NOAEL Studies Fragrance

Beta-Caryophyllene NOAEL Studies

INCI: BETA-CARYOPHYLLENE

CAS: 87-44-5

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =222 mg/kg bw/day Rat oral: feed 90 days subchronic EFSA CEF - 2015 - OutputID 2635 - haematology - systemic - Scientific Opinion on Flavouring Group Evaluation 78, Revision 2 (FGE.78Rev2): Consideration of aliphatic and alicyclic and aromatic hydrocarbons evaluated by JECFA (63rd meeting) structurally related to aliphatic hydrocarbons evaluated by EFSA in FGE.25Rev3. - doi:10.2903/j.efsa.2015.4067
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =222 mg/kg bw/day Rat oral: feed 90 days subchronic EFSA CEF - 2015 - OutputID 2635 - haematology - systemic - Scientific Opinion on Flavouring Group Evaluation 78, Revision 2 (FGE.78Rev2): Consideration of aliphatic and alicyclic and aromatic hydrocarbons evaluated by JECFA (63rd meeting) structurally related to aliphatic hydrocarbons evaluated by EFSA in FGE.25Rev3. - doi:10.2903/j.efsa.2015.4067
EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx NOAEL =200 mg/kg bw/day Rat oral: feed 90 days subchronic ENDPOINTSTUDY_ID 701320; TOX_ID 12931 - OP_ID 3354 - EFSA FEEDAP - 2019 - Safety and efficacy of an essential oil from Origanum vulgare ssp. hirtum (Link) Ietsw. for all animal species - doi:10.2903/j.efsa.2019.5909
EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx NOAEL =200 mg/kg bw/day Rat oral: feed 90 days subchronic ENDPOINTSTUDY_ID 701320; TOX_ID 12931 - OP_ID 3354 - EFSA FEEDAP - 2019 - Safety and efficacy of an essential oil from Origanum vulgare ssp. hirtum (Link) Ietsw. for all animal species - doi:10.2903/j.efsa.2019.5909
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=10898; Record_ID=skin_sensitization_invivo_2380; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8024739; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1971: report to RIFM|Opdyke 1973; Not available; 10.1016/0015-6264(73)90250-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024739; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024739
NTP_ICE_skin_sensitization Induction dose per skin area 2592 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=10897; Record_ID=skin_sensitization_invivo_2380; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8024739; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=2592; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1971: report to RIFM|Opdyke 1973; Not available; 10.1016/0015-6264(73)90250-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024739; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024739
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=10901; Record_ID=skin_sensitization_invivo_2380; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8024739; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1971: report to RIFM|Opdyke 1973; Not available; 10.1016/0015-6264(73)90250-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024739; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024739
ToxValDB_EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA NOAEL =222 mg/kg bw/day Rat oral subchronic; 90 days subchronic LONG_REF=EFSA CEF (2015). Scientific Opinion on Flavouring Group Evaluation 78, Revision 2 (FGE.78Rev2): Consideration of aliphatic and alicyclic and aromatic hydrocarbons evaluated by JECFA (63rd meeting) structurally related to aliphatic hydrocarbons evaluated by EFSA in FGE.25Rev3. doi:10.2903/j.efsa.2015.4067.; TITLE=Scientific Opinion on Flavouring Group Evaluation 78, Revision 2 (FGE.78Rev2): Consideration of aliphatic and alicyclic and aromatic hydrocarbons evaluated by JECFA (63rd meeting) structurally related to aliphatic hydrocarbons evaluated by EFSA in FGE.25Rev3.; AUTHOR=EFSA CEF; DOI=doi:10.2903/j.efsa.2015.4067; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2015; ORIGINAL_YEAR=2015; TOXICOLOGICAL_EFFECT=hematological; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=EFSA_dup_-_15621534_15621535:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_938f63e65a2c11ecf75ef4c8ee7187f5
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier BHW853AU9H UNII - - - chemical {"approval_status":null,"molecular_formula":"C15H24","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"BHW853AU9H"}
openFDA substances FDA UNII substance identifier BHW853AU9H UNII - - - chemical {"approval_status":null,"molecular_formula":"C15H24","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"BHW853AU9H"}
openFDA substances FDA UNII substance identifier BHW853AU9H UNII - - - chemical {"approval_status":null,"molecular_formula":"C15H24","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"BHW853AU9H"}
openFDA substances FDA UNII substance identifier BHW853AU9H UNII - - - chemical {"approval_status":null,"molecular_formula":"C15H24","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"BHW853AU9H"}