NOAEL Studies Fragrance

Alpha-Isomethyl Ionone NOAEL Studies

INCI: ALPHA-ISOMETHYL IONONE

CAS: 127-51-5

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 4.1 mg/kg bw/day rat oral 90 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
NTP_ICE_adme_parameters 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_adme_parameters Clint 10.8 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=2890; Record_ID=adme_parameters_303; Data_Type=Measured; DTXSID=DTXSID7027047; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=10.8; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wetmore 2015; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7027047
NTP_ICE_adme_parameters Fu 0.006334 fraction Human - - Measured; httk, Human Plasma Fraction Unbound sheet=Data; excel_row=2891; Record_ID=adme_parameters_303; Data_Type=Measured; DTXSID=DTXSID7027047; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.006334; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wetmore 2015; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7027047
NTP_ICE_endocrine 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine AC50 18.7250137139806 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=10722; RecordID=ERPathway2016_346; DatasetName=ERPathway2016; DTXSID=DTXSID7027047; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=18.7250137139806; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7027047
NTP_ICE_endocrine ACC 13.5084895145576 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=10723; RecordID=ERPathway2016_346; DatasetName=ERPathway2016; DTXSID=DTXSID7027047; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=13.5084895145576; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7027047
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Agonist sheet=Integrated_approaches; excel_row=10718; RecordID=ARPathway2016_759; DatasetName=ARPathway2016; DTXSID=DTXSID7027047; Assay=AR Pathway Model, Agonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7027047
NTP_ICE_endocrine Model Score 0.0185 unitless - - - ERPathway2016; ER Pathway Model, Agonist sheet=Integrated_approaches; excel_row=10724; RecordID=ERPathway2016_346; DatasetName=ERPathway2016; DTXSID=DTXSID7027047; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.0185; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7027047
NTP_ICE_skin_sensitization 22 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization CD54, EC200 52.47 ug/mL - Dermal - In Vitro; Urbisch_SkinSensitization2020; h-CLAT sheet=Data_invitro; excel_row=1713; Record_ID=skin_sensitization_invitro_409; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID7027047; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=52.47; Reported_Response_Unit=ug/mL; Response=52.47; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7027047
NTP_ICE_skin_sensitization CD86, EC150 22.28 ug/mL - Dermal - In Vitro; CE_USENSE2018; U-SENS sheet=Data_invitro; excel_row=8729; Record_ID=skin_sensitization_invitro_2419; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID7027047; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=22.28; Reported_Response_Unit=ug/mL; Response=22.28; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7027047
NTP_ICE_skin_sensitization CV70 35.85 ug/mL - Dermal - In Vitro; CE_USENSE2018; U-SENS sheet=Data_invitro; excel_row=8730; Record_ID=skin_sensitization_invitro_2419; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID7027047; Assay=U-SENS; Endpoint=CV70; Reported_Response=35.85; Reported_Response_Unit=ug/mL; Response=35.85; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7027047
NTP_ICE_skin_sensitization CV75 62.3 ug/mL - Dermal - In Vitro; Urbisch_SkinSensitization2020; h-CLAT sheet=Data_invitro; excel_row=1665; Record_ID=skin_sensitization_invitro_409; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID7027047; Assay=h-CLAT; Endpoint=CV75; Reported_Response=62.3; Reported_Response_Unit=ug/mL; Response=62.3; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7027047
NTP_ICE_skin_sensitization Depletion Cys 4.5 % - Dermal - In Vitro; Urbisch_SkinSensitization2020; DPRA sheet=Data_invitro; excel_row=204; Record_ID=skin_sensitization_invitro_80; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID7027047; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=4.5; Reported_Response_Unit=%; Response=4.5; Response_Unit=%; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7027047
NTP_ICE_skin_sensitization Depletion Lys 0 % - Dermal - In Vitro; Urbisch_SkinSensitization2020; DPRA sheet=Data_invitro; excel_row=243; Record_ID=skin_sensitization_invitro_80; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID7027047; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=0; Reported_Response_Unit=%; Response=0; Response_Unit=%; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7027047
NTP_ICE_skin_sensitization EC1.5 >2000 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=4989; Record_ID=skin_sensitization_invitro_1155; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID7027047; Assay=KeratinoSens; Endpoint=EC1.5; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2000; Reported_Response_Unit=uM; Response=2000; Response_Unit=uM; Reference=Natsch et al. 2015; 25338925; 10.1093/toxsci/kfu229; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7027047
NTP_ICE_skin_sensitization EC1.5 4000 uM - Dermal - In Vitro; Urbisch_SkinSensitization2020; KeratinoSens sheet=Data_invitro; excel_row=4990; Record_ID=skin_sensitization_invitro_1156; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID7027047; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=4000; Reported_Response_Unit=uM; Response=4000; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7027047
NTP_ICE_skin_sensitization EC3 21.8 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13436; Record_ID=skin_sensitization_invivo_3585; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7027047; Assay=LLNA; Endpoint=EC3; Response=21.8; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Kern et al. 2010; 20137736; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7027047
NTP_ICE_skin_sensitization EC3 21.8 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13436; Record_ID=skin_sensitization_invivo_3585; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7027047; Assay=LLNA; Endpoint=EC3; Response=21.8; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Kern et al. 2010; 20137736; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7027047
NTP_ICE_skin_sensitization EC3 21.8 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13436; Record_ID=skin_sensitization_invivo_3585; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7027047; Assay=LLNA; Endpoint=EC3; Response=21.8; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Kern et al. 2010; 20137736; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7027047
NTP_ICE_skin_sensitization EC3 21.8 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13436; Record_ID=skin_sensitization_invivo_3585; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7027047; Assay=LLNA; Endpoint=EC3; Response=21.8; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Kern et al. 2010; 20137736; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7027047
NTP_ICE_skin_sensitization IC50 60.03 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=4992; Record_ID=skin_sensitization_invitro_1155; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID7027047; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=60.025221819999999; Reported_Response_Unit=uM; Response=60.03; Response_Unit=uM; Reference=Natsch et al. 2015; 25338925; 10.1093/toxsci/kfu229; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7027047
NTP_ICE_skin_sensitization Imax 1.028 ratio - Dermal - In Vitro; Urbisch_SkinSensitization2020; KeratinoSens sheet=Data_invitro; excel_row=4994; Record_ID=skin_sensitization_invitro_1156; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID7027047; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.027932831; Reported_Response_Unit=Unitless; Response=1.028; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7027047
NTP_ICE_skin_sensitization Imax 1.03 ratio - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=4995; Record_ID=skin_sensitization_invitro_1155; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID7027047; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.03; Reported_Response_Unit=Unitless; Response=1.03; Response_Unit=Ratio; Reference=Natsch et al. 2015; 25338925; 10.1093/toxsci/kfu229; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7027047
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=4653; Record_ID=skin_sensitization_invivo_1117; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=60.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7027047; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 2004; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2007; 18022744; 10.1016/j.fct.2007.09.067|Lapczynski et al. 2007; 18037210; 10.1016/j.fct.2007.09.051|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425|Api et al. 2017; 28691948; 10.1097/der.0000000000000304|Api et al. 2019; 31365887; 10.1016/j.fct.2019.110716; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7027047
NTP_ICE_skin_sensitization Induction dose per skin area 70870 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=4650; Record_ID=skin_sensitization_invivo_1117; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=60.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7027047; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=70870; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 2004; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2007; 18022744; 10.1016/j.fct.2007.09.067|Lapczynski et al. 2007; 18037210; 10.1016/j.fct.2007.09.051|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425|Api et al. 2017; 28691948; 10.1097/der.0000000000000304|Api et al. 2019; 31365887; 10.1016/j.fct.2019.110716; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7027047
NTP_ICE_skin_sensitization Induction dose per skin area 1860 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=4656; Record_ID=skin_sensitization_invivo_1119; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7027047; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=1860; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1968; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2007; 18022744; 10.1016/j.fct.2007.09.067|Lapczynski et al. 2007; 18037210; 10.1016/j.fct.2007.09.051|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425|Api et al. 2017; 28691948; 10.1097/der.0000000000000304|Api et al. 2019; 31365887; 10.1016/j.fct.2019.110716; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7027047
NTP_ICE_skin_sensitization Induction dose per skin area 6200 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=4664; Record_ID=skin_sensitization_invivo_1121; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7027047; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=6200; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1962; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2007; 18022744; 10.1016/j.fct.2007.09.067|Lapczynski et al. 2007; 18037210; 10.1016/j.fct.2007.09.051|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425|Api et al. 2017; 28691948; 10.1097/der.0000000000000304; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7027047
NTP_ICE_skin_sensitization Induction dose per skin area 9688 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=4673; Record_ID=skin_sensitization_invivo_1123; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=12.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7027047; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=9688; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1964; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2007; 18022744; 10.1016/j.fct.2007.09.067|Lapczynski et al. 2007; 18037210; 10.1016/j.fct.2007.09.051|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425|Api et al. 2017; 28691948; 10.1097/der.0000000000000304|Api et al. 2019; 31365887; 10.1016/j.fct.2019.110716; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7027047
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=4657; Record_ID=skin_sensitization_invivo_1117; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=60.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7027047; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=RIFM 2004; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2007; 18022744; 10.1016/j.fct.2007.09.067|Lapczynski et al. 2007; 18037210; 10.1016/j.fct.2007.09.051|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425|Api et al. 2017; 28691948; 10.1097/der.0000000000000304|Api et al. 2019; 31365887; 10.1016/j.fct.2019.110716; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7027047
NTP_ICE_skin_sensitization Relative reliability score 4 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=4679; Record_ID=skin_sensitization_invivo_1123; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=12.5; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7027047; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=4; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=RIFM 1964; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Belsito et al. 2007; 18022744; 10.1016/j.fct.2007.09.067|Lapczynski et al. 2007; 18037210; 10.1016/j.fct.2007.09.051|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425|Api et al. 2017; 28691948; 10.1097/der.0000000000000304|Api et al. 2019; 31365887; 10.1016/j.fct.2019.110716; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7027047
ToxValDB_ECHA_IUCLID 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL >=30 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabd2e4b0a7c65d1bbf52; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18612/7/9/3?documentUUID=05c87ee8-bfb3-4cfa-9318-841d16293dc1; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=fetus: reduction in number of live offspring|fetus: fetal/pup body weight changes|fetus: changes in litter size and weights|fetus: skeletal malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development|reproduction; STUDY_GROUP=ECHA IUCLID:15821798:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6ddf2b385db0ccfcc8751d2237a286c8
ToxValDB_ECHA_IUCLID NOAEL >=3.55 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead96e4b0a7c65d1c4e7b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20908/7/6/2?documentUUID=b85a4b9b-c076-4830-854a-c45fca134115; YEAR=1973; ORIGINAL_YEAR=1973; STUDY_GROUP=ECHA IUCLID:15841747:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_aa0201e7402efa508c40d7cf75c56664
ToxValDB_ECHA_IUCLID NOAEL >=4.1 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead96e4b0a7c65d1c4e7b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20908/7/6/2?documentUUID=b85a4b9b-c076-4830-854a-c45fca134115; YEAR=1973; ORIGINAL_YEAR=1973; STUDY_GROUP=ECHA IUCLID:15841748:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_44484ac1e9559e1432a725c3a5dd5aa4
ToxValDB_ECHA_IUCLID NOAEL =500 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa8be4b0a7c65d1b6529; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18612/7/9/2?documentUUID=05c87ee8-bfb3-4cfa-9318-841d16293dc1; YEAR=2008; ORIGINAL_YEAR=2008; STUDY_GROUP=ECHA IUCLID:15860998:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7bf2e64081efa6b9a1dfeca0d141201a
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =8.22 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15633515:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_00900dea19594d061c9a9533cdc8c533
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 9XP4LC555B UNII - - - chemical {"approval_status":null,"molecular_formula":"C14H22O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"9XP4LC555B"}
openFDA substances FDA UNII substance identifier 9XP4LC555B UNII - - - chemical {"approval_status":null,"molecular_formula":"C14H22O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"9XP4LC555B"}
openFDA substances FDA UNII substance identifier 9XP4LC555B UNII - - - chemical {"approval_status":null,"molecular_formula":"C14H22O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"9XP4LC555B"}
openFDA substances FDA UNII substance identifier 9XP4LC555B UNII - - - chemical {"approval_status":null,"molecular_formula":"C14H22O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"9XP4LC555B"}