Is Bee Propolis safe in cosmetics?
Bee Propolis has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Bee Propolis
INCI: PROPOLIS EXTRACT
Bee Propolis (CAS 85665-41-4) is a cosmetic cosmetic ingredient functioning as skin conditioning, antimicrobial, antioxidant, film forming, soothing. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 85665-41-4 →
Auto-generated CPSR Part A draft with source citations
Function
skin conditioning, antimicrobial, antioxidant, film forming, soothing
Safety Rating
MODERATE
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Known allergen; patch testing recommended; included in European Standard patch test series; 1.2-6.6% patch test positivity rate
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Bee Propolis.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
10 property records from structured ingredient metadata.
acne
{"cas_number": "85665-41-4", "anti_acne_mechanism": "antibacterial/anti_inflammatory", "comedogenicity_rating_0_to_5": "1", "acne_type_efficacy": "inflammatory", "p_acnes_mic_ug_per_ml": "100-500", "sebum_reduction_pct_clinical": "5-10", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functi…
anti_pollution
{"cas_number": "9009-62-5", "ingredient_class": "antioxidant_pollution_shield", "primary_mechanism": "free_radical_scavenging", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulatio…
concentration
{"min_concentration_pct": "0.5", "max_concentration_pct": "5.0", "typical_concentration_pct": "2.0", "product_type": "Moisturizer", "function_at_concentration": "Antimicrobial, healing", "source": "Clinical literature"}
cost_pricing
{"cost_tier": "mid-range", "estimated_cost_per_kg_usd_low": "45", "estimated_cost_per_kg_usd_high": "85", "natural_premium_markup_pct": "65", "organic_certified_premium_pct": "110", "supply_chain_volatility": "medium", "primary_source_region": "Brazil/New Zealand", "synthetic_vs_natural_cost_ratio": "2.5", "bulk_discount_threshold_kg": "50", "seasonal_price_variation": "medium", "commodity_or_spec…
deodorant
{"cas_number": "9009-62-5", "ingredient_class": "antimicrobial_deodorant", "mechanism_of_action": "bacterial_growth_inhibition", "antiperspirant_efficacy_sweat_reduction_pct": "0", "deodorant_efficacy_hours": "8-12", "odor_reduction_pct": "45-65", "bacteriostatic": "yes", "bactericidal": "yes", "target_bacteria": "broad_spectrum", "microbiome_impact": "selective", "axillary_microbiome_effect": "va…
depigmentation
{"cas_number": "9009-62-5", "ingredient_class": "combined_mechanism", "primary_mechanism_of_action": "Honey/bee product with enzymatic and antioxidant brightening", "secondary_mechanisms": "Variable", "molecular_target": "other", "tyrosinase_inhibition_IC50_uM": "varies", "tyrosinase_inhibition_type": "competitive", "melanin_reduction_pct_in_vitro": "25-45", "melanin_reduction_pct_clinical": "15-3…
microbiome_impact
{"microbiome_effect": "mixed", "prebiotic": "yes", "probiotic_compatible": "limited", "antimicrobial_spectrum": "selective", "preservative_effect_on_microbiome": "Bee product; antimicrobial; antioxidant; moderate selectivity", "skin_flora_disruption": "mild", "gut_microbiome_risk": "low", "microbiome_recovery_time": "5-7 days", "selective_antimicrobial": "yes", "beneficial_bacteria_support": "S. e…
pediatric_safety
{"safe_for_newborn_0_6m": "caution", "safe_for_infant_6_12m": "yes", "safe_for_toddler_1_3y": "yes", "safe_for_child_3_12y": "yes", "safe_for_teen_12_18y": "yes", "pediatric_max_concentration_pct": "5.0", "adult_max_concentration_pct": "5.0", "pediatric_dermal_absorption_factor": "normal", "immature_skin_barrier_risk": "low", "oral_ingestion_risk": "low", "diaper_area_safe": "yes", "pediatric_alle…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Regulatory List Membership (1)
EU Regulated in Personal Care
Expert Verdict
Expert safety assessment and concern-level summary for Bee Propolis.
Regulatory Flags
allergen
sensitizer
patch-test-recommended
Chemical Function
Softener and conditioner
Humectant
Pharmaceutical
Regulatory Lists
Europe
Personal care
Europe
Personal care
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Bee Propolis allowed in the EU?
Bee Propolis EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Bee Propolis do in cosmetics?
Bee Propolis functions as: skin conditioning, antimicrobial, antioxidant, film forming, soothing. It is classified as a cosmetic ingredient in our database. CAS number: 85665-41-4.
Compliance Tools
Check Bee Propolis compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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