Is Bifonazole safe in cosmetics?
Bifonazole has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Bifonazole
Also known as: 5-23-04-00292, 1-(alpha-(4-Biphenylyl)benzyl)imidazole, 1-((4-Biphenylyl)phenylmethyl)-1H-imidazole, BRN 0618427, EINECS 262-336-6 (+3 more)
INCI: BIFONAZOLE
Bifonazole (CAS 60628-96-8) is a cosmetic cosmetic ingredient functioning as Antifungal agent (pharmaceutical active, not a standard cosmetic function). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 60628-96-8 →
Auto-generated CPSR Part A draft with source citations
Function
Antifungal agent (pharmaceutical active, not a standard cosmetic function)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
1-[phenyl-(4-phenylphenyl)methyl]imidazole
InChIKey
OCAPBUJLXMYKEJ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Regulated as a drug ingredient (antifungal); not approved for over-the-counter cosmetic use; any product containing bifonazole would be classified as a drug
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Bifonazole.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-dandruff
Biocide
Expert Verdict
Expert safety assessment and concern-level summary for Bifonazole.
Regulatory Flags
potential-allergen
Known Synonyms
5-23-04-00292
1-(alpha-(4-Biphenylyl)benzyl)imidazole
1-((4-Biphenylyl)phenylmethyl)-1H-imidazole
BRN 0618427
EINECS 262-336-6
1H-Imidazole, 1-((1,1'-biphenyl)-4-ylphenylmethyl)-
Bifonazolum
UNII-QYJ305Z91O
Chemical Function
Biocide
Anti-dandruff
Regulatory Lists
pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
BIFONAZOLE
ChEMBL ID
CHEMBL277535
Max Phase
3
Frequently Asked Questions
Is Bifonazole allowed in the EU?
Bifonazole EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Bifonazole do in cosmetics?
Bifonazole functions as: Antifungal agent (pharmaceutical active, not a standard cosmetic function). It is classified as a cosmetic ingredient in our database. CAS number: 60628-96-8.
Is Bifonazole used outside cosmetics?
Bifonazole also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Bifonazole compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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