NOAEL Studies Cosmetic Ingredient

Butyloctanol NOAEL Studies

INCI: BUTYLOCTANOL

CAS: 3913-02-8

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_oral 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =26533 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_6227; row=1428; data_type=In Vivo; mixture=Chemical; chemical_name=2-Butyloctan-1-ol; preferred_name=2-Butyloctan-1-ol; dtxsid=DTXSID0044818; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0044818; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =13000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_6225; row=1429; data_type=In Vivo; mixture=Chemical; chemical_name=2-Butyloctan-1-ol; preferred_name=2-Butyloctan-1-ol; dtxsid=DTXSID0044818; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0044818; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =37434 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_6229; row=1430; data_type=In Vivo; mixture=Chemical; chemical_name=2-Butyloctan-1-ol; preferred_name=2-Butyloctan-1-ol; dtxsid=DTXSID0044818; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0044818; source_file=acute_oral.xlsx
NTP_ICE_adme_parameters 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_adme_parameters Clint 0.658 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=331; Record_ID=adme_parameters_1166; Data_Type=Measured; DTXSID=DTXSID0044818; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=0.658; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Paini 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0044818
NTP_ICE_adme_parameters Fu 1 fraction Human - - Measured; httk, Human Plasma Fraction Unbound sheet=Data; excel_row=332; Record_ID=adme_parameters_1166; Data_Type=Measured; DTXSID=DTXSID0044818; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=1.0; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Paini 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0044818
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=2216; RecordID=ARPathway2016_1186; DatasetName=ARPathway2016; DTXSID=DTXSID0044818; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0044818
ToxValDB_ECHA_IUCLID 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =1000 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaafce4b0a7c65d1b849e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11955/7/9/2?documentUUID=56f90b1d-a302-4a78-8b20-60c65f0ae17d; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15857366:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e3d5444f09fe9edfe41fda7a535608fa
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =123.3 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630451:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_59b63d039a8e5690104a548945c26e09
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier N442D9VO79 UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H26O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"N442D9VO79"}
openFDA substances FDA UNII substance identifier N442D9VO79 UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H26O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"N442D9VO79"}
openFDA substances FDA UNII substance identifier N442D9VO79 UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H26O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"N442D9VO79"}
openFDA substances FDA UNII substance identifier N442D9VO79 UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H26O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"N442D9VO79"}