NOAEL Studies Cosmetic Ingredient

Benzyl Isovalerate NOAEL Studies

INCI: BENZYL ISOVALERATE

CAS: 103-38-8

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 >5000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_324; row=3238; data_type=In Vivo; mixture=Chemical; chemical_name=Benzyl 3-methylbutanoate; preferred_name=Benzyl 3-methylbutanoate; dtxsid=DTXSID1047603; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1047603; source_file=acute_oral.xlsx
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2097; Record_ID=skin_sensitization_invivo_611; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1047603; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Epstein 1974: report to RIFM|Opdyke 1974; Not available; 10.1016/0015-6264(74)90139-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1047603
NTP_ICE_skin_sensitization Induction dose per skin area 2592 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2096; Record_ID=skin_sensitization_invivo_611; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1047603; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=2592; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Epstein 1974: report to RIFM|Opdyke 1974; Not available; 10.1016/0015-6264(74)90139-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1047603
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2099; Record_ID=skin_sensitization_invivo_611; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1047603; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Epstein 1974: report to RIFM|Opdyke 1974; Not available; 10.1016/0015-6264(74)90139-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1047603
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 87UKH01DMA UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H16O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"87UKH01DMA"}
openFDA substances FDA UNII substance identifier 87UKH01DMA UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H16O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"87UKH01DMA"}
openFDA substances FDA UNII substance identifier 87UKH01DMA UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H16O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"87UKH01DMA"}
openFDA substances FDA UNII substance identifier 87UKH01DMA UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H16O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"87UKH01DMA"}