Also known as: (1,1-Dimethylethyl)-4-methoxyphenol, 1,1-(Dimethylethyl)-4-methoxyphenol, Phenol, tert-butyl-4-methoxy-, terc-butil-4-metoxifenol, tert-Butyl-4-hydroxyanisole (+14 more)
INCI: BHA
Butylated Hydroxyanisole (CAS 25013-16-5) is a cosmetic antioxidant functioning as Antioxidant; synthetic chain-breaking free radical scavenger (SET/HAT. NOAEL 50 mg/kg bw/day (PDF-verified against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted, max 0.07%; 5 safety opinions reviewed (sccs). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 25013-16-5 →
Butylated Hydroxyanisole is classified GHS CMR hazard (H302, H315, H319, H335, H351, H361, H361f, H411) in the chemicals database but is restricted in EU cosmetics at max 0.07%.
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for Butylated Hydroxyanisole.
Calculate MoS for your specific formulation with the MoS Calculator.
10 study endpoints found for Butylated Hydroxyanisole. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =220 mg/kg/d | oral | rat | reproductive toxicity | CIR_vision_codex |
| NOAEL | =220 mg/kg/d | oral | rat | reproductive toxicity | CIR_vision_codex |
| NOAEL | =220 mg/kg/d | oral | rat | reproductive toxicity | CIR_vision_codex |
| NOAEL | =220 mg/kg/d | oral | rat | reproductive toxicity | CIR_vision_codex |
| NOAEL | =420 mg/kg/d | oral | rat | reproductive toxicity | CIR_vision_codex |
| NOAEL | =420 mg/kg/d | oral | rat | reproductive toxicity | CIR_vision_codex |
| NOAEL | =420 mg/kg/d | oral | rat | reproductive toxicity | CIR_vision_codex |
| NOAEL | =420 mg/kg/d | oral | rat | reproductive toxicity | CIR_vision_codex |
| NOAEL | 50 mg/kg bw/day | oral | swine | Subchronic | COSMOS_DB |
| NOAEL | 60 mg/kg bw/day | oral | dog | Subchronic | COSMOS_DB |
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
Pre-calculated NOAEL → SED → MoS audit trail for Butylated Hydroxyanisole across SCCS product categories, with measured dermal absorption where available.
10 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| cancer slope factor | =0.0002 (mg/kg-day)-1 | Human | inhalation | chronic | Cal OEHHA |
| cancer slope factor | =0.0002 (mg/kg-day)-1 | Human | oral | chronic | Cal OEHHA |
| NOAEL | =100 mg/kg-day | Rat | oral | - | EFSA |
| NOAEL | =100 mg/kg-day | Rat | oral | - | EFSA |
| NOAEL | =100 mg/kg-day | Rat | oral | - | EFSA |
| LOEL | =500 mg/kg-day | Mouse | oral | acute | ECOTOX |
| NOEL | =100 mg/kg-day | Mouse | oral | acute | ECOTOX |
| LOEL | =2 % | Rat | oral | subchronic | ECOTOX |
| NOEL | =2 % | Rat | oral | subchronic | ECOTOX |
| LOEL | =2 % | Rat | oral | subchronic | ECOTOX |
International Agency for Research on Cancer (WHO) monograph evaluation.
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
mixed agonist/antagonist (ER); antagonist (AR, weak)
| Endpoint | Target | Value | Direction |
|---|---|---|---|
| EC_testicular | reproductive | 100 µM — abnormal testicular formation (mice) µM | agonist |
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | restricted | 0.5 | All cosmetics (antioxidant use) |
| AU | restricted | - | antioxidants |
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured_in_vitro | 2.68 | In vitro; human skin; 16h continuous | Human skin in vitro | SCCS/0306 BHA opinion; CIR 2024 (2024) |
| default | 50.0 | method=default | - | - |
| measured | 0.07 | method=measured | - | - |
Reported concentration ranges per product category from SCCS/CIR/industry sources.
| Product Category | Typical Range | Max Reported | Source |
|---|---|---|---|
| Body Lotion | 0.01–0.1 | 0.5 | CIR (max 0.5%) |
1 property record from structured ingredient metadata.
Expert safety assessment and concern-level summary for Butylated Hydroxyanisole.
Public NOAEL study rows linked to Butylated Hydroxyanisole by CAS number or substance name.
Units vary across source rows: mg/kg bw/day, mg/kg/d, mg/kg bw/d
| Absorption % | Method | Vehicle |
|---|---|---|
| 2.68 | In vitro; human skin; 16h continuous | 0.07% BHA solution |
| 50.0 | method=default | - |
| 0.07 | method=measured | - |
Butylated Hydroxyanisole has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted. 10 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by sccs.
Butylated Hydroxyanisole EU regulatory status: restricted. Maximum allowed concentration: 0.07%. This is based on EU Regulation 1223/2009 and its amendments.
Butylated Hydroxyanisole functions as: Antioxidant; synthetic chain-breaking free radical scavenger (SET/HAT mechanism); product preservative against oxidative degradation in oils and waxes. It is classified as a Antioxidant in our database. CAS number: 25013-16-5.
The NOAEL (No Observed Adverse Effect Level) for Butylated Hydroxyanisole is =220 mg/kg/d based on a reproductive toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: CIR_vision_codex.
Butylated Hydroxyanisole also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Butylated Hydroxyanisole is classified GHS CMR hazard (H302, H315, H319, H335, H351, H361, H361f, H411) in the chemicals database but is restricted in EU cosmetics at max 0.07%.
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