NOAEL Studies
Cosmetic Ingredient
Aluminum Sulfate NOAEL Studies
INCI: ALUMINUM SULFATE
CAS: 10043-01-3
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP_ICE_acute_inhalation 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_inhalation | LC50 | 0.05 | mg/L | - | Inhalation | - | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1740; Record_ID=acute_inhalation_640; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID2040317; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.05; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7828/7/3/3/?documentUUID=c73d9007-7c32-4def-a7da-8fe8f377c264; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2040317 |
| NTP_ICE_acute_inhalation | LC50 | 0.2 | mg/L | - | Inhalation | - | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1741; Record_ID=acute_inhalation_643; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID2040317; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.2; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7828/7/3/3/?documentUUID=c73d9007-7c32-4def-a7da-8fe8f377c264; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2040317 |
ToxValDB_ECHA_IUCLID 11 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | LEL | >233.5 | mg/kg bw/day | Pig | dermal | short-term; 5 days | acute | GUIDELINE=OECD Guideline 402 (Acute Dermal Toxicity); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c6157ee4b096bca8757153; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7828/7/3/4?documentUUID=1ffc0d53-db33-48b5-89f1-8abcce7c7461; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Dermal_15790996_15794635:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4285c36bfed89d00f229bb42b5eaf79a |
| ToxValDB_ECHA_IUCLID | LEL | =2335 | mg/kg bw/day | Mouse | dermal | short-term; 5 days | acute | GUIDELINE=OECD Guideline 402 (Acute Dermal Toxicity); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c616f1e4b096bca875d217; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7828/7/3/4?documentUUID=a30514d6-d5c1-472a-aa16-20174271538d; YEAR=1977; ORIGINAL_YEAR=1977; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Dermal_15791654_15791815:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cfd02c5ed70aeccc92f2ee583414dfb6 |
| ToxValDB_ECHA_IUCLID | LOAEL | =1250 | mg/kg bw/day | Rat | oral | - | repeat dose other | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c85ae4b0a7c65d2180b1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7828/7/10/1?documentUUID=1ffc0d53-db33-48b5-89f1-8abcce7c7461; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825558_15825628_15825700_15825709_15826051_15826052:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_08b7b1bf757367fa8a89a27cd295346d |
| ToxValDB_ECHA_IUCLID | LOAEL | =1500 | mg/kg bw/day | Rat | oral | - | repeat dose other | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa3ee4b0a7c65d1b4eb3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7828/7/10/1?documentUUID=1ffc0d53-db33-48b5-89f1-8abcce7c7461; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15826049_15826050:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8cab79bb58b40a75c2c0e23dd30d3cac |
| ToxValDB_ECHA_IUCLID | LOAEL | =150 | mg/kg bw/day | Rat | oral | - | repeat dose other | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa3ee4b0a7c65d1b4ebf; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7828/7/10/1?documentUUID=a30514d6-d5c1-472a-aa16-20174271538d; YEAR=1977; ORIGINAL_YEAR=1977; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825558_15825628_15825700_15825709_15826051_15826052:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3d544470da26055fa012f10ea6cc3dd8 |
| ToxValDB_ECHA_IUCLID | NOAEL | =40 | mg/kg bw/day | Mouse | injection | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d17ce4b0a7c65d22eb45; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7828/7/9/3?documentUUID=1ffc0d53-db33-48b5-89f1-8abcce7c7461; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15821992_15822018_15822656_15823079:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3e92fffc5941efe45db70c2c4d428442 |
| ToxValDB_ECHA_IUCLID | NOAEL | =10265 | mg/kg bw/day | Rat | oral | - | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa35e4b0a7c65d1b4d57; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7828/7/10/2?documentUUID=1ffc0d53-db33-48b5-89f1-8abcce7c7461; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=ECHA IUCLID_dup_Immunotoxicity_15825520_15825521:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_282023d37f7823f140ca0e3ca9f79d5b |
| ToxValDB_ECHA_IUCLID | NOAEL | =1850 | mg/kg bw/day | Rat | oral | - | repeat dose other | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c85ae4b0a7c65d2180b3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7828/7/10/1?documentUUID=1ffc0d53-db33-48b5-89f1-8abcce7c7461; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825558_15825628_15825700_15825709_15826051_15826052:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_33f287a1aa99c461a47c88b99ec0cdc0 |
| ToxValDB_ECHA_IUCLID | NOAEL | =317 | mg/kg bw/day | Rat | oral | - | repeat dose other | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa3ee4b0a7c65d1b4ebc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7828/7/10/1?documentUUID=a30514d6-d5c1-472a-aa16-20174271538d; YEAR=1977; ORIGINAL_YEAR=1977; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15826047_15826048:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_028a75849282b01bd71741d89631d1ce |
| ToxValDB_ECHA_IUCLID | NOAEL | =300 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaca9e4b0a7c65d1c0277; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7828/7/6/2?documentUUID=a30514d6-d5c1-472a-aa16-20174271538d; YEAR=1977; ORIGINAL_YEAR=1977; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15847510_15848638:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2ae3add9510e549a9fe5ffc105ed3776 |
| ToxValDB_ECHA_IUCLID | NOAEL | =342 | mg/kg bw/day | Rat | oral | short-term; 30 days | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaca9e4b0a7c65d1c0275; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7828/7/6/2?documentUUID=a30514d6-d5c1-472a-aa16-20174271538d; YEAR=1977; ORIGINAL_YEAR=1977; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15850120_15850121:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6352a61d802cfd5909f8c18db7b99f12 |
ToxValDB_GESTIS_DNEL 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL local | =3 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15629634_15629635_15629636:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_69fcbbc29689775ab2e36a14f5020c9e |
| ToxValDB_GESTIS_DNEL | DNEL systemic | =13.4 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15629634_15629635_15629636:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8ab5eccc05c497d743dd3fde91047d43 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | I7T908772F | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"2Al.3O4S","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"I7T908772F"} |
| openFDA substances | FDA UNII substance identifier | I7T908772F | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"2Al.3O4S","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"I7T908772F"} |
| openFDA substances | FDA UNII substance identifier | I7T908772F | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"2Al.3O4S","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"I7T908772F"} |
| openFDA substances | FDA UNII substance identifier | I7T908772F | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"2Al.3O4S","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"I7T908772F"} |