NOAEL Studies Cosmetic Ingredient

Ammonium Chloride NOAEL Studies

INCI: AMMONIUM CHLORIDE

CAS: 12125-02-9

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 9 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 2000 mg/kg bw/day cat oral 150 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 1000 mg/kg bw/day rabbit oral 28 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 750 mg/kg bw/day rat oral 330 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 200 mg/kg bw/day dog oral 7 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 700 mg/kg bw/day rat oral 7 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 1500 mg/kg bw/day rat oral 6 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 500 mg/kg bw/day rabbit oral 5 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 253 mg/kg bw/day cattle oral 112 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 1050 mg/kg bw/day rat oral 91 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
ToxValDB_ECHA_IUCLID 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOEL =684 mg/kg bw/day Rat oral subchronic; 70 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead72e4b0a7c65d1c4413; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13376/7/6/2?documentUUID=1bb64f22-9e4c-4f54-991f-a093ab5588fc; YEAR=2008; ORIGINAL_YEAR=2008; STUDY_GROUP=ECHA IUCLID:15843986:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_28112ff3a33295e83b89cd605de1444b
ToxValDB_EFSA 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA LEL =15000 mg/kg bw/day Sheep oral subchronic; 84 days subchronic LONG_REF=EFSA FEEDAP (2012). Scientific Opinion on ammonium chloride (Amoklor) for lambs for fattening. doi:10.2903/j.efsa.2012.2569.; TITLE=Scientific Opinion on ammonium chloride (Amoklor) for lambs for fattening; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2012.2569; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15614161:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2834a66bb638d101251a845d328de3aa
ToxValDB_EFSA LEL =10000 mg/kg bw/day Sheep oral subchronic; 88 days subchronic LONG_REF=EFSA FEEDAP (2012). Scientific Opinion on ammonium chloride (Amoklor) for lambs for fattening. doi:10.2903/j.efsa.2012.2569.; TITLE=Scientific Opinion on ammonium chloride (Amoklor) for lambs for fattening; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2012.2569; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15614162:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0fd54cf87cadf5742e506fbbf5d32bdf
ToxValDB_GESTIS_DNEL 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =43.97 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15629809_15629810:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e4997eb4fa36e880240524cfe324b71c
ToxValDB_GESTIS_DNEL DNEL systemic =33.5 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15629809_15629810:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_459e393ac48e19ff6810d35585fe929f
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 01Q9PC255D UNII - - - chemical {"approval_status":null,"molecular_formula":"Cl.H4N","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"01Q9PC255D"}
openFDA substances FDA UNII substance identifier 01Q9PC255D UNII - - - chemical {"approval_status":null,"molecular_formula":"Cl.H4N","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"01Q9PC255D"}
openFDA substances FDA UNII substance identifier 01Q9PC255D UNII - - - chemical {"approval_status":null,"molecular_formula":"Cl.H4N","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"01Q9PC255D"}
openFDA substances FDA UNII substance identifier 01Q9PC255D UNII - - - chemical {"approval_status":null,"molecular_formula":"Cl.H4N","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"01Q9PC255D"}