Is Bis-Trimethylbenzoyl Phenylphosphine Oxide safe in cosmetics?
Bis-Trimethylbenzoyl Phenylphosphine Oxide has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Bis-Trimethylbenzoyl Phenylphosphine Oxide
Also known as: Phosphine oxide, phenylbis(2,4,6-trimethylbenzoyl)-
INCI: BIS-TRIMETHYLBENZOYL PHENYLPHOSPHINE OXIDE
Bis-Trimethylbenzoyl Phenylphosphine Oxide (CAS 162881-26-7) is a cosmetic cosmetic ingredient functioning as Photoinitiator / Artificial nail builder. NOAEL 15 mg/kg bw/day (PDF-verified against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 162881-26-7 →
Auto-generated CPSR Part A draft with source citations
Function
Photoinitiator / Artificial nail builder
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
[phenyl-(2,4,6-trimethylbenzoyl)phosphoryl]-(2,4,6-trimethylphenyl)methanone
InChIKey
GUCYFKSBFREPBC-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR Draft Tentative Report (2025) on Phosphine Oxide ingredients; related TPO (Trimethylbenzoyl Diphenylphosphine Oxide) assessed — safe when formulated to prevent sensitization
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Bis-Trimethylbenzoyl Phenylphosphine Oxide.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Bis-Trimethylbenzoyl Phenylphosphine Oxide across SCCS product categories, with measured dermal absorption where available.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
Harmful / Irritant
Hazard Class and Category
Skin Sens. 1A; Aquatic Chronic 4
Hazard Statements
- H317 May cause an allergic skin reaction
- H413 May cause long lasting harmful effects to aquatic life
Inserted via ATP: ATP14
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Catalyst
Photosensitizers
Stabilizing agent
Expert Verdict
Expert safety assessment and concern-level summary for Bis-Trimethylbenzoyl Phenylphosphine Oxide.
Regulatory Flags
potential-allergen
Known Synonyms
Phosphine oxide, phenylbis(2,4,6-trimethylbenzoyl)-
Chemical Function
Stabilizing agent
Photosensitizers
Catalyst
Australian Status
AICIS status: listed_with_terms
Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.
Frequently Asked Questions
Is Bis-Trimethylbenzoyl Phenylphosphine Oxide allowed in the EU?
Bis-Trimethylbenzoyl Phenylphosphine Oxide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Bis-Trimethylbenzoyl Phenylphosphine Oxide do in cosmetics?
Bis-Trimethylbenzoyl Phenylphosphine Oxide functions as: Photoinitiator / Artificial nail builder. It is classified as a cosmetic ingredient in our database. CAS number: 162881-26-7.
Is Bis-Trimethylbenzoyl Phenylphosphine Oxide used outside cosmetics?
Bis-Trimethylbenzoyl Phenylphosphine Oxide also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Bis-Trimethylbenzoyl Phenylphosphine Oxide compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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