72070.7 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=DOE Protective Action Criteria:15513143:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2ff7c6cf84130e3f5d6d7b9762a15c05 |
ToxValDB_ECOTOX 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECOTOX | LOEL | =0.1 | mM | European Rabbit | environmental | short-term; 2 days | developmental | LONG_REF=Biol. Reprod.20(2): 323-332 Kane,M.T. Fatty Acids as Energy Sources for Culture of One-Cell Rabbit Ova to Viable Morulae 1979; TITLE=Fatty Acids as Energy Sources for Culture of One-Cell Rabbit Ova to Viable Morulae; AUTHOR=Kane,M.T.; DOI=10.1095/biolreprod20.2.323; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=101665; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=Development: Morula stage; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX:15610132:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=565f4bf19ac21aa4901c31d379a3ced3 |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =36.8 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630487:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_df179226fc3d223a17b5565a411b2655 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 40UIR9Q29H | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H8O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"40UIR9Q29H"} |
| openFDA substances | FDA UNII substance identifier | 40UIR9Q29H | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H8O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"40UIR9Q29H"} |
| openFDA substances | FDA UNII substance identifier | 40UIR9Q29H | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H8O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"40UIR9Q29H"} |
| openFDA substances | FDA UNII substance identifier | 40UIR9Q29H | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H8O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"40UIR9Q29H"} |