NOAEL Studies Cosmetic Ingredient

Benzonitrile NOAEL Studies

INCI: BENZONITRILE

CAS: 100-47-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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ECHA 18 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA LOAEL 600 mg/kg bw/day mouse oral: gavage - short-term repeated dose toxicity: oral dossier=1f267d52-cf78-48e9-aa5b-99dedd534d38.i6z; document=b5284160-42f5-48b0-a7df-ead5ed33cc70_1f267d52-cf78-48e9-aa5b-99dedd534d38.i6d; document_key=b5284160-42f5-48b0-a7df-ead5ed33cc70/1f267d52-cf78-48e9-aa5b-99dedd534d38; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2000; basis=other:; key_result=false; entry_uuid=7912f508-d58e-4599-bd69-ddc3c1a9b8dc
ECHA LOAEL 600 mg/kg bw/day mouse oral: gavage - short-term repeated dose toxicity: oral dossier=1f267d52-cf78-48e9-aa5b-99dedd534d38.i6z; document=b5284160-42f5-48b0-a7df-ead5ed33cc70_1f267d52-cf78-48e9-aa5b-99dedd534d38.i6d; document_key=b5284160-42f5-48b0-a7df-ead5ed33cc70/1f267d52-cf78-48e9-aa5b-99dedd534d38; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2000; basis=other:; key_result=false; entry_uuid=7912f508-d58e-4599-bd69-ddc3c1a9b8dc
ECHA LOAEL 600 mg/kg bw/day mouse oral: gavage - short-term repeated dose toxicity: oral dossier=1f267d52-cf78-48e9-aa5b-99dedd534d38.i6z; document=b5284160-42f5-48b0-a7df-ead5ed33cc70_1f267d52-cf78-48e9-aa5b-99dedd534d38.i6d; document_key=b5284160-42f5-48b0-a7df-ead5ed33cc70/1f267d52-cf78-48e9-aa5b-99dedd534d38; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2000; basis=other:; key_result=false; entry_uuid=7912f508-d58e-4599-bd69-ddc3c1a9b8dc
ECHA NOAEL 40 mg/kg bw/day rat oral: gavage - short-term repeated dose toxicity: oral dossier=1f267d52-cf78-48e9-aa5b-99dedd534d38.i6z; document=bccb19cc-83ab-418f-8005-b896990238c3_1f267d52-cf78-48e9-aa5b-99dedd534d38.i6d; document_key=bccb19cc-83ab-418f-8005-b896990238c3/1f267d52-cf78-48e9-aa5b-99dedd534d38; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2000; ReportDate=2000-01-01; basis=other:; key_result=true; entry_uuid=bbb874c7-898c-46da-b3d7-5992219008de
ECHA NOAEL 200 mg/kg bw/day mouse oral: gavage - short-term repeated dose toxicity: oral dossier=1f267d52-cf78-48e9-aa5b-99dedd534d38.i6z; document=b5284160-42f5-48b0-a7df-ead5ed33cc70_1f267d52-cf78-48e9-aa5b-99dedd534d38.i6d; document_key=b5284160-42f5-48b0-a7df-ead5ed33cc70/1f267d52-cf78-48e9-aa5b-99dedd534d38; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2000; basis=histopathology: non-neoplastic; key_result=true; entry_uuid=5586491d-4b67-4855-a851-7bf5e6abc96f
ECHA NOAEL 300 mg/kg bw/day rat oral: gavage - short-term repeated dose toxicity: oral dossier=1f267d52-cf78-48e9-aa5b-99dedd534d38.i6z; document=c9366964-a260-46ac-ac3e-81c74273725a_1f267d52-cf78-48e9-aa5b-99dedd534d38.i6d; document_key=c9366964-a260-46ac-ac3e-81c74273725a/1f267d52-cf78-48e9-aa5b-99dedd534d38; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2000; ReportDate=2000-01-01; basis=other:; key_result=true; entry_uuid=6d58ad72-07eb-4907-803a-6d54428399c0
ECHA NOAEL 37.5 mg/kg bw/day mouse oral: gavage - sub-chronic toxicity: oral dossier=1f267d52-cf78-48e9-aa5b-99dedd534d38.i6z; document=8f3add8f-a9ed-407c-8ca9-4eff6a15c7e4_1f267d52-cf78-48e9-aa5b-99dedd534d38.i6d; document_key=8f3add8f-a9ed-407c-8ca9-4eff6a15c7e4/1f267d52-cf78-48e9-aa5b-99dedd534d38; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2000; ReportDate=2000-01-01; basis=other:; key_result=true; entry_uuid=641ce957-c45a-458c-a673-b0178a9b2ca8
ECHA NOAEL 75 mg/kg bw/day rat oral: gavage - sub-chronic toxicity: oral dossier=1f267d52-cf78-48e9-aa5b-99dedd534d38.i6z; document=6878c369-e450-4c99-869a-ff1d136c7b6e_1f267d52-cf78-48e9-aa5b-99dedd534d38.i6d; document_key=6878c369-e450-4c99-869a-ff1d136c7b6e/1f267d52-cf78-48e9-aa5b-99dedd534d38; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2000; basis=other:; key_result=false; entry_uuid=a33b470f-76e6-404d-abd9-73e92e4c2145
ECHA NOAEL 40 mg/kg bw/day rat oral: gavage - short-term repeated dose toxicity: oral dossier=1f267d52-cf78-48e9-aa5b-99dedd534d38.i6z; document=bccb19cc-83ab-418f-8005-b896990238c3_1f267d52-cf78-48e9-aa5b-99dedd534d38.i6d; document_key=bccb19cc-83ab-418f-8005-b896990238c3/1f267d52-cf78-48e9-aa5b-99dedd534d38; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2000; ReportDate=2000-01-01; basis=other:; key_result=true; entry_uuid=bbb874c7-898c-46da-b3d7-5992219008de
ECHA NOAEL 200 mg/kg bw/day mouse oral: gavage - short-term repeated dose toxicity: oral dossier=1f267d52-cf78-48e9-aa5b-99dedd534d38.i6z; document=b5284160-42f5-48b0-a7df-ead5ed33cc70_1f267d52-cf78-48e9-aa5b-99dedd534d38.i6d; document_key=b5284160-42f5-48b0-a7df-ead5ed33cc70/1f267d52-cf78-48e9-aa5b-99dedd534d38; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2000; basis=histopathology: non-neoplastic; key_result=true; entry_uuid=5586491d-4b67-4855-a851-7bf5e6abc96f
ECHA NOAEL 300 mg/kg bw/day rat oral: gavage - short-term repeated dose toxicity: oral dossier=1f267d52-cf78-48e9-aa5b-99dedd534d38.i6z; document=c9366964-a260-46ac-ac3e-81c74273725a_1f267d52-cf78-48e9-aa5b-99dedd534d38.i6d; document_key=c9366964-a260-46ac-ac3e-81c74273725a/1f267d52-cf78-48e9-aa5b-99dedd534d38; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2000; ReportDate=2000-01-01; basis=other:; key_result=true; entry_uuid=6d58ad72-07eb-4907-803a-6d54428399c0
ECHA NOAEL 37.5 mg/kg bw/day mouse oral: gavage - sub-chronic toxicity: oral dossier=1f267d52-cf78-48e9-aa5b-99dedd534d38.i6z; document=8f3add8f-a9ed-407c-8ca9-4eff6a15c7e4_1f267d52-cf78-48e9-aa5b-99dedd534d38.i6d; document_key=8f3add8f-a9ed-407c-8ca9-4eff6a15c7e4/1f267d52-cf78-48e9-aa5b-99dedd534d38; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2000; ReportDate=2000-01-01; basis=other:; key_result=true; entry_uuid=641ce957-c45a-458c-a673-b0178a9b2ca8
ECHA NOAEL 75 mg/kg bw/day rat oral: gavage - sub-chronic toxicity: oral dossier=1f267d52-cf78-48e9-aa5b-99dedd534d38.i6z; document=6878c369-e450-4c99-869a-ff1d136c7b6e_1f267d52-cf78-48e9-aa5b-99dedd534d38.i6d; document_key=6878c369-e450-4c99-869a-ff1d136c7b6e/1f267d52-cf78-48e9-aa5b-99dedd534d38; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2000; basis=other:; key_result=false; entry_uuid=a33b470f-76e6-404d-abd9-73e92e4c2145
ECHA NOAEL 40 mg/kg bw/day rat oral: gavage - short-term repeated dose toxicity: oral dossier=1f267d52-cf78-48e9-aa5b-99dedd534d38.i6z; document=bccb19cc-83ab-418f-8005-b896990238c3_1f267d52-cf78-48e9-aa5b-99dedd534d38.i6d; document_key=bccb19cc-83ab-418f-8005-b896990238c3/1f267d52-cf78-48e9-aa5b-99dedd534d38; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2000; ReportDate=2000-01-01; basis=other:; key_result=true; entry_uuid=bbb874c7-898c-46da-b3d7-5992219008de
ECHA NOAEL 200 mg/kg bw/day mouse oral: gavage - short-term repeated dose toxicity: oral dossier=1f267d52-cf78-48e9-aa5b-99dedd534d38.i6z; document=b5284160-42f5-48b0-a7df-ead5ed33cc70_1f267d52-cf78-48e9-aa5b-99dedd534d38.i6d; document_key=b5284160-42f5-48b0-a7df-ead5ed33cc70/1f267d52-cf78-48e9-aa5b-99dedd534d38; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2000; basis=histopathology: non-neoplastic; key_result=true; entry_uuid=5586491d-4b67-4855-a851-7bf5e6abc96f
ECHA NOAEL 300 mg/kg bw/day rat oral: gavage - short-term repeated dose toxicity: oral dossier=1f267d52-cf78-48e9-aa5b-99dedd534d38.i6z; document=c9366964-a260-46ac-ac3e-81c74273725a_1f267d52-cf78-48e9-aa5b-99dedd534d38.i6d; document_key=c9366964-a260-46ac-ac3e-81c74273725a/1f267d52-cf78-48e9-aa5b-99dedd534d38; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2000; ReportDate=2000-01-01; basis=other:; key_result=true; entry_uuid=6d58ad72-07eb-4907-803a-6d54428399c0
ECHA NOAEL 37.5 mg/kg bw/day mouse oral: gavage - sub-chronic toxicity: oral dossier=1f267d52-cf78-48e9-aa5b-99dedd534d38.i6z; document=8f3add8f-a9ed-407c-8ca9-4eff6a15c7e4_1f267d52-cf78-48e9-aa5b-99dedd534d38.i6d; document_key=8f3add8f-a9ed-407c-8ca9-4eff6a15c7e4/1f267d52-cf78-48e9-aa5b-99dedd534d38; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2000; ReportDate=2000-01-01; basis=other:; key_result=true; entry_uuid=641ce957-c45a-458c-a673-b0178a9b2ca8
ECHA NOAEL 75 mg/kg bw/day rat oral: gavage - sub-chronic toxicity: oral dossier=1f267d52-cf78-48e9-aa5b-99dedd534d38.i6z; document=6878c369-e450-4c99-869a-ff1d136c7b6e_1f267d52-cf78-48e9-aa5b-99dedd534d38.i6d; document_key=6878c369-e450-4c99-869a-ff1d136c7b6e/1f267d52-cf78-48e9-aa5b-99dedd534d38; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2000; basis=other:; key_result=false; entry_uuid=a33b470f-76e6-404d-abd9-73e92e4c2145
NTP ICE acute inhalation 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute inhalation LC50 3.9159 mg/L - Inhalation - In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=3896; Record_ID=acute_inhalation_3596; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID7021491; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=3.9159; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021491; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021491
NTP ICE skin sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=1488; Record_ID=skin_sensitization_invivo_509; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7021491; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Epstein 1977: report to RIFM|Anonymous 1979; Not available; 10.1016/S0015-6264(79)80013-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021491; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021491
NTP ICE skin sensitization Induction dose per skin area 1350 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=1486; Record_ID=skin_sensitization_invivo_509; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7021491; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=1350; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Epstein 1977: report to RIFM|Anonymous 1979; Not available; 10.1016/S0015-6264(79)80013-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021491; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021491
NTP ICE skin sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=1493; Record_ID=skin_sensitization_invivo_509; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7021491; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Epstein 1977: report to RIFM|Anonymous 1979; Not available; 10.1016/S0015-6264(79)80013-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021491; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021491
ToxValDB NIOSH IDLH 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB NIOSH IDLH LEL =7971.59 mg/m3 Mouse inhalation acute; 60 minutes acute LONG_REF=MacEwen JD, Vernot EH [1974]. Acute inhalation toxicity of benzonitrile. Toxic Hazards Research Unit Annual Technical Report, pp. 77-80. Wright-Patterson Air Force Base, OH: Aerospace Medical Research Laboratory, Aerospace Medical Division, Air Force Systems Command.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c9b384e4b02565fc7d71cb; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.cdc.gov/niosh/idlh/; SUBSOURCE_URL=https://www.cdc.gov/niosh/docs/2017-104/; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=Extremities irritation; labored breathing; STUDY_GROUP=NIOSH IDLH:15953038:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_356718a27674ffded251d36fc26a8fcd
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 9V9APP5H5S UNII - - - chemical {"approval_status":null,"molecular_formula":"C7H5N","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"9V9APP5H5S"}
openFDA substances FDA UNII substance identifier 9V9APP5H5S UNII - - - chemical {"approval_status":null,"molecular_formula":"C7H5N","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"9V9APP5H5S"}
openFDA substances FDA UNII substance identifier 9V9APP5H5S UNII - - - chemical {"approval_status":null,"molecular_formula":"C7H5N","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"9V9APP5H5S"}
openFDA substances FDA UNII substance identifier 9V9APP5H5S UNII - - - chemical {"approval_status":null,"molecular_formula":"C7H5N","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"9V9APP5H5S"}