NOAEL Studies
Cosmetic Ingredient
ANTHRAQUINONE NOAEL Studies
CAS: 84-65-1
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
California Proposition 65 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| California Proposition 65 | California Proposition 65 listing | ABcancer | listing type | - | - | 2007-09-28 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"2007-09-28","listing_mechanism":"AB","madl":null,"nsrl":null,"source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | ABcancer | listing type | - | - | 2007-09-28 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"2007-09-28","listing_mechanism":"AB","madl":null,"nsrl":null,"source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | ABcancer | listing type | - | - | 2007-09-28 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"2007-09-28","listing_mechanism":"AB","madl":null,"nsrl":null,"source_table":"prop65_listings"} |
IARC Monographs 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 2B | IARC group | - | - | 2011 | IARC Monographs | {"additional_info":"volume_publication_year=2013","evaluation_year":2011,"source_table":"iarc_classifications","volume":"101"} |
WHO/JECFA 10 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| WHO/JECFA | NOEL | =1.7 | mg/m3 | - | - | - | Toxicology study | document_id=iarc_iarcmono_v101iarc; title=some chemicals present in industrial and consumer products, food and drinking-water volume 101 iarc monographs oN the evaluation of carcinogenic risks to humans; path=mirror/documents/iarc/iarcmono/v101iarc.pdf; row_hash=2e437fee5693576c; raw_unit=mg/m3; context=The NOEL for inflamma- tory markers in bronchoalveolar lavage fluid was 1.7 mg/m3, and the number of macrophages in this fluid reached a maximum about 16 hours after exposure (Larsen et al., 2004). |
| WHO/JECFA | NOEL | =1.7 | mg/m3 | - | - | - | Toxicology study | document_id=iarc_iarcmono_v101iarc; title=some chemicals present in industrial and consumer products, food and drinking-water volume 101 iarc monographs oN the evaluation of carcinogenic risks to humans; path=mirror/documents/iarc/iarcmono/v101iarc.pdf; row_hash=2e437fee5693576c; raw_unit=mg/m3; context=The NOEL for inflamma- tory markers in bronchoalveolar lavage fluid was 1.7 mg/m3, and the number of macrophages in this fluid reached a maximum about 16 hours after exposure (Larsen et al., 2004). |
| WHO/JECFA | TDI | =0.002 | mg/kg bw/day | - | - | - | Health guidance value | document_id=iarc_iarcmono_v101iarc; title=some chemicals present in industrial and consumer products, food and drinking-water volume 101 iarc monographs oN the evaluation of carcinogenic risks to humans; path=mirror/documents/iarc/iarcmono/v101iarc.pdf; row_hash=8b1b65e71ca15c5e; raw_unit=ug/kg bw; unit_normalization=converted from micrograms; context=dertaken by government or industry b Range Data updated from Hamlet & Sadd (2009) 3-Monochloro-1,2-propanediol Commission considered that a threshold-based approach for deriving a tolerable daily intake would be appropriate, and determined a value of 2 ug/kg bw (SCF, 2001). |
| WHO/JECFA | TDI | =0.002 | mg/kg bw/day | - | - | - | Health guidance value | document_id=iarc_iarcmono_v101iarc; title=some chemicals present in industrial and consumer products, food and drinking-water volume 101 iarc monographs oN the evaluation of carcinogenic risks to humans; path=mirror/documents/iarc/iarcmono/v101iarc.pdf; row_hash=8b1b65e71ca15c5e; raw_unit=ug/kg bw; unit_normalization=converted from micrograms; context=dertaken by government or industry b Range Data updated from Hamlet & Sadd (2009) 3-Monochloro-1,2-propanediol Commission considered that a threshold-based approach for deriving a tolerable daily intake would be appropriate, and determined a value of 2 ug/kg bw (SCF, 2001). |
| WHO/JECFA | TDI | =0.011 | mg/kg bw/day | - | - | - | Health guidance value | document_id=iarc_iarcmono_v101iarc; title=some chemicals present in industrial and consumer products, food and drinking-water volume 101 iarc monographs oN the evaluation of carcinogenic risks to humans; path=mirror/documents/iarc/iarcmono/v101iarc.pdf; row_hash=4f621978f7331a46; raw_unit=ug/kg bw per day; unit_normalization=converted from micrograms; context=1.4 Regulations and guidelines WHO (2004) has established a tolerable daily intake of 11 ug/kg bw per day for dibromoac- etonitrile. |
| WHO/JECFA | TDI | =0.011 | mg/kg bw/day | - | - | - | Health guidance value | document_id=iarc_iarcmono_v101iarc; title=some chemicals present in industrial and consumer products, food and drinking-water volume 101 iarc monographs oN the evaluation of carcinogenic risks to humans; path=mirror/documents/iarc/iarcmono/v101iarc.pdf; row_hash=4f621978f7331a46; raw_unit=ug/kg bw per day; unit_normalization=converted from micrograms; context=1.4 Regulations and guidelines WHO (2004) has established a tolerable daily intake of 11 ug/kg bw per day for dibromoac- etonitrile. |
| WHO/JECFA | TDI | =0.0323 | mg/kg bw/day | - | - | - | Health guidance value | document_id=iarc_iarcmono_v101iarc; title=some chemicals present in industrial and consumer products, food and drinking-water volume 101 iarc monographs oN the evaluation of carcinogenic risks to humans; path=mirror/documents/iarc/iarcmono/v101iarc.pdf; row_hash=31b2380df06dd1bc; raw_unit=ug/kg per day; unit_normalization=converted from micrograms; context=Mean doses of DEHP for both plateletpheresis techniques (18.1 and 32.3 ug/kg per day) were close to or exceeded the reference dose of the EPA and the tolerable daily intake value of the EU on the day of the apheresis (Koch et al., 2005a). (g) Building materials Afshari et al. (2004) measured phthalate emis- sions from PVC flooring, polyolefine flooring, a refrigerator list, two electric cables, PVC skirting and floor wax. |
| WHO/JECFA | TDI | =0.0323 | mg/kg bw/day | - | - | - | Health guidance value | document_id=iarc_iarcmono_v101iarc; title=some chemicals present in industrial and consumer products, food and drinking-water volume 101 iarc monographs oN the evaluation of carcinogenic risks to humans; path=mirror/documents/iarc/iarcmono/v101iarc.pdf; row_hash=31b2380df06dd1bc; raw_unit=ug/kg per day; unit_normalization=converted from micrograms; context=Mean doses of DEHP for both plateletpheresis techniques (18.1 and 32.3 ug/kg per day) were close to or exceeded the reference dose of the EPA and the tolerable daily intake value of the EU on the day of the apheresis (Koch et al., 2005a). (g) Building materials Afshari et al. (2004) measured phthalate emis- sions from PVC flooring, polyolefine flooring, a refrigerator list, two electric cables, PVC skirting and floor wax. |
| WHO/JECFA | TDI | =0.07 | mg/L | - | oral | - | Health guidance value | document_id=iarc_iarcmono_v101iarc; title=some chemicals present in industrial and consumer products, food and drinking-water volume 101 iarc monographs oN the evaluation of carcinogenic risks to humans; path=mirror/documents/iarc/iarcmono/v101iarc.pdf; row_hash=332f078141b63c73; raw_unit=ug/L; unit_normalization=converted from micrograms; context=A guideline value of 70 ug/L (rounded figure) was calculated by allocating 20% of the tolerable daily intake to drinking-water and assuming a body weight of 60 kg and a daily drinking-water intake of 2 litres (WHO, 2004; |
| WHO/JECFA | TDI | =0.07 | mg/L | - | oral | - | Health guidance value | document_id=iarc_iarcmono_v101iarc; title=some chemicals present in industrial and consumer products, food and drinking-water volume 101 iarc monographs oN the evaluation of carcinogenic risks to humans; path=mirror/documents/iarc/iarcmono/v101iarc.pdf; row_hash=332f078141b63c73; raw_unit=ug/L; unit_normalization=converted from micrograms; context=A guideline value of 70 ug/L (rounded figure) was calculated by allocating 20% of the tolerable daily intake to drinking-water and assuming a body weight of 60 kg and a daily drinking-water intake of 2 litres (WHO, 2004; |
NTP ICE acute inhalation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | LC50 | >1.3 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1891; Record_ID=acute_inhalation_3042; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID3020095; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=1.3; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020095; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020095 |
NTP ICE acute oral 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | >2000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_10832; row=5409; data_type=In Vivo; mixture=Chemical; chemical_name=Anthraquinone; preferred_name=Anthraquinone; dtxsid=DTXSID3020095; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020095; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID3020095; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | >5000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_10833; row=5410; data_type=In Vivo; mixture=Chemical; chemical_name=Anthraquinone; preferred_name=Anthraquinone; dtxsid=DTXSID3020095; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020095; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID3020095; source_file=acute_oral.xlsx |
NTP ICE cancer 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE cancer | IARC group | 2 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=3240; Record_ID=cancer_4467; Data_Type=WOE; Formulation_Name=Anthraquinone; Mixture=Chemical; DTXSID=DTXSID3020095; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=2B; Response_Unit=Unitless; URL=http://publications.iarc.fr/125; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020095; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020095 |
| NTP ICE cancer | POLY-3 lowest dose | 469 | ppm | Rat | Dosed feed | - | In Vivo; Two year cancer bioassay | sheet=Data; excel_row=3226; Record_ID=cancer_4470; Data_Type=In Vivo; Formulation_Name=Anthraquinone; Mixture=Chemical; DTXSID=DTXSID3020095; Assay=Two year cancer bioassay; Endpoint=POLY-3 lowest dose; Response=469; Response_Unit=ppm; Species=Rat; Strain=F344/N; Sex=Female; Route=Dosed feed; Level_of_Evidence=Clear evidence; Tissue=Kidney; Location=Renal tubule; Lesion=Carcinoma or adenoma; Reference=TR-494; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr494/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020095; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020095 |
| NTP ICE cancer | POLY-3 lowest dose | 833 | ppm | Mouse | Dosed feed | - | In Vivo; Two year cancer bioassay | sheet=Data; excel_row=3230; Record_ID=cancer_4462; Data_Type=In Vivo; Formulation_Name=Anthraquinone; Mixture=Chemical; DTXSID=DTXSID3020095; Assay=Two year cancer bioassay; Endpoint=POLY-3 lowest dose; Response=833; Response_Unit=ppm; Species=Mouse; Strain=B6C3F1; Sex=Male; Route=Dosed feed; Level_of_Evidence=Clear evidence; Tissue=Liver; Lesion=Hepatocellular carcinoma or hepatocellular adenoma; Reference=TR-494; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr494/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020095; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020095 |
| NTP ICE cancer | POLY-3 lowest dose | 938 | ppm | Rat | Dosed feed | - | In Vivo; Two year cancer bioassay | sheet=Data; excel_row=3225; Record_ID=cancer_4470; Data_Type=In Vivo; Formulation_Name=Anthraquinone; Mixture=Chemical; DTXSID=DTXSID3020095; Assay=Two year cancer bioassay; Endpoint=POLY-3 lowest dose; Response=938; Response_Unit=ppm; Species=Rat; Strain=F344/N; Sex=Female; Route=Dosed feed; Level_of_Evidence=Clear evidence; Tissue=Liver; Lesion=Hepatocellular adenoma; Reference=TR-494; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr494/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020095; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020095 |
| NTP ICE cancer | POLY-3 lowest dose | 1875 | ppm | Rat | Dosed feed | - | In Vivo; Two year cancer bioassay | sheet=Data; excel_row=3239; Record_ID=cancer_4466; Data_Type=In Vivo; Formulation_Name=Anthraquinone; Mixture=Chemical; DTXSID=DTXSID3020095; Assay=Two year cancer bioassay; Endpoint=POLY-3 lowest dose; Response=1875; Response_Unit=ppm; Species=Rat; Strain=F344/N; Sex=Male; Route=Dosed feed; Level_of_Evidence=Some evidence; Tissue=Urinary bladder; Lesion=Papilloma; Reference=TR-494; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr494/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020095; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020095 |
| NTP ICE cancer | POLY-3 lowest dose | 3750 | ppm | Rat | Dosed feed | - | In Vivo; Two year cancer bioassay | sheet=Data; excel_row=3227; Record_ID=cancer_4470; Data_Type=In Vivo; Formulation_Name=Anthraquinone; Mixture=Chemical; DTXSID=DTXSID3020095; Assay=Two year cancer bioassay; Endpoint=POLY-3 lowest dose; Response=3750; Response_Unit=ppm; Species=Rat; Strain=F344/N; Sex=Female; Route=Dosed feed; Level_of_Evidence=Clear evidence; Tissue=Urinary bladder; Lesion=Carcinoma or papilloma; Reference=TR-494; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr494/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020095; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020095 |
| NTP ICE cancer | Top dose | 3750 | ppm | Rat | Dosed feed | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=3224; Record_ID=cancer_4470; Data_Type=In Vivo; Formulation_Name=Anthraquinone; Mixture=Chemical; DTXSID=DTXSID3020095; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=3750; Response_Unit=ppm; Species=Rat; Strain=F344/N; Sex=Female; Route=Dosed feed; Reference=TR-494; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr494/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020095; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020095 |
| NTP ICE cancer | Top dose | 7500 | ppm | Mouse | Dosed feed | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=3229; Record_ID=cancer_4462; Data_Type=In Vivo; Formulation_Name=Anthraquinone; Mixture=Chemical; DTXSID=DTXSID3020095; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=7500; Response_Unit=ppm; Species=Mouse; Strain=B6C3F1; Sex=Male; Route=Dosed feed; Reference=TR-494; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr494/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020095; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020095 |
ECHA 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LEL | ~10 | mg/m3 | Rat | inhalation | acute; 6 hours | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5769/7/6/3?documentUUID=3dda6f69-b9cf-462f-b1dd-1837bfdc220d; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15829319_15829320:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1b5b352c6f19dc16d990cdee05211364 |
| ECHA | LOAEL | =50 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cbf3e4b0a7c65d228523; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5769/7/6/2?documentUUID=3dda6f69-b9cf-462f-b1dd-1837bfdc220d; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=haematology|histopathology: non-neoplastic|organ weights and organ / body weight ratios|serum/plasma biochemistry; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|hematology|nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID:15849927:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_02322b27709b174e969e28249c81deb4 |
| ECHA | NOAEL | =1.44 | mg/kg bw/day | Rat | oral | subchronic; 3 months | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cbf3e4b0a7c65d228510; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5769/7/6/2?documentUUID=3dda6f69-b9cf-462f-b1dd-1837bfdc220d; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=food consumption and compound intake|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption|organ weight; STUDY_GROUP=ECHA IUCLID:15849926:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_99ff46f61752e0288e213b96c7ae1338 |
| ECHA | NOAEL | ~2 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cbf3e4b0a7c65d2284f3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5769/7/6/2?documentUUID=3dda6f69-b9cf-462f-b1dd-1837bfdc220d; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=clinical signs|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|organ weight; STUDY_GROUP=ECHA IUCLID:15849925:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_09a9ffaf66757d798134b8e7c7def4ee |
| ECHA | NOAEL | <160 | mg/kg bw/day | Rat | oral | - | reproduction developmental | GUIDELINE=EU Method B.31 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d232e4b0a7c65d2320e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5769/7/9/3?documentUUID=3dda6f69-b9cf-462f-b1dd-1837bfdc220d; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID:15825251:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_21be2236d2f80b68143a5c507129868c |
| ECHA | NOEC | ~5.2 | mg/m3 | Rat | inhalation | acute; 6 hours | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5769/7/6/3?documentUUID=3dda6f69-b9cf-462f-b1dd-1837bfdc220d; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15829319_15829320:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_aa219b04589fdcdfad0d0b57890e4313 |
| ECHA | NOEL | <=150 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c95ee4b0a7c65d21c9d1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5769/7/9/2?documentUUID=3dda6f69-b9cf-462f-b1dd-1837bfdc220d; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=P0: clinical signs|P0: mortality|P0: body weight and weight gain|P0: food consumption and compound intake|P0: water consumption and compound intake|P0: organ weights and organ / body weight ratios|P0: gross pathology; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|gross pathology|mortality/survival|organ weight; STUDY_GROUP=ECHA IUCLID:15863032:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_da0428bd08ea3f6ee1585e0dd76522f5 |
ToxValDB GESTIS DNEL 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =0.052 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15629863_15629864:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1d55afce6cf87b842cc26423640ebd6d |
| ToxValDB GESTIS DNEL | DNEL systemic | =2.2 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15629863_15629864:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_96b2da749d88ad98e2b566ee05ebb752 |
ToxValDB HESS 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB HESS | NOEL | <200 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0dd2e4b0a676289dd91e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Clinical Observation: Diarrhea|Body Weight Changes: decrease|Food Consumption: decrease|Urinalysis: Color, Brown|Hematology: RET increase, PT increase, APTT increase, HGB decrease, HCT decrease, RBC decrease|Blood Chemistry: GLUC decrease, CHE decrease, TG decreasegamma-GTP increase, IP increase, Ca increase|Absolute Organ Weight: Liver increase|Relative Organ Weight: Liver increase, Kidney increase, Spleen increase|Necropsy: Liver-Enlargement Kidney-Enlargement, bilateral Spleen-Blackish change|Histopathology: Liver-Ground glass appearance, Hepatocyte, Centrilobular Liver-Hypertrophy, Hepatocyte, Centrilobular Liver-Microgranuloma Liver-Necrosis, Hepatocyte, Focal Kidney-Degeneration, vacuolar, Proximal tubule, outer zone Spleen-Congestion Spleen-Deposit, hemosiderin Spleen-Hematopoiesis, extramedullary, increased; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|gross pathology|hematology|multiple|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=HESS_dup_-_15638372_15638373:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_562ec447a24ebcff1e307ad326326ad5 |
ToxValDB RSL 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB RSL | RfD | =0.002 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15654332:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_13953ef20278dc88498a43ad0129bd25 |
| ToxValDB RSL | RfD | =0.01 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15663168:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1ba7d68d7c8ce31c776a16ce5cbec0b0 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 030MS0JBDO | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C14H8O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"030MS0JBDO"} |
| openFDA substances | FDA UNII substance identifier | 030MS0JBDO | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C14H8O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"030MS0JBDO"} |
| openFDA substances | FDA UNII substance identifier | 030MS0JBDO | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C14H8O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"030MS0JBDO"} |
| openFDA substances | FDA UNII substance identifier | 030MS0JBDO | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C14H8O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"030MS0JBDO"} |