NOAEL Studies Cosmetic Ingredient

Benzyl Butyrate NOAEL Studies

INCI: BENZYL BUTYRATE

CAS: 103-37-7

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 21 mg/kg bw/day rat oral 84 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =2330 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_322; row=12615; data_type=In Vivo; mixture=Chemical; chemical_name=Benzyl butyrate; preferred_name=Benzyl butyrate; dtxsid=DTXSID7047510; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7047510; source_file=acute_oral.xlsx
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2093; Record_ID=skin_sensitization_invivo_610; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7047510; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1973: report to RlFM|RIFM 1973; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1974; Not available; 10.1016/0015-6264(74)90138-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7047510
NTP_ICE_skin_sensitization Induction dose per skin area 2592 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2092; Record_ID=skin_sensitization_invivo_610; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7047510; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=2592; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1973: report to RlFM|RIFM 1973; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1974; Not available; 10.1016/0015-6264(74)90138-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7047510
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2095; Record_ID=skin_sensitization_invivo_610; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7047510; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1973: report to RlFM|RIFM 1973; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1974; Not available; 10.1016/0015-6264(74)90138-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7047510
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =27.4 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630062:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b16f1b93dde26c512d426fc3f270ad3c
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 84L0NDE31F UNII - - - chemical {"approval_status":null,"molecular_formula":"C11H14O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"84L0NDE31F"}
openFDA substances FDA UNII substance identifier 84L0NDE31F UNII - - - chemical {"approval_status":null,"molecular_formula":"C11H14O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"84L0NDE31F"}
openFDA substances FDA UNII substance identifier 84L0NDE31F UNII - - - chemical {"approval_status":null,"molecular_formula":"C11H14O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"84L0NDE31F"}
openFDA substances FDA UNII substance identifier 84L0NDE31F UNII - - - chemical {"approval_status":null,"molecular_formula":"C11H14O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"84L0NDE31F"}