NOAEL Studies Cosmetic Ingredient

Androstenedione NOAEL Studies

INCI: ANDROSTENEDIONE

CAS: 63-05-8

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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California Proposition 65 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
California Proposition 65 California Proposition 65 listing ABcancer listing type - - 2011-05-03 California Proposition 65 listing {"cancer_reproductive":"cancer","listed_date":"2011-05-03","listing_mechanism":"AB","madl":null,"nsrl":null,"source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 listing ABcancer listing type - - 2011-05-03 California Proposition 65 listing {"cancer_reproductive":"cancer","listed_date":"2011-05-03","listing_mechanism":"AB","madl":null,"nsrl":null,"source_table":"prop65_listings"}
California Proposition 65 California Proposition 65 listing ABcancer listing type - - 2011-05-03 California Proposition 65 listing {"cancer_reproductive":"cancer","listed_date":"2011-05-03","listing_mechanism":"AB","madl":null,"nsrl":null,"source_table":"prop65_listings"}
NTP_ICE_adme_parameters 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_adme_parameters Clint 25.92 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=3272; Record_ID=adme_parameters_361; Data_Type=Measured; DTXSID=DTXSID8024523; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=25.92; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wetmore 2015; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_adme_parameters Fu 0.1744 fraction Human - - Measured; httk, Human Plasma Fraction Unbound sheet=Data; excel_row=3273; Record_ID=adme_parameters_361; Data_Type=Measured; DTXSID=DTXSID8024523; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.1744; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wetmore 2015; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_cancer 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_cancer POLY-3 lowest dose 10 mg/kg bw/day Mouse Gavage - In Vivo; Two year cancer bioassay sheet=Data; excel_row=9104; Record_ID=cancer_2923; Data_Type=In Vivo; Formulation_Name=Androstenedione; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=Two year cancer bioassay; Endpoint=POLY-3 lowest dose; Response=10; Response_Unit=mg/kg/day; Species=Mouse; Strain=B6C3F1/N; Sex=Female; Route=Gavage; Level_of_Evidence=Clear evidence; Tissue=Pancreas; Location=Acinar Cell; Lesion=Adenoma; Reference=TR-560; URL=https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr560/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_cancer POLY-3 lowest dose 50 mg/kg bw/day Mouse Gavage - In Vivo; Two year cancer bioassay sheet=Data; excel_row=9105; Record_ID=cancer_2920; Data_Type=In Vivo; Formulation_Name=Androstenedione; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=Two year cancer bioassay; Endpoint=POLY-3 lowest dose; Response=50; Response_Unit=mg/kg/day; Species=Mouse; Strain=B6C3F1/N; Sex=Male; Route=Gavage; Level_of_Evidence=Clear evidence; Tissue=Pancreas; Location=Acinar Cell; Lesion=Adenoma; Reference=TR-560; URL=https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr560/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_cancer Top dose 50 mg/kg Mouse Gavage - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=9106; Record_ID=cancer_2920; Data_Type=In Vivo; Formulation_Name=Androstenedione; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=50; Response_Unit=mg/kg; Species=Mouse; Strain=B6C3F1/N; Sex=Male; Route=Gavage; Reference=TR-560; URL=https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr560/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine 99 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine AC50 0.325428797 uM - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=3616; RecordID=ARPathway2016_378; DatasetName=ARPathway2016; DTXSID=DTXSID8024523; Assay=AR Pathway Model, Antagonist; Endpoint=AC50; Response=0.325428797; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine AC50 0.0308758414104603 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=3622; RecordID=ERPathway2016_203; DatasetName=ERPathway2016; DTXSID=DTXSID8024523; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=0.0308758414104603; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine AC50/EC50/IC50 218.8 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=57; Record_ID=endocrine_invitro_51; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=218.7761624; Reported_Response_Unit=nM; Response=218.8; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Hartig et al. 2008; 18691642; 10.1016/j.toxlet.2008.07.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine AC50/EC50/IC50 281.8 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=58; Record_ID=endocrine_invitro_52; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=281.83829309999999; Reported_Response_Unit=nM; Response=281.8; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Wilson et al. 2007; 17705648; 10.1897/06-593r.1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine AC50/EC50/IC50 91.2 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=60; Record_ID=endocrine_invitro_54; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=91.201083940000004; Reported_Response_Unit=nM; Response=91.2; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Wilson et al. 2007; 17705648; 10.1897/06-593r.1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine AC50/EC50/IC50 1280 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=140; Record_ID=endocrine_invitro_134; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=1280; Reported_Response_Unit=nM; Response=1280; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Fang et al. 2003; 14565775; 10.1021/tx030011g; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine AC50/EC50/IC50 1000 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=201; Record_ID=endocrine_invitro_195; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=1000; Reported_Response_Unit=nmol/L; Response=1000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Roy et al. 2006; 16893644; 10.1016/j.jsbmb.2006.06.014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine AC50/EC50/IC50 50 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=395; Record_ID=endocrine_invitro_389; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=50; Reported_Response_Unit=nM; Response=50; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Sperry and Thomas 1999; 10098494; 10.1210/endo.140.4.6631; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine AC50/EC50/IC50 1800 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=402; Record_ID=endocrine_invitro_396; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=1800; Reported_Response_Unit=nM; Response=1800; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Freyberger and Ahr 2004; 14751668; 10.1016/j.tox.2003.09.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine AC50/EC50/IC50 20 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=405; Record_ID=endocrine_invitro_399; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=20; Reported_Response_Unit=nM; Response=20; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Paris et al. 2002; 12573822; 10.1016/s0303-7207(02)00375-1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine AC50/EC50/IC50 1928 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=409; Record_ID=endocrine_invitro_403; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=1928; Reported_Response_Unit=nM; Response=1928; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Freyberger et al. 2010; 19833195; 10.1016/j.reprotox.2009.10.001; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine AC50/EC50/IC50 41.1 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=415; Record_ID=endocrine_invitro_409; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=41.1; Reported_Response_Unit=nM; Response=41.1; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Jørgensen et al. 2007; 17698417; 10.1016/j.cbpc.2007.07.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine AC50/EC50/IC50 4900 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=416; Record_ID=endocrine_invitro_410; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=4900; Reported_Response_Unit=nM; Response=4900; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Beck et al. 2008; 17935685; 10.1016/j.ab.2007.09.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine AC50/EC50/IC50 3607 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=417; Record_ID=endocrine_invitro_411; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=3607; Reported_Response_Unit=nM; Response=3607; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Freyberger et al. 2010; 19833195; 10.1016/j.reprotox.2009.10.001; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine AC50/EC50/IC50 100 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=418; Record_ID=endocrine_invitro_412; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=100; Reported_Response_Unit=nM; Response=100; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Wilson et al. 2004; 15597887; 10.1021/es049771j; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine AC50/EC50/IC50 90 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=419; Record_ID=endocrine_invitro_413; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=90; Reported_Response_Unit=nM; Response=90; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Sperry and Thomas 1999; 10491657; 10.1095/biolreprod61.4.1152; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine AC50/EC50/IC50 312.5 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=460; Record_ID=endocrine_invitro_454; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=312.5; Reported_Response_Unit=nM; Response=312.5; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Duc et al. 1995; 7893274; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine AC50/EC50/IC50 3.981 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=7867; Record_ID=endocrine_invitro_1745; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=3.9810717059999998; Reported_Response_Unit=nM; Response=3.981; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Sonneveld et al. 2005; 15483189; 10.1093/toxsci/kfi005; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine AC50/EC50/IC50 10.8 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8030; Record_ID=endocrine_invitro_2056; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=10.8; Reported_Response_Unit=nM; Response=10.8; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Dennis et al. 2008; 18340645; 10.1002/cyto.a.20552; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine AC50/EC50/IC50 8.92 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8033; Record_ID=endocrine_invitro_2598; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=8.92; Reported_Response_Unit=nM; Response=8.92; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Teng et al. 2013; 23562765; 10.1016/j.cbi.2013.03.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine AC50/EC50/IC50 0.3 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8035; Record_ID=endocrine_invitro_1386; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=0.3; Reported_Response_Unit=nM; Response=0.3; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Paris et al. 2002; 12573822; 10.1016/s0303-7207(02)00375-1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine AC50/EC50/IC50 203 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8040; Record_ID=endocrine_invitro_2836; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=203; Reported_Response_Unit=nM; Response=203; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Sanseverino et al. 2009; 18996888; 10.1093/toxsci/kfn229; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine AC50/EC50/IC50 55.5 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8042; Record_ID=endocrine_invitro_1440; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=55.5; Reported_Response_Unit=nM; Response=55.5; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Ma et al. 2003; 12730620; 10.1093/toxsci/kfg102; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine AC50/EC50/IC50 24.3 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8043; Record_ID=endocrine_invitro_3245; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=24.3; Reported_Response_Unit=nM; Response=24.3; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine AC50/EC50/IC50 0.27 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8044; Record_ID=endocrine_invitro_1583; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=0.27; Reported_Response_Unit=nM; Response=0.27; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Körner et al. 2004; 15121513; 10.1289/ehp.112-1241964; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine AC50/EC50/IC50 35 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8046; Record_ID=endocrine_invitro_1581; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=35; Reported_Response_Unit=nM; Response=35; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Körner et al. 2004; 15121513; 10.1289/ehp.112-1241964; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine AC50/EC50/IC50 140 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8048; Record_ID=endocrine_invitro_1585; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=140; Reported_Response_Unit=nM; Response=140; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Körner et al. 2004; 15121513; 10.1289/ehp.112-1241964; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine AC50/EC50/IC50 18.87 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8101; Record_ID=endocrine_invitro_2715; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=5406; Reported_Response_Unit=ng/L; Conversion_Factor=Molecular Weight; Conversion_Factor_Value=286.41500000000002; Conversion_Factor_Source=EPA Dashboard; Converted_Response=18.874709774278582; Converted_Response_Unit=nM; Response=18.87; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine AC50/EC50/IC50 3400 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8238; Record_ID=endocrine_invitro_1945; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=3400; Reported_Response_Unit=nM; Response=3400; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Beck et al. 2008; 17935685; 10.1016/j.ab.2007.09.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine AC50/EC50/IC50 99 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8241; Record_ID=endocrine_invitro_2394; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=99; Reported_Response_Unit=nM; Response=99; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Akram et al. 2011; 21329390; 10.1021/ac102845y; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine AC50/EC50/IC50 45 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8243; Record_ID=endocrine_invitro_2384; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=45; Reported_Response_Unit=nM; Response=45; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Akram et al. 2011; 21329390; 10.1021/ac102845y; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine AC50/EC50/IC50 58 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8245; Record_ID=endocrine_invitro_2068; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=58; Reported_Response_Unit=nM; Response=58; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|de Waal et al. 2008; 18469035; 10.1530/rep-08-0055; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine AC50/EC50/IC50 620 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8247; Record_ID=endocrine_invitro_2417; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=620; Reported_Response_Unit=nM; Response=620; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Akram et al. 2011; 21329390; 10.1021/ac102845y; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine AC50/EC50/IC50 15 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8249; Record_ID=endocrine_invitro_2390; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=15; Reported_Response_Unit=nM; Response=15; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Akram et al. 2011; 21329390; 10.1021/ac102845y; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine AC50/EC50/IC50 4.18 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8251; Record_ID=endocrine_invitro_2750; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=4.18; Reported_Response_Unit=nM; Response=4.18; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Bain et al. 2015; 25644213; 10.1016/j.ygcen.2015.01.024; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine AC50/EC50/IC50 37.9 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8258; Record_ID=endocrine_invitro_2368; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=37.9; Reported_Response_Unit=nM; Response=37.9; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Aït-Aïssa et al. 2010; 20736058; 10.1016/j.tiv.2010.08.014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine AC50/EC50/IC50 130 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8261; Record_ID=endocrine_invitro_1949; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=130; Reported_Response_Unit=nM; Response=130; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Beck et al. 2008; 17935685; 10.1016/j.ab.2007.09.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine AC50/EC50/IC50 7200 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8263; Record_ID=endocrine_invitro_1962; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=7200; Reported_Response_Unit=nM; Response=7200; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Bovee et al. 2008; 17945480; 10.1016/j.jsbmb.2007.05.035; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine AC50/EC50/IC50 1020 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8266; Record_ID=endocrine_invitro_3262; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=1020; Reported_Response_Unit=nM; Response=1020; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Rijk et al. 2009; 19286044; 10.1016/j.aca.2008.09.014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine AC50/EC50/IC50 10.1 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8269; Record_ID=endocrine_invitro_2760; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=10.1; Reported_Response_Unit=nM; Response=10.1; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Bain et al. 2015; 25644213; 10.1016/j.ygcen.2015.01.024; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine AC50/EC50/IC50 500 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8271; Record_ID=endocrine_invitro_1682; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=500; Reported_Response_Unit=nM; Response=500; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Michelini et al. 2005; 15797324; 10.1016/j.bios.2004.10.018; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine AC50/EC50/IC50 41.3 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8273; Record_ID=endocrine_invitro_2339; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=41.3; Reported_Response_Unit=nM; Response=41.3; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Blake et al. 2010; 20821581; 10.1002/etc.166; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine AC50/EC50/IC50 0.0072 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8301; Record_ID=endocrine_invitro_3119; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=7.1999999999999998E-3; Reported_Response_Unit=nM; Response=0.0072; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Wang et al. 2010; 20237917; 10.1007/s00216-010-3605-z; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine ACC 0.049702621 uM - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=3617; RecordID=ARPathway2016_378; DatasetName=ARPathway2016; DTXSID=DTXSID8024523; Assay=AR Pathway Model, Antagonist; Endpoint=ACC; Response=0.049702621; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine ACC 0.00414685502410049 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=3623; RecordID=ERPathway2016_203; DatasetName=ERPathway2016; DTXSID=DTXSID8024523; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=0.00414685502410049; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine Ki >1875 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=1816; Record_ID=endocrine_invitro_993; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=Ki; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=1875; Reported_Response_Unit=nM; Response=1875; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Chen et al. 2004; 15336702; 10.1016/j.jsbmb.2004.04.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine Ki 73.36 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=1818; Record_ID=endocrine_invitro_987; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=Ki; Reported_Response=73.36; Reported_Response_Unit=nM; Response=73.36; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Chen et al. 2004; 15336702; 10.1016/j.jsbmb.2004.04.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine Ki 58 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=1819; Record_ID=endocrine_invitro_1004; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=Ki; Reported_Response=58; Reported_Response_Unit=nM; Response=58; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Eil and Edelson 1984; 6725525; 10.1210/jcem-59-1-51; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine Ki 19.6 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=1821; Record_ID=endocrine_invitro_989; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=Ki; Reported_Response=19.600000000000001; Reported_Response_Unit=nM; Response=19.6; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Chen et al. 2004; 15336702; 10.1016/j.jsbmb.2004.04.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine Ki 131 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=1869; Record_ID=endocrine_invitro_1006; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=Ki; Reported_Response=131; Reported_Response_Unit=nM; Response=131; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Chen et al. 2004; 15336702; 10.1016/j.jsbmb.2004.04.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine Ki 60.61 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=1872; Record_ID=endocrine_invitro_983; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=Ki; Reported_Response=60.61; Reported_Response_Unit=nM; Response=60.61; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Chen et al. 2004; 15336702; 10.1016/j.jsbmb.2004.04.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine Ki 44.2 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=1879; Record_ID=endocrine_invitro_982; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=Ki; Reported_Response=44.2; Reported_Response_Unit=nM; Response=44.2; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Chen et al. 2004; 15336702; 10.1016/j.jsbmb.2004.04.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine LEL 1 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10338; Record_ID=endocrine_invitro_1504; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=LEL; Reported_Response=1; Reported_Response_Unit=nM; Response=1; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Lu et al. 2003; 14556282; 10.1002/neu.10260; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine LEL 3 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10465; Record_ID=endocrine_invitro_1599; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=LEL; Reported_Response=3; Reported_Response_Unit=nM; Response=3; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Körner et al. 2004; 15121513; 10.1289/ehp.112-1241964; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine LEL 1000000000000000000 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10481; Record_ID=endocrine_invitro_1576; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=LEL; Reported_Response=1E+18; Reported_Response_Unit=nM; Response=1E+18; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Körner et al. 2004; 15121513; 10.1289/ehp.112-1241964; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine LEL 0.8 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10482; Record_ID=endocrine_invitro_1593; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=LEL; Reported_Response=0.8; Reported_Response_Unit=nM; Response=0.8; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Körner et al. 2004; 15121513; 10.1289/ehp.112-1241964; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine LEL 10 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10506; Record_ID=endocrine_invitro_3112; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=LEL; Reported_Response=10; Reported_Response_Unit=nM; Response=10; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Werner et al. 2006; 16930995; 10.1016/j.jsbmb.2006.06.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine LEL 0.1 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10508; Record_ID=endocrine_invitro_3100; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=LEL; Reported_Response=0.1; Reported_Response_Unit=nM; Response=0.1; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Werner et al. 2006; 16930995; 10.1016/j.jsbmb.2006.06.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine LEL 50 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10709; Record_ID=endocrine_invitro_1232; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=LEL; Reported_Response=50; Reported_Response_Unit=nM; Response=50; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Culig et al. 1993; 8145761; 10.1210/mend.7.12.8145761; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine LEL 10000 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10816; Record_ID=endocrine_invitro_2039; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=LEL; Reported_Response=10000; Reported_Response_Unit=nM; Response=10000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Dennis et al. 2008; 18340645; 10.1002/cyto.a.20552; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=3618; RecordID=ARPathway2016_378; DatasetName=ARPathway2016; DTXSID=DTXSID8024523; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine Model Score 1.3 unitless - - - ARPathway2016; AR Pathway Model, Agonist sheet=Integrated_approaches; excel_row=3619; RecordID=ARPathway2016_378; DatasetName=ARPathway2016; DTXSID=DTXSID8024523; Assay=AR Pathway Model, Agonist; Endpoint=Model Score; Response=1.3; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine Model Score 0.183 unitless - - - ERPathway2016; ER Pathway Model, Agonist sheet=Integrated_approaches; excel_row=3624; RecordID=ERPathway2016_203; DatasetName=ERPathway2016; DTXSID=DTXSID8024523; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.183; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine PC10 3.97 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=8415; Record_ID=endocrine_invitro_1453; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=PC10; Reported_Response=3.97; Reported_Response_Unit=PC10 (nM); Response=3.97; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Takeyoshi et al. 2003; 12734641; 10.1007/s00204-003-0437-z; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine RBA 4.169 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=1942; Record_ID=endocrine_invitro_990; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=RBA; Reported_Response=0.62; Reported_Response_Unit=Unitless; Conversion_Factor=Anti-log; Converted_Response=4.1686938347033546; Converted_Response_Unit=Unitless; Response=4.169; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Leusch et al. 2006; 16473560; 10.1016/j.cbpc.2005.12.010; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine RBA 0.2399 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=1943; Record_ID=endocrine_invitro_134; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=RBA; Reported_Response=-0.62; Reported_Response_Unit=Unitless; Conversion_Factor=Anti-log; Converted_Response=0.23988329190194901; Converted_Response_Unit=Unitless; Response=0.2399; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Fang et al. 2003; 14565775; 10.1021/tx030011g; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine RBA 50.12 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=1946; Record_ID=endocrine_invitro_985; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=RBA; Reported_Response=1.7; Reported_Response_Unit=Unitless; Conversion_Factor=Anti-log; Converted_Response=50.118723362727238; Converted_Response_Unit=Unitless; Response=50.12; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Bohl et al. 2004; 15239655; 10.1021/jm0499007; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine RBA 0.1 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2352; Record_ID=endocrine_invitro_995; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=RBA; Reported_Response=0.1; Reported_Response_Unit=Unitless; Response=0.1; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Sonneveld et al. 2006; 16221957; 10.1093/toxsci/kfj009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine RBA 67.9 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2354; Record_ID=endocrine_invitro_984; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=RBA; Reported_Response=67.900000000000006; Reported_Response_Unit=Unitless; Response=67.9; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine RBA 0.14 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2355; Record_ID=endocrine_invitro_52; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=RBA; Reported_Response=0.14000000000000001; Reported_Response_Unit=Unitless; Response=0.14; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Wilson et al. 2007; 17705648; 10.1897/06-593r.1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine RBA 0.2577 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2357; Record_ID=endocrine_invitro_403; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=RBA; Reported_Response=0.25769999999999998; Reported_Response_Unit=Unitless; Response=0.2577; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Freyberger et al. 2010; 19833195; 10.1016/j.reprotox.2009.10.001; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine RBA 57.1 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2358; Record_ID=endocrine_invitro_991; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=RBA; Reported_Response=57.1; Reported_Response_Unit=Unitless; Response=57.1; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine RBA 187.6 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2359; Record_ID=endocrine_invitro_1005; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=RBA; Reported_Response=187.6; Reported_Response_Unit=Unitless; Response=187.6; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine RBA 1.96 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2362; Record_ID=endocrine_invitro_54; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=RBA; Reported_Response=1.96; Reported_Response_Unit=Unitless; Response=1.96; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Wilson et al. 2007; 17705648; 10.1897/06-593r.1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine RBA 0.9 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2363; Record_ID=endocrine_invitro_454; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=RBA; Reported_Response=0.9; Reported_Response_Unit=Unitless; Response=0.9; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Duc et al. 1995; 7893274; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine RBA 1.42 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2364; Record_ID=endocrine_invitro_59; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=RBA; Reported_Response=1.42; Reported_Response_Unit=Unitless; Response=1.42; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Wilson et al. 2007; 17705648; 10.1897/06-593r.1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine RBA 0.4 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2365; Record_ID=endocrine_invitro_51; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=RBA; Reported_Response=0.4; Reported_Response_Unit=Unitless; Response=0.4; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Hartig et al. 2008; 18691642; 10.1016/j.toxlet.2008.07.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine RBA 0.1417 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2366; Record_ID=endocrine_invitro_411; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=RBA; Reported_Response=0.14169999999999999; Reported_Response_Unit=Unitless; Response=0.1417; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Freyberger et al. 2010; 19833195; 10.1016/j.reprotox.2009.10.001; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine RBA 1.6 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2367; Record_ID=endocrine_invitro_998; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=RBA; Reported_Response=1.6; Reported_Response_Unit=Unitless; Response=1.6; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Culig et al. 1993; 8145761; 10.1210/mend.7.12.8145761; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine RBA 3 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2368; Record_ID=endocrine_invitro_1000; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=RBA; Reported_Response=3; Reported_Response_Unit=Unitless; Response=3; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Braun and Thomas 2004; 14985249; 10.1095/biolreprod.103.025825; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine RBA 2 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2369; Record_ID=endocrine_invitro_1004; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=RBA; Reported_Response=2; Reported_Response_Unit=Unitless; Response=2; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Eil and Edelson 1984; 6725525; 10.1210/jcem-59-1-51; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine RBA 150 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2370; Record_ID=endocrine_invitro_988; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=RBA; Reported_Response=150; Reported_Response_Unit=Unitless; Response=150; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Friedel et al. 2006; 16356667; 10.1016/j.toxlet.2005.11.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine RBA 1.4 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2371; Record_ID=endocrine_invitro_997; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=RBA; Reported_Response=1.4; Reported_Response_Unit=Unitless; Response=1.4; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Culig et al. 1993; 8145761; 10.1210/mend.7.12.8145761; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine RBA 0.2407 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2372; Record_ID=endocrine_invitro_134; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=RBA; Reported_Response=0.2407; Reported_Response_Unit=Unitless; Response=0.2407; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Fang et al. 2003; 14565775; 10.1021/tx030011g; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine RBA 10 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2374; Record_ID=endocrine_invitro_996; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=RBA; Reported_Response=10; Reported_Response_Unit=Unitless; Response=10; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Thieulant et al. 1975; 170477; 10.1016/0022-4731(75)90116-8; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine RBA 0.25 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2375; Record_ID=endocrine_invitro_994; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=RBA; Reported_Response=0.25; Reported_Response_Unit=Unitless; Response=0.25; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Freyberger and Scholz 2004; 15057405; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine RBA 52.6 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2378; Record_ID=endocrine_invitro_1002; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=RBA; Reported_Response=52.6; Reported_Response_Unit=Unitless; Response=52.6; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine RBA 0.33 unitless - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=2381; Record_ID=endocrine_invitro_413; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Binding; Endpoint=RBA; Reported_Response=0.33; Reported_Response_Unit=Unitless; Response=0.33; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Sperry and Thomas 1999; 10491657; 10.1095/biolreprod61.4.1152; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine Relative potency 5.5 % - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10990; Record_ID=endocrine_invitro_2418; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=Relative potency; Reported_Response=5.5; Reported_Response_Unit=%; Response=5.5; Response_Unit=%; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Akram et al. 2011; 21329390; 10.1021/ac102845y; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine Relative potency 24 % - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10992; Record_ID=endocrine_invitro_2750; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=Relative potency; Reported_Response=24; Reported_Response_Unit=%; Response=24; Response_Unit=%; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Bain et al. 2015; 25644213; 10.1016/j.ygcen.2015.01.024; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine Relative potency 0.21 % - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10995; Record_ID=endocrine_invitro_1440; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=Relative potency; Reported_Response=0.21; Reported_Response_Unit=%; Response=0.21; Response_Unit=%; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Ma et al. 2003; 12730620; 10.1093/toxsci/kfg102; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine Relative potency 5.13 % - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10996; Record_ID=endocrine_invitro_2715; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=Relative potency; Reported_Response=5.13; Reported_Response_Unit=%; Response=5.13; Response_Unit=%; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine Relative potency 20 % - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=10998; Record_ID=endocrine_invitro_3081; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=Relative potency; Reported_Response=20; Reported_Response_Unit=%; Response=20; Response_Unit=%; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Mak et al. 1999; 10544151; 10.1289/ehp.99107855; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine Relative potency 2.5 % - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=11001; Record_ID=endocrine_invitro_2417; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=Relative potency; Reported_Response=2.5; Reported_Response_Unit=%; Response=2.5; Response_Unit=%; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Akram et al. 2011; 21329390; 10.1021/ac102845y; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine Relative potency 1.1 % - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=11003; Record_ID=endocrine_invitro_3245; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=Relative potency; Reported_Response=1.1000000000000001; Reported_Response_Unit=%; Response=1.1; Response_Unit=%; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine Relative potency 5.7 % - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=11004; Record_ID=endocrine_invitro_1745; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=Relative potency; Reported_Response=5.7; Reported_Response_Unit=%; Response=5.7; Response_Unit=%; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Sonneveld et al. 2005; 15483189; 10.1093/toxsci/kfi005; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine Relative potency 4.9 % - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=11006; Record_ID=endocrine_invitro_3262; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=Relative potency; Reported_Response=4.9000000000000004; Reported_Response_Unit=%; Response=4.9; Response_Unit=%; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Rijk et al. 2009; 19286044; 10.1016/j.aca.2008.09.014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine Relative potency 0.5 % - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=11008; Record_ID=endocrine_invitro_2410; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=Relative potency; Reported_Response=0.5; Reported_Response_Unit=%; Response=0.5; Response_Unit=%; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Akram et al. 2011; 21329390; 10.1021/ac102845y; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
NTP_ICE_endocrine Relative potency 82 % - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=11019; Record_ID=endocrine_invitro_1621; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8024523; Assay=AR Transactivation-Agonist; Endpoint=Relative potency; Reported_Response=82; Reported_Response_Unit=%; Response=82; Response_Unit=%; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Sonneveld et al. 2005; 15483189; 10.1093/toxsci/kfi005; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8024523; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8024523
ToxRefDB_ToxRefDB_v3_pod.csv 10 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxRefDB_ToxRefDB_v3_pod.csv LEL =1 mg/kg bw/day rat (fischer; Fischer 344) oral 0 day to 14 week SUB study_id=6223; toxval_study_source_id=studyid6223_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-body weight-body weight gain|organ weight-thymus-absolute; dose_level=1; study_year=2010; study_citation=(2010) NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF ANDROSTENEDIONE (CAS NO. 63-05-8) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES). NTP TR 560, NIH Publication No. 10-5901. (Subchronic Rat); dsstox_substance_id=DTXSID8024523; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv LEL =10 mg/kg bw/day rat (fischer; Fischer 344) oral 0 day to 14 week SUB study_id=6223; toxval_study_source_id=studyid6223_Adult_F0_M_systemic; toxval_effect_list=pathology gross-sperm measure-sperm count; dose_level=3; study_year=2010; study_citation=(2010) NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF ANDROSTENEDIONE (CAS NO. 63-05-8) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES). NTP TR 560, NIH Publication No. 10-5901. (Subchronic Rat); dsstox_substance_id=DTXSID8024523; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv LEL =5 mg/kg bw/day mouse (b6c3f1; B6C3F1) oral 0 day to 14 week SUB study_id=6224; toxval_study_source_id=studyid6224_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-adrenal gland-atrophy|pathology microscopic-adrenal gland-vacuolization; dose_level=2; study_year=2010; study_citation=(2010) NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF ANDROSTENEDIONE (CAS NO. 63-05-8) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES). NTP TR 560, NIH Publication No. 10-5901. (Subchronic Mouse); dsstox_substance_id=DTXSID8024523; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv LEL =20 mg/kg bw/day mouse (b6c3f1; B6C3F1) oral 0 day to 14 week SUB study_id=6224; toxval_study_source_id=studyid6224_Adult_F0_M_systemic; toxval_effect_list=pathology gross-sperm measure-sperm count|pathology gross-sperm measure-sperm motility|pathology microscopic-bone marrow-hyperplasia; dose_level=4; study_year=2010; study_citation=(2010) NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF ANDROSTENEDIONE (CAS NO. 63-05-8) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES). NTP TR 560, NIH Publication No. 10-5901. (Subchronic Mouse); dsstox_substance_id=DTXSID8024523; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv LEL =2 mg/kg bw/day mouse (b6c3f1; B6C3F1) oral 0 day to 104 week CHR study_id=6226; toxval_study_source_id=studyid6226_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-salivary glands-cytoplasmic alteration|pathology microscopic-liver-carcinoma|pathology microscopic-clitoral gland-hyperplasia|in life observation-body weight-body weight|pathology microscopic-clitoral gland-dilatation|pathology microscopic-liver-adenoma/carcinoma combined|pathology microscopic-pancreas-adenoma|pathology microscopic-kidney-metaplasia|pathology microscopic-liver-mixed cell focus|pathology microscopic-liver-adenoma|pathology microscopic-liver-vacuolization cytoplasmic; dose_level=1; study_year=2010; study_citation=(2010) NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF ANDROSTENEDIONE (CAS NO. 63-05-8) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES). NTP TR 560, NIH Publication No. 10-5901. (Chronic Mouse); dsstox_substance_id=DTXSID8024523; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv LOAEL =50 mg/kg bw/day rat (fischer; Fischer 344) oral 0 day to 104 week CHR study_id=6225; toxval_study_source_id=studyid6225_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-spleen-hyperplasia|pathology microscopic-pancreas-atrophy|pathology microscopic-pancreas-hyperplasia; dose_level=3; study_year=2010; study_citation=(2010) NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF ANDROSTENEDIONE (CAS NO. 63-05-8) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES). NTP TR 560, NIH Publication No. 10-5901. (Chronic Rat); dsstox_substance_id=DTXSID8024523; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv NEL >0 mg/kg bw/day rat (fischer; Fischer 344) oral 0 day to 14 week SUB study_id=6223; toxval_study_source_id=studyid6223_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-body weight-body weight gain|organ weight-thymus-absolute; dose_level=0; study_year=2010; study_citation=(2010) NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF ANDROSTENEDIONE (CAS NO. 63-05-8) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES). NTP TR 560, NIH Publication No. 10-5901. (Subchronic Rat); dsstox_substance_id=DTXSID8024523; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv NEL =5 mg/kg bw/day rat (fischer; Fischer 344) oral 0 day to 14 week SUB study_id=6223; toxval_study_source_id=studyid6223_Adult_F0_M_systemic; toxval_effect_list=pathology gross-sperm measure-sperm count; dose_level=2; study_year=2010; study_citation=(2010) NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF ANDROSTENEDIONE (CAS NO. 63-05-8) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES). NTP TR 560, NIH Publication No. 10-5901. (Subchronic Rat); dsstox_substance_id=DTXSID8024523; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv NEL =1 mg/kg bw/day mouse (b6c3f1; B6C3F1) oral 0 day to 14 week SUB study_id=6224; toxval_study_source_id=studyid6224_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-adrenal gland-vacuolization|pathology microscopic-adrenal gland-atrophy; dose_level=1; study_year=2010; study_citation=(2010) NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF ANDROSTENEDIONE (CAS NO. 63-05-8) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES). NTP TR 560, NIH Publication No. 10-5901. (Subchronic Mouse); dsstox_substance_id=DTXSID8024523; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv NEL =10 mg/kg bw/day mouse (b6c3f1; B6C3F1) oral 0 day to 14 week SUB study_id=6224; toxval_study_source_id=studyid6224_Adult_F0_M_systemic; toxval_effect_list=pathology gross-sperm measure-sperm motility|pathology microscopic-bone marrow-hyperplasia|pathology gross-sperm measure-sperm count; dose_level=3; study_year=2010; study_citation=(2010) NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF ANDROSTENEDIONE (CAS NO. 63-05-8) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES). NTP TR 560, NIH Publication No. 10-5901. (Subchronic Mouse); dsstox_substance_id=DTXSID8024523; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxValDB_ECHA_IUCLID 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LOAEL =50 mg/kg bw/day Mouse oral chronic; 14 weeks chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae8ce4b0a7c65d1c9ced; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13632/7/6/2?documentUUID=0acee5eb-4396-4858-8c3f-de462eea5e2c; YEAR=1987; ORIGINAL_YEAR=1987; STUDY_GROUP=ECHA IUCLID:15832818:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_aff47b4164c6335af35b9ca19618df80
ToxValDB_ECHA_IUCLID LOAEL =15 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae8ce4b0a7c65d1c9cf9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13632/7/6/2?documentUUID=0acee5eb-4396-4858-8c3f-de462eea5e2c; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=uterus; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15837424:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6113816cb799d6ebef5013e5c7271467
ToxValDB_ECHA_IUCLID LOAEL =5 mg/kg bw/day Rat injection short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c620f5e4b096bca87834d9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13632/7/6/5?documentUUID=0acee5eb-4396-4858-8c3f-de462eea5e2c; YEAR=1987; ORIGINAL_YEAR=1987; STUDY_GROUP=ECHA IUCLID:15854569:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5a7a316f929bcdec5b2751faa6fd3832
ToxValDB_ECHA_IUCLID NOAEL =60 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac4ae4b0a7c65d1be52f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13632/7/9/3?documentUUID=0acee5eb-4396-4858-8c3f-de462eea5e2c; YEAR=1987; ORIGINAL_YEAR=1987; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820590_15821004:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2836719c287f221e6cf1eaf05066d393
ToxValDB_ECHA_IUCLID NOAEL =10 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1ece4b0a7c65d230d1c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13632/7/9/3?documentUUID=0acee5eb-4396-4858-8c3f-de462eea5e2c; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=fetus: reduction in number of live offspring; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820590_15821004:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_33a3369f5b0f3d183ca6b0b4719157cb
ToxValDB_ECHA_IUCLID NOAEL =30 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac4ae4b0a7c65d1be52f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13632/7/9/3?documentUUID=0acee5eb-4396-4858-8c3f-de462eea5e2c; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=maternal: endocrine findings; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15821945_15822335:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8e929ea0d4cb625ceb6aa7c3582b81af
ToxValDB_ECHA_IUCLID NOAEL =5 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1ece4b0a7c65d230d1c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13632/7/9/3?documentUUID=0acee5eb-4396-4858-8c3f-de462eea5e2c; YEAR=1987; ORIGINAL_YEAR=1987; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15821945_15822335:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_497b23f6810652a2a03cc887bd47a68d
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =0.176 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15629847:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ec096247fba9d1a95394f0749f9c8ca7
ToxValDB_ToxRefDB 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ToxRefDB LEL =1 mg/kg bw/day Rat oral chronic; 14 weeks chronic LONG_REF=(2010) NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF ANDROSTENEDIONE (CAS NO. 63-05-8) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES). NTP TR 560, NIH Publication No. 10-5901. (Subchronic Rat); TITLE=NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF ANDROSTENEDIONE (CAS NO. 63-05-8) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=6223; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: in life observation-body weight-body weight gain|systemic: organ weight-thymus-absolute; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|organ weight; STUDY_GROUP=ToxRefDB:15711274:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4e89181b0e3e1aa3d640bc62f98fa0a8
ToxValDB_ToxRefDB LEL =10 mg/kg bw/day Rat oral chronic; 14 weeks chronic LONG_REF=(2010) NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF ANDROSTENEDIONE (CAS NO. 63-05-8) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES). NTP TR 560, NIH Publication No. 10-5901. (Subchronic Rat); TITLE=NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF ANDROSTENEDIONE (CAS NO. 63-05-8) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=6223; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=systemic: pathology gross-sperm measure-sperm count; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ToxRefDB_dup_-_15711275_15711276:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_375c261ff73281f3b8db7dad5b3b624c
ToxValDB_ToxRefDB LEL =5 mg/kg bw/day Mouse oral chronic; 14 weeks chronic LONG_REF=(2010) NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF ANDROSTENEDIONE (CAS NO. 63-05-8) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES). NTP TR 560, NIH Publication No. 10-5901. (Subchronic Mouse); TITLE=NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF ANDROSTENEDIONE (CAS NO. 63-05-8) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=6224; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-adrenal gland-atrophy|systemic: pathology microscopic-adrenal gland-vacuolization; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15711277_15711278:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_10a40bcd8f507a8d6f17ac03f73d3591
ToxValDB_ToxRefDB LEL =20 mg/kg bw/day Mouse oral chronic; 14 weeks chronic LONG_REF=(2010) NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF ANDROSTENEDIONE (CAS NO. 63-05-8) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES). NTP TR 560, NIH Publication No. 10-5901. (Subchronic Mouse); TITLE=NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF ANDROSTENEDIONE (CAS NO. 63-05-8) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=6224; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=systemic: pathology gross-sperm measure-sperm count|systemic: pathology gross-sperm measure-sperm motility|systemic: pathology microscopic-bone marrow-hyperplasia; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology|nonneoplastic histopathology|reproduction; STUDY_GROUP=ToxRefDB_dup_-_15711279_15711280:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ed75d39c9a9ad217c6870541a6d316a9
ToxValDB_ToxRefDB LEL =2 mg/kg bw/day Mouse oral chronic; 104 weeks chronic LONG_REF=(2010) NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF ANDROSTENEDIONE (CAS NO. 63-05-8) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES). NTP TR 560, NIH Publication No. 10-5901. (Chronic Mouse); TITLE=NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF ANDROSTENEDIONE (CAS NO. 63-05-8) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=6226; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-liver-carcinoma|systemic: pathology microscopic-salivary glands-cytoplasmic alteration|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-clitoral gland-hyperplasia|systemic: pathology microscopic-clitoral gland-dilatation|systemic: pathology microscopic-liver-adenoma/carcinoma combined|systemic: pathology microscopic-pancreas-adenoma|systemic: pathology microscopic-liver-mixed cell focus|systemic: pathology microscopic-liver-adenoma|systemic: pathology microscopic-liver-vacuolization cytoplasmic|systemic: pathology microscopic-kidney-metaplasia; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15711286_15711287:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2ea36de9c1cb25166bca2455205d41ee
ToxValDB_ToxRefDB LOAEL =50 mg/kg bw/day Rat oral chronic; 104 weeks chronic LONG_REF=(2010) NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF ANDROSTENEDIONE (CAS NO. 63-05-8) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES). NTP TR 560, NIH Publication No. 10-5901. (Chronic Rat); TITLE=NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF ANDROSTENEDIONE (CAS NO. 63-05-8) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=6225; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-spleen-hyperplasia|systemic: pathology microscopic-pancreas-atrophy|systemic: pathology microscopic-pancreas-hyperplasia; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15711281_15711282_15711283_15711284:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2d8101140dfc83ea0f1bf7eb26e60029
ToxValDB_ToxRefDB NEL =1 mg/kg bw/day Mouse oral chronic; 14 weeks chronic LONG_REF=(2010) NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF ANDROSTENEDIONE (CAS NO. 63-05-8) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES). NTP TR 560, NIH Publication No. 10-5901. (Subchronic Mouse); TITLE=NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF ANDROSTENEDIONE (CAS NO. 63-05-8) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=6224; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-adrenal gland-vacuolization|systemic: pathology microscopic-adrenal gland-atrophy; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15711277_15711278:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_882eb6326d28ec06a926dbf56340ccc2
ToxValDB_ToxRefDB NEL =10 mg/kg bw/day Mouse oral chronic; 14 weeks chronic LONG_REF=(2010) NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF ANDROSTENEDIONE (CAS NO. 63-05-8) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES). NTP TR 560, NIH Publication No. 10-5901. (Subchronic Mouse); TITLE=NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF ANDROSTENEDIONE (CAS NO. 63-05-8) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=6224; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=systemic: pathology gross-sperm measure-sperm motility|systemic: pathology microscopic-bone marrow-hyperplasia|systemic: pathology gross-sperm measure-sperm count; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology|nonneoplastic histopathology|reproduction; STUDY_GROUP=ToxRefDB_dup_-_15711279_15711280:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8a940bfa2d39de34846c3c2e4f5b553e
ToxValDB_Uterotrophic_Hershberger_DB 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_Uterotrophic_Hershberger_DB LEL =2 mg/day Rat injection short-term; 14 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713356:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3c55bf43e175bab91cedd1734a7ceffc
ToxValDB_Uterotrophic_Hershberger_DB LEL =5 mg/day Rat injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713368:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8c526b0bd4db092d647611625095498b
ToxValDB_Uterotrophic_Hershberger_DB LEL =1 mg/kg bw/day Rat injection subchronic; 36 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713464:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0a7e1545c1498c8d14704d1278872ad0
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 409J2J96VR UNII - - - chemical {"approval_status":null,"molecular_formula":"C19H26O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"409J2J96VR"}
openFDA substances FDA UNII substance identifier 409J2J96VR UNII - - - chemical {"approval_status":null,"molecular_formula":"C19H26O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"409J2J96VR"}
openFDA substances FDA UNII substance identifier 409J2J96VR UNII - - - chemical {"approval_status":null,"molecular_formula":"C19H26O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"409J2J96VR"}
openFDA substances FDA UNII substance identifier 409J2J96VR UNII - - - chemical {"approval_status":null,"molecular_formula":"C19H26O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"409J2J96VR"}