NOAEL Studies
Cosmetic Ingredient
Benzyl Acetate NOAEL Studies
INCI: BENZYL ACETATE
CAS: 140-11-4
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
IARC Monographs 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 1998 | IARC Monographs | {"additional_info":"volume_publication_year=1999","evaluation_year":1998,"source_table":"iarc_classifications","volume":"40, Sup 7, 71"} |
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 1998 | IARC Monographs | {"additional_info":"volume_publication_year=1999","evaluation_year":1998,"source_table":"iarc_classifications","volume":"40, Sup 7, 71"} |
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 1998 | IARC Monographs | {"additional_info":"volume_publication_year=1999","evaluation_year":1998,"source_table":"iarc_classifications","volume":"40, Sup 7, 71"} |
INCHEM_WHO_jecfa_jecmono_v26je03 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| INCHEM_WHO_jecfa_jecmono_v26je03 | ADI | range:0-55 | mg/kg bw/day | - | - | - | Health guidance value | document_id=jecfa_jecmono_v26je03; title=682. Benzyl acetate (WHO Food Additives Series 26); path=mirror/documents/jecfa/jecmono/v26je03.htm; row_hash=3b79715312c4c16b; raw_unit=mg/kg bw/day; context=The ADI of 0-5 mg/kg bw/day which was established at the eleventh Meeting was made temporary at the twenty-seventh meeting. |
| INCHEM_WHO_jecfa_jecmono_v26je03 | ADI | range:0-55 | mg/kg bw/day | - | - | - | Health guidance value | document_id=jecfa_jecmono_v26je03; title=682. Benzyl acetate (WHO Food Additives Series 26); path=mirror/documents/jecfa/jecmono/v26je03.htm; row_hash=3b79715312c4c16b; raw_unit=mg/kg bw/day; context=The ADI of 0-5 mg/kg bw/day which was established at the eleventh Meeting was made temporary at the twenty-seventh meeting. |
INCHEM_WHO_jecfa_jecmono_v32je03 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| INCHEM_WHO_jecfa_jecmono_v32je03 | ADI | range:0-55 | mg/kg bw/day | Rat; Mouse | - | long-term | Health guidance value | document_id=jecfa_jecmono_v32je03; title=785. Benzyl acetate (WHO Food Additives Series 32); path=mirror/documents/jecfa/jecmono/v32je03.htm; row_hash=ce6e9faa47ea1226; raw_unit=mg per kg; context=rcinogenicity study in mice and on the basis of the NOEL of 550 mg per kg of body weight per day in the long-term study in rats, the Committee included benzyl acetate in the group ADI of 0-5 mg per kg of body weight with benzyl alcohol, benzaldehyde and benzoic acid, and the benzoate salts. |
| INCHEM_WHO_jecfa_jecmono_v32je03 | ADI | range:0-55 | mg/kg bw/day | Rat; Mouse | - | long-term | Health guidance value | document_id=jecfa_jecmono_v32je03; title=785. Benzyl acetate (WHO Food Additives Series 32); path=mirror/documents/jecfa/jecmono/v32je03.htm; row_hash=ce6e9faa47ea1226; raw_unit=mg per kg; context=rcinogenicity study in mice and on the basis of the NOEL of 550 mg per kg of body weight per day in the long-term study in rats, the Committee included benzyl acetate in the group ADI of 0-5 mg per kg of body weight with benzyl alcohol, benzaldehyde and benzoic acid, and the benzoate salts. |
| INCHEM_WHO_jecfa_jecmono_v32je03 | NOEL | =550 | mg/kg bw/day | Rat; Mouse | - | long-term | Carcinogenicity | document_id=jecfa_jecmono_v32je03; title=785. Benzyl acetate (WHO Food Additives Series 32); path=mirror/documents/jecfa/jecmono/v32je03.htm; row_hash=21d708830efc1a8e; raw_unit=mg per kg; context=EVALUATION In the absence of associated pathological lesions in the long-term toxicity/carcinogenicity study in mice and on the basis of the NOEL of 550 mg per kg of body weight per day in the long-term study in rats, the Committee included benzyl acetate in the group ADI of 0-5 mg per kg of body weight with benzyl alcohol, benzaldehyde and benzoic acid, and the benzoate salts. |
| INCHEM_WHO_jecfa_jecmono_v32je03 | NOEL | =550 | mg/kg bw/day | Rat; Mouse | - | long-term | Carcinogenicity | document_id=jecfa_jecmono_v32je03; title=785. Benzyl acetate (WHO Food Additives Series 32); path=mirror/documents/jecfa/jecmono/v32je03.htm; row_hash=21d708830efc1a8e; raw_unit=mg per kg; context=EVALUATION In the absence of associated pathological lesions in the long-term toxicity/carcinogenicity study in mice and on the basis of the NOEL of 550 mg per kg of body weight per day in the long-term study in rats, the Committee included benzyl acetate in the group ADI of 0-5 mg per kg of body weight with benzyl alcohol, benzaldehyde and benzoic acid, and the benzoate salts. |
INCHEM_WHO_jecfa_jecmono_v37je05 14 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| INCHEM_WHO_jecfa_jecmono_v37je05 | LOAEL | =750 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v37je05; title=868. Benzyl acetate (WHO Food Additives Series 37); path=mirror/documents/jecfa/jecmono/v37je05.htm; row_hash=d9a91d764ab57bdc; raw_unit=mg/kg bw per day; context=The LOAEL was 750 mg/kg bw per day (US National Institute of Occupational Safety and Health, 1983; |
| INCHEM_WHO_jecfa_jecmono_v37je05 | LOAEL | =750 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v37je05; title=868. Benzyl acetate (WHO Food Additives Series 37); path=mirror/documents/jecfa/jecmono/v37je05.htm; row_hash=d9a91d764ab57bdc; raw_unit=mg/kg bw per day; context=The LOAEL was 750 mg/kg bw per day (US National Institute of Occupational Safety and Health, 1983; |
| INCHEM_WHO_jecfa_jecmono_v37je05 | NOAEL | =550 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v37je05; title=868. Benzyl acetate (WHO Food Additives Series 37); path=mirror/documents/jecfa/jecmono/v37je05.htm; row_hash=7c54defd8f10f3e2; raw_unit=mg/kg bw per day; context=The NOAEL was 550 mg/kg bw per day (York et al., 1986). |
| INCHEM_WHO_jecfa_jecmono_v37je05 | NOAEL | ~5 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v37je05; title=868. Benzyl acetate (WHO Food Additives Series 37); path=mirror/documents/jecfa/jecmono/v37je05.htm; row_hash=478778817867013b; raw_unit=mg/kg bw per day; context=The NOAEL was about 5 mg/kg bw per day (Sporn et al., 1967). |
| INCHEM_WHO_jecfa_jecmono_v37je05 | NOAEL | =500 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v37je05; title=868. Benzyl acetate (WHO Food Additives Series 37); path=mirror/documents/jecfa/jecmono/v37je05.htm; row_hash=4fa6687ebb1d98be; raw_unit=mg/kg bw per day; context=The NOAEL was 500 mg/kg bw per day on the basis of fetotoxic effects at the highest dose tested (Ishiguro et al., 1993). |
| INCHEM_WHO_jecfa_jecmono_v37je05 | NOAEL | =315 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v37je05; title=868. Benzyl acetate (WHO Food Additives Series 37); path=mirror/documents/jecfa/jecmono/v37je05.htm; row_hash=db5778da3d8e1760; raw_unit=mg/kg bw per day; context=The apparent NOAEL in this study was 315 mg/kg bw per day (Minor & Becker, 1971). |
| INCHEM_WHO_jecfa_jecmono_v37je05 | NOAEL | =175 | mg/kg bw/day | Rat; Mouse; Rabbit; Hamster | - | - | Toxicology study | document_id=jecfa_jecmono_v37je05; title=868. Benzyl acetate (WHO Food Additives Series 37); path=mirror/documents/jecfa/jecmono/v37je05.htm; row_hash=434b7caafd7608fd; raw_unit=mg/kg bw per day; context=As no adverse effects occurred with any of the treatment schedules, the NOAEL values were 175 mg/kg bw per day for mice and rats, 300 mg/kg bw per day for hamsters, and 250 mg/kg bw per day for rabbits. |
| INCHEM_WHO_jecfa_jecmono_v37je05 | NOAEL | =1310 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v37je05; title=868. Benzyl acetate (WHO Food Additives Series 37); path=mirror/documents/jecfa/jecmono/v37je05.htm; row_hash=2c4970490ed0bb8c; raw_unit=mg/kg bw per day; context=The NOAEL was 1310 mg/kg bw per day (Onodera et al., 1978). |
| INCHEM_WHO_jecfa_jecmono_v37je05 | NOAEL | =550 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v37je05; title=868. Benzyl acetate (WHO Food Additives Series 37); path=mirror/documents/jecfa/jecmono/v37je05.htm; row_hash=7c54defd8f10f3e2; raw_unit=mg/kg bw per day; context=The NOAEL was 550 mg/kg bw per day (York et al., 1986). |
| INCHEM_WHO_jecfa_jecmono_v37je05 | NOAEL | ~5 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v37je05; title=868. Benzyl acetate (WHO Food Additives Series 37); path=mirror/documents/jecfa/jecmono/v37je05.htm; row_hash=478778817867013b; raw_unit=mg/kg bw per day; context=The NOAEL was about 5 mg/kg bw per day (Sporn et al., 1967). |
| INCHEM_WHO_jecfa_jecmono_v37je05 | NOAEL | =500 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v37je05; title=868. Benzyl acetate (WHO Food Additives Series 37); path=mirror/documents/jecfa/jecmono/v37je05.htm; row_hash=4fa6687ebb1d98be; raw_unit=mg/kg bw per day; context=The NOAEL was 500 mg/kg bw per day on the basis of fetotoxic effects at the highest dose tested (Ishiguro et al., 1993). |
| INCHEM_WHO_jecfa_jecmono_v37je05 | NOAEL | =315 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v37je05; title=868. Benzyl acetate (WHO Food Additives Series 37); path=mirror/documents/jecfa/jecmono/v37je05.htm; row_hash=db5778da3d8e1760; raw_unit=mg/kg bw per day; context=The apparent NOAEL in this study was 315 mg/kg bw per day (Minor & Becker, 1971). |
| INCHEM_WHO_jecfa_jecmono_v37je05 | NOAEL | =175 | mg/kg bw/day | Rat; Mouse; Rabbit; Hamster | - | - | Toxicology study | document_id=jecfa_jecmono_v37je05; title=868. Benzyl acetate (WHO Food Additives Series 37); path=mirror/documents/jecfa/jecmono/v37je05.htm; row_hash=434b7caafd7608fd; raw_unit=mg/kg bw per day; context=As no adverse effects occurred with any of the treatment schedules, the NOAEL values were 175 mg/kg bw per day for mice and rats, 300 mg/kg bw per day for hamsters, and 250 mg/kg bw per day for rabbits. |
| INCHEM_WHO_jecfa_jecmono_v37je05 | NOAEL | =1310 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v37je05; title=868. Benzyl acetate (WHO Food Additives Series 37); path=mirror/documents/jecfa/jecmono/v37je05.htm; row_hash=2c4970490ed0bb8c; raw_unit=mg/kg bw per day; context=The NOAEL was 1310 mg/kg bw per day (Onodera et al., 1978). |
INCHEM_WHO_jecfa_jecmono_v52je14 26 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| INCHEM_WHO_jecfa_jecmono_v52je14 | ADI | =25 | mg/kg bw/day | - | oral | - | Health guidance value | document_id=jecfa_jecmono_v52je14; title=ALIPHATIC, ALICYCLIC, LINEAR, alpha,beta-UNSATURATED, DI-AND TRIENALS AND RELATED ALCOHOLS, ACIDS AND ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je14.htm; row_hash=f8f5867e8e2adf3b; raw_unit=mg/kg bw per day; context=1176, sorbic acid) in its capacity as an antimicrobial preservative at the seventeenth meeting (Annex 1, reference 32 ), when an ADI of 025 mg/kg bw per day was established. alpha,beta- Unsaturated aldehydes are formed endogenously by lipid peroxidation of polyunsaturated fatty acids (Frankel et al. , 1987) or can be consumed as naturally-occurring constituents of food (Stofberg & Grundschober, 1987; |
| INCHEM_WHO_jecfa_jecmono_v52je14 | ADI | =25 | mg/kg bw/day | - | oral | - | Health guidance value | document_id=jecfa_jecmono_v52je14; title=ALIPHATIC, ALICYCLIC, LINEAR, alpha,beta-UNSATURATED, DI-AND TRIENALS AND RELATED ALCOHOLS, ACIDS AND ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je14.htm; row_hash=f8f5867e8e2adf3b; raw_unit=mg/kg bw per day; context=1176, sorbic acid) in its capacity as an antimicrobial preservative at the seventeenth meeting (Annex 1, reference 32 ), when an ADI of 025 mg/kg bw per day was established. alpha,beta- Unsaturated aldehydes are formed endogenously by lipid peroxidation of polyunsaturated fatty acids (Frankel et al. , 1987) or can be consumed as naturally-occurring constituents of food (Stofberg & Grundschober, 1987; |
| INCHEM_WHO_jecfa_jecmono_v52je14 | NOEL | =15 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v52je14; title=ALIPHATIC, ALICYCLIC, LINEAR, alpha,beta-UNSATURATED, DI-AND TRIENALS AND RELATED ALCOHOLS, ACIDS AND ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je14.htm; row_hash=d8850d268943d27b; raw_unit=mg/kg body weight per day; context=The NOEL of 15 mg/kg body weight per day (National Toxicology Program, 2001) for the related substance trans,trans -2,4-hexadienal is >1 million times the estimated daily intake of 2,4-pentadienal when used as a flavouring agent. |
| INCHEM_WHO_jecfa_jecmono_v52je14 | NOEL | =33.9 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v52je14; title=ALIPHATIC, ALICYCLIC, LINEAR, alpha,beta-UNSATURATED, DI-AND TRIENALS AND RELATED ALCOHOLS, ACIDS AND ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je14.htm; row_hash=2aa4c6228d2f8f17; raw_unit=mg/kg bw per day; context=The NOEL of 33.9 mg/kg bw per day (Damske et al., 1980) for the related substance 2- trans ,4- trans -decadienal is >10 000 times the estimated daily intake of 2,4-nonadien-1-ol when used as a flavouring agent. |
| INCHEM_WHO_jecfa_jecmono_v52je14 | NOEL | =33 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v52je14; title=ALIPHATIC, ALICYCLIC, LINEAR, alpha,beta-UNSATURATED, DI-AND TRIENALS AND RELATED ALCOHOLS, ACIDS AND ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je14.htm; row_hash=134a6e1fe490cfc3; raw_unit=mg/kg bw per day; context=The NOEL of 33 mg/kg bw per day (Edwards, 1973) is >1 million times the estimated daily intake of 2- trans -4- cis -7-cis-tridecatrienal when used as a flavouring agent See note 1 CAS: |
| INCHEM_WHO_jecfa_jecmono_v52je14 | NOEL | =7.5 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v52je14; title=ALIPHATIC, ALICYCLIC, LINEAR, alpha,beta-UNSATURATED, DI-AND TRIENALS AND RELATED ALCOHOLS, ACIDS AND ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je14.htm; row_hash=9bec67673ff9fa95; raw_unit=mg /kg bw per day; context=Consequently, the NOEL for trans , trans -2,4-hexadienal was 7.5 mg /kg bw per day, the highest dose tested (de Groot et al., 1974). |
| INCHEM_WHO_jecfa_jecmono_v52je14 | NOEL | =2.23 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v52je14; title=ALIPHATIC, ALICYCLIC, LINEAR, alpha,beta-UNSATURATED, DI-AND TRIENALS AND RELATED ALCOHOLS, ACIDS AND ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je14.htm; row_hash=b849449841518f1e; raw_unit=mg/kg bw per day; context=The authors reported that the NOEL for 2,4-hexadienal was 2.23 mg/kg bw per day (Mecler & Craig, 1980). (ii) (E,E)-2,4-Hexadienoic acid (No. |
| INCHEM_WHO_jecfa_jecmono_v52je14 | NOEL | =400 | mg/kg bw/day | Mouse | - | - | Toxicology study | document_id=jecfa_jecmono_v52je14; title=ALIPHATIC, ALICYCLIC, LINEAR, alpha,beta-UNSATURATED, DI-AND TRIENALS AND RELATED ALCOHOLS, ACIDS AND ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je14.htm; row_hash=bbb7e161fa2c78ae; raw_unit=mg/kg bw per day; context=The NOEL for 2 -trans ,4 -trans -decadienal was 400 mg/kg bw per day in mice on the basis of no treatment-related effects at this dose (National Toxicology Program, 1997). |
| INCHEM_WHO_jecfa_jecmono_v52je14 | NOEL | =200 | mg/kg bw/day | Mouse | - | - | Toxicology study | document_id=jecfa_jecmono_v52je14; title=ALIPHATIC, ALICYCLIC, LINEAR, alpha,beta-UNSATURATED, DI-AND TRIENALS AND RELATED ALCOHOLS, ACIDS AND ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je14.htm; row_hash=7ba4592734c64ad6; raw_unit=mg/kg bw per day; context=On the basis of these findings, the NOEL for 2 -trans ,4 -trans -decadienal was 100 and 200 mg/kg bw per day for male and female B6C3F 1 mice, respectively (National Toxicology Program, 1997). |
| INCHEM_WHO_jecfa_jecmono_v52je14 | NOEL | =100 | mg/kg bw/day | Rat | - | 13-week | Subchronic toxicity | document_id=jecfa_jecmono_v52je14; title=ALIPHATIC, ALICYCLIC, LINEAR, alpha,beta-UNSATURATED, DI-AND TRIENALS AND RELATED ALCOHOLS, ACIDS AND ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je14.htm; row_hash=a2cefb03740af0a8; raw_unit=mg/kg bw per day; context=50 and 100 mg/kg bw per day) and the rats recovered from both within minutes, the NOEL for 2 -trans, 4 -trans -decadienal in this 13-week study in rats was 100 mg/kg bw per day (National Toxicology Program, 1997). |
| INCHEM_WHO_jecfa_jecmono_v52je14 | NOEL | =27 | mg/kg bw/day | Mouse | - | - | Toxicology study | document_id=jecfa_jecmono_v52je14; title=ALIPHATIC, ALICYCLIC, LINEAR, alpha,beta-UNSATURATED, DI-AND TRIENALS AND RELATED ALCOHOLS, ACIDS AND ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je14.htm; row_hash=1e65b4a62adf66bf; raw_unit=mg/kg bw per day; context=The NOEL for trans , trans - 2,4-hexadienal was 27 mg/kg bw per day in male and female mice (National Toxicology Program, 2001). |
| INCHEM_WHO_jecfa_jecmono_v52je14 | NOEL | =30 | mg/kg bw/day | Mouse | - | - | Toxicology study | document_id=jecfa_jecmono_v52je14; title=ALIPHATIC, ALICYCLIC, LINEAR, alpha,beta-UNSATURATED, DI-AND TRIENALS AND RELATED ALCOHOLS, ACIDS AND ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je14.htm; row_hash=48457813e59afb8d; raw_unit=mg/kg bw per day; context=The NOEL for trans , trans - 2,4-hexadienal was 30 mg/kg bw per day in male B6C3F 1 mice in this study. |
| INCHEM_WHO_jecfa_jecmono_v52je14 | NOEL | =60 | mg/kg bw/day | Rat | - | - | Toxicology study | document_id=jecfa_jecmono_v52je14; title=ALIPHATIC, ALICYCLIC, LINEAR, alpha,beta-UNSATURATED, DI-AND TRIENALS AND RELATED ALCOHOLS, ACIDS AND ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je14.htm; row_hash=01d96e87c962b9b9; raw_unit=mg/kg bw per day; context=The NOEL for trans,trans- 2,4-hexadienal was 15 and 60 mg/kg bw per day in male and female rats, respectively (National Toxicology Program, 2001). |
| INCHEM_WHO_jecfa_jecmono_v52je14 | NOEL | ~750 | mg/kg bw/day | Rat | - | - | Toxicology study | document_id=jecfa_jecmono_v52je14; title=ALIPHATIC, ALICYCLIC, LINEAR, alpha,beta-UNSATURATED, DI-AND TRIENALS AND RELATED ALCOHOLS, ACIDS AND ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je14.htm; row_hash=8b38e2a4f5ec2adc; raw_unit=mg/kg bw per day; context=The NOEL for ( E , E )-2,4-hexadienoic acid was 1.5%, equivalent to approximately 750 mg/kg bw per day in rats (Gaunt et al., 1975). |
| INCHEM_WHO_jecfa_jecmono_v52je14 | NOEL | =15 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v52je14; title=ALIPHATIC, ALICYCLIC, LINEAR, alpha,beta-UNSATURATED, DI-AND TRIENALS AND RELATED ALCOHOLS, ACIDS AND ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je14.htm; row_hash=d8850d268943d27b; raw_unit=mg/kg body weight per day; context=The NOEL of 15 mg/kg body weight per day (National Toxicology Program, 2001) for the related substance trans,trans -2,4-hexadienal is >1 million times the estimated daily intake of 2,4-pentadienal when used as a flavouring agent. |
| INCHEM_WHO_jecfa_jecmono_v52je14 | NOEL | =33.9 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v52je14; title=ALIPHATIC, ALICYCLIC, LINEAR, alpha,beta-UNSATURATED, DI-AND TRIENALS AND RELATED ALCOHOLS, ACIDS AND ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je14.htm; row_hash=2aa4c6228d2f8f17; raw_unit=mg/kg bw per day; context=The NOEL of 33.9 mg/kg bw per day (Damske et al., 1980) for the related substance 2- trans ,4- trans -decadienal is >10 000 times the estimated daily intake of 2,4-nonadien-1-ol when used as a flavouring agent. |
| INCHEM_WHO_jecfa_jecmono_v52je14 | NOEL | =33 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v52je14; title=ALIPHATIC, ALICYCLIC, LINEAR, alpha,beta-UNSATURATED, DI-AND TRIENALS AND RELATED ALCOHOLS, ACIDS AND ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je14.htm; row_hash=134a6e1fe490cfc3; raw_unit=mg/kg bw per day; context=The NOEL of 33 mg/kg bw per day (Edwards, 1973) is >1 million times the estimated daily intake of 2- trans -4- cis -7-cis-tridecatrienal when used as a flavouring agent See note 1 CAS: |
| INCHEM_WHO_jecfa_jecmono_v52je14 | NOEL | =7.5 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v52je14; title=ALIPHATIC, ALICYCLIC, LINEAR, alpha,beta-UNSATURATED, DI-AND TRIENALS AND RELATED ALCOHOLS, ACIDS AND ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je14.htm; row_hash=9bec67673ff9fa95; raw_unit=mg /kg bw per day; context=Consequently, the NOEL for trans , trans -2,4-hexadienal was 7.5 mg /kg bw per day, the highest dose tested (de Groot et al., 1974). |
| INCHEM_WHO_jecfa_jecmono_v52je14 | NOEL | =2.23 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v52je14; title=ALIPHATIC, ALICYCLIC, LINEAR, alpha,beta-UNSATURATED, DI-AND TRIENALS AND RELATED ALCOHOLS, ACIDS AND ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je14.htm; row_hash=b849449841518f1e; raw_unit=mg/kg bw per day; context=The authors reported that the NOEL for 2,4-hexadienal was 2.23 mg/kg bw per day (Mecler & Craig, 1980). (ii) (E,E)-2,4-Hexadienoic acid (No. |
| INCHEM_WHO_jecfa_jecmono_v52je14 | NOEL | =400 | mg/kg bw/day | Mouse | - | - | Toxicology study | document_id=jecfa_jecmono_v52je14; title=ALIPHATIC, ALICYCLIC, LINEAR, alpha,beta-UNSATURATED, DI-AND TRIENALS AND RELATED ALCOHOLS, ACIDS AND ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je14.htm; row_hash=bbb7e161fa2c78ae; raw_unit=mg/kg bw per day; context=The NOEL for 2 -trans ,4 -trans -decadienal was 400 mg/kg bw per day in mice on the basis of no treatment-related effects at this dose (National Toxicology Program, 1997). |
| INCHEM_WHO_jecfa_jecmono_v52je14 | NOEL | =200 | mg/kg bw/day | Mouse | - | - | Toxicology study | document_id=jecfa_jecmono_v52je14; title=ALIPHATIC, ALICYCLIC, LINEAR, alpha,beta-UNSATURATED, DI-AND TRIENALS AND RELATED ALCOHOLS, ACIDS AND ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je14.htm; row_hash=7ba4592734c64ad6; raw_unit=mg/kg bw per day; context=On the basis of these findings, the NOEL for 2 -trans ,4 -trans -decadienal was 100 and 200 mg/kg bw per day for male and female B6C3F 1 mice, respectively (National Toxicology Program, 1997). |
| INCHEM_WHO_jecfa_jecmono_v52je14 | NOEL | =100 | mg/kg bw/day | Rat | - | 13-week | Subchronic toxicity | document_id=jecfa_jecmono_v52je14; title=ALIPHATIC, ALICYCLIC, LINEAR, alpha,beta-UNSATURATED, DI-AND TRIENALS AND RELATED ALCOHOLS, ACIDS AND ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je14.htm; row_hash=a2cefb03740af0a8; raw_unit=mg/kg bw per day; context=50 and 100 mg/kg bw per day) and the rats recovered from both within minutes, the NOEL for 2 -trans, 4 -trans -decadienal in this 13-week study in rats was 100 mg/kg bw per day (National Toxicology Program, 1997). |
| INCHEM_WHO_jecfa_jecmono_v52je14 | NOEL | =27 | mg/kg bw/day | Mouse | - | - | Toxicology study | document_id=jecfa_jecmono_v52je14; title=ALIPHATIC, ALICYCLIC, LINEAR, alpha,beta-UNSATURATED, DI-AND TRIENALS AND RELATED ALCOHOLS, ACIDS AND ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je14.htm; row_hash=1e65b4a62adf66bf; raw_unit=mg/kg bw per day; context=The NOEL for trans , trans - 2,4-hexadienal was 27 mg/kg bw per day in male and female mice (National Toxicology Program, 2001). |
| INCHEM_WHO_jecfa_jecmono_v52je14 | NOEL | =30 | mg/kg bw/day | Mouse | - | - | Toxicology study | document_id=jecfa_jecmono_v52je14; title=ALIPHATIC, ALICYCLIC, LINEAR, alpha,beta-UNSATURATED, DI-AND TRIENALS AND RELATED ALCOHOLS, ACIDS AND ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je14.htm; row_hash=48457813e59afb8d; raw_unit=mg/kg bw per day; context=The NOEL for trans , trans - 2,4-hexadienal was 30 mg/kg bw per day in male B6C3F 1 mice in this study. |
| INCHEM_WHO_jecfa_jecmono_v52je14 | NOEL | =60 | mg/kg bw/day | Rat | - | - | Toxicology study | document_id=jecfa_jecmono_v52je14; title=ALIPHATIC, ALICYCLIC, LINEAR, alpha,beta-UNSATURATED, DI-AND TRIENALS AND RELATED ALCOHOLS, ACIDS AND ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je14.htm; row_hash=01d96e87c962b9b9; raw_unit=mg/kg bw per day; context=The NOEL for trans,trans- 2,4-hexadienal was 15 and 60 mg/kg bw per day in male and female rats, respectively (National Toxicology Program, 2001). |
| INCHEM_WHO_jecfa_jecmono_v52je14 | NOEL | ~750 | mg/kg bw/day | Rat | - | - | Toxicology study | document_id=jecfa_jecmono_v52je14; title=ALIPHATIC, ALICYCLIC, LINEAR, alpha,beta-UNSATURATED, DI-AND TRIENALS AND RELATED ALCOHOLS, ACIDS AND ESTERS (JECFA 52, 2004); path=mirror/documents/jecfa/jecmono/v52je14.htm; row_hash=8b38e2a4f5ec2adc; raw_unit=mg/kg bw per day; context=The NOEL for ( E , E )-2,4-hexadienoic acid was 1.5%, equivalent to approximately 750 mg/kg bw per day in rats (Gaunt et al., 1975). |
NTP_ICE_acute_oral 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | =2490 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM ChemIDplus TEST (undated); record_id=acute_oral_2540; row=227; data_type=In Vivo; mixture=Chemical; chemical_name=Benzyl acetate; preferred_name=Benzyl acetate; dtxsid=DTXSID0020151; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020151; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0020151; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | >2000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_2538; row=228; data_type=In Vivo; mixture=Chemical; chemical_name=Benzyl acetate; preferred_name=Benzyl acetate; dtxsid=DTXSID0020151; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020151; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0020151; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =2490 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM ChemIDplus TEST (undated); record_id=acute_oral_2540; row=227; data_type=In Vivo; mixture=Chemical; chemical_name=Benzyl acetate; preferred_name=Benzyl acetate; dtxsid=DTXSID0020151; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020151; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0020151; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | >2000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_2538; row=228; data_type=In Vivo; mixture=Chemical; chemical_name=Benzyl acetate; preferred_name=Benzyl acetate; dtxsid=DTXSID0020151; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020151; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0020151; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =2490 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM ChemIDplus TEST (undated); record_id=acute_oral_2540; row=227; data_type=In Vivo; mixture=Chemical; chemical_name=Benzyl acetate; preferred_name=Benzyl acetate; dtxsid=DTXSID0020151; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020151; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0020151; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | >2000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_2538; row=228; data_type=In Vivo; mixture=Chemical; chemical_name=Benzyl acetate; preferred_name=Benzyl acetate; dtxsid=DTXSID0020151; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020151; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0020151; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =2490 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM ChemIDplus TEST (undated); record_id=acute_oral_2540; row=227; data_type=In Vivo; mixture=Chemical; chemical_name=Benzyl acetate; preferred_name=Benzyl acetate; dtxsid=DTXSID0020151; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020151; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0020151; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | >2000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_2538; row=228; data_type=In Vivo; mixture=Chemical; chemical_name=Benzyl acetate; preferred_name=Benzyl acetate; dtxsid=DTXSID0020151; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020151; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0020151; source_file=acute_oral.xlsx |
NTP_ICE_cancer 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_cancer | IARC group | 3 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=37; Record_ID=cancer_6839; Data_Type=WOE; Formulation_Name=Benzyl acetate; Mixture=Chemical; DTXSID=DTXSID0020151; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/58; http://publications.iarc.fr/139; http://publications.iarc.fr/89; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020151 |
| NTP_ICE_cancer | Top dose | 1.2 | % | Rat | Gavage | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=20; Record_ID=cancer_6845; Data_Type=In Vivo; Formulation_Name=Benzyl acetate; Mixture=Chemical; DTXSID=DTXSID0020151; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=1.2; Response_Unit=%; Species=Rat; Strain=F344/N; Sex=Female; Route=Gavage; Reference=TR-250; URL=https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr250/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020151 |
| NTP_ICE_cancer | Top dose | 0.3 | % | Mouse | Dosed feed | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=21; Record_ID=cancer_6835; Data_Type=In Vivo; Formulation_Name=Benzyl Acetate; Mixture=Chemical; DTXSID=DTXSID0020151; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=0.3; Response_Unit=%; Species=Mouse; Strain=B6C3F1; Sex=Male; Route=Dosed feed; Reference=TR-431; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr431/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020151 |
NTP_ICE_endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=5392; RecordID=ARPathway2016_826; DatasetName=ARPathway2016; DTXSID=DTXSID0020151; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020151 |
NTP_ICE_skin_irritation 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_irritation | Viability | 113.6 | % | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=99; Record_ID=skin_irritation_invitro_616; Data_Type=In Vitro; Formulation_Name=Benzyl acetate; Concentration=99; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0020151; Assay=EpiDerm Irritation; Endpoint=Viability; Response=113.6; Response_Unit=%; Reference=Kandarova et al. 2005; 16185104; 10.1177/026119290503300408; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020151 |
| NTP_ICE_skin_irritation | Viability | 17.32 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=101; Record_ID=skin_irritation_invitro_611; Data_Type=In Vitro; Formulation_Name=Benzyl acetate; Concentration=99; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0020151; Assay=EpiSkin Irritation; Endpoint=Viability; Response=17.32; Response_Unit=%; Reference=Cotovio et al. 2005; 16185103; 10.1177/026119290503300403; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020151 |
| NTP_ICE_skin_irritation | Viability | 21.67 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=102; Record_ID=skin_irritation_invitro_612; Data_Type=In Vitro; Formulation_Name=Benzyl acetate; Concentration=99; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0020151; Assay=EpiSkin Irritation; Endpoint=Viability; Response=21.67; Response_Unit=%; Reference=Cotovio et al. 2005; 16185103; 10.1177/026119290503300403; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020151 |
| NTP_ICE_skin_irritation | Viability | 91.3 | % | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=103; Record_ID=skin_irritation_invitro_614; Data_Type=In Vitro; Formulation_Name=Benzyl acetate; Concentration=99; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0020151; Assay=EpiDerm Irritation; Endpoint=Viability; Response=91.3; Response_Unit=%; Reference=Kandarova et al. 2005; 16185104; 10.1177/026119290503300408; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020151 |
| NTP_ICE_skin_irritation | Viability | 103.5 | % | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=104; Record_ID=skin_irritation_invitro_615; Data_Type=In Vitro; Formulation_Name=Benzyl acetate; Concentration=99; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0020151; Assay=EpiDerm Irritation; Endpoint=Viability; Response=103.5; Response_Unit=%; Reference=Kandarova et al. 2005; 16185104; 10.1177/026119290503300408; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020151 |
| NTP_ICE_skin_irritation | Viability (18 hours) | 99.9 | % | - | Dermal | - | In Vitro; Vitrolife-Skin Irritation | sheet=Data_invitro; excel_row=95; Record_ID=skin_irritation_invitro_198; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0020151; Assay=Vitrolife-Skin Irritation; Endpoint=Viability (18 hours); Response=99.9; Response_Unit=%; Reference=Morikawa et al. 2008; Not available; 10.11232/AATEX.13.11; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020151 |
| NTP_ICE_skin_irritation | Viability (42 hours) | 94.1 | % | - | Dermal | - | In Vitro; Vitrolife-Skin Irritation | sheet=Data_invitro; excel_row=97; Record_ID=skin_irritation_invitro_198; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0020151; Assay=Vitrolife-Skin Irritation; Endpoint=Viability (42 hours); Response=94.1; Response_Unit=%; Reference=Morikawa et al. 2008; Not available; 10.11232/AATEX.13.11; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020151 |
NTP_ICE_skin_sensitization 15 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_sensitization | Concentration, 5% incidence of positive responses | 15.2 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=5072; Record_ID=skin_sensitization_invivo_1204; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0020151; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=15.2; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1988; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2012; 22407231; 10.1016/j.fct.2012.02.091|McGinty et al. 2012; 22387848; 10.1016/j.fct.2012.02.057; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020151 |
| NTP_ICE_skin_sensitization | Concentration, one positive response | 8 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=5068; Record_ID=skin_sensitization_invivo_1204; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0020151; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, one positive response; Response=8; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1988; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2012; 22407231; 10.1016/j.fct.2012.02.091|McGinty et al. 2012; 22387848; 10.1016/j.fct.2012.02.057; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020151 |
| NTP_ICE_skin_sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=5025; Record_ID=skin_sensitization_invivo_1194; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0020151; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Greif 1967; Not available; Not available|Opdyke 1973; Not available; 10.1016/0015-6264(73)90155-7|Belsito et al. 2012; 22407231; 10.1016/j.fct.2012.02.091|McGinty et al. 2012; 22387848; 10.1016/j.fct.2012.02.057; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020151 |
| NTP_ICE_skin_sensitization | Incidence of positive responses | 2.632 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=5065; Record_ID=skin_sensitization_invivo_1204; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0020151; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=2.632; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1988; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2012; 22407231; 10.1016/j.fct.2012.02.091|McGinty et al. 2012; 22387848; 10.1016/j.fct.2012.02.057; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020151 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 4966 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=5023; Record_ID=skin_sensitization_invivo_1194; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0020151; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=4966; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Greif 1967; Not available; Not available|Opdyke 1973; Not available; 10.1016/0015-6264(73)90155-7|Belsito et al. 2012; 22407231; 10.1016/j.fct.2012.02.091|McGinty et al. 2012; 22387848; 10.1016/j.fct.2012.02.057; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020151 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 1860 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=5031; Record_ID=skin_sensitization_invivo_1196; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=3.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0020151; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=1860; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2012; 22407231; 10.1016/j.fct.2012.02.091|McGinty et al. 2012; 22387848; 10.1016/j.fct.2012.02.057|Api et al. 2015; 26192989; 10.1016/j.fct.2015.07.010; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020151 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 2093 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=5037; Record_ID=skin_sensitization_invivo_1198; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=3.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0020151; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=2093; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2012; 22407231; 10.1016/j.fct.2012.02.091|McGinty et al. 2012; 22387848; 10.1016/j.fct.2012.02.057|Api et al. 2015; 26192989; 10.1016/j.fct.2015.07.010; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020151 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 8504 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=5041; Record_ID=skin_sensitization_invivo_1199; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0020151; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=8504; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1988; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2012; 22407231; 10.1016/j.fct.2012.02.091|McGinty et al. 2012; 22387848; 10.1016/j.fct.2012.02.057; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020151 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 4650 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=5044; Record_ID=skin_sensitization_invivo_1200; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=7.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0020151; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=4650; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2012; 22407231; 10.1016/j.fct.2012.02.091|McGinty et al. 2012; 22387848; 10.1016/j.fct.2012.02.057|Api et al. 2015; 26192989; 10.1016/j.fct.2015.07.010; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020151 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 5231 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=5052; Record_ID=skin_sensitization_invivo_1202; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=7.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0020151; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=5231; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2012; 22407231; 10.1016/j.fct.2012.02.091|McGinty et al. 2012; 22387848; 10.1016/j.fct.2012.02.057|Api et al. 2015; 26192989; 10.1016/j.fct.2015.07.010; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020151 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 5580 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=5060; Record_ID=skin_sensitization_invivo_1197; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0020151; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=5580; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1987; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2012; 22407231; 10.1016/j.fct.2012.02.091|McGinty et al. 2012; 22387848; 10.1016/j.fct.2012.02.057|Api et al. 2015; 26192989; 10.1016/j.fct.2015.07.010; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020151 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 11590 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=5078; Record_ID=skin_sensitization_invivo_1208; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=18.7; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0020151; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=11590; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2012; 22407231; 10.1016/j.fct.2012.02.091|McGinty et al. 2012; 22387848; 10.1016/j.fct.2012.02.057|Api et al. 2015; 26192989; 10.1016/j.fct.2015.07.010; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020151 |
| NTP_ICE_skin_sensitization | Induction dose per skin area, 5% incidence of positive responses | 16160 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=5074; Record_ID=skin_sensitization_invivo_1204; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0020151; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=16160; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1988; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2012; 22407231; 10.1016/j.fct.2012.02.091|McGinty et al. 2012; 22387848; 10.1016/j.fct.2012.02.057; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020151 |
| NTP_ICE_skin_sensitization | Relative reliability score | 2 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=5029; Record_ID=skin_sensitization_invivo_1194; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0020151; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=2; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Greif 1967; Not available; Not available|Opdyke 1973; Not available; 10.1016/0015-6264(73)90155-7|Belsito et al. 2012; 22407231; 10.1016/j.fct.2012.02.091|McGinty et al. 2012; 22387848; 10.1016/j.fct.2012.02.057; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020151 |
| NTP_ICE_skin_sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=5035; Record_ID=skin_sensitization_invivo_1196; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=3.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0020151; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=RIFM 1975; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2012; 22407231; 10.1016/j.fct.2012.02.091|McGinty et al. 2012; 22387848; 10.1016/j.fct.2012.02.057|Api et al. 2015; 26192989; 10.1016/j.fct.2015.07.010; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020151; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020151 |
ToxRefDB_ToxRefDB_v3_pod.csv 9 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =500 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 2 year | CHR | study_id=7373; toxval_study_source_id=studyid7373_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight; dose_level=2; study_year=1986; study_citation=NTP. (1986) TOXICOLOGY AND CARCINOGENESIS STUDIES OF BENZYL ACETATE (CAS NO. 140-11-4) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES). NTP TR 250, NIH Publication No. 86-2506. (Chronic rat); dsstox_substance_id=DTXSID0020151; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =40 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 2 year | CHR | study_id=7379; toxval_study_source_id=studyid7379_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-nose-exudate|pathology microscopic-nose-degeneration|pathology microscopic-nose-atrophy|pathology microscopic-nose-pigmentation|pathology microscopic-nose-hyperplasia|in life observation-body weight-body weight; dose_level=1; study_year=1993; study_citation=(1993) TOXICOLOGY AND CARCINOGENESIS STUDIES OF BENZYL ACETATE (CAS NO. 140-11-4) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES). NTP TR 431, NIH Publication No. 93-316. (Chronic mouse); dsstox_substance_id=DTXSID0020151; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =35 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 2 year | CHR | study_id=7379; toxval_study_source_id=studyid7379_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-nose-degeneration|pathology microscopic-nose-pigmentation|pathology microscopic-nose-hyperplasia|pathology microscopic-nose-exudate|pathology microscopic-nose-atrophy|in life observation-body weight-body weight; dose_level=1; study_year=1993; study_citation=(1993) TOXICOLOGY AND CARCINOGENESIS STUDIES OF BENZYL ACETATE (CAS NO. 140-11-4) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES). NTP TR 431, NIH Publication No. 93-316. (Chronic mouse); dsstox_substance_id=DTXSID0020151; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =145 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 2 year | CHR | study_id=7380; toxval_study_source_id=studyid7380_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight; dose_level=1; study_year=1993; study_citation=NTP (1993) TOXICOLOGY AND CARCINOGENESIS STUDIES OF BENZYL ACETATE (CAS NO. 140-11-4) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES). NTP TR 431, NIH Publication No. 93-316. (Chronic rat); dsstox_substance_id=DTXSID0020151; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =510 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 2 year | CHR | study_id=7380; toxval_study_source_id=studyid7380_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight; dose_level=3; study_year=1993; study_citation=NTP (1993) TOXICOLOGY AND CARCINOGENESIS STUDIES OF BENZYL ACETATE (CAS NO. 140-11-4) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES). NTP TR 431, NIH Publication No. 93-316. (Chronic rat); dsstox_substance_id=DTXSID0020151; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | >575 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 2 year | CHR | study_id=7380; toxval_study_source_id=studyid7380_Adult_F0_F_NA; dose_level=3; study_year=1993; study_citation=NTP (1993) TOXICOLOGY AND CARCINOGENESIS STUDIES OF BENZYL ACETATE (CAS NO. 140-11-4) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES). NTP TR 431, NIH Publication No. 93-316. (Chronic rat); dsstox_substance_id=DTXSID0020151; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =250 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 2 year | CHR | study_id=7373; toxval_study_source_id=studyid7373_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight; dose_level=1; study_year=1986; study_citation=NTP. (1986) TOXICOLOGY AND CARCINOGENESIS STUDIES OF BENZYL ACETATE (CAS NO. 140-11-4) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES). NTP TR 250, NIH Publication No. 86-2506. (Chronic rat); dsstox_substance_id=DTXSID0020151; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | >0 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 2 year | CHR | study_id=7373; toxval_study_source_id=studyid7373_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-testes-hyperplasia|pathology microscopic-pancreas-adenoma|pathology microscopic-pancreas-hyperplasia|pathology microscopic-eye-retinopathy|pathology microscopic-eye-cataract; dose_level=0; study_year=1986; study_citation=NTP. (1986) TOXICOLOGY AND CARCINOGENESIS STUDIES OF BENZYL ACETATE (CAS NO. 140-11-4) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES). NTP TR 250, NIH Publication No. 86-2506. (Chronic rat); dsstox_substance_id=DTXSID0020151; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =260 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 2 year | CHR | study_id=7380; toxval_study_source_id=studyid7380_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight; dose_level=2; study_year=1993; study_citation=NTP (1993) TOXICOLOGY AND CARCINOGENESIS STUDIES OF BENZYL ACETATE (CAS NO. 140-11-4) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES). NTP TR 431, NIH Publication No. 93-316. (Chronic rat); dsstox_substance_id=DTXSID0020151; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ToxValDB_ECHA_IUCLID 13 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | LOAEL | =936 | mg/kg bw/day | Rat | oral | chronic; 103 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead10e4b0a7c65d1c251c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12165/7/6/2?documentUUID=a1bbf100-498d-421b-895a-deaa3f67f0d0; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15850582:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1d0ff41bc20fb09e3b6c988c96ee51c2 |
| ToxValDB_ECHA_IUCLID | LOAEL | =4800 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead10e4b0a7c65d1c251e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12165/7/6/2?documentUUID=a1bbf100-498d-421b-895a-deaa3f67f0d0; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15850583:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4eadfd6b1cb892c1ea5e9f1390630711 |
| ToxValDB_ECHA_IUCLID | NOAEL | =1200 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9e4e4b0a7c65d1b3464; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14570/7/8?documentUUID=dceee63d-323b-4fcf-bc39-df538471570c; YEAR=1980; ORIGINAL_YEAR=1980; STUDY_GROUP=ECHA IUCLID:15820347:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_407f60f47421ec7ed79f0036ffc98080 |
| ToxValDB_ECHA_IUCLID | NOAEL | =300 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9e4e4b0a7c65d1b346a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14570/7/8?documentUUID=dceee63d-323b-4fcf-bc39-df538471570c; YEAR=1980; ORIGINAL_YEAR=1980; TOXICOLOGICAL_EFFECT=histopathology: neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=cancer; STUDY_GROUP=ECHA IUCLID:15820348:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4e8ca9e2fcb05bcda2fedf7795da14d2 |
| ToxValDB_ECHA_IUCLID | NOAEL | =100 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabd2e4b0a7c65d1bbe7f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12165/7/9/3?documentUUID=a1bbf100-498d-421b-895a-deaa3f67f0d0; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820698_15824334:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_674e9d24092ba559d7e9d12b1fb352db |
| ToxValDB_ECHA_IUCLID | NOAEL | >1000 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabe9e4b0a7c65d1bc62c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14570/7/9/3?documentUUID=dceee63d-323b-4fcf-bc39-df538471570c; YEAR=1980; ORIGINAL_YEAR=1980; STUDY_GROUP=ECHA IUCLID:15824333:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d75203fd3ca027e0226ac54242fdf542 |
| ToxValDB_ECHA_IUCLID | NOAEL | =20000 | ppm | Rat | oral | - | repeat dose other | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c85ae4b0a7c65d218193; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14570/7/10/1?documentUUID=dceee63d-323b-4fcf-bc39-df538471570c; YEAR=1980; ORIGINAL_YEAR=1980; TOXICOLOGICAL_EFFECT=behavior: functional findings; STUDY_GROUP=ECHA IUCLID:15826014:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_093fb291d7a525466b550504e54b412d |
| ToxValDB_ECHA_IUCLID | NOAEL | =900 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead59e4b0a7c65d1c3cd4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14570/7/6/2?documentUUID=dceee63d-323b-4fcf-bc39-df538471570c; YEAR=1980; ORIGINAL_YEAR=1980; STUDY_GROUP=ECHA IUCLID:15850735:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_16d3940304974e074c92cd215cf18fc4 |
| ToxValDB_ECHA_IUCLID | NOAEL | =480 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead59e4b0a7c65d1c3cd4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14570/7/6/2?documentUUID=dceee63d-323b-4fcf-bc39-df538471570c; YEAR=1980; ORIGINAL_YEAR=1980; STUDY_GROUP=ECHA IUCLID:15850736:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5568f83d63d784e1b190d0d724d53231 |
| ToxValDB_ECHA_IUCLID | NOAEL | ~250 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead59e4b0a7c65d1c3cdc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14570/7/6/2?documentUUID=dceee63d-323b-4fcf-bc39-df538471570c; YEAR=1980; ORIGINAL_YEAR=1980; STUDY_GROUP=ECHA IUCLID:15850738:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_10bbeb5402b542da1f5b055eaf556c95 |
| ToxValDB_ECHA_IUCLID | NOAEL | ~500 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead59e4b0a7c65d1c3cdc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14570/7/6/2?documentUUID=dceee63d-323b-4fcf-bc39-df538471570c; YEAR=1980; ORIGINAL_YEAR=1980; STUDY_GROUP=ECHA IUCLID:15850739:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c0d7dad6e933f68dbbdc9e1716ac2090 |
| ToxValDB_ECHA_IUCLID | NOAEL | =1870 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa7ee4b0a7c65d1b6146; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12165/7/9/2?documentUUID=a1bbf100-498d-421b-895a-deaa3f67f0d0; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15861125:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_521826e83760a8c815f879b0a7c184cf |
| ToxValDB_ECHA_IUCLID | NOAEL | =1750 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa7ee4b0a7c65d1b6146; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12165/7/9/2?documentUUID=a1bbf100-498d-421b-895a-deaa3f67f0d0; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15861227:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_32bd4885e68392cfe47e9b271d19a84e |
ToxValDB_ECOTOX 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECOTOX | NOEL | =1600 | mg/kg bw/day | Mouse | oral | short-term; 2 days | short-term | LONG_REF=Mutat. Res.343(2/3): 157-183 Miyagawa,M., H. Takasawa, A. Sugiyama, Y. Inoue, T. Murata, Y. Uno, and K. Yoshikawa The In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test with Hepatocytes Prepared from Male B6C3F1 Mice as an Early Prediction Assay for Putative Nongenotoxic (Ames-Negative) Mouse Hepatocarcinogens 1995; TITLE=The In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test with Hepatocytes Prepared from Male B6C3F1 Mice as an Early Prediction Assay for Putative Nongenotoxic (Ames-Negative) Mouse Hepatocarcinogens; AUTHOR=Miyagawa,M., H. Takasawa, A. Sugiyama, Y. Inoue, T. Murata, Y. Uno, and K. Yoshikawa; DOI=10.1016/0165-1218(95)90082-9; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=75052; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Cell(s): Viability; STUDY_GROUP=ECOTOX:15606483:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8b9821cf13f083997f6a55be515d9214 |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =9 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630052:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c9c6241bacfd1bc082d9e32af6a59136 |
ToxValDB_HESS 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_HESS | NOEL | <200 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0dd1e4b0a676289dd90b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Clinical Observation: Salivation Locomotor activity decrease|Necropsy: Glandular stomach-Blackish area on the mucosa Kidney-Dilatation of renal pelvis|Histopathology: Glandular stomach-Focal necrosis of the mucosa in an area of fundic gland Kidney-Bilateral dilatation of renal pelvis; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|gross pathology|nonneoplastic histopathology; STUDY_GROUP=HESS_dup_-_15638395_15638396:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_20a65ca0d224f0d9cd866969fe33a7b7 |
| ToxValDB_HESS | NOEL | =600 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0df7e4b0a676289deb47; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=HESS:15638397:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_880abf373b1cf595900a4f30dade4b08 |
ToxValDB_ToxRefDB 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ToxRefDB | LEL | =500 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | LONG_REF=NTP. (1986) TOXICOLOGY AND CARCINOGENESIS STUDIES OF BENZYL ACETATE (CAS NO. 140-11-4) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES). NTP TR 250, NIH Publication No. 86-2506. (Chronic rat); TITLE=TOXICOLOGY AND CARCINOGENESIS STUDIES OF BENZYL ACETATE (CAS NO. 140-11-4) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=7373; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15712521_15712522:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cc58c44626db8e3e1f72f2132b24ed46 |
| ToxValDB_ToxRefDB | LEL | =40 | mg/kg bw/day | Mouse | oral | chronic; 2 years | chronic | LONG_REF=(1993) TOXICOLOGY AND CARCINOGENESIS STUDIES OF BENZYL ACETATE (CAS NO. 140-11-4) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES). NTP TR 431, NIH Publication No. 93-316. (Chronic mouse); TITLE=TOXICOLOGY AND CARCINOGENESIS STUDIES OF BENZYL ACETATE (CAS NO. 140-11-4) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=7379; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-nose-degeneration|systemic: pathology microscopic-nose-pigmentation|systemic: pathology microscopic-nose-exudate|systemic: pathology microscopic-nose-atrophy|systemic: pathology microscopic-nose-hyperplasia|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15712539_15712540:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_52754f4bf12a54b7440ac03edd6091d3 |
| ToxValDB_ToxRefDB | LEL | =35 | mg/kg bw/day | Mouse | oral | chronic; 2 years | chronic | LONG_REF=(1993) TOXICOLOGY AND CARCINOGENESIS STUDIES OF BENZYL ACETATE (CAS NO. 140-11-4) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES). NTP TR 431, NIH Publication No. 93-316. (Chronic mouse); TITLE=TOXICOLOGY AND CARCINOGENESIS STUDIES OF BENZYL ACETATE (CAS NO. 140-11-4) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=7379; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-nose-degeneration|systemic: pathology microscopic-nose-exudate|systemic: pathology microscopic-nose-pigmentation|systemic: pathology microscopic-nose-hyperplasia|systemic: pathology microscopic-nose-atrophy|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15712541_15712542:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3bdca05d294c9e647b3ce5d45ece6454 |
| ToxValDB_ToxRefDB | LEL | =145 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | LONG_REF=NTP (1993) TOXICOLOGY AND CARCINOGENESIS STUDIES OF BENZYL ACETATE (CAS NO. 140-11-4) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES). NTP TR 431, NIH Publication No. 93-316. (Chronic rat); TITLE=TOXICOLOGY AND CARCINOGENESIS STUDIES OF BENZYL ACETATE (CAS NO. 140-11-4) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=7380; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15712543_15712544_15712545:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_733de5061fa005c9c9647cfea99e377a |
| ToxValDB_ToxRefDB | LEL | =510 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | LONG_REF=NTP (1993) TOXICOLOGY AND CARCINOGENESIS STUDIES OF BENZYL ACETATE (CAS NO. 140-11-4) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES). NTP TR 431, NIH Publication No. 93-316. (Chronic rat); TITLE=TOXICOLOGY AND CARCINOGENESIS STUDIES OF BENZYL ACETATE (CAS NO. 140-11-4) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=7380; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15712546_15712547_15712548_15712549:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_148f013f952ba646bfebc3d12a06b0ba |
| ToxValDB_ToxRefDB | LOAEL | >575 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | LONG_REF=NTP (1993) TOXICOLOGY AND CARCINOGENESIS STUDIES OF BENZYL ACETATE (CAS NO. 140-11-4) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES). NTP TR 431, NIH Publication No. 93-316. (Chronic rat); TITLE=TOXICOLOGY AND CARCINOGENESIS STUDIES OF BENZYL ACETATE (CAS NO. 140-11-4) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=7380; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=ToxRefDB_dup_-_15712543_15712544_15712545:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9f69e516cf9f5bec15271cdcdc95ea64 |
| ToxValDB_ToxRefDB | NEL | =250 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | LONG_REF=NTP. (1986) TOXICOLOGY AND CARCINOGENESIS STUDIES OF BENZYL ACETATE (CAS NO. 140-11-4) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES). NTP TR 250, NIH Publication No. 86-2506. (Chronic rat); TITLE=TOXICOLOGY AND CARCINOGENESIS STUDIES OF BENZYL ACETATE (CAS NO. 140-11-4) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=7373; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15712521_15712522:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9a1ea1d50cd8f0412472c34617bc733c |
| ToxValDB_ToxRefDB | NEL | =260 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | LONG_REF=NTP (1993) TOXICOLOGY AND CARCINOGENESIS STUDIES OF BENZYL ACETATE (CAS NO. 140-11-4) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES). NTP TR 431, NIH Publication No. 93-316. (Chronic rat); TITLE=TOXICOLOGY AND CARCINOGENESIS STUDIES OF BENZYL ACETATE (CAS NO. 140-11-4) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=7380; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15712546_15712547_15712548_15712549:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dc82d0df8a7614370c0462a5a8dac720 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 0ECG3V79ZJ | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C9H10O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"0ECG3V79ZJ"} |
| openFDA substances | FDA UNII substance identifier | 0ECG3V79ZJ | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C9H10O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"0ECG3V79ZJ"} |
| openFDA substances | FDA UNII substance identifier | 0ECG3V79ZJ | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C9H10O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"0ECG3V79ZJ"} |
| openFDA substances | FDA UNII substance identifier | 0ECG3V79ZJ | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C9H10O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"0ECG3V79ZJ"} |