NOAEL Studies Cosmetic Ingredient

Bischofite Magnesium Chloride NOAEL Studies

INCI: MAGNESIUM CHLORIDE

CAS: 7786-30-3

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

COSMOS_DB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 1840 mg/kg bw/day mouse oral 672 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 3532 mg/kg bw/day mouse oral 91 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
ToxValDB_ECHA_IUCLID 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL >=1531 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaad2e4b0a7c65d1b7977; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5837/7/9/2?documentUUID=a573366d-c344-49dd-bac0-2e83d9a6b056; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15860783_15861406:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ee0da28f160299346b645297172cf60e
ToxValDB_ECHA_IUCLID NOAEL >=11400 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaad2e4b0a7c65d1b797d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5837/7/9/2?documentUUID=a573366d-c344-49dd-bac0-2e83d9a6b056; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15861243_15861475:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_78b14b3bf2c303acabd7436b6762fa54
ToxValDB_ECHA_IUCLID NOAEL >=13830 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaab5e4b0a7c65d1b7167; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/30185/7/9/2?documentUUID=2a07db0f-f7ad-4656-bd9d-925cff8df415; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15861450_15862323:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e14cfe8ed89ccbf93eceb818fe68f49a
ToxValDB_ECHA_IUCLID NOAEL >=1600 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaad2e4b0a7c65d1b7977; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5837/7/9/2?documentUUID=a573366d-c344-49dd-bac0-2e83d9a6b056; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15861705_15862207:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8bc2e3bdf372c121cf4c1f91d4946034
ToxValDB_ECOTOX 12 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECOTOX LOEL =46.4 mM Rat oral short-term; 2 days short-term LONG_REF=Am. J. Physiol., Regul. Integr. Comp. Physiol.267(2, Pt. 2): R470 - R475 Tordoff,M.G. Voluntary Intake of Calcium and Other Minerals by Rats 1994; TITLE=Voluntary Intake of Calcium and Other Minerals by Rats; AUTHOR=Tordoff,M.G.; DOI=10.1152/ajpregu.1994.267.2.R470; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=88679; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Avoidance: Chemical avoidance; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594594_15604192_15610699_15610765:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f3008156355eb018783ffc8a9d4449fe
ToxValDB_ECOTOX LOEL =2 % Mouse oral subchronic; 56 days subchronic LONG_REF=Food Chem. Toxicol.27(9): 559-563 Kurata,Y., S. Tamano, M.A. Shibata, A. Hagiwara, S. Fukushima, and N. Ito Lack of Carcinogenicity of Magnesium Chloride in a Long-Term Feeding Study in B6C3F1 Mice 1989; TITLE=Lack of Carcinogenicity of Magnesium Chloride in a Long-Term Feeding Study in B6C3F1 Mice; AUTHOR=Kurata,Y., S. Tamano, M.A. Shibata, A. Hagiwara, S. Fukushima, and N. Ito; DOI=10.1016/0278-6915(89)90014-8; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=107453; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598381_15598382:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=530d2dafedb1932ac88877d528011046
ToxValDB_ECOTOX LOEL =4.5 mM/kg Dog injection acute; 0.0069 days acute LONG_REF=J. Clin. Invest.51(4): 831-836 Bottger,I., G.R. Faloona, and R.H. Unger The Effect of Calcium and Other Salts upon the Release of Glucagon-Like Immunoreactivity from the Gut 1972; TITLE=The Effect of Calcium and Other Salts upon the Release of Glucagon-Like Immunoreactivity from the Gut; AUTHOR=Bottger,I., G.R. Faloona, and R.H. Unger; DOI=10.1172/JCI106878; QUALITY=Control type: Baseline control; EXTERNAL_SOURCE_ID=88479; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1972; ORIGINAL_YEAR=1972; TOXICOLOGICAL_EFFECT=Biochemistry: Glucagon-Like Peptides; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15601978:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5ea3ab819f25c7ac18a07b456b01c59e
ToxValDB_ECOTOX LOEL =0.0046 mM Rat oral short-term; 2 days short-term LONG_REF=Am. J. Physiol., Regul. Integr. Comp. Physiol.267(2, Pt. 2): R470 - R475 Tordoff,M.G. Voluntary Intake of Calcium and Other Minerals by Rats 1994; TITLE=Voluntary Intake of Calcium and Other Minerals by Rats; AUTHOR=Tordoff,M.G.; DOI=10.1152/ajpregu.1994.267.2.R470; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=88679; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Feeding behavior: Water consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594594_15604192_15610699_15610765:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5b64116bb83acfd53366dcc049f06652
ToxValDB_ECOTOX LOEL =5 % Mouse oral chronic; 91 days chronic LONG_REF=Toxicol. Lett.73(1): 25-32 Tanaka,H., A. Hagiwara, Y. Kurata, T. Ogiso, M. Futakuchi, and N. Ito Thirteen-Week Oral Toxicity Study of Magnesium Chloride in B6C3F1 Mice 1994; TITLE=Thirteen-Week Oral Toxicity Study of Magnesium Chloride in B6C3F1 Mice; AUTHOR=Tanaka,H., A. Hagiwara, Y. Kurata, T. Ogiso, M. Futakuchi, and N. Ito; DOI=10.1016/0378-4274(94)90185-6; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=106328; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Growth: Weight|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15607649_15607652:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=04f68f735f29891d871b7fbd017504cd
ToxValDB_ECOTOX LOEL =0.00125 mg Mouse injection short-term; 14 days short-term LONG_REF=Dev. Toxicol. Environ. Sci.11:525-528 Hoshishima,K. \"Play\" Behavior and Trace Dose of Metal(s) in Mice 1983; TITLE="Play" Behavior and Trace Dose of Metal(s) in Mice; AUTHOR=Hoshishima,K.; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=78308; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=Avoidance: Avoidance, general; STUDY_GROUP=ECOTOX:15609257:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5d52b1746eec09b6fab55216d0e58290
ToxValDB_ECOTOX LOEL =0.00002 mmol Rat injection acute; 0.0104 days acute LONG_REF=Arch. Toxicol.74(1): 1-4 Sutoo,D., and K. Akiyama Effect of Cadmium or Magnesium on Calcium-Dependent Central Function that Reduces Blood Pressure 2000; TITLE=Effect of Cadmium or Magnesium on Calcium-Dependent Central Function that Reduces Blood Pressure; AUTHOR=Sutoo,D., and K. Akiyama; DOI=10.1007/s002040050644; QUALITY=Control type: Baseline control; EXTERNAL_SOURCE_ID=83743; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Physiology: Blood pressure; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX:15610489:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2cbdb82a9b1f3b52226a9a94fece7015
ToxValDB_ECOTOX NOEL =0.5 % Mouse oral subchronic; 56 days subchronic LONG_REF=Food Chem. Toxicol.27(9): 559-563 Kurata,Y., S. Tamano, M.A. Shibata, A. Hagiwara, S. Fukushima, and N. Ito Lack of Carcinogenicity of Magnesium Chloride in a Long-Term Feeding Study in B6C3F1 Mice 1989; TITLE=Lack of Carcinogenicity of Magnesium Chloride in a Long-Term Feeding Study in B6C3F1 Mice; AUTHOR=Kurata,Y., S. Tamano, M.A. Shibata, A. Hagiwara, S. Fukushima, and N. Ito; DOI=10.1016/0278-6915(89)90014-8; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=107453; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598381_15598382:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2d7e092f86c08e6275ce0dae6b8b9da7
ToxValDB_ECOTOX NOEL =2 % Mouse oral chronic; 672 days chronic LONG_REF=Food Chem. Toxicol.27(9): 559-563 Kurata,Y., S. Tamano, M.A. Shibata, A. Hagiwara, S. Fukushima, and N. Ito Lack of Carcinogenicity of Magnesium Chloride in a Long-Term Feeding Study in B6C3F1 Mice 1989; TITLE=Lack of Carcinogenicity of Magnesium Chloride in a Long-Term Feeding Study in B6C3F1 Mice; AUTHOR=Kurata,Y., S. Tamano, M.A. Shibata, A. Hagiwara, S. Fukushima, and N. Ito; DOI=10.1016/0278-6915(89)90014-8; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=107453; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Histology: Lesions; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX:15599899:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f4365d78e816349197e1cb2952d71225
ToxValDB_ECOTOX NOEL =2.5 % Mouse oral chronic; 91 days chronic LONG_REF=Toxicol. Lett.73(1): 25-32 Tanaka,H., A. Hagiwara, Y. Kurata, T. Ogiso, M. Futakuchi, and N. Ito Thirteen-Week Oral Toxicity Study of Magnesium Chloride in B6C3F1 Mice 1994; TITLE=Thirteen-Week Oral Toxicity Study of Magnesium Chloride in B6C3F1 Mice; AUTHOR=Tanaka,H., A. Hagiwara, Y. Kurata, T. Ogiso, M. Futakuchi, and N. Ito; DOI=10.1016/0378-4274(94)90185-6; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=106328; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Histology: Vacuolization; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15607650_15607651_15607653_15607654:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e0cbd05e0c926dde0277f96806148706
ToxValDB_ECOTOX NOEL =1.25 % Mouse oral chronic; 91 days chronic LONG_REF=Toxicol. Lett.73(1): 25-32 Tanaka,H., A. Hagiwara, Y. Kurata, T. Ogiso, M. Futakuchi, and N. Ito Thirteen-Week Oral Toxicity Study of Magnesium Chloride in B6C3F1 Mice 1994; TITLE=Thirteen-Week Oral Toxicity Study of Magnesium Chloride in B6C3F1 Mice; AUTHOR=Tanaka,H., A. Hagiwara, Y. Kurata, T. Ogiso, M. Futakuchi, and N. Ito; DOI=10.1016/0378-4274(94)90185-6; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=106328; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15607650_15607651_15607653_15607654:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f7ced18b6a8ead560b64477d51939dc6
ToxValDB_ECOTOX NOEL =20 mg/L Rat oral chronic; 196 days chronic LONG_REF=Jpn. J. Cancer Res.81(12): 1239-1246 Rao,A.R.N., A.R. Rao, L.N. Jannu, and S.P. Hussain Chemoprevention of 7,12-Dimethylbenz(a)anthracene-Induced Mammary Carcinogenesis in Rat by the Combined Actions of Selenium, Magnesium, Ascorbic Acid and Retinyl Acetate 1990; TITLE=Chemoprevention of 7,12-Dimethylbenz(a)anthracene-Induced Mammary Carcinogenesis in Rat by the Combined Actions of Selenium, Magnesium, Ascorbic Acid and Retinyl Acetate; AUTHOR=Rao,A.R.N., A.R. Rao, L.N. Jannu, and S.P. Hussain; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=92460; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=Injury: Tumor induction; TOXICOLOGICAL_EFFECT_CATEGORY=cancer; STUDY_GROUP=ECOTOX:15610988:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=39106099bdb23abaec2904f633a9e9c5
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 59XN63C8VM UNII - - - chemical {"approval_status":null,"molecular_formula":"2Cl.Mg","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"59XN63C8VM"}
openFDA substances FDA UNII substance identifier 59XN63C8VM UNII - - - chemical {"approval_status":null,"molecular_formula":"2Cl.Mg","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"59XN63C8VM"}
openFDA substances FDA UNII substance identifier 59XN63C8VM UNII - - - chemical {"approval_status":null,"molecular_formula":"2Cl.Mg","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"59XN63C8VM"}
openFDA substances FDA UNII substance identifier 59XN63C8VM UNII - - - chemical {"approval_status":null,"molecular_formula":"2Cl.Mg","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"59XN63C8VM"}