NOAEL Studies
Cosmetic Ingredient
Benzylparaben NOAEL Studies
INCI: BENZYLPARABEN
CAS: 94-18-8
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP_ICE_adme_parameters 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_adme_parameters | Clint | 633 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=3569; Record_ID=adme_parameters_791; Data_Type=Measured; DTXSID=DTXSID9022526; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=633.0; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9022526 |
| NTP_ICE_adme_parameters | Clint | 639.1 | uL/min/10^6 cells | Rat | - | - | Measured; httk, Rat Hepatic Intrinsic Clearance | sheet=Data; excel_row=3571; Record_ID=adme_parameters_791; Data_Type=Measured; DTXSID=DTXSID9022526; Assay=httk, Rat Hepatic Intrinsic Clearance; Endpoint=Clint; Response=639.1; Response_Unit=ul/min/10^6 cells; Species=Rat; Reference=httk2.3.1, Honda 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9022526 |
| NTP_ICE_adme_parameters | Fu | 0.00674 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=3570; Record_ID=adme_parameters_791; Data_Type=Measured; DTXSID=DTXSID9022526; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.00674; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9022526 |
NTP_ICE_endocrine 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | AC50 | 5.84189349377303 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=5386; RecordID=ERPathway2016_195; DatasetName=ERPathway2016; DTXSID=DTXSID9022526; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=5.84189349377303; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9022526 |
| NTP_ICE_endocrine | ACC | 1.761544913204 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=5387; RecordID=ERPathway2016_195; DatasetName=ERPathway2016; DTXSID=DTXSID9022526; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=1.761544913204; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9022526 |
| NTP_ICE_endocrine | LOEL | 0.16 | mg/kg bw/day | Rat | Oral | Treatment_Duration=3 days; Age_at_First_Dose=PND 21; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=2 to 5 | In Vivo; Uterotrophic-Agonist | sheet=Data_invivo; excel_row=1048; Record_ID=endocrine_invivo_411; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID9022526; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=0.16; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=SD; Strain=Sprague-Dawley; Sex=Female; Route=Oral; Maximum_Dose=100; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Hu et al. 2013; 23220609; 10.1016/j.fct.2012.11.043|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9022526 |
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=5382; RecordID=ARPathway2016_1737; DatasetName=ARPathway2016; DTXSID=DTXSID9022526; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9022526 |
| NTP_ICE_endocrine | Model Score | 0.234 | unitless | - | - | - | ERPathway2016; ER Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=5388; RecordID=ERPathway2016_195; DatasetName=ERPathway2016; DTXSID=DTXSID9022526; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.234; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9022526 |
| NTP_ICE_endocrine | Uterine weight increase vs control | 120 | % | Rat | Oral | Treatment_Duration=3 days; Age_at_First_Dose=PND 21; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=2 to 5 | In Vivo; Uterotrophic-Agonist | sheet=Data_invivo; excel_row=733; Record_ID=endocrine_invivo_411; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID9022526; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=120; Response_Unit=%; Species=Rat; Reported_Strain=SD; Strain=Sprague-Dawley; Sex=Female; Route=Oral; Maximum_Dose=100; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Hu et al. 2013; 23220609; 10.1016/j.fct.2012.11.043|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9022526 |
ToxValDB_ECHA_IUCLID 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | LEL | =0.16 | mg/kg bw/day | Rat | oral | short-term; 3 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cc27e4b0a7c65d2292fc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17658/7/6/2?documentUUID=9b735672-9ba2-473a-af73-e79c9b9f63d1; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15841986:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_84785213e86c1690ba60be8cb45dcc08 |
| ToxValDB_ECHA_IUCLID | LOAEL | =33 | mg/kg bw/day | Mouse | dermal | short-term; 3 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61f82e4b096bca877dccc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17658/7/6/4?documentUUID=9b735672-9ba2-473a-af73-e79c9b9f63d1; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826870_15826871:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b93f0059274d962c50ce7a8424301f2b |
| ToxValDB_ECHA_IUCLID | NOAEL | =10 | mg/kg bw/day | Mouse | dermal | short-term; 3 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61f82e4b096bca877dccc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17658/7/6/4?documentUUID=9b735672-9ba2-473a-af73-e79c9b9f63d1; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826870_15826871:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_149a5ba56347fb4bdfb21348b5944f39 |
| ToxValDB_ECHA_IUCLID | NOAEL | =3000 | mg/kg bw/day | Mouse | oral | short-term; 5 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cc27e4b0a7c65d2292f2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17658/7/6/2?documentUUID=9b735672-9ba2-473a-af73-e79c9b9f63d1; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15840987:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9c98bee243f6aea3056aecd18057d81c |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =0.33 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630069:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_eb76f3d1cfd2bbce595f1305aae94171 |
ToxValDB_Uterotrophic_Hershberger_DB 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_Uterotrophic_Hershberger_DB | LEL | =0.16 | mg/kg bw/day | Rat | oral | short-term; 3 days | uterotrophic | LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713443:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fcdf87201af9e79d87761cf7931d3095 |
| ToxValDB_Uterotrophic_Hershberger_DB | LEL | =100 | mg/day | Mouse | dermal | short-term; 3 days | uterotrophic | LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713377:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_736e16752c6803fe679ea0f892a46a3d |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 8Y41DYV4VG | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C14H12O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8Y41DYV4VG"} |
| openFDA substances | FDA UNII substance identifier | 8Y41DYV4VG | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C14H12O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8Y41DYV4VG"} |
| openFDA substances | FDA UNII substance identifier | 8Y41DYV4VG | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C14H12O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8Y41DYV4VG"} |
| openFDA substances | FDA UNII substance identifier | 8Y41DYV4VG | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C14H12O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8Y41DYV4VG"} |