NOAEL Studies
Cosmetic Ingredient
Ammonia NOAEL Studies
INCI: AMMONIA
CAS: 7664-41-7
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
Regulatory source 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | LOAEL | =34.8284 | mg/m3 | Human (M/F) | inhalation | acute; 2 hours | clinical | ATSDR MRLs; row_hash=d39f96879977bbd3; source_hash=ToxValhc_4cfe6e3b8aafd25400417bd5d31cf630; raw_endpoint_type=LOAEL; raw_endpoint_subtype=; raw_value=50; raw_unit=ppm; effect=respiratory; effect_category=clinical signs; file=toxval_ATSDR_MRLs.xlsx; long_ref=Verberk MM. 1977. Effects of ammonia in volunteers. Int Arch Occup Environ Health 39:73-81.; stored_source_record=https://clowder.edap-cluster.com/files/6568f404e4b063812d584c0d |
| Regulatory source | NOAEL | =6.40842 | mg/m3 | Human (M) | inhalation | chronic; 12.2 years | occupational | ATSDR MRLs; row_hash=09c8166dfe58f347; source_hash=ToxValhc_4e142f9578b04c6d5d2c7097a05bf5bd; raw_endpoint_type=NOAEL; raw_endpoint_subtype=; raw_value=9.2; raw_unit=ppm; effect=respiratory; effect_category=clinical signs; file=toxval_ATSDR_MRLs.xlsx; long_ref=Holness DL, Purdham JT, Nethercott JR. 1989. Acute and chronic respiratory effects of occupational exposure to ammonia. Am Ind Hyg Assoc J 50:646-650.; stored_source_record=https://clowder.edap-cluster.com/files/6568f404e4b063812d584c0d |
| Regulatory source | NOAEL (ADJ) | =4.9 | mg/m^3 | - | inhalation | chronic | IRIS chronic inhalation RfC system PoD | row_hash=b254ab572897ef75; file=iris_rfc_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=NOAEL (ADJ): 4.9 mg/m^3; system=Respiratory; basis=Decreased lung function and respiratory symptoms; point_of_departure=NOAEL (ADJ): 4.9 mg/m^3; composite_uf=10; confidence=Medium; dtxsid=DTXSID0023872; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=422; rfc_last_updated=09/20/2016; rfc_pdf_url=https://iris.epa.gov/static/pdfs/0422_summary.pdf |
| Regulatory source | RfC | =0.5 | mg/m^3 | - | inhalation | chronic | IRIS chronic inhalation RfC system | row_hash=c8e2cde93b4687ff; file=iris_rfc_systems.csv; kind=reference_value; raw_column=rfc_mg_per_m3; raw_value=5e-1; system=Respiratory; basis=Decreased lung function and respiratory symptoms; point_of_departure=NOAEL (ADJ): 4.9 mg/m^3; composite_uf=10; confidence=Medium; dtxsid=DTXSID0023872; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=422; rfc_last_updated=09/20/2016; rfc_pdf_url=https://iris.epa.gov/static/pdfs/0422_summary.pdf |
CIR Safety Assessment 16 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| CIR Safety Assessment | NOAEL | =9.2 | ppm | human | inhalation | chronic | inhalation toxicity | {"citation":"0; 1; 9","dose":"MRL of 0.1 ppm for Ammonia from this study.9 An MRL is an estimate of the daily human exposure to a hazardous substance that is likely to be without appreciable risk of adverse non-cancer health effects over a specified duration of exposure.","effect":"MRL of 0.1 ppm for Ammonia from this study.9 An MRL is an estimate of the daily human exposure to a hazardous substance that is likely to be without appreciable risk of adverse non-cancer health effects over a specified duration of exposure. MRLs are based on non- cancer health effects only and are not based on a consideration of cancer effects. Derivation of the MRL is described below. An MRL of 0.1 ppm has been derived for chronic-duration inhalation exposure (365 days or more) to Ammonia. The MRL is based on a NOAEL of 9.2 ppm for sense of smell, prevalence of respiratory symptoms (cough, bronchitis, wheeze, dyspnea, and others), eye and throat irritation, and lung function parameters (forced vital capacity (FVC), forced expiratory volume at end of 1 second of forced expiration (FEV1), FEV1/FVC, forced expiratory flow at 50% of FVC (FEF50), and FEF at 75% of FVC (FEF75)) in humans exposed for an average of 12.2 years in a soda ash plant; no LOAEL was determined.85 The cohort consisted of 52 workers and 35 controls (all males). The subjects were assessed on the first and last wo...","page":13,"pdf":"FR752.pdf","row_type":"noael_study","study_id":"FR752_noael_004"} |
| CIR Safety Assessment | NOAEL | =9.2 | ppm | human | inhalation | chronic | inhalation toxicity | {"citation":"0; 1; 9","dose":"MRL of 0.1 ppm for Ammonia from this study.9 An MRL is an estimate of the daily human exposure to a hazardous substance that is likely to be without appreciable risk of adverse non-cancer health effects over a specified duration of exposure.","effect":"MRL of 0.1 ppm for Ammonia from this study.9 An MRL is an estimate of the daily human exposure to a hazardous substance that is likely to be without appreciable risk of adverse non-cancer health effects over a specified duration of exposure. MRLs are based on non- cancer health effects only and are not based on a consideration of cancer effects. Derivation of the MRL is described below. An MRL of 0.1 ppm has been derived for chronic-duration inhalation exposure (365 days or more) to Ammonia. The MRL is based on a NOAEL of 9.2 ppm for sense of smell, prevalence of respiratory symptoms (cough, bronchitis, wheeze, dyspnea, and others), eye and throat irritation, and lung function parameters (forced vital capacity (FVC), forced expiratory volume at end of 1 second of forced expiration (FEV1), FEV1/FVC, forced expiratory flow at 50% of FVC (FEF50), and FEF at 75% of FVC (FEF75)) in humans exposed for an average of 12.2 years in a soda ash plant; no LOAEL was determined.85 The cohort consisted of 52 workers and 35 controls (all males). The subjects were assessed on the first and last wo...","page":13,"pdf":"FR752.pdf","row_type":"noael_study","study_id":"FR752_noael_004"} |
| CIR Safety Assessment | NOAEL | =9.2 | ppm | human | inhalation | chronic | inhalation toxicity | {"citation":"0; 1; 9","dose":"MRL of 0.1 ppm for Ammonia from this study.9 An MRL is an estimate of the daily human exposure to a hazardous substance that is likely to be without appreciable risk of adverse non-cancer health effects over a specified duration of exposure.","effect":"MRL of 0.1 ppm for Ammonia from this study.9 An MRL is an estimate of the daily human exposure to a hazardous substance that is likely to be without appreciable risk of adverse non-cancer health effects over a specified duration of exposure. MRLs are based on non- cancer health effects only and are not based on a consideration of cancer effects. Derivation of the MRL is described below. An MRL of 0.1 ppm has been derived for chronic-duration inhalation exposure (365 days or more) to Ammonia. The MRL is based on a NOAEL of 9.2 ppm for sense of smell, prevalence of respiratory symptoms (cough, bronchitis, wheeze, dyspnea, and others), eye and throat irritation, and lung function parameters (forced vital capacity (FVC), forced expiratory volume at end of 1 second of forced expiration (FEV1), FEV1/FVC, forced expiratory flow at 50% of FVC (FEF50), and FEF at 75% of FVC (FEF75)) in humans exposed for an average of 12.2 years in a soda ash plant; no LOAEL was determined.85 The cohort consisted of 52 workers and 35 controls (all males). The subjects were assessed on the first and last wo...","page":13,"pdf":"FR752.pdf","row_type":"noael_study","study_id":"FR752_noael_004"} |
| CIR Safety Assessment | NOAEL | =9.2 | ppm | human | inhalation | chronic | inhalation toxicity | {"citation":"0; 1; 9","dose":"MRL of 0.1 ppm for Ammonia from this study.9 An MRL is an estimate of the daily human exposure to a hazardous substance that is likely to be without appreciable risk of adverse non-cancer health effects over a specified duration of exposure.","effect":"MRL of 0.1 ppm for Ammonia from this study.9 An MRL is an estimate of the daily human exposure to a hazardous substance that is likely to be without appreciable risk of adverse non-cancer health effects over a specified duration of exposure. MRLs are based on non- cancer health effects only and are not based on a consideration of cancer effects. Derivation of the MRL is described below. An MRL of 0.1 ppm has been derived for chronic-duration inhalation exposure (365 days or more) to Ammonia. The MRL is based on a NOAEL of 9.2 ppm for sense of smell, prevalence of respiratory symptoms (cough, bronchitis, wheeze, dyspnea, and others), eye and throat irritation, and lung function parameters (forced vital capacity (FVC), forced expiratory volume at end of 1 second of forced expiration (FEV1), FEV1/FVC, forced expiratory flow at 50% of FVC (FEF50), and FEF at 75% of FVC (FEF75)) in humans exposed for an average of 12.2 years in a soda ash plant; no LOAEL was determined.85 The cohort consisted of 52 workers and 35 controls (all males). The subjects were assessed on the first and last wo...","page":13,"pdf":"FR752.pdf","row_type":"noael_study","study_id":"FR752_noael_004"} |
| CIR Safety Assessment | NOAEL | =250 | mg/kg/day | rat | oral | 8 weeks | inhalation toxicity | {"citation":"7; 0; 01","dose":"Oral Mucosal atrophy in the stomach antrum and enlargement of the proliferative zone in the mucosa of the stomach antrum and body were observed in rats that received 0.01% Ammonium Hydroxide (in drinking water) for 8 weeks.67 A no- observed-adverse effect-level (NOAEL) of 250 mg/kg/day for general toxicity and a lowest-observed-adverse effect-level (LOAEL...","effect":"ies Animal Dermal Short-term dermal toxicity data on Ammonium Hydroxide or Ammonia were not found in the published literature, nor were these data submitted. Short-term oral and inhalation toxicity studies are summarized below and presented in Table 7. Oral Mucosal atrophy in the stomach antrum and enlargement of the proliferative zone in the mucosa of the stomach antrum and body were observed in rats that received 0.01% Ammonium Hydroxide (in drinking water) for 8 weeks.67 A no- observed-adverse effect-level (NOAEL) of 250 mg/kg/day for general toxicity and a lowest-observed-adverse effect-level (LOAEL) of 750 mg/kg/day for general toxicity were reported for diammonium phosphate (identified as an appropriate read across material for short-term oral toxicity and included herein to support the overall weight of evidence) in rats dosed orally (by gavage) for 5 weeks.6,48 Inhalation Rhinitis and pathological lesions with metaplasia and necrosis wee observed in mice exposed to Ammonia for 14 days at a concentration of 711 ppm, but not at concentrations of 78 and 271 ppm.24,68 Histopat...","page":7,"pdf":"FR752.pdf","row_type":"noael_study","study_id":"FR752_noael_001"} |
| CIR Safety Assessment | NOAEL | =250 | mg/kg/day | rat | oral | 8 weeks | inhalation toxicity | {"citation":"7; 0; 01","dose":"Oral Mucosal atrophy in the stomach antrum and enlargement of the proliferative zone in the mucosa of the stomach antrum and body were observed in rats that received 0.01% Ammonium Hydroxide (in drinking water) for 8 weeks.67 A no- observed-adverse effect-level (NOAEL) of 250 mg/kg/day for general toxicity and a lowest-observed-adverse effect-level (LOAEL...","effect":"ies Animal Dermal Short-term dermal toxicity data on Ammonium Hydroxide or Ammonia were not found in the published literature, nor were these data submitted. Short-term oral and inhalation toxicity studies are summarized below and presented in Table 7. Oral Mucosal atrophy in the stomach antrum and enlargement of the proliferative zone in the mucosa of the stomach antrum and body were observed in rats that received 0.01% Ammonium Hydroxide (in drinking water) for 8 weeks.67 A no- observed-adverse effect-level (NOAEL) of 250 mg/kg/day for general toxicity and a lowest-observed-adverse effect-level (LOAEL) of 750 mg/kg/day for general toxicity were reported for diammonium phosphate (identified as an appropriate read across material for short-term oral toxicity and included herein to support the overall weight of evidence) in rats dosed orally (by gavage) for 5 weeks.6,48 Inhalation Rhinitis and pathological lesions with metaplasia and necrosis wee observed in mice exposed to Ammonia for 14 days at a concentration of 711 ppm, but not at concentrations of 78 and 271 ppm.24,68 Histopat...","page":7,"pdf":"FR752.pdf","row_type":"noael_study","study_id":"FR752_noael_001"} |
| CIR Safety Assessment | NOAEL | =250 | mg/kg/day | rat | oral | 8 weeks | inhalation toxicity | {"citation":"7; 0; 01","dose":"Oral Mucosal atrophy in the stomach antrum and enlargement of the proliferative zone in the mucosa of the stomach antrum and body were observed in rats that received 0.01% Ammonium Hydroxide (in drinking water) for 8 weeks.67 A no- observed-adverse effect-level (NOAEL) of 250 mg/kg/day for general toxicity and a lowest-observed-adverse effect-level (LOAEL...","effect":"ies Animal Dermal Short-term dermal toxicity data on Ammonium Hydroxide or Ammonia were not found in the published literature, nor were these data submitted. Short-term oral and inhalation toxicity studies are summarized below and presented in Table 7. Oral Mucosal atrophy in the stomach antrum and enlargement of the proliferative zone in the mucosa of the stomach antrum and body were observed in rats that received 0.01% Ammonium Hydroxide (in drinking water) for 8 weeks.67 A no- observed-adverse effect-level (NOAEL) of 250 mg/kg/day for general toxicity and a lowest-observed-adverse effect-level (LOAEL) of 750 mg/kg/day for general toxicity were reported for diammonium phosphate (identified as an appropriate read across material for short-term oral toxicity and included herein to support the overall weight of evidence) in rats dosed orally (by gavage) for 5 weeks.6,48 Inhalation Rhinitis and pathological lesions with metaplasia and necrosis wee observed in mice exposed to Ammonia for 14 days at a concentration of 711 ppm, but not at concentrations of 78 and 271 ppm.24,68 Histopat...","page":7,"pdf":"FR752.pdf","row_type":"noael_study","study_id":"FR752_noael_001"} |
| CIR Safety Assessment | NOAEL | =250 | mg/kg/day | rat | oral | 8 weeks | inhalation toxicity | {"citation":"7; 0; 01","dose":"Oral Mucosal atrophy in the stomach antrum and enlargement of the proliferative zone in the mucosa of the stomach antrum and body were observed in rats that received 0.01% Ammonium Hydroxide (in drinking water) for 8 weeks.67 A no- observed-adverse effect-level (NOAEL) of 250 mg/kg/day for general toxicity and a lowest-observed-adverse effect-level (LOAEL...","effect":"ies Animal Dermal Short-term dermal toxicity data on Ammonium Hydroxide or Ammonia were not found in the published literature, nor were these data submitted. Short-term oral and inhalation toxicity studies are summarized below and presented in Table 7. Oral Mucosal atrophy in the stomach antrum and enlargement of the proliferative zone in the mucosa of the stomach antrum and body were observed in rats that received 0.01% Ammonium Hydroxide (in drinking water) for 8 weeks.67 A no- observed-adverse effect-level (NOAEL) of 250 mg/kg/day for general toxicity and a lowest-observed-adverse effect-level (LOAEL) of 750 mg/kg/day for general toxicity were reported for diammonium phosphate (identified as an appropriate read across material for short-term oral toxicity and included herein to support the overall weight of evidence) in rats dosed orally (by gavage) for 5 weeks.6,48 Inhalation Rhinitis and pathological lesions with metaplasia and necrosis wee observed in mice exposed to Ammonia for 14 days at a concentration of 711 ppm, but not at concentrations of 78 and 271 ppm.24,68 Histopat...","page":7,"pdf":"FR752.pdf","row_type":"noael_study","study_id":"FR752_noael_001"} |
| CIR Safety Assessment | NOAEL | =256 | mg/kg/day | - | oral | - | developmental toxicity | {"citation":"3; 2; 0","dose":"n kidney and/or liver weights in males and females of the 3% dietary group, but there were no effects on survival rate, body weights, or hematological, serum biochemical, or histopathological parameters at any concentration.","effect":"n kidney and/or liver weights in males and females of the 3% dietary group, but there were no effects on survival rate, body weights, or hematological, serum biochemical, or histopathological parameters at any concentration. Several non- neoplastic lesions, such as bile duct proliferation in the liver and focal myocarditis in the heart were observed in the 3% dietary group, but also in animals of the control group, and the difference in results was not statistically significant when the 2 groups were compared. The NOAEL for ammonium sulfate was estimated to be 0.6% in both sexes, which is equivalent to 256 and 284 mg/kg/day in males and females, respectively.6,84 Neoplastic lesions (classified as unrelated to ammonium sulfate in the diet) reported in a carcinogenicity study in the same report are included in Table 9. DEVELOPMENTAL AND REPRODUCTIVE TOXICITY STUDIES Developmental/reproductive toxicity studies are summarized below and presented in Table 8. A relationship between the duration of exposure and the incidence of exencephaly (concentration-related increase) was observed in...","page":8,"pdf":"FR752.pdf","row_type":"noael_study","study_id":"FR752_noael_002"} |
| CIR Safety Assessment | NOAEL | =256 | mg/kg/day | - | oral | - | developmental toxicity | {"citation":"3; 2; 0","dose":"n kidney and/or liver weights in males and females of the 3% dietary group, but there were no effects on survival rate, body weights, or hematological, serum biochemical, or histopathological parameters at any concentration.","effect":"n kidney and/or liver weights in males and females of the 3% dietary group, but there were no effects on survival rate, body weights, or hematological, serum biochemical, or histopathological parameters at any concentration. Several non- neoplastic lesions, such as bile duct proliferation in the liver and focal myocarditis in the heart were observed in the 3% dietary group, but also in animals of the control group, and the difference in results was not statistically significant when the 2 groups were compared. The NOAEL for ammonium sulfate was estimated to be 0.6% in both sexes, which is equivalent to 256 and 284 mg/kg/day in males and females, respectively.6,84 Neoplastic lesions (classified as unrelated to ammonium sulfate in the diet) reported in a carcinogenicity study in the same report are included in Table 9. DEVELOPMENTAL AND REPRODUCTIVE TOXICITY STUDIES Developmental/reproductive toxicity studies are summarized below and presented in Table 8. A relationship between the duration of exposure and the incidence of exencephaly (concentration-related increase) was observed in...","page":8,"pdf":"FR752.pdf","row_type":"noael_study","study_id":"FR752_noael_002"} |
| CIR Safety Assessment | NOAEL | =256 | mg/kg/day | - | oral | - | developmental toxicity | {"citation":"3; 2; 0","dose":"n kidney and/or liver weights in males and females of the 3% dietary group, but there were no effects on survival rate, body weights, or hematological, serum biochemical, or histopathological parameters at any concentration.","effect":"n kidney and/or liver weights in males and females of the 3% dietary group, but there were no effects on survival rate, body weights, or hematological, serum biochemical, or histopathological parameters at any concentration. Several non- neoplastic lesions, such as bile duct proliferation in the liver and focal myocarditis in the heart were observed in the 3% dietary group, but also in animals of the control group, and the difference in results was not statistically significant when the 2 groups were compared. The NOAEL for ammonium sulfate was estimated to be 0.6% in both sexes, which is equivalent to 256 and 284 mg/kg/day in males and females, respectively.6,84 Neoplastic lesions (classified as unrelated to ammonium sulfate in the diet) reported in a carcinogenicity study in the same report are included in Table 9. DEVELOPMENTAL AND REPRODUCTIVE TOXICITY STUDIES Developmental/reproductive toxicity studies are summarized below and presented in Table 8. A relationship between the duration of exposure and the incidence of exencephaly (concentration-related increase) was observed in...","page":8,"pdf":"FR752.pdf","row_type":"noael_study","study_id":"FR752_noael_002"} |
| CIR Safety Assessment | NOAEL | =256 | mg/kg/day | - | oral | - | developmental toxicity | {"citation":"3; 2; 0","dose":"n kidney and/or liver weights in males and females of the 3% dietary group, but there were no effects on survival rate, body weights, or hematological, serum biochemical, or histopathological parameters at any concentration.","effect":"n kidney and/or liver weights in males and females of the 3% dietary group, but there were no effects on survival rate, body weights, or hematological, serum biochemical, or histopathological parameters at any concentration. Several non- neoplastic lesions, such as bile duct proliferation in the liver and focal myocarditis in the heart were observed in the 3% dietary group, but also in animals of the control group, and the difference in results was not statistically significant when the 2 groups were compared. The NOAEL for ammonium sulfate was estimated to be 0.6% in both sexes, which is equivalent to 256 and 284 mg/kg/day in males and females, respectively.6,84 Neoplastic lesions (classified as unrelated to ammonium sulfate in the diet) reported in a carcinogenicity study in the same report are included in Table 9. DEVELOPMENTAL AND REPRODUCTIVE TOXICITY STUDIES Developmental/reproductive toxicity studies are summarized below and presented in Table 8. A relationship between the duration of exposure and the incidence of exencephaly (concentration-related increase) was observed in...","page":8,"pdf":"FR752.pdf","row_type":"noael_study","study_id":"FR752_noael_002"} |
| CIR Safety Assessment | NOAEL | =1500 | mg/kg/day | rat | oral | 6 weeks | developmental toxicity | {"citation":"7; 35; 6","dose":"ductive nor developmental toxicity was reported in a study in which female pigs were exposed (inhalation exposure) to ~7 ppm or ~35 ppm Ammonia from 6 weeks prior to breeding until day 30 of gestation.91 In an oral reproductive and developmental toxicity study on diammonium phosphate (identified as an appropriate read across material for developmental and...","effect":"ductive nor developmental toxicity was reported in a study in which female pigs were exposed (inhalation exposure) to ~7 ppm or ~35 ppm Ammonia from 6 weeks prior to breeding until day 30 of gestation.91 In an oral reproductive and developmental toxicity study on diammonium phosphate (identified as an appropriate read across material for developmental and reproductive toxicity and included herein to support the overall weight of evidence) involving rats in which embryos were treated in vitro and then implanted, an NOAEL of 1500 mg/kg/day (highest dose tested) was reported.6,44 The only histological findings relating to maternal toxicity in this study were the inflammatory/degenerative changes in all treatment groups (diammonium phosphate at 250, 750, and 1500 mg/kg/day),","page":8,"pdf":"FR752.pdf","row_type":"noael_study","study_id":"FR752_noael_003"} |
| CIR Safety Assessment | NOAEL | =1500 | mg/kg/day | rat | oral | 6 weeks | developmental toxicity | {"citation":"7; 35; 6","dose":"ductive nor developmental toxicity was reported in a study in which female pigs were exposed (inhalation exposure) to ~7 ppm or ~35 ppm Ammonia from 6 weeks prior to breeding until day 30 of gestation.91 In an oral reproductive and developmental toxicity study on diammonium phosphate (identified as an appropriate read across material for developmental and...","effect":"ductive nor developmental toxicity was reported in a study in which female pigs were exposed (inhalation exposure) to ~7 ppm or ~35 ppm Ammonia from 6 weeks prior to breeding until day 30 of gestation.91 In an oral reproductive and developmental toxicity study on diammonium phosphate (identified as an appropriate read across material for developmental and reproductive toxicity and included herein to support the overall weight of evidence) involving rats in which embryos were treated in vitro and then implanted, an NOAEL of 1500 mg/kg/day (highest dose tested) was reported.6,44 The only histological findings relating to maternal toxicity in this study were the inflammatory/degenerative changes in all treatment groups (diammonium phosphate at 250, 750, and 1500 mg/kg/day),","page":8,"pdf":"FR752.pdf","row_type":"noael_study","study_id":"FR752_noael_003"} |
| CIR Safety Assessment | NOAEL | =1500 | mg/kg/day | rat | oral | 6 weeks | developmental toxicity | {"citation":"7; 35; 6","dose":"ductive nor developmental toxicity was reported in a study in which female pigs were exposed (inhalation exposure) to ~7 ppm or ~35 ppm Ammonia from 6 weeks prior to breeding until day 30 of gestation.91 In an oral reproductive and developmental toxicity study on diammonium phosphate (identified as an appropriate read across material for developmental and...","effect":"ductive nor developmental toxicity was reported in a study in which female pigs were exposed (inhalation exposure) to ~7 ppm or ~35 ppm Ammonia from 6 weeks prior to breeding until day 30 of gestation.91 In an oral reproductive and developmental toxicity study on diammonium phosphate (identified as an appropriate read across material for developmental and reproductive toxicity and included herein to support the overall weight of evidence) involving rats in which embryos were treated in vitro and then implanted, an NOAEL of 1500 mg/kg/day (highest dose tested) was reported.6,44 The only histological findings relating to maternal toxicity in this study were the inflammatory/degenerative changes in all treatment groups (diammonium phosphate at 250, 750, and 1500 mg/kg/day),","page":8,"pdf":"FR752.pdf","row_type":"noael_study","study_id":"FR752_noael_003"} |
| CIR Safety Assessment | NOAEL | =1500 | mg/kg/day | rat | oral | 6 weeks | developmental toxicity | {"citation":"7; 35; 6","dose":"ductive nor developmental toxicity was reported in a study in which female pigs were exposed (inhalation exposure) to ~7 ppm or ~35 ppm Ammonia from 6 weeks prior to breeding until day 30 of gestation.91 In an oral reproductive and developmental toxicity study on diammonium phosphate (identified as an appropriate read across material for developmental and...","effect":"ductive nor developmental toxicity was reported in a study in which female pigs were exposed (inhalation exposure) to ~7 ppm or ~35 ppm Ammonia from 6 weeks prior to breeding until day 30 of gestation.91 In an oral reproductive and developmental toxicity study on diammonium phosphate (identified as an appropriate read across material for developmental and reproductive toxicity and included herein to support the overall weight of evidence) involving rats in which embryos were treated in vitro and then implanted, an NOAEL of 1500 mg/kg/day (highest dose tested) was reported.6,44 The only histological findings relating to maternal toxicity in this study were the inflammatory/degenerative changes in all treatment groups (diammonium phosphate at 250, 750, and 1500 mg/kg/day),","page":8,"pdf":"FR752.pdf","row_type":"noael_study","study_id":"FR752_noael_003"} |
WHO/JECFA 32 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| WHO/JECFA | LOAEL | =143 | ppm | Rat | inhalation | 2-month | Inhalation toxicity | document_id=kemi_kemi_ah2005_13; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals 137. Ammonia; path=mirror/documents/kemi/kemi/ah2005_13.pdf; row_hash=c39ab8d01e82df81; raw_unit=ppm; context=A NOAEL of 57 ppm and a LOAEL of 143 ppm for toxic effects were reported in a 2-month inhalation exposure of white rats. |
| WHO/JECFA | LOAEL | =143 | ppm | Rat | inhalation | 2-month | Inhalation toxicity | document_id=kemi_kemi_ah2005_13; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals 137. Ammonia; path=mirror/documents/kemi/kemi/ah2005_13.pdf; row_hash=c39ab8d01e82df81; raw_unit=ppm; context=A NOAEL of 57 ppm and a LOAEL of 143 ppm for toxic effects were reported in a 2-month inhalation exposure of white rats. |
| WHO/JECFA | LOAEL | =143 | ppm | Rat | inhalation | 2-month | Inhalation toxicity | document_id=kemi_kemi_ah2005_13; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals 137. Ammonia; path=mirror/documents/kemi/kemi/ah2005_13.pdf; row_hash=c39ab8d01e82df81; raw_unit=ppm; context=A NOAEL of 57 ppm and a LOAEL of 143 ppm for toxic effects were reported in a 2-month inhalation exposure of white rats. |
| WHO/JECFA | LOAEL | =143 | ppm | Rat | inhalation | 2-month | Inhalation toxicity | document_id=kemi_kemi_ah2005_13; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals 137. Ammonia; path=mirror/documents/kemi/kemi/ah2005_13.pdf; row_hash=c39ab8d01e82df81; raw_unit=ppm; context=A NOAEL of 57 ppm and a LOAEL of 143 ppm for toxic effects were reported in a 2-month inhalation exposure of white rats. |
| WHO/JECFA | NOAEL | =25 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2005_13; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals 137. Ammonia; path=mirror/documents/kemi/kemi/ah2005_13.pdf; row_hash=6f70d6df57c4dccb; raw_unit=ppm; context=NEG therefore considers 5 ppm as a pragmatic NOAEL and 25 ppm as a LOAEL for irritation. |
| WHO/JECFA | NOAEL | =25 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2005_13; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals 137. Ammonia; path=mirror/documents/kemi/kemi/ah2005_13.pdf; row_hash=6f70d6df57c4dccb; raw_unit=ppm; context=NEG therefore considers 5 ppm as a pragmatic NOAEL and 25 ppm as a LOAEL for irritation. |
| WHO/JECFA | NOAEL | =25 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2005_13; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals 137. Ammonia; path=mirror/documents/kemi/kemi/ah2005_13.pdf; row_hash=6f70d6df57c4dccb; raw_unit=ppm; context=NEG therefore considers 5 ppm as a pragmatic NOAEL and 25 ppm as a LOAEL for irritation. |
| WHO/JECFA | NOAEL | =25 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2005_13; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals 137. Ammonia; path=mirror/documents/kemi/kemi/ah2005_13.pdf; row_hash=6f70d6df57c4dccb; raw_unit=ppm; context=NEG therefore considers 5 ppm as a pragmatic NOAEL and 25 ppm as a LOAEL for irritation. |
| WHO/JECFA | NOAEL | =40 | mg/m3 | - | - | - | Toxicology study | document_id=kemi_kemi_ah2005_13; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals 137. Ammonia; path=mirror/documents/kemi/kemi/ah2005_13.pdf; row_hash=b9ab3057a3b7ab9a; raw_unit=mg/m3; context=A NOAEL of 40 mg/m3 (57 ppm) can be concluded from this study. |
| WHO/JECFA | NOAEL | =40 | mg/m3 | - | - | - | Toxicology study | document_id=kemi_kemi_ah2005_13; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals 137. Ammonia; path=mirror/documents/kemi/kemi/ah2005_13.pdf; row_hash=b9ab3057a3b7ab9a; raw_unit=mg/m3; context=A NOAEL of 40 mg/m3 (57 ppm) can be concluded from this study. |
| WHO/JECFA | NOAEL | =40 | mg/m3 | - | - | - | Toxicology study | document_id=kemi_kemi_ah2005_13; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals 137. Ammonia; path=mirror/documents/kemi/kemi/ah2005_13.pdf; row_hash=b9ab3057a3b7ab9a; raw_unit=mg/m3; context=A NOAEL of 40 mg/m3 (57 ppm) can be concluded from this study. |
| WHO/JECFA | NOAEL | =40 | mg/m3 | - | - | - | Toxicology study | document_id=kemi_kemi_ah2005_13; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals 137. Ammonia; path=mirror/documents/kemi/kemi/ah2005_13.pdf; row_hash=b9ab3057a3b7ab9a; raw_unit=mg/m3; context=A NOAEL of 40 mg/m3 (57 ppm) can be concluded from this study. |
| WHO/JECFA | NOAEL | =57 | ppm | Rat | inhalation | 2-month | Inhalation toxicity | document_id=kemi_kemi_ah2005_13; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals 137. Ammonia; path=mirror/documents/kemi/kemi/ah2005_13.pdf; row_hash=04255de161eb7f53; raw_unit=ppm; context=A NOAEL of 57 ppm and a LOAEL of 143 ppm for toxic effects were reported in a 2-month inhalation exposure of white rats. |
| WHO/JECFA | NOAEL | =57 | ppm | Rat | inhalation | 2-month | Inhalation toxicity | document_id=kemi_kemi_ah2005_13; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals 137. Ammonia; path=mirror/documents/kemi/kemi/ah2005_13.pdf; row_hash=04255de161eb7f53; raw_unit=ppm; context=A NOAEL of 57 ppm and a LOAEL of 143 ppm for toxic effects were reported in a 2-month inhalation exposure of white rats. |
| WHO/JECFA | NOAEL | =57 | ppm | Rat | inhalation | 2-month | Inhalation toxicity | document_id=kemi_kemi_ah2005_13; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals 137. Ammonia; path=mirror/documents/kemi/kemi/ah2005_13.pdf; row_hash=04255de161eb7f53; raw_unit=ppm; context=A NOAEL of 57 ppm and a LOAEL of 143 ppm for toxic effects were reported in a 2-month inhalation exposure of white rats. |
| WHO/JECFA | NOAEL | =57 | ppm | Rat | inhalation | 2-month | Inhalation toxicity | document_id=kemi_kemi_ah2005_13; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals 137. Ammonia; path=mirror/documents/kemi/kemi/ah2005_13.pdf; row_hash=04255de161eb7f53; raw_unit=ppm; context=A NOAEL of 57 ppm and a LOAEL of 143 ppm for toxic effects were reported in a 2-month inhalation exposure of white rats. |
| WHO/JECFA | LOAEL | =2 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2006_11; title=Scientific Basis for Swedish Occupational Standards XXVII; path=mirror/documents/kemi/kemi/ah2006_11.pdf; row_hash=830266de5f9345e0; raw_unit=ppm; context=The authors concluded that 10 ppm hexanal has a weak irritating effect, and in this study it was the LOAEL (lowest observed adverse effect level) and 2 ppm was the NOAEL (no observed adverse effect level). |
| WHO/JECFA | LOAEL | =2 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2006_11; title=Scientific Basis for Swedish Occupational Standards XXVII; path=mirror/documents/kemi/kemi/ah2006_11.pdf; row_hash=830266de5f9345e0; raw_unit=ppm; context=The authors concluded that 10 ppm hexanal has a weak irritating effect, and in this study it was the LOAEL (lowest observed adverse effect level) and 2 ppm was the NOAEL (no observed adverse effect level). |
| WHO/JECFA | LOAEL | =2 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2006_11; title=Scientific Basis for Swedish Occupational Standards XXVII; path=mirror/documents/kemi/kemi/ah2006_11.pdf; row_hash=830266de5f9345e0; raw_unit=ppm; context=The authors concluded that 10 ppm hexanal has a weak irritating effect, and in this study it was the LOAEL (lowest observed adverse effect level) and 2 ppm was the NOAEL (no observed adverse effect level). |
| WHO/JECFA | LOAEL | =2 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2006_11; title=Scientific Basis for Swedish Occupational Standards XXVII; path=mirror/documents/kemi/kemi/ah2006_11.pdf; row_hash=830266de5f9345e0; raw_unit=ppm; context=The authors concluded that 10 ppm hexanal has a weak irritating effect, and in this study it was the LOAEL (lowest observed adverse effect level) and 2 ppm was the NOAEL (no observed adverse effect level). |
| WHO/JECFA | LOAEL | =10 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2006_11; title=Scientific Basis for Swedish Occupational Standards XXVII; path=mirror/documents/kemi/kemi/ah2006_11.pdf; row_hash=072cabdf0505f39c; raw_unit=ppm; context=The authors concluded that 10 ppm hexanal has a weak irritating effect, and in this study it was the LOAEL (lowest observed adverse effect level) and 2 ppm was the NOAEL (no observed adverse effect level). |
| WHO/JECFA | LOAEL | =10 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2006_11; title=Scientific Basis for Swedish Occupational Standards XXVII; path=mirror/documents/kemi/kemi/ah2006_11.pdf; row_hash=072cabdf0505f39c; raw_unit=ppm; context=The authors concluded that 10 ppm hexanal has a weak irritating effect, and in this study it was the LOAEL (lowest observed adverse effect level) and 2 ppm was the NOAEL (no observed adverse effect level). |
| WHO/JECFA | LOAEL | =10 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2006_11; title=Scientific Basis for Swedish Occupational Standards XXVII; path=mirror/documents/kemi/kemi/ah2006_11.pdf; row_hash=072cabdf0505f39c; raw_unit=ppm; context=The authors concluded that 10 ppm hexanal has a weak irritating effect, and in this study it was the LOAEL (lowest observed adverse effect level) and 2 ppm was the NOAEL (no observed adverse effect level). |
| WHO/JECFA | LOAEL | =10 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2006_11; title=Scientific Basis for Swedish Occupational Standards XXVII; path=mirror/documents/kemi/kemi/ah2006_11.pdf; row_hash=072cabdf0505f39c; raw_unit=ppm; context=The authors concluded that 10 ppm hexanal has a weak irritating effect, and in this study it was the LOAEL (lowest observed adverse effect level) and 2 ppm was the NOAEL (no observed adverse effect level). |
| WHO/JECFA | NOAEL | =5 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2006_11; title=Scientific Basis for Swedish Occupational Standards XXVII; path=mirror/documents/kemi/kemi/ah2006_11.pdf; row_hash=6ec473e8be7b3422; raw_unit=ppm; context=In this study, therefore, the NOAEL was concluded to be 5 ppm. |
| WHO/JECFA | NOAEL | =5 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2006_11; title=Scientific Basis for Swedish Occupational Standards XXVII; path=mirror/documents/kemi/kemi/ah2006_11.pdf; row_hash=6ec473e8be7b3422; raw_unit=ppm; context=In this study, therefore, the NOAEL was concluded to be 5 ppm. |
| WHO/JECFA | NOAEL | =5 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2006_11; title=Scientific Basis for Swedish Occupational Standards XXVII; path=mirror/documents/kemi/kemi/ah2006_11.pdf; row_hash=6ec473e8be7b3422; raw_unit=ppm; context=In this study, therefore, the NOAEL was concluded to be 5 ppm. |
| WHO/JECFA | NOAEL | =5 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2006_11; title=Scientific Basis for Swedish Occupational Standards XXVII; path=mirror/documents/kemi/kemi/ah2006_11.pdf; row_hash=6ec473e8be7b3422; raw_unit=ppm; context=In this study, therefore, the NOAEL was concluded to be 5 ppm. |
| WHO/JECFA | NOAEL | =125 | mg/kg bw/day | Rat; Mouse | inhalation | 4 weeks | Inhalation toxicity | document_id=kemi_kemi_ah2006_11; title=Scientific Basis for Swedish Occupational Standards XXVII; path=mirror/documents/kemi/kemi/ah2006_11.pdf; row_hash=3c273e82a65c7443; raw_unit=mg/kg/day; context=study 2 ppm (8 mg/m3) 2 hours No clear effects 13 10 ppm (40 mg/m3) 2 hours Irritation with increased blinking frequency Rat study Hexanal in drinking water 12,6 mg/kg/day 4 weeks NOAEL for most endpoints 26 125 mg/kg/day 4 weeks Slight effects on thyroid, liver, kidneys Mouse study Inhalation 1116 ppm (4.6 g/m3) (Swiss-Webster) 1029 ppm (4.2 g/m3) (B6C3F1) 10 minutes RD50 (the concentration that reduces respiratory rate by 50%) 42 In vitro studies β-cells (rats) 0,001 mM LOAE |
| WHO/JECFA | NOAEL | =125 | mg/kg bw/day | Rat; Mouse | inhalation | 4 weeks | Inhalation toxicity | document_id=kemi_kemi_ah2006_11; title=Scientific Basis for Swedish Occupational Standards XXVII; path=mirror/documents/kemi/kemi/ah2006_11.pdf; row_hash=3c273e82a65c7443; raw_unit=mg/kg/day; context=study 2 ppm (8 mg/m3) 2 hours No clear effects 13 10 ppm (40 mg/m3) 2 hours Irritation with increased blinking frequency Rat study Hexanal in drinking water 12,6 mg/kg/day 4 weeks NOAEL for most endpoints 26 125 mg/kg/day 4 weeks Slight effects on thyroid, liver, kidneys Mouse study Inhalation 1116 ppm (4.6 g/m3) (Swiss-Webster) 1029 ppm (4.2 g/m3) (B6C3F1) 10 minutes RD50 (the concentration that reduces respiratory rate by 50%) 42 In vitro studies β-cells (rats) 0,001 mM LOAE |
| WHO/JECFA | NOAEL | =125 | mg/kg bw/day | Rat; Mouse | inhalation | 4 weeks | Inhalation toxicity | document_id=kemi_kemi_ah2006_11; title=Scientific Basis for Swedish Occupational Standards XXVII; path=mirror/documents/kemi/kemi/ah2006_11.pdf; row_hash=3c273e82a65c7443; raw_unit=mg/kg/day; context=study 2 ppm (8 mg/m3) 2 hours No clear effects 13 10 ppm (40 mg/m3) 2 hours Irritation with increased blinking frequency Rat study Hexanal in drinking water 12,6 mg/kg/day 4 weeks NOAEL for most endpoints 26 125 mg/kg/day 4 weeks Slight effects on thyroid, liver, kidneys Mouse study Inhalation 1116 ppm (4.6 g/m3) (Swiss-Webster) 1029 ppm (4.2 g/m3) (B6C3F1) 10 minutes RD50 (the concentration that reduces respiratory rate by 50%) 42 In vitro studies β-cells (rats) 0,001 mM LOAE |
| WHO/JECFA | NOAEL | =125 | mg/kg bw/day | Rat; Mouse | inhalation | 4 weeks | Inhalation toxicity | document_id=kemi_kemi_ah2006_11; title=Scientific Basis for Swedish Occupational Standards XXVII; path=mirror/documents/kemi/kemi/ah2006_11.pdf; row_hash=3c273e82a65c7443; raw_unit=mg/kg/day; context=study 2 ppm (8 mg/m3) 2 hours No clear effects 13 10 ppm (40 mg/m3) 2 hours Irritation with increased blinking frequency Rat study Hexanal in drinking water 12,6 mg/kg/day 4 weeks NOAEL for most endpoints 26 125 mg/kg/day 4 weeks Slight effects on thyroid, liver, kidneys Mouse study Inhalation 1116 ppm (4.6 g/m3) (Swiss-Webster) 1029 ppm (4.2 g/m3) (B6C3F1) 10 minutes RD50 (the concentration that reduces respiratory rate by 50%) 42 In vitro studies β-cells (rats) 0,001 mM LOAE |
NTP ICE acute inhalation 29 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | LC50 | 17.759 | mg/L | - | Inhalation | Duration=20 min | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=206; Record_ID=acute_inhalation_2057; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=17.759; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 12.1134 | mg/L | - | Inhalation | Duration=0.25 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=207; Record_ID=acute_inhalation_1733; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=12.1134; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 7.04 | mg/L | - | Inhalation | Duration=0.5 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=208; Record_ID=acute_inhalation_1731; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=7.04; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 18.6 | mg/L | - | Inhalation | Duration=5 min | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=209; Record_ID=acute_inhalation_1730; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=18.6; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 19.96 | mg/L | - | Inhalation | Duration=20 min | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=210; Record_ID=acute_inhalation_732; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=19.96; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15557/7/3/3/?documentUUID=a88749e0-6c4b-4bd9-ad56-63951375228d; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 1.3923 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=211; Record_ID=acute_inhalation_1331; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=1.3923; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 9.85 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=212; Record_ID=acute_inhalation_729; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=9.85; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15557/7/3/3/?documentUUID=a88749e0-6c4b-4bd9-ad56-63951375228d; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 11.59 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=213; Record_ID=acute_inhalation_730; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=11.59; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15557/7/3/3/?documentUUID=a88749e0-6c4b-4bd9-ad56-63951375228d; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 13.77 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=214; Record_ID=acute_inhalation_728; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=13.77; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15557/7/3/3/?documentUUID=a88749e0-6c4b-4bd9-ad56-63951375228d; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 7.939 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=215; Record_ID=acute_inhalation_724; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=7.939; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15557/7/3/3/?documentUUID=1090d680-6e4d-4c9e-a54e-d972a2edfbf4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 28.13 | mg/L | - | Inhalation | Duration=10 min | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=216; Record_ID=acute_inhalation_733; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=28.13; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15557/7/3/3/?documentUUID=a88749e0-6c4b-4bd9-ad56-63951375228d; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 14.17 | mg/L | - | Inhalation | Duration=40 min | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=217; Record_ID=acute_inhalation_731; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=14.17; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15557/7/3/3/?documentUUID=a88749e0-6c4b-4bd9-ad56-63951375228d; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 11.5558 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=218; Record_ID=acute_inhalation_2065; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=11.5558; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 13.7075 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=219; Record_ID=acute_inhalation_2064; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=13.7075; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 9.8057 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=220; Record_ID=acute_inhalation_2063; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=9.8057; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 14.1315 | mg/L | - | Inhalation | Duration=40 min | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=221; Record_ID=acute_inhalation_2062; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=14.1315; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 16.515 | mg/L | - | Inhalation | Duration=40 min | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=222; Record_ID=acute_inhalation_2061; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=16.515; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 12.2046 | mg/L | - | Inhalation | Duration=40 min | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=223; Record_ID=acute_inhalation_2060; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=12.2046; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 19.9059 | mg/L | - | Inhalation | Duration=20 min | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=224; Record_ID=acute_inhalation_2059; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=19.9059; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 22.7363 | mg/L | - | Inhalation | Duration=20 min | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=225; Record_ID=acute_inhalation_2058; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=22.7363; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 7.035 | mg/L | - | Inhalation | Duration=0.5 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=226; Record_ID=acute_inhalation_725; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=7.035; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15557/7/3/3/?documentUUID=1090d680-6e4d-4c9e-a54e-d972a2edfbf4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 11.342 | mg/L | - | Inhalation | Duration=0.25 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=227; Record_ID=acute_inhalation_726; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=11.342; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15557/7/3/3/?documentUUID=1090d680-6e4d-4c9e-a54e-d972a2edfbf4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 18.693 | mg/L | - | Inhalation | Duration=5 min | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=228; Record_ID=acute_inhalation_727; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=18.693; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15557/7/3/3/?documentUUID=1090d680-6e4d-4c9e-a54e-d972a2edfbf4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 28.0541 | mg/L | - | Inhalation | Duration=10 min | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=229; Record_ID=acute_inhalation_2056; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=28.0541; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 31.2876 | mg/L | - | Inhalation | Duration=10 min | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=230; Record_ID=acute_inhalation_2055; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=31.2876; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 25.8223 | mg/L | - | Inhalation | Duration=10 min | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=231; Record_ID=acute_inhalation_2054; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=25.8223; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 5.1082 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=232; Record_ID=acute_inhalation_2053; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=5.1082; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 4673 | mg/m3 | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=233; Record_ID=acute_inhalation_1735; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=4673; Response_Unit=mg/m3; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 6.6132 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=234; Record_ID=acute_inhalation_1734; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=6.6132; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
NTP ICE eye irritation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE eye irritation | GHS Classification | 1 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=117; Record_ID=eye_irritation_116; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=1; Response_Unit=Unitless; Species=Rabbit; Reference=ICCVAM 2006; URL=https://ntp.niehs.nih.gov/sites/default/files/iccvam/docs/ocutox_docs/oteval/otevalrpt.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
ToxValDB ATSDR MRLs 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ATSDR MRLs | LOAEL | =34.8284 | mg/m3 | Human | inhalation | acute; 2 hours | clinical | LONG_REF=Verberk MM. 1977. Effects of ammonia in volunteers. Int Arch Occup Environ Health 39:73-81.; TITLE=Effects of ammonia in volunteers; AUTHOR=Verberk MM; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f404e4b063812d584c0d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp126.pdf; TOXICOLOGICAL_EFFECT=respiratory; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ATSDR MRLs:15447343:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4cfe6e3b8aafd25400417bd5d31cf630 |
| ToxValDB ATSDR MRLs | MRL | =1.18417 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=respiratory; STUDY_GROUP=ATSDR MRLs_dup_-_15446862_15446863:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9d3c75d0f990481175e28c5b9d9df07d |
| ToxValDB ATSDR MRLs | MRL | =0.0696568 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=respiratory; STUDY_GROUP=ATSDR MRLs_dup_-_15446862_15446863:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3124e287f830247182bbe9f1a4673638 |
| ToxValDB ATSDR MRLs | MRL | =1.18417 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=respiratory; STUDY_GROUP=ATSDR MRLs_dup_-_15446862_15446863:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9d3c75d0f990481175e28c5b9d9df07d |
| ToxValDB ATSDR MRLs | MRL | =0.0696568 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=respiratory; STUDY_GROUP=ATSDR MRLs_dup_-_15446862_15446863:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3124e287f830247182bbe9f1a4673638 |
| ToxValDB ATSDR MRLs | NOAEL | =6.40842 | mg/m3 | Human | inhalation | chronic; 12.2 years | occupational | LONG_REF=Holness DL, Purdham JT, Nethercott JR. 1989. Acute and chronic respiratory effects of occupational exposure to ammonia. Am Ind Hyg Assoc J 50:646-650.; TITLE=Acute and chronic respiratory effects of occupational exposure to ammonia; AUTHOR=Holness DL; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f404e4b063812d584c0d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp126.pdf; TOXICOLOGICAL_EFFECT=respiratory; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ATSDR MRLs:15447344:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4e142f9578b04c6d5d2c7097a05bf5bd |
ToxValDB Cal OEHHA REL derivations 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Cal OEHHA REL derivations | BMC (05) | =9.47332 | mg/m3 | Human | inhalation | acute; 5 minutes | clinical | LONG_REF=Industrial Bio-Test Laboratories, Inc. Report to International Institute of Ammonia Refrigeration: Irritation threshold evaluation study with ammonia. IBT No 1973; 663-03161 (March 23, 1973). MacEwen J, Theodore J, Vernot EH. Human exposure to EEL concentration of monomethylhydrazine. AMRL-TR- 1970; 70-102, 23. Wright-Patterson Air Force Base (OH): SysteMed Corp.; 1970. Silverman L, Whittenberger JL, Muller J. Physiological response of man to ammonia in low concentrations. J Ind Hyg Toxicol 1949;31:74-78. Verberk M. Effects of ammonia in volunteers. Int Arch Occup Health 1977;39:73-81; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32b8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd2final.pdf; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=eye and respiratory irritation; STUDY_GROUP=Cal OEHHA REL derivations:15951902:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a04aa4d925e35a13c73dfb9858d4cc5e |
| ToxValDB Cal OEHHA REL derivations | NOAEL | =6.40842 | mg/m3 | Human | inhalation | chronic; 12.2 years | occupational | LONG_REF=Holness DL, Purdham JT, and Nethercott JR. 1989. Acute and chronic respiratory effects of occupational exposure to ammonia. Am. Ind. Hyg. Assoc. J. 50(12):646-650.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32ce; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd3final.pdf; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Pulmonary function, eye, skin, and respiratory symptoms of irritation; STUDY_GROUP=Cal OEHHA REL derivations:15952001:-:-workers in soda ash plant; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cc100f6b5e215b6b51c22dd8fe35a7fd |
ToxValDB DOE Protective Action Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB DOE Protective Action Criteria | LEL | =104485 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=DOE Protective Action Criteria:15512100:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0783d0f165af33ba5ab6487cf145460c |
ToxValDB ECOTOX 11 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | LOEL | =20 | g/kg sd | Rat | oral | short-term; 28 days | short-term | LONG_REF=Drug Chem. Toxicol.21(3): 387-404 Simeone,A., G.A. Boissonneault, L.P. Bush, and G.E.Jr. Mitchell Comparison of Two Ammoniation Procedures to Reduce the Toxicity of Endophyte-Infected Tall Fescue Seed Fed to Rats 1998; TITLE=Comparison of Two Ammoniation Procedures to Reduce the Toxicity of Endophyte-Infected Tall Fescue Seed Fed to Rats; AUTHOR=Simeone,A., G.A. Boissonneault, L.P. Bush, and G.E.Jr. Mitchell; DOI=10.3109/01480549809002213; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112406; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Feeding behavior: Food consumption|Morphology: Organ weight in relationship to body weight|Physiology: Food conversion efficiency; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption|organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594447_15595358:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=173f36dbe4871517b9884b8e1a0637d1 |
| ToxValDB ECOTOX | LOEL | =0.1 | % | Rat | oral | short-term; 21 days | short-term | LONG_REF=Digestion57(6): 411-419 Endo,H., Y. Tsukamoto, T. Arisawa, H. Goto, S. Hase, and T. Hayakawa Effects of Intragastric Ammonia on Collagen Metabolism of Gastric Ulcer Base in Rats 1996; TITLE=Effects of Intragastric Ammonia on Collagen Metabolism of Gastric Ulcer Base in Rats; AUTHOR=Endo,H., Y. Tsukamoto, T. Arisawa, H. Goto, S. Hase, and T. Hayakawa; DOI=10.1159/000201369; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112405; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=Biochemistry: Collagen to hydroxyproline ratio|Biochemistry: Hydroxyproline|Injury: Ulcer; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594740_15594741_15597156:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=a7f708075607e2aacc414b540c386cf9 |
| ToxValDB ECOTOX | LOEL | =0.01 | % | Rat | oral | chronic; 168 days | chronic | LONG_REF=Cancer Lett.65(1): 15-18 Tsujii,M., S. Kawano, S. Tsuji, K. Nagano, T. Ito, N. Hayasahi, H. Fusamoto, T. Kamada, and K. Tamura Ammonia: A Possible Promotor in Helicobacter pylori-Related Gastric Carcinogenesis 1992; TITLE=Ammonia: A Possible Promotor in Helicobacter pylori-Related Gastric Carcinogenesis; AUTHOR=Tsujii,M., S. Kawano, S. Tsuji, K. Nagano, T. Ito, N. Hayasahi, H. Fusamoto, T. Kamada, and K. Tamura; DOI=10.1016/0304-3835(92)90207-c; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112436; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Injury: Tumor induction; TOXICOLOGICAL_EFFECT_CATEGORY=cancer; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595109_15596341:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=ba702d09ba5d266418eb434631d28a77 |
| ToxValDB ECOTOX | LOEL | =0.02 | % | Rat | oral | chronic; 168 days | chronic | LONG_REF=Eur. J. Histochem.38(1): 41-52 Hata,M., Y. Yamazaki, T. Ueda, T. Kato, Y. Kohli, and N. Fujiki Influence of Ammonia Solution on Gastric Mucosa and Acetic Acid Induced Ulcer in Rats 1994; TITLE=Influence of Ammonia Solution on Gastric Mucosa and Acetic Acid Induced Ulcer in Rats; AUTHOR=Hata,M., Y. Yamazaki, T. Ueda, T. Kato, Y. Kohli, and N. Fujiki; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112743; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Cell(s): Height|Cell(s): Number of cells; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595144_15597498:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=3b225d731b7aceba58667f3218a3b6c6 |
| ToxValDB ECOTOX | LOEL | =187.5 | mM | Rat | oral | acute; 0.0208 days | acute | LONG_REF=Gastroenterology102(6): 1881-1888 Tsujii,M., S. Kawano, S. Tsuji, H. Fusamoto, T. Kamada, and N. Sato Mechanism of Gastric Mucosal Damage Induced by Ammonia 1992; TITLE=Mechanism of Gastric Mucosal Damage Induced by Ammonia; AUTHOR=Tsujii,M., S. Kawano, S. Tsuji, H. Fusamoto, T. Kamada, and N. Sato; DOI=10.1016/0016-5085(92)90309-m; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113020; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Injury: Ulcer; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594329_15595664_15608141_15608142:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=9abc8ad9afd2ef5c708802f78945b738 |
| ToxValDB ECOTOX | NOEL | =0.1 | % | Rat | oral | subchronic; 84 days | subchronic | LONG_REF=Eur. J. Histochem.38(1): 41-52 Hata,M., Y. Yamazaki, T. Ueda, T. Kato, Y. Kohli, and N. Fujiki Influence of Ammonia Solution on Gastric Mucosa and Acetic Acid Induced Ulcer in Rats 1994; TITLE=Influence of Ammonia Solution on Gastric Mucosa and Acetic Acid Induced Ulcer in Rats; AUTHOR=Hata,M., Y. Yamazaki, T. Ueda, T. Kato, Y. Kohli, and N. Fujiki; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112743; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Cell(s): Number of cells|Physiology: Mucus production; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|nonneoplastic histopathology; STUDY_GROUP=ECOTOX:15594212:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=07c371a7a7bb64c7f92cfb6f29aa274b |
| ToxValDB ECOTOX | NOEL | =250 | mM | Rat | oral | acute; 0.0208 days | acute | LONG_REF=Gastroenterology102(6): 1881-1888 Tsujii,M., S. Kawano, S. Tsuji, H. Fusamoto, T. Kamada, and N. Sato Mechanism of Gastric Mucosal Damage Induced by Ammonia 1992; TITLE=Mechanism of Gastric Mucosal Damage Induced by Ammonia; AUTHOR=Tsujii,M., S. Kawano, S. Tsuji, H. Fusamoto, T. Kamada, and N. Sato; DOI=10.1016/0016-5085(92)90309-m; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=113020; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Biochemistry: Adenosine diphosphate (ADP)|Biochemistry: Adenosine monophosphate (AMP)|Biochemistry: Hemoglobin|Physiology: Blood volume; TOXICOLOGICAL_EFFECT_CATEGORY=hematology|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594329_15595664_15608141_15608142:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e8cd9b4305311449b7a237365c474a46 |
| ToxValDB ECOTOX | NOEL | =0.01 | % | Mouse | oral | short-term; 10 days | short-term | LONG_REF=Free Radic. Biol. Med.33(8): 1073-1081 Nagahashi,S., H. Suzuki, M. Miyazawa, H. Nagata, M. Suzuki, S. Miura, and H. Ishii Ammonia Aggravates Stress-Induced Gastric Mucosal Oxidative Injury Through the Cancellation of Cytoprotective Heat Shock Protein 70 2002; TITLE=Ammonia Aggravates Stress-Induced Gastric Mucosal Oxidative Injury Through the Cancellation of Cytoprotective Heat Shock Protein 70; AUTHOR=Nagahashi,S., H. Suzuki, M. Miyazawa, H. Nagata, M. Suzuki, S. Miura, and H. Ishii; DOI=10.1016/s0891-5849(02)00998-x; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112322; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Biochemistry: Heat shock protein 70|Biochemistry: Thiobarbituric acid reactive substances|Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594398_15601222:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=0a94e39b236171696337b74911ea2f00 |
| ToxValDB ECOTOX | NOEL | =55 | umol/kg-minute | Rat | injection | acute; 0.125 days | acute | LONG_REF=Liver Transplant.10(7): 922-927 Dethloff,T., B.A. Hansen, and F.S. Larsen Tacrolimus Ameliorates Cerebral Vasodilatation and Intracranial Hypertension in the Rat with Portacaval Anastomosis and Hyperammonemia 2004; TITLE=Tacrolimus Ameliorates Cerebral Vasodilatation and Intracranial Hypertension in the Rat with Portacaval Anastomosis and Hyperammonemia; AUTHOR=Dethloff,T., B.A. Hansen, and F.S. Larsen; DOI=10.1002/lt.20141; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=85361; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Biochemistry: CO2 concentration|Biochemistry: Oxygen content|Biochemistry: pH|Physiology: Blood pressure|Physiology: Pressure; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|other|urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594495_15598684:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=322f69df15dfa0fec1f24067816096de |
| ToxValDB ECOTOX | NOEL | =0.02 | % | Rat | oral | short-term; 21 days | short-term | LONG_REF=Digestion57(6): 411-419 Endo,H., Y. Tsukamoto, T. Arisawa, H. Goto, S. Hase, and T. Hayakawa Effects of Intragastric Ammonia on Collagen Metabolism of Gastric Ulcer Base in Rats 1996; TITLE=Effects of Intragastric Ammonia on Collagen Metabolism of Gastric Ulcer Base in Rats; AUTHOR=Endo,H., Y. Tsukamoto, T. Arisawa, H. Goto, S. Hase, and T. Hayakawa; DOI=10.1159/000201369; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112405; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=Biochemistry: Collagen to hydroxyproline ratio|Biochemistry: Hydroxyproline|Injury: Ulcer; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594740_15594741_15597156:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=08b5eecbb63991345836ce3478b43609 |
| ToxValDB ECOTOX | NOEL | =125 | mM | Rat | oral | acute; 0.0208 days | acute | LONG_REF=Gastroenterology102(6): 1881-1888 Tsujii,M., S. Kawano, S. Tsuji, H. Fusamoto, T. Kamada, and N. Sato Mechanism of Gastric Mucosal Damage Induced by Ammonia 1992; TITLE=Mechanism of Gastric Mucosal Damage Induced by Ammonia; AUTHOR=Tsujii,M., S. Kawano, S. Tsuji, H. Fusamoto, T. Kamada, and N. Sato; DOI=10.1016/0016-5085(92)90309-m; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113020; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Injury: Ulcer; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594329_15595664_15608141_15608142:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d72e6879e59d1d7e85277bc1936bb802 |
ToxValDB EU SCOEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB EU SCOEL | LOAEL | =34.8284 | mg/m3 | Human | inhalation | acute; 360 minutes | clinical | LONG_REF=MacEwen, J.D., Theodore, J., Vernot, E.H. (1970). Human exposure to EEL concentrations of monoethylhydrazine. In: Proceedings of the 1st Annual Conference on Environmental Toxicology, Ohio, Wright-Patterson Air Force Base, 911 September 1970, Aerospace Medical Research Laboratory, pp 355-363 (AMRL-TR70-102, Paper No 23). Industrial Biotest Laboratories, Inc. (1973). Irritation threshold evaluation study with ammonia, IBL Inc. (Report to International Institute of Ammonia Refrigeration, Publ. No. 663-03161. Ferguson, W.S., Koch, W.C., Webster, L.B., Gould, J.R. (1977). Human physiological response and adaptation to ammonia. J. Occup. Med. 19. 319-326. Verberck, M.M. (1977). Effects of ammonia in volunteers. Int. Arch. Occup. Environ. Health 39,73-81.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c985c4e4b02565fc7d399d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu; SUBSOURCE_URL=https://echa.europa.eu/documents/10162/35144386/018_ammonia_oel_en.pdf; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=mild irritation; STUDY_GROUP=EU SCOEL:15952324:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fef51c10f193c12ab5564d1a4445d85b |
ToxValDB GESTIS DNEL 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL local | =14 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15629794_15629795:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0dd70024d5a41086b67bbed562401b4e |
| ToxValDB GESTIS DNEL | DNEL systemic | =47.6 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15629794_15629795:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3969d1d8a22c48f5b366328dad72b6b3 |
ToxValDB HPVIS 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB HPVIS | LOAEL | =62.6911 | mg/m3 | Rat | inhalation | - | repeat dose other | LONG_REF=Stolpe J, Sedlag R; 1976; Die Einzel- und Komplexwirkung von Ammoniak und Schwefelwasserstoff in der Luft auf kleine Versuchstiere (Ratten) bei unterschiedlichen Umweltbedingungen; Ach. Exper. Vet. Med. 30, 533-539.; TITLE=Die Einzel- und Komplexwirkung von Ammoniak und Schwefelwasserstoff in der Luft auf kleine Versuchstiere (Ratten) bei unterschiedlichen Umweltbedingungen; AUTHOR=Stolpe J, Sedlag R; QUALITY=4; EXTERNAL_SOURCE_ID=64122; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1981; ORIGINAL_YEAR=1981; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15640160_15640221:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_943f266a0c80e62e0c90814bef3e8ab4 |
| ToxValDB HPVIS | NOAEL | =34.8284 | mg/m3 | Rat | inhalation | - | repeat dose other | LONG_REF=Stolpe J, Sedlag R; 1976; Die Einzel- und Komplexwirkung von Ammoniak und Schwefelwasserstoff in der Luft auf kleine Versuchstiere (Ratten) bei unterschiedlichen Umweltbedingungen; Ach. Exper. Vet. Med. 30, 533-539.; TITLE=Die Einzel- und Komplexwirkung von Ammoniak und Schwefelwasserstoff in der Luft auf kleine Versuchstiere (Ratten) bei unterschiedlichen Umweltbedingungen; AUTHOR=Stolpe J, Sedlag R; QUALITY=4; EXTERNAL_SOURCE_ID=60229; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1981; ORIGINAL_YEAR=1981; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15640160_15640221:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ac1d74e050f574ffc9ccb4b069dfa4dd |
| ToxValDB HPVIS | NOAEL | =24.3799 | mg/m3 | Pig | inhalation | - | reproduction developmental | LONG_REF=Diekman, MA., Scheidt, AB., Sutton, AL., Green, ML., Clapper, JA, Kelly, DT., and Van Alstine, WG. 1993. Growth and reproductive performance, during exposure to ammonia, of gilts afflicted with pneumonia and atrophic rhinitis. Am J Vet Res 54(12):2128-2131.; TITLE=Growth and reproductive performance, during exposure to ammonia, of gilts afflicted with pneumonia and atrophic rhinitis; AUTHOR=Diekman, MA., Scheidt, AB., Sutton, AL., Green, ML., Clapper, JA, Kelly, DT., and Van Alstine, WG; QUALITY=4; EXTERNAL_SOURCE_ID=58070; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=HPVIS:15642343:-:F1offspring; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_31b4df8b7490798844c23380c92c632d |
ToxValDB IRIS 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB IRIS | NOAEL | =13.6 | mg/m3 | Human | inhalation | - | occupational | LONG_REF=Holness, DL; Purdham, JT; Nethercott, JR. (1989). Acute and chronic respiratory effects of occupational exposure to ammonia. AIHA J 50: 646-650. http://dx.doi.org/10.1080/15298668991375308. ; Rahman, MH; Bratveit, M; Moen, BE. (2007). Exposure to ammonia and acute respiratory effects in a urea fertilizer factory. Int J Occup Environ Health 13: 153-159. http://dx.doi.org/10.1179/oeh.2007.13.2.153. ; Ballal, SG; Ali, BA; Albar, AA; Ahmed, HO; Al-Hasan, AY. (1998). Bronchial asthma in two chemical fertilizer producing factories in eastern Saudi Arabia. Int J Tuberc Lung Dis 2: 330-335. ; Ali, BA, Ahmed, HO, Ballal, SG, Albar, AA. (2001). Pulmonary function of workers exposed to ammonia: A study in the Eastern Province of Saudi Arabia. Int J Occup Environ Health 7: 19-22. http://dx.doi.org/10.1179/oeh.2001.7.1.19.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5aaa; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=422; TOXICOLOGICAL_EFFECT=reduced lung function and respiratory symptoms; STUDY_GROUP=IRIS_dup_IRIS Summary_15644284_15644285:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0a768b2c34bbe35f9bacf4567a5f7df2 |
| ToxValDB IRIS | NOAEL (ADJ) | =4.9 | mg/m3 | Human | inhalation | - | occupational | LONG_REF=Holness, DL; Purdham, JT; Nethercott, JR. (1989). Acute and chronic respiratory effects of occupational exposure to ammonia. AIHA J 50: 646-650. http://dx.doi.org/10.1080/15298668991375308. ; Rahman, MH; Bratveit, M; Moen, BE. (2007). Exposure to ammonia and acute respiratory effects in a urea fertilizer factory. Int J Occup Environ Health 13: 153-159. http://dx.doi.org/10.1179/oeh.2007.13.2.153. ; Ballal, SG; Ali, BA; Albar, AA; Ahmed, HO; Al-Hasan, AY. (1998). Bronchial asthma in two chemical fertilizer producing factories in eastern Saudi Arabia. Int J Tuberc Lung Dis 2: 330-335. ; Ali, BA, Ahmed, HO, Ballal, SG, Albar, AA. (2001). Pulmonary function of workers exposed to ammonia: A study in the Eastern Province of Saudi Arabia. Int J Occup Environ Health 7: 19-22. http://dx.doi.org/10.1179/oeh.2001.7.1.19.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5aaa; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=422; TOXICOLOGICAL_EFFECT=reduced lung function and respiratory symptoms; STUDY_GROUP=IRIS_dup_IRIS Summary_15644284_15644285:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_74c2979096afd9eef045cc50f88ff841 |
| ToxValDB IRIS | RfC | =0.5 | mg/m3 | Human | inhalation | - | Toxicity Value | LONG_REF=Holness, DL; Purdham, JT; Nethercott, JR. (1989). Acute and chronic respiratory effects of occupational exposure to ammonia. AIHA J 50: 646-650. http://dx.doi.org/10.1080/15298668991375308. ; Rahman, MH; Bratveit, M; Moen, BE. (2007). Exposure to ammonia and acute respiratory effects in a urea fertilizer factory. Int J Occup Environ Health 13: 153-159. http://dx.doi.org/10.1179/oeh.2007.13.2.153. ; Ballal, SG; Ali, BA; Albar, AA; Ahmed, HO; Al-Hasan, AY. (1998). Bronchial asthma in two chemical fertilizer producing factories in eastern Saudi Arabia. Int J Tuberc Lung Dis 2: 330-335. ; Ali, BA, Ahmed, HO, Ballal, SG, Albar, AA. (2001). Pulmonary function of workers exposed to ammonia: A study in the Eastern Province of Saudi Arabia. Int J Occup Environ Health 7: 19-22. http://dx.doi.org/10.1179/oeh.2001.7.1.19.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5aaa; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=422; TOXICOLOGICAL_EFFECT=reduced lung function and respiratory symptoms; STUDY_GROUP=IRIS:15644286:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_13eade588ff40a5ad96a49818642783a |
ToxValDB NIOSH IDLH 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB NIOSH IDLH | LEL | =348.284 | mg/m3 | Human | inhalation | acute; 30 min | occupational | LONG_REF=Silverman L, Whittenberger JL, Muller J [1946]. Physiological response of man to ammonia in low concentrations. J Ind Hyg Toxicol 31:74-78.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c9b369e4b02565fc7d6a98; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.cdc.gov/niosh/idlh/; SUBSOURCE_URL=https://www.cdc.gov/niosh/idlh/7664417.html; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=change in respiration rate and moderate to severe irritation; STUDY_GROUP=NIOSH IDLH:15953015:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_621ec7a9640e576c947d1c7d8e246c93 |
ToxValDB PPRTV (CPHEA) 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB PPRTV (CPHEA) | NOAEL (HEC) | =2.3 | mg/m3 | Human | inhalation | chronic; 12.2 years | occupational | LONG_REF=Holness et al. 1989; AUTHOR=Holness et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b339; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1569; TOXICOLOGICAL_EFFECT=Cardiovascular; STUDY_GROUP=PPRTV (CPHEA):15653383:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a68d65f5d7493113915d48b6c9421e77 |
| ToxValDB PPRTV (CPHEA) | RfC (provisional) | =0.1 | mg/m3 | Human | inhalation | - | Toxicity Value | LONG_REF=Holness et al. 1989; AUTHOR=Holness et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b339; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1569; TOXICOLOGICAL_EFFECT=Cardiovascular; STUDY_GROUP=PPRTV (CPHEA):15653382:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a6291cbb92e614581573e5be5de705b7 |
ToxValDB Pennsylvania DEP ToxValues 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Pennsylvania DEP ToxValues | RfD | =0.85 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67599fbae4b0a7c65d37b2e3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://files.dep.state.pa.us/EnvironmentalCleanupBrownfields/LandRecyclingProgram/LandRecyclingProgramPortalFiles/GuidanceTechTools/VaporIntrusion/November_2021/Table%205a.pdf; STUDY_GROUP=Pennsylvania DEP ToxValues:15649802:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_770efc3cec0b272b0f688de0daab2590 |
ToxValDB TX TCEQ 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB TX TCEQ | LOAEL | =3.48284 | mg/m3 | Human | inhalation | acute; 3 hours | clinical | LONG_REF=Sundblad B-M, B-M Larsson, F Acevedo, L Ernstgard, G Johanson, K Larsson, and L Palmberg. 2004. Acute respiratory effects of exposure to ammonia on health persons. Scandinavian Journal of Work, Environment, & Health 30(4): 313-321; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5b41; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/ammonia.pdf; YEAR=2014 (revised 2015); ORIGINAL_YEAR=2014 (revised 2015); TOXICOLOGICAL_EFFECT=Mild, transient upper respiratory symptoms and CNS effects (eye discomfort, smell, headache, dizziness, and feelings of intoxication); STUDY_GROUP=TX TCEQ:15954318:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2784e032f3e99f032bef26d11ac4e89e |
| ToxValDB TX TCEQ | NOAEL | =12.5 | ppm | Human | occupational | chronic; 12.2 years | occupational | LONG_REF=Holness DL, JT Purdham, and JR Nethercott. 1989. Acute and chronic respiratory effects of occupational exposure to ammonia. American Industrial Hygiene Association Journal 50(12): 646-650.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5b41; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/ammonia.pdf; YEAR=2014 (revised 2015); ORIGINAL_YEAR=2014 (revised 2015); STUDY_GROUP=TX TCEQ:15954319:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7e8c78352eb2bcb6798b965f0286574e |
openFDA substances 16 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 5138Q19F1X | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"H3N","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"5138Q19F1X"} |
| openFDA substances | FDA UNII substance identifier | 5138Q19F1X | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"H3N","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"5138Q19F1X"} |
| openFDA substances | FDA UNII substance identifier | 5138Q19F1X | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"H3N","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"5138Q19F1X"} |
| openFDA substances | FDA UNII substance identifier | 5138Q19F1X | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"H3N","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"5138Q19F1X"} |
| openFDA substances | FDA UNII substance identifier | 5138Q19F1X | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"H3N","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"5138Q19F1X"} |
| openFDA substances | FDA UNII substance identifier | 5138Q19F1X | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"H3N","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"5138Q19F1X"} |
| openFDA substances | FDA UNII substance identifier | 5138Q19F1X | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"H3N","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"5138Q19F1X"} |
| openFDA substances | FDA UNII substance identifier | 5138Q19F1X | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"H3N","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"5138Q19F1X"} |
| openFDA substances | FDA UNII substance identifier | concept | identifier | - | - | - | concept | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"concept","unii_code":null} |
| openFDA substances | FDA UNII substance identifier | concept | identifier | - | - | - | concept | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"concept","unii_code":null} |
| openFDA substances | FDA UNII substance identifier | concept | identifier | - | - | - | concept | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"concept","unii_code":null} |
| openFDA substances | FDA UNII substance identifier | concept | identifier | - | - | - | concept | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"concept","unii_code":null} |
| openFDA substances | FDA UNII substance identifier | concept | identifier | - | - | - | concept | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"concept","unii_code":null} |
| openFDA substances | FDA UNII substance identifier | concept | identifier | - | - | - | concept | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"concept","unii_code":null} |
| openFDA substances | FDA UNII substance identifier | concept | identifier | - | - | - | concept | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"concept","unii_code":null} |
| openFDA substances | FDA UNII substance identifier | concept | identifier | - | - | - | concept | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"concept","unii_code":null} |