NOAEL Studies Cosmetic Ingredient

Alcohol NOAEL Studies

INCI: ALCOHOL

CAS: 64-17-5

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =1730 mg/kg bw/day Rat oral: gavage 90 days subchronic EFSA FEEDAP - 2013 - OutputID 2209 - organ weights - nephrotoxicity - Scientific Opinion on the safety and efficacy of straight-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing saturated alcohols and acetals containing saturated aldehydes (chemical group 1) when used as flavourings for all animal species - doi:10.2903/j.efsa.2013.3169
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =1730 mg/kg bw/day Rat oral: gavage 90 days subchronic EFSA FEEDAP - 2013 - OutputID 2209 - organ weights - nephrotoxicity - Scientific Opinion on the safety and efficacy of straight-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing saturated alcohols and acetals containing saturated aldehydes (chemical group 1) when used as flavourings for all animal species - doi:10.2903/j.efsa.2013.3169
IARC Monographs 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
IARC Monographs IARC carcinogenicity classification 1 IARC group - - 2009 IARC Monographs {"additional_info":"volume_publication_year=2012","evaluation_year":2009,"source_table":"iarc_classifications","volume":"96, 100E"}
NTP_ICE_acute_dermal 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_dermal EPA classification 4 unitless Rat Dermal - In Vivo; Rat Acute Dermal Toxicity sheet=Data; excel_row=2429; Record_ID=acute_dermal_91; Data_Type=In Vivo; Formulation_ID=MIX90; Formulation_Name=Cavicide 1; Percent_Active_Ingredient=7.5; Mixture=Mixture; DTXSID=DTXSID9020584; Assay=Rat Acute Dermal Toxicity; Endpoint=EPA classification; Response=4.0; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_acute_dermal GHS classification 5 unitless Rat Dermal - In Vivo; Rat Acute Dermal Toxicity sheet=Data; excel_row=2430; Record_ID=acute_dermal_91; Data_Type=In Vivo; Formulation_ID=MIX90; Formulation_Name=Cavicide 1; Percent_Active_Ingredient=7.5; Mixture=Mixture; DTXSID=DTXSID9020584; Assay=Rat Acute Dermal Toxicity; Endpoint=GHS classification; Response=5.0; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_acute_dermal LD50 >5050 mg/kg Rat Dermal - In Vivo; Rat Acute Dermal Toxicity sheet=Data; excel_row=2428; Record_ID=acute_dermal_91; Data_Type=In Vivo; Formulation_ID=MIX90; Formulation_Name=Cavicide 1; Percent_Active_Ingredient=7.5; Mixture=Mixture; DTXSID=DTXSID9020584; Assay=Rat Acute Dermal Toxicity; Endpoint=LD50; Response_Modifier=>; Response=5050.0; Response_Unit=mg/kg; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_acute_inhalation 10 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_inhalation EPA Classification 4 unitless - Inhalation - In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity sheet=Data; excel_row=5007; Record_ID=acute_inhalation_481; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX90; Formulation_Name=Cavicide 1; Percent_Active_Ingredient=7.5; Mixture=Mixture; DTXSID=DTXSID9020584; Assay=Rat Acute Inhalation Toxicity; Endpoint=EPA Classification; Response=4; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_acute_inhalation LC50 51.3 mg/L - Inhalation Duration=6 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=5005; Record_ID=acute_inhalation_817; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=51.3; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16105/7/3/3/?documentUUID=9f17e6ca-e439-4a0f-9c18-2f7f3887149d; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_acute_inhalation LC50 2.16 mg/L - Inhalation - In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity sheet=Data; excel_row=5006; Record_ID=acute_inhalation_481; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX90; Formulation_Name=Cavicide 1; Percent_Active_Ingredient=7.5; Mixture=Mixture; DTXSID=DTXSID9020584; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=2.16; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_acute_inhalation LC50 54.8 mg/L - Inhalation Duration=6 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=5009; Record_ID=acute_inhalation_815; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=54.8; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16105/7/3/3/?documentUUID=9f17e6ca-e439-4a0f-9c18-2f7f3887149d; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_acute_inhalation LC50 133.8 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=5010; Record_ID=acute_inhalation_821; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=133.8; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16105/7/3/3/?documentUUID=845622a3-bda0-4a98-a202-2e65b2a74c9d; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_acute_inhalation LC50 52.9 mg/L - Inhalation Duration=6 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=5011; Record_ID=acute_inhalation_819; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=52.9; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16105/7/3/3/?documentUUID=9f17e6ca-e439-4a0f-9c18-2f7f3887149d; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_acute_inhalation LC50 5.9 mg/L - Inhalation Duration=6 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=5012; Record_ID=acute_inhalation_1692; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=5.9; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_acute_inhalation LC50 37.6608 mg/L - Inhalation Duration=10 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=5013; Record_ID=acute_inhalation_973; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=37.6608; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_acute_inhalation LC50 116.9 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=5014; Record_ID=acute_inhalation_823; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=116.9; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16105/7/3/3/?documentUUID=845622a3-bda0-4a98-a202-2e65b2a74c9d; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_acute_inhalation LC50 124.7 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=5015; Record_ID=acute_inhalation_2704; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=124.7; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_acute_oral 19 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral EPA classification =4 Unitless Rat (Female) oral acute Rat Acute Oral Toxicity Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12331; row=15305; data_type=In Vivo; mixture=Mixture; formulation_id=MIX90; formulation_name=Cavicide 1; chemical_name=Alcohol; preferred_name=Ethanol; percent_active_ingredient=7.5; dtxsid=DTXSID9020584; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9020584; source_file=acute_oral.xlsx
NTP_ICE_acute_oral GHS classification =5 Unitless Rat (Female) oral acute Rat Acute Oral Toxicity Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12331; row=15306; data_type=In Vivo; mixture=Mixture; formulation_id=MIX90; formulation_name=Cavicide 1; chemical_name=Alcohol; preferred_name=Ethanol; percent_active_ingredient=7.5; dtxsid=DTXSID9020584; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9020584; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 >5000 mg/kg bw Rat (Female) oral acute Rat Acute Oral Toxicity Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12331; row=15304; data_type=In Vivo; mixture=Mixture; formulation_id=MIX90; formulation_name=Cavicide 1; chemical_name=Alcohol; preferred_name=Ethanol; percent_active_ingredient=7.5; dtxsid=DTXSID9020584; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9020584; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =6200 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_8815; row=15307; data_type=In Vivo; mixture=Chemical; chemical_name=Ethanol; preferred_name=Ethanol; dtxsid=DTXSID9020584; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9020584; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 >7692 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_8818; row=15308; data_type=In Vivo; mixture=Chemical; chemical_name=Ethanol; preferred_name=Ethanol; dtxsid=DTXSID9020584; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9020584; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =12400 mg/kg bw Rat oral acute Rat Acute Oral Toxicity OECD eChemPortal (undated); record_id=acute_oral_8825; row=15309; data_type=In Vivo; mixture=Chemical; chemical_name=Ethanol; preferred_name=Ethanol; dtxsid=DTXSID9020584; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9020584; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =17800 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_8830; row=15310; data_type=In Vivo; mixture=Chemical; chemical_name=Ethanol; preferred_name=Ethanol; dtxsid=DTXSID9020584; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9020584; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =11500 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_8824; row=15311; data_type=In Vivo; mixture=Chemical; chemical_name=Ethanol; preferred_name=Ethanol; dtxsid=DTXSID9020584; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9020584; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =11204 mg/kg bw Rat oral acute Rat Acute Oral Toxicity JRC AcutoxBase (undated); record_id=acute_oral_8823; row=15312; data_type=In Vivo; mixture=Chemical; chemical_name=Ethanol; preferred_name=Ethanol; dtxsid=DTXSID9020584; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9020584; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =17753 mg/kg bw Rat (Male) oral acute Rat Acute Oral Toxicity JRC AcutoxBase (undated); record_id=acute_oral_8829; row=15313; data_type=In Vivo; mixture=Chemical; chemical_name=Ethanol; preferred_name=Ethanol; dtxsid=DTXSID9020584; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9020584; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =10600 mg/kg bw Rat (Male) oral acute Rat Acute Oral Toxicity JRC AcutoxBase (undated); record_id=acute_oral_8822; row=15314; data_type=In Vivo; mixture=Chemical; chemical_name=Ethanol; preferred_name=Ethanol; dtxsid=DTXSID9020584; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9020584; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =10470 mg/kg bw Rat oral acute Rat Acute Oral Toxicity OECD eChemPortal (undated); record_id=acute_oral_8821; row=15315; data_type=In Vivo; mixture=Chemical; chemical_name=Ethanol; preferred_name=Ethanol; dtxsid=DTXSID9020584; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9020584; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =10335 mg/kg bw Rat oral acute Rat Acute Oral Toxicity JRC AcutoxBase (undated); record_id=acute_oral_8820; row=15316; data_type=In Vivo; mixture=Chemical; chemical_name=Ethanol; preferred_name=Ethanol; dtxsid=DTXSID9020584; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9020584; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =9900 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_8819; row=15317; data_type=In Vivo; mixture=Chemical; chemical_name=Ethanol; preferred_name=Ethanol; dtxsid=DTXSID9020584; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9020584; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =7400 mg/kg bw Rat (Male) oral acute Rat Acute Oral Toxicity JRC AcutoxBase (undated); record_id=acute_oral_8817; row=15318; data_type=In Vivo; mixture=Chemical; chemical_name=Ethanol; preferred_name=Ethanol; dtxsid=DTXSID9020584; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9020584; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =15543 mg/kg bw Rat (Male) oral acute Rat Acute Oral Toxicity JRC AcutoxBase (undated); record_id=acute_oral_8828; row=15319; data_type=In Vivo; mixture=Chemical; chemical_name=Ethanol; preferred_name=Ethanol; dtxsid=DTXSID9020584; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9020584; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =7060 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_8816; row=15320; data_type=In Vivo; mixture=Chemical; chemical_name=Ethanol; preferred_name=Ethanol; dtxsid=DTXSID9020584; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9020584; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =15010 mg/kg bw Rat oral acute Rat Acute Oral Toxicity ECHA ChemProp (undated); record_id=acute_oral_8827; row=15321; data_type=In Vivo; mixture=Chemical; chemical_name=Ethanol; preferred_name=Ethanol; dtxsid=DTXSID9020584; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9020584; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =13660 mg/kg bw Rat (Male) oral acute Rat Acute Oral Toxicity JRC AcutoxBase (undated); record_id=acute_oral_8826; row=15322; data_type=In Vivo; mixture=Chemical; chemical_name=Ethanol; preferred_name=Ethanol; dtxsid=DTXSID9020584; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9020584; source_file=acute_oral.xlsx
NTP_ICE_adme_parameters 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_adme_parameters Clint 19.98 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=3515; Record_ID=adme_parameters_1183; Data_Type=Measured; DTXSID=DTXSID9020584; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=19.98; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_adme_parameters Clint 31.1 uL/min/10^6 cells Rat - - Measured; httk, Rat Hepatic Intrinsic Clearance sheet=Data; excel_row=3517; Record_ID=adme_parameters_1183; Data_Type=Measured; DTXSID=DTXSID9020584; Assay=httk, Rat Hepatic Intrinsic Clearance; Endpoint=Clint; Response=31.1; Response_Unit=ul/min/10^6 cells; Species=Rat; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_adme_parameters Fu 0.9338 fraction Human - - Measured; httk, Human Plasma Fraction Unbound sheet=Data; excel_row=3514; Record_ID=adme_parameters_1183; Data_Type=Measured; DTXSID=DTXSID9020584; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.9338; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_adme_parameters Fu 0.842 fraction Rat - - Measured; httk, Rat Plasma Fraction Unbound sheet=Data; excel_row=3516; Record_ID=adme_parameters_1183; Data_Type=Measured; DTXSID=DTXSID9020584; Assay=httk, Rat Plasma Fraction Unbound; Endpoint=Fu; Response=0.842; Response_Unit=Unitless Fraction; Species=Rat; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_cancer 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_cancer IARC group 1 unitless - - - WOE; IARC Carcinogenicity sheet=Data; excel_row=9719; Record_ID=cancer_3024; Data_Type=WOE; Formulation_Name=Ethanol; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=1; Response_Unit=Unitless; URL=http://publications.iarc.fr/114; http://publications.iarc.fr/122; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_cancer Top dose 5 % Mouse Dosed drinking water - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=9716; Record_ID=cancer_3021; Data_Type=In Vivo; Formulation_Name=Ethanol; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=5; Response_Unit=%; Species=Mouse; Strain=B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-); Sex=Male; Route=Dosed drinking water; Reference=TR-510; URL=https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr510/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_eye_irritation 24 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_eye_irritation Draize rabbit irritation score 24 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=2729; Record_ID=eye_irritation_205; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=24; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_eye_irritation Draize rabbit irritation score 24 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=2729; Record_ID=eye_irritation_205; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=24; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_eye_irritation Draize rabbit irritation score 24 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=2729; Record_ID=eye_irritation_205; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=24; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_eye_irritation Draize rabbit irritation score 24 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=2729; Record_ID=eye_irritation_205; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=24; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_eye_irritation EPA Classification 1 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=2727; Record_ID=eye_irritation_205; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=1; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_eye_irritation EPA Classification 1 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=2727; Record_ID=eye_irritation_205; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=1; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_eye_irritation EPA Classification 1 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=2727; Record_ID=eye_irritation_205; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=1; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_eye_irritation EPA Classification 1 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=2727; Record_ID=eye_irritation_205; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=1; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_eye_irritation GHS Classification 2 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=2728; Record_ID=eye_irritation_205; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=2A; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_eye_irritation GHS Classification 2 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=2728; Record_ID=eye_irritation_205; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=2A; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_eye_irritation GHS Classification 2 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=2728; Record_ID=eye_irritation_205; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=2A; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_eye_irritation GHS Classification 2 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=2728; Record_ID=eye_irritation_205; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=2A; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_eye_irritation Intensity 0.12 %/sec - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2733; Record_ID=eye_irritation_1275; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=Vitrigel; Endpoint=Intensity; Response=0.12; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_eye_irritation Intensity 0.12 %/sec - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2733; Record_ID=eye_irritation_1275; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=Vitrigel; Endpoint=Intensity; Response=0.12; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_eye_irritation Intensity 0.12 %/sec - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2733; Record_ID=eye_irritation_1275; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=Vitrigel; Endpoint=Intensity; Response=0.12; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_eye_irritation Intensity 0.12 %/sec - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2733; Record_ID=eye_irritation_1275; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=Vitrigel; Endpoint=Intensity; Response=0.12; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_eye_irritation Lag time 10 s - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2732; Record_ID=eye_irritation_1275; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=Vitrigel; Endpoint=Lag time; Response=10; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_eye_irritation Lag time 10 s - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2732; Record_ID=eye_irritation_1275; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=Vitrigel; Endpoint=Lag time; Response=10; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_eye_irritation Lag time 10 s - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2732; Record_ID=eye_irritation_1275; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=Vitrigel; Endpoint=Lag time; Response=10; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_eye_irritation Lag time 10 s - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2732; Record_ID=eye_irritation_1275; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=Vitrigel; Endpoint=Lag time; Response=10; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_eye_irritation Plateau level 23 % - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2734; Record_ID=eye_irritation_1275; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=Vitrigel; Endpoint=Plateau level; Response=23; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_eye_irritation Plateau level 23 % - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2734; Record_ID=eye_irritation_1275; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=Vitrigel; Endpoint=Plateau level; Response=23; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_eye_irritation Plateau level 23 % - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2734; Record_ID=eye_irritation_1275; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=Vitrigel; Endpoint=Plateau level; Response=23; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_eye_irritation Plateau level 23 % - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2734; Record_ID=eye_irritation_1275; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=Vitrigel; Endpoint=Plateau level; Response=23; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_skin_irritation 23 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_irritation EPA classification 4 unitless Rabbit Dermal - In Vivo; Draize Skin Irritation/Corrosion Test sheet=Data_invivo; excel_row=1841; Record_ID=skin_irritation_invivo_423; Data_Type=In Vivo; Formulation_ID=MIX90; Formulation_Name=Cavicide 1; Percent_Active_Ingredient=7.5; Mixture=Mixture; DTXSID=DTXSID9020584; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=EPA classification; Response=4; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_skin_irritation EPA classification 4 unitless Rabbit Dermal - In Vivo; Draize Skin Irritation/Corrosion Test sheet=Data_invivo; excel_row=1842; Record_ID=skin_irritation_invivo_713; Data_Type=In Vivo; Formulation_ID=MIX90; Formulation_Name=Cavicide 1; Percent_Active_Ingredient=7.5; Mixture=Mixture; DTXSID=DTXSID9020584; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=EPA classification; Response=4; Response_Unit=Unitless; Species=Rabbit; Reported_Strain=New Zealand White; Strain=New Zealand White; Sex=Male/Female; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_skin_irritation Positive reaction 3.2 % Human Dermal - In Vivo; Four-hour Human Patch Test sheet=Data_invivo; excel_row=1840; Record_ID=skin_irritation_invivo_9; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=Four-hour Human Patch Test; Endpoint=Positive reaction; Response=3.2; Response_Unit=%; Species=Human; Reference=Basketter et al. 2004; 15291823; 10.1111/j.0105-1873.2004.00385.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_skin_irritation Viability 67.31 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=5663; Record_ID=skin_irritation_invitro_1121; Data_Type=In Vitro; Formulation_Name=Ethanol; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=67.31; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_skin_irritation Viability 4.68 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=5664; Record_ID=skin_irritation_invitro_1108; Data_Type=In Vitro; Formulation_Name=Ethanol; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=4.68; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_skin_irritation Viability 5.23 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=5665; Record_ID=skin_irritation_invitro_1109; Data_Type=In Vitro; Formulation_Name=Ethanol; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=5.23; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_skin_irritation Viability 6.67 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=5666; Record_ID=skin_irritation_invitro_1110; Data_Type=In Vitro; Formulation_Name=Ethanol; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=6.67; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_skin_irritation Viability 33.03 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=5667; Record_ID=skin_irritation_invitro_1111; Data_Type=In Vitro; Formulation_Name=Ethanol; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=33.03; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_skin_irritation Viability 40.52 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=5674; Record_ID=skin_irritation_invitro_1112; Data_Type=In Vitro; Formulation_Name=Ethanol; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=40.52; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_skin_irritation Viability 68.57 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=5675; Record_ID=skin_irritation_invitro_1113; Data_Type=In Vitro; Formulation_Name=Ethanol; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=68.57; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_skin_irritation Viability 39.12 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=5676; Record_ID=skin_irritation_invitro_1114; Data_Type=In Vitro; Formulation_Name=Ethanol; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=39.12; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_skin_irritation Viability 46.61 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=5677; Record_ID=skin_irritation_invitro_1115; Data_Type=In Vitro; Formulation_Name=Ethanol; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=46.61; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_skin_irritation Viability 62.67 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=5678; Record_ID=skin_irritation_invitro_1116; Data_Type=In Vitro; Formulation_Name=Ethanol; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=62.67; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_skin_irritation Viability 47.98 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=5679; Record_ID=skin_irritation_invitro_1117; Data_Type=In Vitro; Formulation_Name=Ethanol; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=47.98; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_skin_irritation Viability 64.16 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=5680; Record_ID=skin_irritation_invitro_1118; Data_Type=In Vitro; Formulation_Name=Ethanol; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=64.16; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_skin_irritation Viability 34.13 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=5682; Record_ID=skin_irritation_invitro_1120; Data_Type=In Vitro; Formulation_Name=Ethanol; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=34.13; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_skin_irritation Viability 68.13 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=5683; Record_ID=skin_irritation_invitro_1122; Data_Type=In Vitro; Formulation_Name=Ethanol; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=68.13; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_skin_irritation Viability 41.08 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=5684; Record_ID=skin_irritation_invitro_1123; Data_Type=In Vitro; Formulation_Name=Ethanol; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=41.08; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_skin_irritation Viability 50.86 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=5685; Record_ID=skin_irritation_invitro_1124; Data_Type=In Vitro; Formulation_Name=Ethanol; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=50.86; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_skin_irritation Viability 86.58 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=5686; Record_ID=skin_irritation_invitro_1125; Data_Type=In Vitro; Formulation_Name=Ethanol; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=86.58; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_skin_irritation Viability 54.19 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=5687; Record_ID=skin_irritation_invitro_1126; Data_Type=In Vitro; Formulation_Name=Ethanol; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=54.19; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_skin_irritation Viability 60.55 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=5688; Record_ID=skin_irritation_invitro_1127; Data_Type=In Vitro; Formulation_Name=Ethanol; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=60.55; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_skin_irritation Viability 72.08 % - Dermal - In Vitro; LabCyte EPI-MODEL24 Irritation sheet=Data_invitro; excel_row=5689; Record_ID=skin_irritation_invitro_1128; Data_Type=In Vitro; Formulation_Name=Ethanol; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=LabCyte EPI-MODEL24 Irritation; Endpoint=Viability; Response=72.08; Response_Unit=%; Reference=Kojima et al. 2012; 22558976; 10.1177/026119291204000108; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9020584
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=9243; Record_ID=skin_sensitization_invivo_2045; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=100.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maguire 1983; 7200057; 10.1016/s0278-6915(82)80011-2|Gad et al. (1986; 3715870; 10.1016/0041-008X(86)90419-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584
NTP_ICE_skin_sensitization Induction dose per skin area 62990 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=9242; Record_ID=skin_sensitization_invivo_2045; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=100.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=62990; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maguire 1983; 7200057; 10.1016/s0278-6915(82)80011-2|Gad et al. (1986; 3715870; 10.1016/0041-008X(86)90419-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584
NTP_ICE_skin_sensitization Relative reliability score 2 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=9246; Record_ID=skin_sensitization_invivo_2045; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=100.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9020584; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=2; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Marzulli and Maguire 1983; 7200057; 10.1016/s0278-6915(82)80011-2|Gad et al. (1986; 3715870; 10.1016/0041-008X(86)90419-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9020584
ToxValDB_DOE_Protective_Action_Criteria 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_DOE_Protective_Action_Criteria LEL =62179.3 mg/m3 Human inhalation - acute LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=DOE Protective Action Criteria:15515232:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ee283ea86c6955faa47eea6019f9ccd7
ToxValDB_DOE_Wildlife_Benchmarks 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_DOE_Wildlife_Benchmarks LOAEL =319 mg/kg bw/day Rat oral - repeat dose other STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65bd1d53e4b063812d68c240; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://rais.ornl.gov/documents/tm86r3.pdf; STUDY_GROUP=DOE Wildlife Benchmarks_dup_-_15511626_15511627:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e2b6742875e6f8cb0d80d3681554ad1b
ToxValDB_DOE_Wildlife_Benchmarks NOAEL =31.9 mg/kg bw/day Rat oral - repeat dose other STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65bd1d53e4b063812d68c240; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://rais.ornl.gov/documents/tm86r3.pdf; STUDY_GROUP=DOE Wildlife Benchmarks_dup_-_15511626_15511627:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_579477db77e2d7af99fb0cd9a4f41a9a
ToxValDB_ECHA_IUCLID 15 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LEL =93400.9 mg/m3 Mouse inhalation - acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/30185/7/3/3?documentUUID=2a07db0f-f7ad-4656-bd9d-925cff8df415; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Inhalation_15797161_15797162_15797163_15797486_15797487_15797488_15797489:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7f12f018691c06a25592bca9f8bafbec
ToxValDB_ECHA_IUCLID LEL =61237.2 mg/m3 Mouse inhalation - acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/30185/7/3/3?documentUUID=2a07db0f-f7ad-4656-bd9d-925cff8df415; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Inhalation_15797161_15797162_15797163_15797486_15797487_15797488_15797489:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_699da5097787ed024bf627bea4352083
ToxValDB_ECHA_IUCLID LEL =57091.9 mg/m3 Mouse inhalation - acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6310/7/3/3?documentUUID=7f79c569-21a0-4ccb-9930-dc3cd9ad0ae5; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Inhalation_15797161_15797162_15797163_15797486_15797487_15797488_15797489:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_891341b04247f44a5b2b645b81d7b5eb
ToxValDB_ECHA_IUCLID NOAEC >=11550.3 mg/m3 Rat inhalation short-term; 20 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6310/7/6/3?documentUUID=7f79c569-21a0-4ccb-9930-dc3cd9ad0ae5; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID:15827377:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_11face94f558f3a2aa5f834f3fc2a99f
ToxValDB_ECHA_IUCLID NOAEL >=37684.4 mg/m3 Rat inhalation - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1ece4b0a7c65d230d47; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6310/7/9/3?documentUUID=7f79c569-21a0-4ccb-9930-dc3cd9ad0ae5; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID:15821883:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e3981e8cf625684c402a3fa4e93ad82a
ToxValDB_ECHA_IUCLID NOAEL >20000 mg/m3 Rat inhalation short-term; 3 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6310/7/6/3?documentUUID=7f79c569-21a0-4ccb-9930-dc3cd9ad0ae5; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID:15828027:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_daa9aa2ac64e6e1fee5f1b0a4ce8b2f0
ToxValDB_ECHA_IUCLID NOAEL =1730 mg/kg bw/day Rat oral chronic; 14 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eada2e4b0a7c65d1c537a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/30185/7/6/2?documentUUID=2a07db0f-f7ad-4656-bd9d-925cff8df415; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID:15848368:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_31d3ab0b52640b8b1d498f97e30d9664
ToxValDB_ECHA_IUCLID NOAEL ~3250 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cac8e4b0a7c65d2238c4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/27557/7/6/2?documentUUID=0c70bbca-ec5f-47b6-ac6f-ed5d9523ca97; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID:15849256:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4e5c839e507b5cbe792e9dc76d918b70
ToxValDB_ECHA_IUCLID NOAEL <4400 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cac8e4b0a7c65d2238c4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/27557/7/6/2?documentUUID=0c70bbca-ec5f-47b6-ac6f-ed5d9523ca97; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID:15849257:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8f68b826ba230b9825b3ffdfa71badc8
ToxValDB_ECHA_IUCLID NOAEL >9400 mg/kg bw/day Mouse oral subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae97e4b0a7c65d1c9f59; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6310/7/6/2?documentUUID=7f79c569-21a0-4ccb-9930-dc3cd9ad0ae5; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15849681_15849682:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c9a8c8e55b3e7e0e5ddc2a4c752c2526
ToxValDB_ECHA_IUCLID NOAEL <9700 mg/kg bw/day Mouse oral subchronic; 90 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca27e4b0a7c65d22092a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/27557/7/6/2?documentUUID=0c70bbca-ec5f-47b6-ac6f-ed5d9523ca97; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15849683_15849684:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_307f9572ddf47d73a0a9c951bf075b46
ToxValDB_ECHA_IUCLID NOAEL >30147.6 mg/m3 Rat inhalation - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c89fe4b0a7c65d2196e4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/27557/7/9/2?documentUUID=0c70bbca-ec5f-47b6-ac6f-ed5d9523ca97; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID:15856950:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_983f9c1fb939b5dad55ce9ccfbaa7344
ToxValDB_ECHA_IUCLID NOAEL =2500 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaab5e4b0a7c65d1b716b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/30185/7/9/2?documentUUID=2a07db0f-f7ad-4656-bd9d-925cff8df415; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15860547_15861136:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8de782de57b623a406340cc20e704bb4
ToxValDB_ECHA_IUCLID NOAEL >5000 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaab5e4b0a7c65d1b716b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/30185/7/9/2?documentUUID=2a07db0f-f7ad-4656-bd9d-925cff8df415; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15862151_15862351:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0201921cee27d9781f605170131353a1
ToxValDB_ECHA_IUCLID NOEL <6200 mg/kg bw/day Monkey oral chronic; 48 months chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7caf2e4b0a7c65d2241a1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5837/7/6/2?documentUUID=a573366d-c344-49dd-bac0-2e83d9a6b056; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15830022_15830023_15844276_15844277_15846262_15846263:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5a117d3a044a0a3fb744306ec3cd09ee
ToxValDB_ECOTOX 138 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECOTOX LOEL =5000 mg/kg bw/day Mouse oral acute; 0.1667 days acute LONG_REF=Toxicol. Appl. Pharmacol.74(2): 230-236 Waalkes,M.P., J.J. Hjelle, and C.D. Klaassen Transient Induction of Hepatic Metallothionein Following Oral Ethanol Administration 1984; TITLE=Transient Induction of Hepatic Metallothionein Following Oral Ethanol Administration; AUTHOR=Waalkes,M.P., J.J. Hjelle, and C.D. Klaassen; DOI=10.1016/0041-008x(84)90147-9; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=87717; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Biochemistry: Metallothionein; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15594096:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f1922bf8eb4325252dc8b2c5696b8598
ToxValDB_ECOTOX LOEL =5 % Rat oral short-term; 11 days short-term LONG_REF=Exp. Pathol. (Jena)25(4): 205-213 Jones,W.L., and D.B. Stewart Effects of Orally-Administered Ethanol on Mammary Gland Morphology and Functional Efficiency in Lactating Rats 1984; TITLE=Effects of Orally-Administered Ethanol on Mammary Gland Morphology and Functional Efficiency in Lactating Rats; AUTHOR=Jones,W.L., and D.B. Stewart; DOI=10.1016/s0232-1513(84)80022-5; QUALITY=Control type: Baseline control; EXTERNAL_SOURCE_ID=113117; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Morphology: Length|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15594613:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c9d31d2815ef397601a1faae98348529
ToxValDB_ECOTOX LOEL =9 % w/v Dog oral acute; 0.0208 days acute LONG_REF=Am. J. Physiol. Gasterointest. Liver Physiol.269(3, Pt. 1): G363 - G369 Charles,F., and S.F. Phillips Effects of Ethanol, Xylose, and Glucose on Canine Jejunal Motility 1995; TITLE=Effects of Ethanol, Xylose, and Glucose on Canine Jejunal Motility; AUTHOR=Charles,F., and S.F. Phillips; DOI=10.1152/ajpgi.1995.269.3.G363; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=113204; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Physiology: Contraction rate; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594709_15594710:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=ae2bd5d82deade9a3fcbe5c93cff685a
ToxValDB_ECOTOX LOEL =6 % vol Rat oral acute (developmental); 1 days developmental LONG_REF=Alcohol Alcohol.28(6): 657-666 Fuseler,J.W. Maternal Ethanol Consumption Induces Transient Compensatory Hyperplasia of Developing Cardiac Tissue in the Neonatal Rat 1993; TITLE=Maternal Ethanol Consumption Induces Transient Compensatory Hyperplasia of Developing Cardiac Tissue in the Neonatal Rat; AUTHOR=Fuseler,J.W.; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=115289; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Genetics: Mitotic index (# mitoses/total cells)|Growth: Weight|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|organ weight; STUDY_GROUP=ECOTOX:15594796:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=a97616008b6011b4948acff4fc39f5cd
ToxValDB_ECOTOX LOEL =15 % v/v Mouse oral short-term; 8 days short-term LONG_REF=Can. J. Physiol. Pharmacol.64(7): 1032-1037 Kennedy,L.A., S. Mukerji, and M.J. Elliott The Ontogeny of Placental Na+-K+ Atpase in the Mouse and Its Impairment by Ethanol 1986; TITLE=The Ontogeny of Placental Na+-K+ Atpase in the Mouse and Its Impairment by Ethanol; AUTHOR=Kennedy,L.A., S. Mukerji, and M.J. Elliott; DOI=10.1139/y86-176; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112961; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=Enzyme(s): Sodium potassium ATPase; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595148_15595149_15604255:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c5db1fc821d4a22a8534080ad6ad9953
ToxValDB_ECOTOX LOEL =5.202 g/org-day Rat oral short-term; 28 days short-term LONG_REF=Alcohol Alcohol.37(3): 213-221 Brzoska,M.M., J. Moniuszko-Jakoniuk, M. Jurczuk, and M. Galazyn-Sidorczuk Cadmium Turnover and Changes of Zinc and Copper Body Status of Rats Continuously Exposed to Cadmium and Ethanol 2002; TITLE=Cadmium Turnover and Changes of Zinc and Copper Body Status of Rats Continuously Exposed to Cadmium and Ethanol; AUTHOR=Brzoska,M.M., J. Moniuszko-Jakoniuk, M. Jurczuk, and M. Galazyn-Sidorczuk; DOI=10.1093/alcalc/37.3.213; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=82501; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Feeding behavior: Water consumption|Physiology: Zinc excretion; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595265_15602781:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b0442229408ff68b4a8bfd555d4b1356
ToxValDB_ECOTOX LOEL =20 % Rat oral short-term; 30 days reproduction developmental LONG_REF=www.unisa.it/Centri_e_Vari/pharmacologyonline3:862-876 Muche,A., E. Makonnen, Y. Kinfu, and M. Afework The Effect of Ethanol and Khat (Catha edulis Forsk) on the Cerebellar Cortex of Early Postnatal Rats 2006; TITLE=The Effect of Ethanol and Khat (Catha edulis Forsk) on the Cerebellar Cortex of Early Postnatal Rats; AUTHOR=Muche,A., E. Makonnen, Y. Kinfu, and M. Afework; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112936; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=Cell(s): Diameter|Growth: Weight|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|other; STUDY_GROUP=ECOTOX:15595347:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=3cb37372218a10fb573f897e82abb11a
ToxValDB_ECOTOX LOEL =6000 mg/kg bw/day Mouse oral acute; 0.0625 days acute LONG_REF=Am. J. Pathol.164(6): 1959-1966 Lambert,J.C., Z. Zhou, L. Wang, Z. Song, C.J. McClain, and Y.J. Kang Preservation of Intestinal Structural Integrity by Zinc is Independent of Metallothionein in Alcohol-Intoxicated Mice 2004; TITLE=Preservation of Intestinal Structural Integrity by Zinc is Independent of Metallothionein in Alcohol-Intoxicated Mice; AUTHOR=Lambert,J.C., Z. Zhou, L. Wang, Z. Song, C.J. McClain, and Y.J. Kang; DOI=10.1016/S0002-9440(10)63756-X; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=100802; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Biochemistry: Endotoxin|Biochemistry: Metallothionein|Biochemistry: Tumor necrosis factor-alpha|Enzyme(s): Alanine transaminase (ALT); TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595417_15597718:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=fad87e109d5f459e5d79b73c15713922
ToxValDB_ECOTOX LOEL =10 % v/v Mouse oral short-term; 21 days reproduction developmental LONG_REF=Physiol. Behav.30(3): 485-488 Perez,V.J., G.E.,Jr. Gonzalez, and C.J. Smith Exposure to Ethanol During Pregnancy in Mice: Potential Importance of Dose for the Development of Tolerance in Offspring 1983; TITLE=Exposure to Ethanol During Pregnancy in Mice: Potential Importance of Dose for the Development of Tolerance in Offspring; AUTHOR=Perez,V.J., G.E.,Jr. Gonzalez, and C.J. Smith; DOI=10.1016/0031-9384(83)90156-7; QUALITY=Control type: Control outside of primary exposure system; EXTERNAL_SOURCE_ID=112740; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=Growth: Weight|Reproduction: Progeny counts/numbers; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|reproduction; STUDY_GROUP=ECOTOX:15595516:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5b444366bdfabf31f9e3199270943526
ToxValDB_ECOTOX LOEL =3000 ppm Rat oral short-term; 6 days developmental LONG_REF=Alcohol41(4): 253-261 Oladehin,A., C.P. Margret, S.E. Maier, C.X. Li, T.A. Jan, T.D. Chappell, and R.S. Waters Early Postnatal Alcohol Exposure Reduced the Size of Vibrissal Barrel Field in Rat Somatosensory Cortex (SI) but did not Disrupt Barrel Field Organization 2007; TITLE=Early Postnatal Alcohol Exposure Reduced the Size of Vibrissal Barrel Field in Rat Somatosensory Cortex (SI) but did not Disrupt Barrel Field Organization; AUTHOR=Oladehin,A., C.P. Margret, S.E. Maier, C.X. Li, T.A. Jan, T.D. Chappell, and R.S. Waters; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=113182; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=Development: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX:15595691:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=252e9a4d72d57f50af9c9a8c18f694a6
ToxValDB_ECOTOX LOEL =25 % v/v Mouse oral short-term; 4 days short-term LONG_REF=J. Reprod. Fertil.80(1): 49-57 Wiebold,J.L., and W.C. Becker In-Vivo and In-Vitro Effects of Ethanol on Mouse Preimplantation Embryos 1987; TITLE=In-Vivo and In-Vitro Effects of Ethanol on Mouse Preimplantation Embryos; AUTHOR=Wiebold,J.L., and W.C. Becker; DOI=10.1530/jrf.0.0800049; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113118; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Feeding behavior: Food consumption|Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595716_15601220:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=40df39ed6c45069667ee26747b27efec
ToxValDB_ECOTOX LOEL =130 mg/kg bw/day Dog oral acute; 0.0833 days acute LONG_REF=Dig. Dis. Sci.29(1): 12-18 Eysselein,V.E., M.V. Singer, H. Wentz, and H. Goebell Action of Ethanol on Gastrin Release in the Dog 1984; TITLE=Action of Ethanol on Gastrin Release in the Dog; AUTHOR=Eysselein,V.E., M.V. Singer, H. Wentz, and H. Goebell; DOI=10.1007/BF01296856; QUALITY=Control type: Baseline control; EXTERNAL_SOURCE_ID=113119; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Hormone(s): Gastrin; STUDY_GROUP=ECOTOX:15595717:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=80540d4c8435db175fced66dcbe93062
ToxValDB_ECOTOX LOEL =10 % w/v Mouse oral short-term; 27 days developmental LONG_REF=Prostaglandins Leukot. Essent. Fatty Acids76(3): 141-151 Cebral,E., A. Faletti, A. Jawerbaum, and D. Paz Periconceptional Alcohol Consumption-Induced Changes in Embryonic Prostaglandin E Levels in Mouse Organogenesis: Modulation by Nitric Oxide 2007; TITLE=Periconceptional Alcohol Consumption-Induced Changes in Embryonic Prostaglandin E Levels in Mouse Organogenesis: Modulation by Nitric Oxide; AUTHOR=Cebral,E., A. Faletti, A. Jawerbaum, and D. Paz; DOI=10.1016/j.plefa.2006.12.001; QUALITY=Control type: Control outside of primary exposure system; EXTERNAL_SOURCE_ID=113188; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=Biochemistry: Prostaglandin E2|Development: Stage|Reproduction: Resorbed embryos; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|development|reproduction; STUDY_GROUP=ECOTOX:15595979:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f4ef5de0f8ce84c7332b4b6ec4ef3df7
ToxValDB_ECOTOX LOEL =10 % Rat oral chronic; 365.28 days chronic LONG_REF=Jpn. J. Cancer Res.83:1267-1272 Watanabe,H., T. Okamoto, T. Takahashi, P.O. Ogundigie, and A. Ito The Effects of Sodium Chloride, Miso or Ethanol on Development of Intestinal Metaplasia After X-Irradiation of the Rat Glandular Stomach 1992; TITLE=The Effects of Sodium Chloride, Miso or Ethanol on Development of Intestinal Metaplasia After X-Irradiation of the Rat Glandular Stomach; AUTHOR=Watanabe,H., T. Okamoto, T. Takahashi, P.O. Ogundigie, and A. Ito; DOI=10.1111/j.1349-7006.1992.tb02757.x; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=107468; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Growth: Weight|Morphology: Height; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|other; STUDY_GROUP=ECOTOX:15596343:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=a423b36bad0634fc94c9274033eedec8
ToxValDB_ECOTOX LOEL =65.4 mL Rat oral short-term; 19 days developmental LONG_REF=Alcohol33(2): 83-89 Peres,W.A.F., M.G.T. Carmo, S. Zucoloto, A.C. Iglesias, and V.B. Braulio Ethanol Intake Inhibits Growth of the Epithelium in the Intestine of Pregnant Rats 2004; TITLE=Ethanol Intake Inhibits Growth of the Epithelium in the Intestine of Pregnant Rats; AUTHOR=Peres,W.A.F., M.G.T. Carmo, S. Zucoloto, A.C. Iglesias, and V.B. Braulio; DOI=10.1016/j.alcohol.2004.05.001; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113181; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Cell(s): Number of cells|Development: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=development|nonneoplastic histopathology; STUDY_GROUP=ECOTOX:15596543:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=71f9d8d7f5238948679b071e4e80be7f
ToxValDB_ECOTOX LOEL =7100000 ppm European Rabbit environmental short-term; 2 days developmental LONG_REF=Teratology59(2): 102-109 Pitt,J.A., and E.W. Carney Evaluation of Various Toxicants in Rabbit Whole-Embryo Culture Using a New Morphologically-Based Evaluation System 1999; TITLE=Evaluation of Various Toxicants in Rabbit Whole-Embryo Culture Using a New Morphologically-Based Evaluation System; AUTHOR=Pitt,J.A., and E.W. Carney; DOI=10.1002/(SICI)1096-9926(199902)59:2<102::AID-TERA4>3.0.CO;2-6; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=117298; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=Biochemistry: Protein, total|Development: Abnormal|Morphology: Length; TOXICOLOGICAL_EFFECT_CATEGORY=development|other|urinalysis; STUDY_GROUP=ECOTOX:15596563:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c6f3f755e08ea4239b4348fdd626f952
ToxValDB_ECOTOX LOEL =0.57 g/100 g bw/day Rat oral subchronic; 84 days subchronic LONG_REF=Food Cosmet. Toxicol.17(4): 333-338 Antal,M., M. Bedo, G. Constantinovits, K. Nagy, and J. Szepvolgyi Studies on the Interaction of Methomyl and Ethanol in Rats 1979; TITLE=Studies on the Interaction of Methomyl and Ethanol in Rats; AUTHOR=Antal,M., M. Bedo, G. Constantinovits, K. Nagy, and J. Szepvolgyi; DOI=10.1016/0015-6264(79)90325-0; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=74539; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=Biochemistry: Glucose|Enzyme(s): Aniline hydrogenase|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|enzyme activity|organ weight; STUDY_GROUP=ECOTOX:15596633:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=86bff223307a6039014bbcd93ed2b1f2
ToxValDB_ECOTOX LOEL =0.5 % Rat environmental short-term; 2 days developmental LONG_REF=Toxicology30(1): 45-57 Kitchin,K.T., and M.T. Ebron Further Development of Rodent Whole Embryo Culture: Solvent Toxicity and Water Insoluble Compound Delivery System 1984; TITLE=Further Development of Rodent Whole Embryo Culture: Solvent Toxicity and Water Insoluble Compound Delivery System; AUTHOR=Kitchin,K.T., and M.T. Ebron; DOI=10.1016/0300-483x(84)90061-1; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=115431; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Development: Abnormal|Genetics: DNA concentration; TOXICOLOGICAL_EFFECT_CATEGORY=development|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596656_15596657:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=9637264c7bdb54aba883c47944f00bfe
ToxValDB_ECOTOX LOEL =21350 ppm Mouse oral short-term; 13 days reproduction developmental LONG_REF=Alcohol11(6): 517-522 Weathersby,R.T., H.C. Becker, and R.L. Hale Reduced Sensitivity to the Effects of Clonidine on Ethanol-Stimulated Locomotor Activity in Adult Mouse Offspring Prenatally Exposed to Ethanol 1994; TITLE=Reduced Sensitivity to the Effects of Clonidine on Ethanol-Stimulated Locomotor Activity in Adult Mouse Offspring Prenatally Exposed to Ethanol; AUTHOR=Weathersby,R.T., H.C. Becker, and R.L. Hale; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=116714; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Growth: Weight|Growth: Weight gain|Reproduction: Progeny counts/numbers; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596717_15604220_15609677:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=3c53bf03f0e09ce21dbc9bcd1af46ef2
ToxValDB_ECOTOX LOEL =4000 mg/kg bw/day Rat oral short-term; 11 days short-term LONG_REF=Teratology29(2): 251-258 Burns,E.M., T.W. Kruckeberg, H. Stibler, E. Cerven, and S. Borg The Effects of Ethanol Exposure During the Brain Growth Spurt in Rats 1984; TITLE=The Effects of Ethanol Exposure During the Brain Growth Spurt in Rats; AUTHOR=Burns,E.M., T.W. Kruckeberg, H. Stibler, E. Cerven, and S. Borg; DOI=10.1002/tera.1420290211; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=116923; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Biochemistry: Protein content|Cell(s): Structural changes|Growth: Weight gain|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|other|urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596897_15608154:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7bf4a5bdcacbf612d7c6f629f7086830
ToxValDB_ECOTOX LOEL =4.49 % v/v Mouse oral short-term; 8 days developmental LONG_REF=J. Mol. Neurosci.24(2): 189-199 Zhou,F.C., Y. Sari, T.A. Powrozek, and C.Y. Spong A Neuroprotective Peptide Antagonizes Fetal Alcohol Exposure-Compromised Brain Growth 2004; TITLE=A Neuroprotective Peptide Antagonizes Fetal Alcohol Exposure-Compromised Brain Growth; AUTHOR=Zhou,F.C., Y. Sari, T.A. Powrozek, and C.Y. Spong; DOI=10.1385/JMN:24:2:189; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=116870; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Development: Abnormal|Growth: Weight|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|development|other; STUDY_GROUP=ECOTOX:15597123:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1804b9c289a01b8b673748c3ba799b01
ToxValDB_ECOTOX LOEL =13000 ppm Rat oral short-term; 30.44 days short-term LONG_REF=Exp. Mol. Pathol.77(3): 210-213 Li,J., P. Fu, B.A. French, and S.W. French The Effect of Rotenone on the Urinary Ethanol Cycle in Rats Fed Ethanol Intragastrically 2004; TITLE=The Effect of Rotenone on the Urinary Ethanol Cycle in Rats Fed Ethanol Intragastrically; AUTHOR=Li,J., P. Fu, B.A. French, and S.W. French; QUALITY=Control type: Control outside of primary exposure system; EXTERNAL_SOURCE_ID=76246; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Injury: Injury, general|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight|other; STUDY_GROUP=ECOTOX:15597467:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e82a422f42dab49c22fd4b066660cb7d
ToxValDB_ECOTOX LOEL =6.36 % v/v Rat oral short-term; 21 days developmental LONG_REF=Pharmacol. Res.47(4): 341-347 Ren,J., Z.K. Roughead, L.E. Wold, F.L. Norby, S. Rakoczy, R.L. Mabey, and H.M. Brown-Borg Increases in Insulin-Like Growth Factor-1 Level and Peroxidative Damage After Gestational Ethanol Exposure in Rats 2003; TITLE=Increases in Insulin-Like Growth Factor-1 Level and Peroxidative Damage After Gestational Ethanol Exposure in Rats; AUTHOR=Ren,J., Z.K. Roughead, L.E. Wold, F.L. Norby, S. Rakoczy, R.L. Mabey, and H.M. Brown-Borg; DOI=10.1016/s1043-6618(03)00005-7; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112360; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=Development: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX:15598160:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=ab58e1f3d1aededaa67a6d9669eafba3
ToxValDB_ECOTOX LOEL =9 % v/v Rat oral short-term; 18 days reproduction developmental LONG_REF=Nutr. Res.4(3): 469-475 Gordon,E.F., and M.B. Zemel Effects of Prenatal Ethanol Exposure on Iron Utilization in the Rat 1984; TITLE=Effects of Prenatal Ethanol Exposure on Iron Utilization in the Rat; AUTHOR=Gordon,E.F., and M.B. Zemel; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=112737; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Feeding behavior: Food consumption|Feeding behavior: Water consumption|Growth: Weight|Physiology: Iron uptake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598310_15601527:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=881100eb01ff56b0a1c6f19ba0bc5424
ToxValDB_ECOTOX LOEL =1 % v/v Mouse environmental short-term; 3 days developmental LONG_REF=J. Reprod. Fertil.80(1): 49-57 Wiebold,J.L., and W.C. Becker In-Vivo and In-Vitro Effects of Ethanol on Mouse Preimplantation Embryos 1987; TITLE=In-Vivo and In-Vitro Effects of Ethanol on Mouse Preimplantation Embryos; AUTHOR=Wiebold,J.L., and W.C. Becker; DOI=10.1530/jrf.0.0800049; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113118; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Development: Morula stage; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX:15598315:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=456f12e6a35a29ffe28e58f958c0cbdd
ToxValDB_ECOTOX LOEL =0.3 % w/v Mouse environmental acute; 1 days acute LONG_REF=Toxicology242(1-3): 109-122 Huang,L.H., N.H. Shiao, Y.D. Hsuuw, and W.H. Chan Protective Effects of Resveratrol on Ethanol-Induced Apoptosis in Embryonic Stem Cells and Disruption of Embryonic Development in Mouse Blastocysts 2007; TITLE=Protective Effects of Resveratrol on Ethanol-Induced Apoptosis in Embryonic Stem Cells and Disruption of Embryonic Development in Mouse Blastocysts; AUTHOR=Huang,L.H., N.H. Shiao, Y.D. Hsuuw, and W.H. Chan; DOI=10.1016/j.tox.2007.09.015; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=107979; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=Cell(s): Number of cells|Genetics: Apoptosis; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|other; STUDY_GROUP=ECOTOX:15598391:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7e0bbb7461db95e4154f58ad35590d72
ToxValDB_ECOTOX LOEL =1000 mg/kg bw/day Dog oral acute; 0.0625 days acute LONG_REF=Acta Physiol. Scand.118(3): 209-214 Kettunen,R., J. Timisjaervi, P. Saukko, and M. Koskela Influence of Ethanol on Systemic and Pulmonary Hemodynamics in Anesthetized Dogs 1983; TITLE=Influence of Ethanol on Systemic and Pulmonary Hemodynamics in Anesthetized Dogs; AUTHOR=Kettunen,R., J. Timisjaervi, P. Saukko, and M. Koskela; DOI=10.1111/j.1748-1716.1983.tb07264.x; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=112968; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=Biochemistry: pH; TOXICOLOGICAL_EFFECT_CATEGORY=urinalysis; STUDY_GROUP=ECOTOX:15598464:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=39c332e97192ad6abb68a3c8adcb9f98
ToxValDB_ECOTOX LOEL =30 % Rat oral subchronic; 56 days subchronic LONG_REF=Biol. Trace Elem. Res.100(3): 247-257 Pathak,A., A. Mahmood, R. Pathak, and D. Dhawan Role of Zinc on Lipid Peroxidation and Antioxidative Enzymes in Intestines of Ethanol-Fed Rats 2004; TITLE=Role of Zinc on Lipid Peroxidation and Antioxidative Enzymes in Intestines of Ethanol-Fed Rats; AUTHOR=Pathak,A., A. Mahmood, R. Pathak, and D. Dhawan; DOI=10.1385/BTER:100:3:247; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=100367; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Enzyme(s): Catalase|Enzyme(s): Glutathione peroxidase|Enzyme(s): Glutathione reductase|Enzyme(s): Superoxide dismutase (SOD) enzyme activity|Physiology: Lipid peroxidation; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598593_15602311:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=db81ce643c68086b88bce3291a262ef6
ToxValDB_ECOTOX LOEL =0.1 % v/v Mouse environmental short-term; 19.5 days short-term LONG_REF=J. Reprod. Fertil.80(1): 49-57 Wiebold,J.L., and W.C. Becker In-Vivo and In-Vitro Effects of Ethanol on Mouse Preimplantation Embryos 1987; TITLE=In-Vivo and In-Vitro Effects of Ethanol on Mouse Preimplantation Embryos; AUTHOR=Wiebold,J.L., and W.C. Becker; DOI=10.1530/jrf.0.0800049; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113118; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Reproduction: Number of implantations; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15599262_15603809:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=ab4bf5f45fb252f930f75b19b4b28ca9
ToxValDB_ECOTOX LOEL =6.5 % v/v Rat oral short-term; 28 days short-term LONG_REF=Ph.D.Thesis, Vanderbilt Univ., Nashville, TN:174 p. Wu,T. Normal and Abnormal Development of Dendritic Spines in Tissue Culture 1998; TITLE=Normal and Abnormal Development of Dendritic Spines in Tissue Culture; AUTHOR=Wu,T.; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113920; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Morphology: Abnormal|Morphology: Length; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology|other; STUDY_GROUP=ECOTOX:15599497:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2a035a34f99838337e90552f72e9ee79
ToxValDB_ECOTOX LOEL =2 % w/v Mouse oral short-term; 5 days short-term LONG_REF=Toxicology242(1-3): 109-122 Huang,L.H., N.H. Shiao, Y.D. Hsuuw, and W.H. Chan Protective Effects of Resveratrol on Ethanol-Induced Apoptosis in Embryonic Stem Cells and Disruption of Embryonic Development in Mouse Blastocysts 2007; TITLE=Protective Effects of Resveratrol on Ethanol-Induced Apoptosis in Embryonic Stem Cells and Disruption of Embryonic Development in Mouse Blastocysts; AUTHOR=Huang,L.H., N.H. Shiao, Y.D. Hsuuw, and W.H. Chan; DOI=10.1016/j.tox.2007.09.015; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=107979; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=Cell(s): Number of cells|Genetics: Apoptosis; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|other; STUDY_GROUP=ECOTOX:15599907:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=33f6e375266b1007e84674750bd3b4f6
ToxValDB_ECOTOX LOEL =2200 mg/kg bw/day Rat injection short-term; 7 days short-term LONG_REF=Acta Endocrinol.119(1): 99-105 Salonen,I., and I. Huhtaniemi Specific and Weight Loss-Associated Effects of One-Week Exposure to Ethanol on Pituitary-Gonadal Function of Male Rats 1988; TITLE=Specific and Weight Loss-Associated Effects of One-Week Exposure to Ethanol on Pituitary-Gonadal Function of Male Rats; AUTHOR=Salonen,I., and I. Huhtaniemi; DOI=10.1530/acta.0.1190099; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=112953; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=Growth: Weight|Hormone(s): Testosterone|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|other; STUDY_GROUP=ECOTOX:15599976:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=dc71b90344114c852109741e16c7a876
ToxValDB_ECOTOX LOEL =2.7 g/org-day Rat oral short-term; 21 days reproduction developmental LONG_REF=J. Lab. Clin. Med.104(2): 176-184 Singh,S.P., A.K. Snyder, and S.K. Singh Effects of Ethanol Ingestion on Maternal and Fetal Glucose Homeostasis 1984; TITLE=Effects of Ethanol Ingestion on Maternal and Fetal Glucose Homeostasis; AUTHOR=Singh,S.P., A.K. Snyder, and S.K. Singh; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=112958; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Biochemistry: Glucose|Biochemistry: Glycogen|Feeding behavior: Food consumption|Growth: Weight|Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|food and/or water consumption|other; STUDY_GROUP=ECOTOX:15600030:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=21ee1148458f5e3cb021c347ccd8f230
ToxValDB_ECOTOX LOEL =5 % v/v Mouse oral subchronic; 35 days subchronic LONG_REF=J. Pharmacol. Exp. Ther.225(2): 479-484 Anderson,R.A.,Jr., B.R. Willis, C. Oswald, and L.J.D. Zaneveld Ethanol-Induced Male Infertility: Impairment of Spermatozoa 1983; TITLE=Ethanol-Induced Male Infertility: Impairment of Spermatozoa; AUTHOR=Anderson,R.A.,Jr., B.R. Willis, C. Oswald, and L.J.D. Zaneveld; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=117197; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=Morphology: Abnormal|Reproduction: Velocity; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology|reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600583_15608732:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=111d6927c8d93161ebb73e5fd8176e91
ToxValDB_ECOTOX LOEL =4 mg/mL Mouse environmental short-term; 2 days developmental LONG_REF=Toxicol. Lett.167(3): 167-172 Xu,Y., L. Li, Z. Zhang, and Y. Li Effects of Folinic Acid and Vitamin B12 on Ethanol-Induced Developmental Toxicity in Mouse 2006; TITLE=Effects of Folinic Acid and Vitamin B12 on Ethanol-Induced Developmental Toxicity in Mouse; AUTHOR=Xu,Y., L. Li, Z. Zhang, and Y. Li; DOI=10.1016/j.toxlet.2006.07.341; QUALITY=Control type: Baseline control; EXTERNAL_SOURCE_ID=113158; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=Development: Abnormal; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX:15600829:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f9a6920a1d8fe5b1eed900d67ab5b869
ToxValDB_ECOTOX LOEL =0.4 mL/kg Rat oral subchronic; 45 days subchronic LONG_REF=J. Toxicol. Environ. Health10:267-276 Mankes,R.F., I. Rosenblum, K.F. Benitz, R. LeFevre, and R. Abraham Teratogenic and Reproductive Effects of Ethanol in Long-Evans Rats 1982; TITLE=Teratogenic and Reproductive Effects of Ethanol in Long-Evans Rats; AUTHOR=Mankes,R.F., I. Rosenblum, K.F. Benitz, R. LeFevre, and R. Abraham; DOI=10.1080/15287398209530249; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112708; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601198_15604950:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2d4d2cfb8e38ba67a545fbd94b58b1d5
ToxValDB_ECOTOX LOEL =1500 mg/kg bw/day Dog oral acute; 0.0417 days acute LONG_REF=Digestion32(2): 77-85 Diaz,G.R., M.A. Devaux, and H. Sarles Effect of Acute and Chronic Oral Administration of Ethanol on Canine Exocrine Pancreatic Secretion 1985; TITLE=Effect of Acute and Chronic Oral Administration of Ethanol on Canine Exocrine Pancreatic Secretion; AUTHOR=Diaz,G.R., M.A. Devaux, and H. Sarles; DOI=10.1159/000199222; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113103; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=Biochemistry: Bicarbonate (HCO3-) concentration|Physiology: Secretion; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15601279:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=6541cd6c3ae2a0c2ecf80470bcd7cf95
ToxValDB_ECOTOX LOEL =0.5 % w/v Mouse environmental acute; 1 days developmental LONG_REF=Toxicology242(1-3): 109-122 Huang,L.H., N.H. Shiao, Y.D. Hsuuw, and W.H. Chan Protective Effects of Resveratrol on Ethanol-Induced Apoptosis in Embryonic Stem Cells and Disruption of Embryonic Development in Mouse Blastocysts 2007; TITLE=Protective Effects of Resveratrol on Ethanol-Induced Apoptosis in Embryonic Stem Cells and Disruption of Embryonic Development in Mouse Blastocysts; AUTHOR=Huang,L.H., N.H. Shiao, Y.D. Hsuuw, and W.H. Chan; DOI=10.1016/j.tox.2007.09.015; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=107979; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=Development: Normal; STUDY_GROUP=ECOTOX:15601293:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c899a51f224a6ed9ccc45c696295b999
ToxValDB_ECOTOX LOEL =2.15 % w/v Rat oral short-term; 8.4 days reproduction developmental LONG_REF=Neurotoxicol. Teratol.12(1): 15-22 Meyer,L.S., L.E. Kotch, and E.P. Riley Neonatal Ethanol Exposure: Functional Alterations Associated with Cerebellar Growth Retardation 1990; TITLE=Neonatal Ethanol Exposure: Functional Alterations Associated with Cerebellar Growth Retardation; AUTHOR=Meyer,L.S., L.E. Kotch, and E.P. Riley; DOI=10.1016/0892-0362(90)90107-n; QUALITY=Control type: Control outside of primary exposure system; EXTERNAL_SOURCE_ID=116938; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=Behavior: Head lift; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX:15601353:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=90628735945e743f988f356d4bbb5dba
ToxValDB_ECOTOX LOEL =3300 mg/kg bw/day Rat oral short-term; 6 days short-term LONG_REF=Alcohol12(4): 351-355 Chen,W.J.A., R.E.,Jr. McAlhany, and J.R. West 4-Methylpyrazole, an Alcohol Dehydrogenase Inhibitor, Exacerbates Alcohol-Induced Microencephaly During the Brain Growth Spurt 1995; TITLE=4-Methylpyrazole, an Alcohol Dehydrogenase Inhibitor, Exacerbates Alcohol-Induced Microencephaly During the Brain Growth Spurt; AUTHOR=Chen,W.J.A., R.E.,Jr. McAlhany, and J.R. West; DOI=10.1016/0741-8329(95)00017-l; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=116696; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15602323_15609201:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2210ea715b6b15f15c254e43c0b95dc6
ToxValDB_ECOTOX LOEL =2.5 % Rat environmental short-term; 2 days short-term LONG_REF=Toxicology30(1): 45-57 Kitchin,K.T., and M.T. Ebron Further Development of Rodent Whole Embryo Culture: Solvent Toxicity and Water Insoluble Compound Delivery System 1984; TITLE=Further Development of Rodent Whole Embryo Culture: Solvent Toxicity and Water Insoluble Compound Delivery System; AUTHOR=Kitchin,K.T., and M.T. Ebron; DOI=10.1016/0300-483x(84)90061-1; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=115431; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Biochemistry: Protein content; TOXICOLOGICAL_EFFECT_CATEGORY=urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15602437_15602438:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4cb04c2d335c35eb1655e9034bacbb24
ToxValDB_ECOTOX LOEL =310 mg/kg bw/day Mouse oral short-term; 5 days short-term LONG_REF=Steroids23(6): 921-928 Badr,F.M., and A. Bartke Effect of Ethyl Alcohol on Plasma Testosterone Level in Mice 1974; TITLE=Effect of Ethyl Alcohol on Plasma Testosterone Level in Mice; AUTHOR=Badr,F.M., and A. Bartke; DOI=10.1016/0039-128x(74)90064-6; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112967; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1974; ORIGINAL_YEAR=1974; TOXICOLOGICAL_EFFECT=Hormone(s): Testosterone; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601680_15602688_15602689:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=16916000aaa9e518d44fb1432760922b
ToxValDB_ECOTOX LOEL =0.46 g/100 g bw/day Rat oral subchronic; 84 days subchronic LONG_REF=Food Cosmet. Toxicol.17(4): 333-338 Antal,M., M. Bedo, G. Constantinovits, K. Nagy, and J. Szepvolgyi Studies on the Interaction of Methomyl and Ethanol in Rats 1979; TITLE=Studies on the Interaction of Methomyl and Ethanol in Rats; AUTHOR=Antal,M., M. Bedo, G. Constantinovits, K. Nagy, and J. Szepvolgyi; DOI=10.1016/0015-6264(79)90325-0; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=74539; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=Enzyme(s): Aniline hydrogenase|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity|organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15603185_15604830:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=bc19d08b0f5965414d863eb611f63354
ToxValDB_ECOTOX LOEL =174 mmol/kg Rat oral acute; 0.0556 days acute LONG_REF=Arch. Toxicol.61(1): 79-82 Hoffmann,P. Cardiotoxicity Testing of Organic Solvents by Coronary Artery Ligation in Closed-Chest Rats 1987; TITLE=Cardiotoxicity Testing of Organic Solvents by Coronary Artery Ligation in Closed-Chest Rats; AUTHOR=Hoffmann,P.; DOI=10.1007/BF00324553; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=97720; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Mortality: Survival|Physiology: Heart rate; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|mortality/survival; STUDY_GROUP=ECOTOX:15603593:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=6fa2eeb31db394ed4eb2b335d1a2d404
ToxValDB_ECOTOX LOEL =80 mg/kg bw/day Dog injection acute; 0.0042 days acute LONG_REF=Alcohol. Clin. Exp. Res.5(1): 56-63 Stratton,R., K.J. Dormer, and A.R. Zeiner The Cardiovascular Effects of Ethanol and Acetaldehyde in Exercising Dogs 1981; TITLE=The Cardiovascular Effects of Ethanol and Acetaldehyde in Exercising Dogs; AUTHOR=Stratton,R., K.J. Dormer, and A.R. Zeiner; DOI=10.1111/j.1530-0277.1981.tb04865.x; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=112741; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1981; ORIGINAL_YEAR=1981; TOXICOLOGICAL_EFFECT=Physiology: Heart rate; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX_dup_EPA ORD_15604075_15604076:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=72be9fd811977df9df5065a1b5a4029d
ToxValDB_ECOTOX LOEL =2000 mg/kg bw/day Rat injection acute; 0.0174 days acute LONG_REF=Neurotoxicol. Teratol.21(5): 551-557 Virgolini,M.B., L.M. Cancela, and S. Fulginiti Behavioral Responses to Ethanol in Rats Perinatally Exposed to Low Lead Levels 1999; TITLE=Behavioral Responses to Ethanol in Rats Perinatally Exposed to Low Lead Levels; AUTHOR=Virgolini,M.B., L.M. Cancela, and S. Fulginiti; DOI=10.1016/s0892-0362(99)00020-3; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=113348; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=Behavior: Activity, general; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX_dup_EPA ORD_15605082_15605083:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=498a90d1bed4c591a0b6c286dd36f0b8
ToxValDB_ECOTOX LOEL =2900 mg/kg bw/day Dog injection acute; 0.0021 days acute LONG_REF=Cardiovasc. Res.17(10): 604-607 Pescio,S., P. Macho, M. Penna, and R.J. Domenech Changes in Total and Transmural Coronary Blood Flow Induced by Ethanol 1983; TITLE=Changes in Total and Transmural Coronary Blood Flow Induced by Ethanol; AUTHOR=Pescio,S., P. Macho, M. Penna, and R.J. Domenech; DOI=10.1093/cvr/17.10.604; QUALITY=Control type: Baseline control; EXTERNAL_SOURCE_ID=112971; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=Physiology: Oxygen consumption; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX:15606751:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=0ae08827e1b5767e10072d7b7e3e0b81
ToxValDB_ECOTOX LOEL =2.5 mL/kg bw Mouse oral acute; 1 days acute LONG_REF=J. Toxicol. Environ. Health18(4): 575-587 Lin,S.C., H. Saito, T. Yohro, and J. Shiga Acute Hepatotoxicity Induced by Hepatotoxins in Suncus murinus 1986; TITLE=Acute Hepatotoxicity Induced by Hepatotoxins in Suncus murinus; AUTHOR=Lin,S.C., H. Saito, T. Yohro, and J. Shiga; DOI=10.1080/15287398609530895; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=112721; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=Enzyme(s): Glutamic-oxaloacetic transaminase; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX_dup_EPA ORD_15606994_15606995_15606996:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2aa4ca7cd91d2b9b7f303d61f8818cae
ToxValDB_ECOTOX LOEL =10 mL/kg bw Mouse oral acute; 1 days acute LONG_REF=J. Toxicol. Environ. Health18(4): 575-587 Lin,S.C., H. Saito, T. Yohro, and J. Shiga Acute Hepatotoxicity Induced by Hepatotoxins in Suncus murinus 1986; TITLE=Acute Hepatotoxicity Induced by Hepatotoxins in Suncus murinus; AUTHOR=Lin,S.C., H. Saito, T. Yohro, and J. Shiga; DOI=10.1080/15287398609530895; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=112721; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=Enzyme(s): Alanine transaminase (ALT); TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX_dup_EPA ORD_15606994_15606995_15606996:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=45a08ffef0281043bbcd08e31b0018eb
ToxValDB_ECOTOX LOEL =3720 mg/day Rat oral subchronic; 60 days subchronic LONG_REF=Alcohol11(5): 355-360 Gonzalez-Reimers,E., A. Martinez-Riera, F. Santolaria-Fernandez, A. Conde-Martel, H. Alvarez-Arguelles, C. Santana-Herr Relative and Combined Effects of Ethanol and Protein Deficiency on Gonadal Function and Histology 1994; TITLE=Relative and Combined Effects of Ethanol and Protein Deficiency on Gonadal Function and Histology; AUTHOR=Gonzalez-Reimers,E., A. Martinez-Riera, F. Santolaria-Fernandez, A. Conde-Martel, H. Alvarez-Arguelles, C. Santana-Herr; DOI=10.1016/0741-8329(94)90017-5; QUALITY=Control type: Control outside of primary exposure system; EXTERNAL_SOURCE_ID=116711; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596808_15598880_15607332:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2f49b725284eea44de0bc7f417ba34e6
ToxValDB_ECOTOX LOEL =390 mg/100 mL Rat environmental short-term; 2 days short-term LONG_REF=Biochem. Pharmacol.31(22): 3641-3643 Priscott,P.K. The Effects of Ethanol on Rat Embryos Developing In Vitro 1982; TITLE=The Effects of Ethanol on Rat Embryos Developing In Vitro; AUTHOR=Priscott,P.K.; DOI=10.1016/0006-2952(82)90588-3; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112969; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=Morphology: Length; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15607345_15607346:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=39f1bcf971d2cdc274e3cb00a14bf124
ToxValDB_ECOTOX LOEL =3000 mg/kg bw/day Rat injection short-term; 14 days reproduction developmental LONG_REF=Biol. Pharm. Bull.17(2): 270-274 Okamura,N., K. Kobayashi, A. Akaike, and A. Yagi Protective Effect of Ginseng Saponins Against Impaired Brain Growth in Neonatal Rats Exposed to Ethanol 1994; TITLE=Protective Effect of Ginseng Saponins Against Impaired Brain Growth in Neonatal Rats Exposed to Ethanol; AUTHOR=Okamura,N., K. Kobayashi, A. Akaike, and A. Yagi; DOI=10.1248/bpb.17.270; QUALITY=Control type: Control outside of primary exposure system; EXTERNAL_SOURCE_ID=116189; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15607385:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=0bc912b6de65a2aa2d8f8bc15317b9cf
ToxValDB_ECOTOX LOEL =590 mg/100 mL Rat environmental short-term; 2 days developmental LONG_REF=Biochem. Pharmacol.31(22): 3641-3643 Priscott,P.K. The Effects of Ethanol on Rat Embryos Developing In Vitro 1982; TITLE=The Effects of Ethanol on Rat Embryos Developing In Vitro; AUTHOR=Priscott,P.K.; DOI=10.1016/0006-2952(82)90588-3; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112969; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=Development: Stage; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX_dup_EPA ORD_15608138_15608139:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=cb2c382bca6ea36f18fab357f73a3696
ToxValDB_ECOTOX LOEL =6 % v/v Mouse oral subchronic; 35 days subchronic LONG_REF=J. Pharmacol. Exp. Ther.225(2): 479-484 Anderson,R.A.,Jr., B.R. Willis, C. Oswald, and L.J.D. Zaneveld Ethanol-Induced Male Infertility: Impairment of Spermatozoa 1983; TITLE=Ethanol-Induced Male Infertility: Impairment of Spermatozoa; AUTHOR=Anderson,R.A.,Jr., B.R. Willis, C. Oswald, and L.J.D. Zaneveld; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=117197; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=Reproduction: Velocity; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600583_15608732:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c68893d447cc9fd4e66cb5a8e3065cfe
ToxValDB_ECOTOX LOEL =200 uL Rat injection acute; 1 days acute LONG_REF=Biosci. Biotechnol. Biochem.58(1): 55-59 Ashida,H., K. Kanazawa, and G. Danno Hepatic Phosphoglucomutase Activity as a Marker of Oxidative Stress Induced by Pro-Oxidative Drugs 1994; TITLE=Hepatic Phosphoglucomutase Activity as a Marker of Oxidative Stress Induced by Pro-Oxidative Drugs; AUTHOR=Ashida,H., K. Kanazawa, and G. Danno; DOI=10.1271/bbb.58.55; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=95525; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Biochemistry: Thiobarbituric acid|Enzyme(s): 6-Phosphogluconate dehydrogenase; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX:15608822:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=49fbecab2fe9d9e391996f60b33d96d2
ToxValDB_ECOTOX LOEL =1500 ppm Mouse oral short-term; 13 days reproduction developmental LONG_REF=Alcohol11(6): 517-522 Weathersby,R.T., H.C. Becker, and R.L. Hale Reduced Sensitivity to the Effects of Clonidine on Ethanol-Stimulated Locomotor Activity in Adult Mouse Offspring Prenatally Exposed to Ethanol 1994; TITLE=Reduced Sensitivity to the Effects of Clonidine on Ethanol-Stimulated Locomotor Activity in Adult Mouse Offspring Prenatally Exposed to Ethanol; AUTHOR=Weathersby,R.T., H.C. Becker, and R.L. Hale; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=116714; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Behavior: Activity, general; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596717_15604220_15609677:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4eb0cae4e63c341fbeac30ddb1f1b780
ToxValDB_ECOTOX LOEL =7.1 mL/kg bw Mouse oral short-term; 8 days developmental LONG_REF=Dev. Pharmacol. Ther.11(4): 237-242 Kennedy,L.A., S. Mukerji, and B. Bhaumick Mouse Placental Receptor for Basic Somatomedin Following Maternal Ethanol Administration 1988; TITLE=Mouse Placental Receptor for Basic Somatomedin Following Maternal Ethanol Administration; AUTHOR=Kennedy,L.A., S. Mukerji, and B. Bhaumick; DOI=10.1159/000457694; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112739; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=Development: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX_dup_EPA ORD_15610158_15610159:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=65861c047dc03af54a7bb08fd8cc603f
ToxValDB_ECOTOX LOEL =3 % v/v Mouse oral short-term; 30 days short-term LONG_REF=Reprod. Toxicol.3(2): 101-113 Anderson,R.A.,Jr., J.F. Phillips, S.H. Berryman, and L.J.D. Zaneveld Ethanol-Induced Delayed Male Puberty in Mice is not Due to Impaired Leydig Cell Function 1989; TITLE=Ethanol-Induced Delayed Male Puberty in Mice is not Due to Impaired Leydig Cell Function; AUTHOR=Anderson,R.A.,Jr., J.F. Phillips, S.H. Berryman, and L.J.D. Zaneveld; DOI=10.1016/0890-6238(89)90044-0; QUALITY=Control type: Control outside of primary exposure system; EXTERNAL_SOURCE_ID=116881; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Hormone(s): Androstenedione; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX_dup_EPA ORD_15611043_15611133:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=05de28c9631243a349b100f970dea0b0
ToxValDB_ECOTOX LOEL =3.32 g/org-day Rat oral short-term; 7 days reproduction developmental LONG_REF=J. Pharmacobio-Dyn.6(12): 913-921 Terada,N., T. Nakai, M. Yamaguchi, A. Hatta, K. Arizono, and T. Ariyoshi Influences of Maternal Ethanol Intake on Maternal and Perinatal Hepatic Heme and Drug Metabolizing Enzymes in Rats 1983; TITLE=Influences of Maternal Ethanol Intake on Maternal and Perinatal Hepatic Heme and Drug Metabolizing Enzymes in Rats; AUTHOR=Terada,N., T. Nakai, M. Yamaguchi, A. Hatta, K. Arizono, and T. Ariyoshi; DOI=10.1248/bpb1978.6.913; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113098; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=Enzyme(s): Aminopyrine n-demethylase|Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|enzyme activity; STUDY_GROUP=ECOTOX:15611044:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7cde3024d4fac9741f912eaca7411916
ToxValDB_ECOTOX LOEL =2.4 % v/v Mouse oral subchronic; 37 days developmental LONG_REF=Alcohol. Clin. Exp. Res.30(10): 1791-1798 Parnell,S.E., D.B. Dehart, T.A. Wills, S.Y. Chen, C.W. Hodge, J. Besheer, H.G. Waage-Baudet, M.E. Charness, and K.K. Su Maternal Oral Intake Mouse Model for Fetal Alcohol Spectrum Disorders: Ocular Defects as a Measure of Effect 2006; TITLE=Maternal Oral Intake Mouse Model for Fetal Alcohol Spectrum Disorders: Ocular Defects as a Measure of Effect; AUTHOR=Parnell,S.E., D.B. Dehart, T.A. Wills, S.Y. Chen, C.W. Hodge, J. Besheer, H.G. Waage-Baudet, M.E. Charness, and K.K. Su; DOI=10.1111/j.1530-0277.2006.00212.x; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=113183; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=Development: Weight|Morphology: Shape; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX:15611078:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=9c3609257039f6b3b07732c854dd0280
ToxValDB_ECOTOX LOEL =25000 mg/kg bw/day Mouse oral short-term; 11 days short-term LONG_REF=Biochem. Pharmacol.36(13): 2157-2167 Anderson,R.A.,Jr., B.R. Willis, J.F. Phillips, C. Oswald, and L.J.D. Zaneveld Delayed Pubertal Development of the Male Reproductive Tract Associated with Chronic Ethanol Ingestion 1987; TITLE=Delayed Pubertal Development of the Male Reproductive Tract Associated with Chronic Ethanol Ingestion; AUTHOR=Anderson,R.A.,Jr., B.R. Willis, J.F. Phillips, C. Oswald, and L.J.D. Zaneveld; DOI=10.1016/0006-2952(87)90145-6; QUALITY=Control type: Control outside of primary exposure system; EXTERNAL_SOURCE_ID=116882; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Hormone(s): Testosterone; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX:15611095:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=6ca04de79808cead285fe1a497c2fb82
ToxValDB_ECOTOX LOEL =3 mg/kg bw/day Rat oral subchronic; 8 weeks subchronic LONG_REF=- | Basic Clin. Pharmacol. Toxicol.96(6): 475-479 Verma,S.K., R. Dua, and K.D. Gill Impaired Energy Metabolism After Co-Exposure to Lead and Ethanol 2005; TITLE=Impaired Energy Metabolism After Co-Exposure to Lead and Ethanol; AUTHOR=Verma,S.K., R. Dua, and K.D. Gill; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=113195; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Metabolism: Brain ATP (Adenosine triphosphate) levels|Metabolism: Brain cytochrome oxidase activity | Metabolism: Brain succinate dehydrogenase activity | Metabolism: NADH dehydrogenase activity | Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|enzyme activity|other; STUDY_GROUP=ECOTOX:15612918:M:-adult; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=28f74482280184a27265d399d346cd5d
ToxValDB_ECOTOX LOEL =3500 mg/kg bw/day Rat oral short-term; 10 days reproduction developmental LONG_REF=- | Neurobehav. Toxicol. Teratol.7(3): 263-266 Abel,E.L., and B.A. Dintcheff Factors Affecting the Outcome of Maternal Alcohol Exposure: II. Maternal Age 1985; TITLE=Factors Affecting the Outcome of Maternal Alcohol Exposure: II. Maternal Age; AUTHOR=Abel,E.L., and B.A. Dintcheff; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=116883; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=Feeding behavior: Food consumption|Growth: Weight gain|Reproduction: Gestation time; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|reproduction; STUDY_GROUP=ECOTOX:15612989:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=4185d5a00c4ed2898eaaf5aa62f7aa1f
ToxValDB_ECOTOX LOEL =1600 mg/kg bw/day Mouse oral short-term; 4 weeks short-term LONG_REF=- | Indian J. Physiol. Pharmacol.49(4): 422-426 Maneesh,M., and H. Jayalekshmi Effect of Ascorbic Acid, alpha-Tocopherol, Lecithin and L-Ornithine-L-Aspartate on Ethanol Induced Hypoproteinemia and Hyperlipidemia in Rats 2005; TITLE=Effect of Ascorbic Acid, alpha-Tocopherol, Lecithin and L-Ornithine-L-Aspartate on Ethanol Induced Hypoproteinemia and Hyperlipidemia in Rats; AUTHOR=Maneesh,M., and H. Jayalekshmi; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=117480; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Serum protein, albumin, globulin, A:G ratio | Serum cholesterol, triglyceride, LDLC; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|other; STUDY_GROUP=ECOTOX:15612992:M:-adult; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=c76856edd75c647e122283ad4210ff62
ToxValDB_ECOTOX LOEL =2400 mg/kg bw/day Rat oral short-term; 6 days reproduction developmental LONG_REF=- | Alcohol14(6): 569-573 Addolorato,G., A. Gasbarrini, S. Marcoccia, M. Simoncini, P. Baccarini, G. Vagni, A. Grieco, A. Sbriccoli, A. Granato, Prenatal Exposure to Ethanol in Rats: Effects on Liver Energy Level and Antioxidant Status in Mothers, Fetuses, and Newborns 1997; TITLE=Prenatal Exposure to Ethanol in Rats: Effects on Liver Energy Level and Antioxidant Status in Mothers, Fetuses, and Newborns; AUTHOR=Addolorato,G., A. Gasbarrini, S. Marcoccia, M. Simoncini, P. Baccarini, G. Vagni, A. Grieco, A. Sbriccoli, A. Granato,; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=116698; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Biochemistry: Glutathione (reduced glutathione)|Growth: decreased body Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|other; STUDY_GROUP=ECOTOX:15612998:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=262d85f7e693864725b8eee6a4a5f2e2
ToxValDB_ECOTOX LOEL =5800 mg/kg bw/day Rat oral short-term; 4 days reproduction developmental LONG_REF=- | Neurotoxicol. Teratol.28(2): 229-237 Fakoya,F.A., and E.A. Caxton-Martins Neocortical Neurodegeneration in Young Adult Wistar Rats Prenatally Exposed to Ethanol 2006; TITLE=Neocortical Neurodegeneration in Young Adult Wistar Rats Prenatally Exposed to Ethanol; AUTHOR=Fakoya,F.A., and E.A. Caxton-Martins; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=112978; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=Cell(s): Density|Growth: Weight, brain weight|Morphology: Weight| Reproductive: birth weight; TOXICOLOGICAL_EFFECT_CATEGORY=development|multiple|other; STUDY_GROUP=ECOTOX:15613108:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=435b64a7e7941b55298e1f0e45241a94
ToxValDB_ECOTOX LOEL =2.23 mg/kg bw/day Rat oral chronic; 108 days chronic LONG_REF=- | J. Toxicol. Environ. Health10(21): 247-254 Messiha,F.S. Ethanol and Hypobarometric Simulated High Altitude: A Gonadal-Hepatic Toxicity Study in the Male Rat 1982; TITLE=Ethanol and Hypobarometric Simulated High Altitude: A Gonadal-Hepatic Toxicity Study in the Male Rat; AUTHOR=Messiha,F.S.; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=113112; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=Enzyme(s): Aldehyde dehydrogenase (ALDH)|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity|other; STUDY_GROUP=ECOTOX:15613334:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=144b4b7cae50bad99d94766c9d9fe483
ToxValDB_ECOTOX LOEL =6600 mg/kg bw/day Rat oral short-term; 6 days reproduction developmental LONG_REF=- | Neurotoxicol. Teratol.11(2): 135-143 Bonthius,D.J., and J.R. West Aspirin Augments Alcohol in Restricting Brain Growth in the Neonatal Rat 1989; TITLE=Aspirin Augments Alcohol in Restricting Brain Growth in the Neonatal Rat; AUTHOR=Bonthius,D.J., and J.R. West; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=116879; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Morphology: brain weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECOTOX:15613447:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=01da57cd936fd444b2c65b058d88f346
ToxValDB_ECOTOX LOEL =7200 mg/kg bw/day Rat oral chronic; 98 days chronic LONG_REF=- | J. Toxicol. Environ. Health Part A68(10): 797-809 Morvai,V., E. Szakmary, and G. Ungvary The Effects of Carbon Disulfide and Ethanol on the Circulatory System of Rats 2005; TITLE=The Effects of Carbon Disulfide and Ethanol on the Circulatory System of Rats; AUTHOR=Morvai,V., E. Szakmary, and G. Ungvary; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=81806; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Growth: Weight gain|Daily food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECOTOX:15613454:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=8a8613121214b66eb3585b690df6ca21
ToxValDB_ECOTOX LOEL =12950 mg/kg bw/day Rat oral short-term; 15 days reproduction developmental LONG_REF=- | Neurotoxicol. Teratol.15(2): 97-105 Hannigan,J.H., E.L. Abel, and M.L. Kruger \\\"Population\\\" Characteristics of Birthweight in an Animal Model of Alcohol-Related Developmental Effects 1993; TITLE="Population" Characteristics of Birthweight in an Animal Model of Alcohol-Related Developmental Effects; AUTHOR=Hannigan,J.H., E.L. Abel, and M.L. Kruger; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=113329; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Growth: Weight|Reproduction: Progeny counts/numbers, gestational length, litter birth weights; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|reproduction; STUDY_GROUP=ECOTOX:15613526:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=3299baab9eb488ff6426c18d3c0b41a6
ToxValDB_ECOTOX LOEL =10000 mg/kg bw/day Mouse oral subchronic; 12 weeks subchronic LONG_REF=- | Am. J. Pathol.166(6): 1681-1690 Zhou,Z., L. Wang, Z. Song, J.T. Saari, C.J. McClain, and Y.J. Kang Zinc Supplementation Prevents Alcoholic Liver Injury in Mice Through Attenuation of Oxidative Stress 2005; TITLE=Zinc Supplementation Prevents Alcoholic Liver Injury in Mice Through Attenuation of Oxidative Stress; AUTHOR=Zhou,Z., L. Wang, Z. Song, J.T. Saari, C.J. McClain, and Y.J. Kang; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=100803; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Decreased hepatic zinc concentrations in liver | Decreased hepatic MT concentrations in liver | Increased serum ALT levels | Increased hepatic TNF-a levels | Increased malondialdehyde in liver | Increased protein carbonyl concentrations in liver | Increased CYP2E1 and ALDH activity | Increased CYP2E1 and ALHD protein | Decreased cytosolic GHS, mitochondrial GHS, GPx concentration | Increased liver: body weight ratio, Ultrastructural changes: lipid droplet accumulation, Enlargement and degeneration of mitochondria, Disorganization of rough endoplasmic reticulum, Chromatin condensation; STUDY_GROUP=ECOTOX:15613596:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=cec6dd09177131d3b68e7fe6de9acd67
ToxValDB_ECOTOX LOEL =7600 mg/kg bw/day Rat oral short-term; 4 days developmental LONG_REF=- | Neurobehav. Toxicol. Teratol.4(3): 315-321 Grant,K.A., and H.H. Samson Ethanol and Tertiary Butanol Induced Microcephaly in the Neonatal Rat: Comparison of Brain Growth Parameters 1982; TITLE=Ethanol and Tertiary Butanol Induced Microcephaly in the Neonatal Rat: Comparison of Brain Growth Parameters; AUTHOR=Grant,K.A., and H.H. Samson; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112931; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=Behavior: Righting response and ability to cliff avoid, and abstinence syndrom|Biochemistry: Cholesterol reduction|Cell(s): Structural changes|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|neurobehavior|nonneoplastic histopathology|organ weight; STUDY_GROUP=ECOTOX:15613597:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=192a31eaa91a865904fec63e6af7eb8d
ToxValDB_ECOTOX LOEL =9000 mg/kg bw/day Rat oral subchronic; 5 weeks subchronic LONG_REF=- | Toxicol. Sci.82(2): 656-660 Perrien,D.S., E.C. Wahl, W.R. Hogue, U. Feige, J. Aronson, M.J.J. Ronis, T.M. Badger, and C.K.,Jr. Lumpkin IL-1 and TNF Antagonists Prevent Inhibition of Fracture Healing by Ethanol in Rats 2004; TITLE=IL-1 and TNF Antagonists Prevent Inhibition of Fracture Healing by Ethanol in Rats; AUTHOR=Perrien,D.S., E.C. Wahl, W.R. Hogue, U. Feige, J. Aronson, M.J.J. Ronis, T.M. Badger, and C.K.,Jr. Lumpkin; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=80478; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Bone: mineral content | Fracture healing (callus analysis); TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15613603:M:-adult; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=f2630ba7edaf3800c68278b3398e43c9
ToxValDB_ECOTOX LOEL =36 % diet Rat oral short-term; 21 days reproduction developmental LONG_REF=- | J. Neuroendocrinol.18(9): 672-684 Lan,N., F. Yamashita, A.G. Halpert, L. Ellis, W.K. Yu, V. Viau, and J. Weinberg Prenatal Ethanol Exposure Alters the Effects of Gonadectomy on Hypothalamic-Pituitary-Adrenal Activity in Male Rats 2006; TITLE=Prenatal Ethanol Exposure Alters the Effects of Gonadectomy on Hypothalamic-Pituitary-Adrenal Activity in Male Rats; AUTHOR=Lan,N., F. Yamashita, A.G. Halpert, L. Ellis, W.K. Yu, V. Viau, and J. Weinberg; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=112949; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=Genetics: Messenger RNA levels of Gonadotrophin-releasing hormone|Growth: Body weight|Reproduction: Gestation time|Hormone(s): Adrenocorticotropic hormone; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|reproduction; STUDY_GROUP=ECOTOX:15613606:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=75827c0bde0129e05f8141e27e16d579
ToxValDB_ECOTOX LOEL =12600 mg/kg bw/day Mouse oral short-term; 14 days reproduction developmental LONG_REF=- | Teratology30(1): 119-129 Uphoff,C., C. Nyquist-Battie, and R. Toth Cardiac Muscle Development in Mice Exposed to Ethanol In Utero 1984; TITLE=Cardiac Muscle Development in Mice Exposed to Ethanol In Utero; AUTHOR=Uphoff,C., C. Nyquist-Battie, and R. Toth; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=112959; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Cell(s): Myocyte|Growth: Weight | Growth: length; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology|other; STUDY_GROUP=ECOTOX:15613618:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=dc2c887f1856404a11ce8dede5fc2572
ToxValDB_ECOTOX NOEL =7.1 mL/kg bw Mouse oral short-term; 8 days reproduction developmental LONG_REF=Dev. Pharmacol. Ther.11(4): 237-242 Kennedy,L.A., S. Mukerji, and B. Bhaumick Mouse Placental Receptor for Basic Somatomedin Following Maternal Ethanol Administration 1988; TITLE=Mouse Placental Receptor for Basic Somatomedin Following Maternal Ethanol Administration; AUTHOR=Kennedy,L.A., S. Mukerji, and B. Bhaumick; DOI=10.1159/000457694; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112739; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=Growth: Weight|Hormone(s): Somatomedins|Mortality: Survival; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|mortality/survival; STUDY_GROUP=ECOTOX:15594055:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d6c8471576434fde25105abe7c5b076e
ToxValDB_ECOTOX NOEL =14400 mg Mouse oral short-term; 28 days short-term LONG_REF=Alcohol Alcohol.32(5): 563-572 Cebral,E., A. Lasserre, V. Rettori, and M.A.F. De Gimeno Impaired Mouse Fertilization by Low Chronic Alcohol Treatment 1997; TITLE=Impaired Mouse Fertilization by Low Chronic Alcohol Treatment; AUTHOR=Cebral,E., A. Lasserre, V. Rettori, and M.A.F. De Gimeno; DOI=10.1093/oxfordjournals.alcalc.a008297; QUALITY=Control type: Control outside of primary exposure system; EXTERNAL_SOURCE_ID=116874; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Growth: Weight|Reproduction: Fertilization; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|reproduction; STUDY_GROUP=ECOTOX:15594202:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=07fa83e16e343f8d316f592ef4b62731
ToxValDB_ECOTOX NOEL =6 % w/v Rat oral short-term; 17 days reproduction developmental LONG_REF=Neuropharmacology22(7): 931-933 Thadani,P.V. Effect of Maternal Ethanol Administration on Synaptic Vesicles Development in Heart of Rat Offspring 1983; TITLE=Effect of Maternal Ethanol Administration on Synaptic Vesicles Development in Heart of Rat Offspring; AUTHOR=Thadani,P.V.; DOI=10.1016/0028-3908(83)90144-2; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112928; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=Hormone(s): Norepinephrine|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=neurotransmitter|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594237_15610219:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7a8e83d0defeab31ad22ac45f15a9ce6
ToxValDB_ECOTOX NOEL =42200 ppm Rat oral short-term (developmental); 22 days developmental LONG_REF=Metab. Clin. Exp.38(2): 149-152 Snyder,A.K., and S.P. Singh Effects of Ethanol on Glucose Turnover in Pregnant Rats 1989; TITLE=Effects of Ethanol on Glucose Turnover in Pregnant Rats; AUTHOR=Snyder,A.K., and S.P. Singh; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=112955; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Growth: Weight|Reproduction: Progeny counts/numbers; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594300_15601480:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=a686486f033bfff4e7f5cf6b9fd9f92a
ToxValDB_ECOTOX NOEL =20 % w/v Mouse oral chronic; 140 days chronic LONG_REF=Ann. Nutr. Metab.53(3-4): 252-259 Smith,R.R., J. Hong, A.E. Harvey, T. Lewis, D. Diaz, and N.P. Nunez Ethanol Consumption does Not Promote Weight Gain in Female Mice 2008; TITLE=Ethanol Consumption does Not Promote Weight Gain in Female Mice; AUTHOR=Smith,R.R., J. Hong, A.E. Harvey, T. Lewis, D. Diaz, and N.P. Nunez; DOI=10.1159/000189128; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=116707; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=Growth: Weight|Morphology: Calcium weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594310_15597888:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=ea9d4514378afdf35ce6830d2e78271d
ToxValDB_ECOTOX NOEL =10 % v/v Rat oral subchronic; 70 days subchronic LONG_REF=Arch. Environ. Health28(4): 217-222 Mahaffey,K.R., R.A. Goyer, and M.H. Wilson Influence of Ethanol Ingestion on Lead Toxicity in Rats Fed Isocaloric Diets 1974; TITLE=Influence of Ethanol Ingestion on Lead Toxicity in Rats Fed Isocaloric Diets; AUTHOR=Mahaffey,K.R., R.A. Goyer, and M.H. Wilson; DOI=10.1080/00039896.1974.10666471; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=51799; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1974; ORIGINAL_YEAR=1974; TOXICOLOGICAL_EFFECT=Biochemistry: Hematocrit (anemia)|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=hematology|other; STUDY_GROUP=ECOTOX:15594312:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7d41806ffa50e6c6b1b676b48338b622
ToxValDB_ECOTOX NOEL =20 % v/v Mouse oral short-term; 17 days developmental LONG_REF=Toxicol. Lett.4:79-82 Hood,R.D., J.M. Lary, and J.B. Blacklock Lack of Prenatal Effects of Maternal Ethanol Consumption in CD-1 Mice 1979; TITLE=Lack of Prenatal Effects of Maternal Ethanol Consumption in CD-1 Mice; AUTHOR=Hood,R.D., J.M. Lary, and J.B. Blacklock; DOI=10.1016/0378-4274(79)90077-8; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=37177; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=Development: Abnormal|Growth: Weight|Reproduction: Resorbed embryos; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|development|reproduction; STUDY_GROUP=ECOTOX:15594595:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5b5b5d54e7e47bbf65dc030ae779c6c0
ToxValDB_ECOTOX NOEL =4.5 % w/v Dog oral acute; 0.0208 days acute LONG_REF=Am. J. Physiol. Gasterointest. Liver Physiol.269(3, Pt. 1): G363 - G369 Charles,F., and S.F. Phillips Effects of Ethanol, Xylose, and Glucose on Canine Jejunal Motility 1995; TITLE=Effects of Ethanol, Xylose, and Glucose on Canine Jejunal Motility; AUTHOR=Charles,F., and S.F. Phillips; DOI=10.1152/ajpgi.1995.269.3.G363; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=113204; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Physiology: Contraction rate; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594709_15594710:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=23b134d21522150b1a1eff791cc7dded
ToxValDB_ECOTOX NOEL =5 % v/v Rat oral subchronic; 56 days subchronic LONG_REF=Biol. Trace Elem. Res.28(2): 157-164 Flora,S.J.S., D. Kumar, S.R.S. Sachan, and S. Das Gupta Combined Exposure to Lead and Ethanol on Tissue Concentration of Essential Metals and Some Biochemical Indices in Rat 1991; TITLE=Combined Exposure to Lead and Ethanol on Tissue Concentration of Essential Metals and Some Biochemical Indices in Rat; AUTHOR=Flora,S.J.S., D. Kumar, S.R.S. Sachan, and S. Das Gupta; DOI=10.1007/BF02863081; QUALITY=Control type: Baseline control; EXTERNAL_SOURCE_ID=86414; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=Biochemistry: Calcium content|Physiology: Lipid peroxidation; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594732_15594733_15597153:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2b668d79bf20c25216a67761d9c67c8a
ToxValDB_ECOTOX NOEL =13900 mg Mouse oral short-term; 28 days short-term LONG_REF=Alcohol Alcohol.32(5): 563-572 Cebral,E., A. Lasserre, V. Rettori, and M.A.F. De Gimeno Impaired Mouse Fertilization by Low Chronic Alcohol Treatment 1997; TITLE=Impaired Mouse Fertilization by Low Chronic Alcohol Treatment; AUTHOR=Cebral,E., A. Lasserre, V. Rettori, and M.A.F. De Gimeno; DOI=10.1093/oxfordjournals.alcalc.a008297; QUALITY=Control type: Control outside of primary exposure system; EXTERNAL_SOURCE_ID=116874; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595538_15598190_15600014:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b81cdee36add8330adfbee5e60a5935d
ToxValDB_ECOTOX NOEL =30 % Rat oral short-term; 14 days short-term LONG_REF=Biol. Trace Elem. Res.100(3): 247-257 Pathak,A., A. Mahmood, R. Pathak, and D. Dhawan Role of Zinc on Lipid Peroxidation and Antioxidative Enzymes in Intestines of Ethanol-Fed Rats 2004; TITLE=Role of Zinc on Lipid Peroxidation and Antioxidative Enzymes in Intestines of Ethanol-Fed Rats; AUTHOR=Pathak,A., A. Mahmood, R. Pathak, and D. Dhawan; DOI=10.1385/BTER:100:3:247; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=100367; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Biochemistry: Glutathione (reduced glutathione)|Enzyme(s): Glutathione reductase|Physiology: Lipid peroxidation; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595694_15596875:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8c333ec9188c0394d72819ab5fa77e69
ToxValDB_ECOTOX NOEL =0.4 mL/kg Rat oral short-term; 27 days short-term LONG_REF=J. Toxicol. Environ. Health10:267-276 Mankes,R.F., I. Rosenblum, K.F. Benitz, R. LeFevre, and R. Abraham Teratogenic and Reproductive Effects of Ethanol in Long-Evans Rats 1982; TITLE=Teratogenic and Reproductive Effects of Ethanol in Long-Evans Rats; AUTHOR=Mankes,R.F., I. Rosenblum, K.F. Benitz, R. LeFevre, and R. Abraham; DOI=10.1080/15287398209530249; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112708; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=Growth: Weight|Mortality: Mortality; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|mortality/survival; STUDY_GROUP=ECOTOX:15596085:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=96b7aa003325c258d7c1015b9b16fbf8
ToxValDB_ECOTOX NOEL =5 % w/v Rat oral chronic; 119 days chronic LONG_REF=Pharmacol. Biochem. Behav.19(4): 583-585 Krueger,W.A., W.J. Bo, and P.K. Rudeen Estrous Cyclicity in Rats Fed an Ethanol Diet for Four Months 1983; TITLE=Estrous Cyclicity in Rats Fed an Ethanol Diet for Four Months; AUTHOR=Krueger,W.A., W.J. Bo, and P.K. Rudeen; DOI=10.1016/0091-3057(83)90331-3; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=115198; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=Growth: Weight|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596244_15597376:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=3a39ddf18558bf8578459ad18c97b504
ToxValDB_ECOTOX NOEL =15 % v/v Mouse oral short-term; 8 days developmental LONG_REF=Can. J. Physiol. Pharmacol.64(7): 1032-1037 Kennedy,L.A., S. Mukerji, and M.J. Elliott The Ontogeny of Placental Na+-K+ Atpase in the Mouse and Its Impairment by Ethanol 1986; TITLE=The Ontogeny of Placental Na+-K+ Atpase in the Mouse and Its Impairment by Ethanol; AUTHOR=Kennedy,L.A., S. Mukerji, and M.J. Elliott; DOI=10.1139/y86-176; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112961; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=Development: Weight|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=development|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596371_15596372:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8b088535a6064cb24a4f419613b9415d
ToxValDB_ECOTOX NOEL =0.1 % Rat environmental short-term; 2 days developmental LONG_REF=Toxicology30(1): 45-57 Kitchin,K.T., and M.T. Ebron Further Development of Rodent Whole Embryo Culture: Solvent Toxicity and Water Insoluble Compound Delivery System 1984; TITLE=Further Development of Rodent Whole Embryo Culture: Solvent Toxicity and Water Insoluble Compound Delivery System; AUTHOR=Kitchin,K.T., and M.T. Ebron; DOI=10.1016/0300-483x(84)90061-1; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=115431; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Development: Abnormal|Genetics: DNA concentration; TOXICOLOGICAL_EFFECT_CATEGORY=development|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596656_15596657:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=fbb537b38511f705710c616cc63c4bc7
ToxValDB_ECOTOX NOEL =3790 mg/day Rat oral subchronic; 60 days subchronic LONG_REF=Alcohol11(5): 355-360 Gonzalez-Reimers,E., A. Martinez-Riera, F. Santolaria-Fernandez, A. Conde-Martel, H. Alvarez-Arguelles, C. Santana-Herr Relative and Combined Effects of Ethanol and Protein Deficiency on Gonadal Function and Histology 1994; TITLE=Relative and Combined Effects of Ethanol and Protein Deficiency on Gonadal Function and Histology; AUTHOR=Gonzalez-Reimers,E., A. Martinez-Riera, F. Santolaria-Fernandez, A. Conde-Martel, H. Alvarez-Arguelles, C. Santana-Herr; DOI=10.1016/0741-8329(94)90017-5; QUALITY=Control type: Control outside of primary exposure system; EXTERNAL_SOURCE_ID=116711; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Cell(s): Number of cells; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596808_15598880_15607332:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f0979b8516fcd2ac98ced94b01fca9b1
ToxValDB_ECOTOX NOEL =2400 mg/kg bw/day Rat oral acute; 0.1667 days acute LONG_REF=Food Chem.99(2): 305-314 Yao,P., K. Li, Y. Jin, F. Song, S. Zhou, X. Sun, A.K. Nussler, and L. Liu Oxidative Damage After Chronic Ethanol Intake in Rat Tissues: Prophylaxis of Ginkgo biloba Extract 2006; TITLE=Oxidative Damage After Chronic Ethanol Intake in Rat Tissues: Prophylaxis of Ginkgo biloba Extract; AUTHOR=Yao,P., K. Li, Y. Jin, F. Song, S. Zhou, X. Sun, A.K. Nussler, and L. Liu; DOI=10.1016/j.foodchem.2005.07.047; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=114291; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=Feeding behavior: Food consumption|Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597022_15598079:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=06ff942cb5fb46590c04ada118696a7a
ToxValDB_ECOTOX NOEL =25 % v/v Mouse injection subchronic; 51 days developmental LONG_REF=Behav. Brain Res.186(2): 230-238 Summers,B.L., C.M.A. Henry, A.M. Rofe, and P. Coyle Dietary Zinc Supplementation During Pregnancy Prevents Spatial and Object Recognition Memory Impairments Caused by Early Prenatal Ethanol Exposure 2008; TITLE=Dietary Zinc Supplementation During Pregnancy Prevents Spatial and Object Recognition Memory Impairments Caused by Early Prenatal Ethanol Exposure; AUTHOR=Summers,B.L., C.M.A. Henry, A.M. Rofe, and P. Coyle; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=101711; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=Development: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX:15597309:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=391b8267421eafe5fa087c83bd771328
ToxValDB_ECOTOX NOEL =6 % v/v Rat oral short-term; 14 days short-term LONG_REF=Dev. Pharmacol. Ther.7(3): 177-187 Henderson,G.I., and S. Schenker Effects of Ethanol and/or Caffeine on Fetal Development and Placental Amino Acid Uptake in Rats 1984; TITLE=Effects of Ethanol and/or Caffeine on Fetal Development and Placental Amino Acid Uptake in Rats; AUTHOR=Henderson,G.I., and S. Schenker; DOI=10.1159/000457161; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113104; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX:15597406:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b48008a38127eead03bd9cd449e672d8
ToxValDB_ECOTOX NOEL =13050 ppm Rat oral short-term; 22.03 days reproduction developmental LONG_REF=Neurotoxicol. Teratol.16(1): 31-39 Blanchard,B.A., and J.H. Hannigan Prenatal Ethanol Exposure: Effects on Androgen and Nonandrogen Dependent Behaviors and on Gonadal Development in Male Rats 1994; TITLE=Prenatal Ethanol Exposure: Effects on Androgen and Nonandrogen Dependent Behaviors and on Gonadal Development in Male Rats; AUTHOR=Blanchard,B.A., and J.H. Hannigan; DOI=10.1016/0892-0362(94)90006-x; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=116927; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Population: Sex ratio|Reproduction: Gestation time; TOXICOLOGICAL_EFFECT_CATEGORY=development|reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597955_15604973:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=58ba578d5d7738d80e69c472c9de4f28
ToxValDB_ECOTOX NOEL =2.5 mL/kg Rat injection acute; 1 days acute LONG_REF=Toxicology124:125-134 Valentovic,M.A., T. Yahia, J.G. Ball, S.K. Hong, P.I. Brown, and G.O. Rankin 3,4-Dicholoroaniline Acute Toxicity in Male Fischer 344 Rats 1997; TITLE=3,4-Dicholoroaniline Acute Toxicity in Male Fischer 344 Rats; AUTHOR=Valentovic,M.A., T. Yahia, J.G. Ball, S.K. Hong, P.I. Brown, and G.O. Rankin; DOI=10.1016/s0300-483x(97)00143-1; QUALITY=Control type: Baseline control; EXTERNAL_SOURCE_ID=102307; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Growth: Weight|Physiology: Excretion rate; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598255_15598543:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e8ec70af18a0c167f98308e3d62216f1
ToxValDB_ECOTOX NOEL =10 mmol/kg Rat oral short-term; 1.75 days short-term LONG_REF=Fundam. Appl. Toxicol.15(3): 429-440 Ray,S.D., and H.M. Mehendale Potentiation of CCL4 and CHCL3 Hepatotoxicity and Lethality by Various Alcohols 1990; TITLE=Potentiation of CCL4 and CHCL3 Hepatotoxicity and Lethality by Various Alcohols; AUTHOR=Ray,S.D., and H.M. Mehendale; DOI=10.1016/0272-0590(90)90029-j; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=78954; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=Enzyme(s): Alanine transaminase (ALT)|Enzyme(s): Aspartate aminotransferase; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX:15598446:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7ed4d6709103a0e240381da7bea6ad93
ToxValDB_ECOTOX NOEL =4 mL/kg Rat oral short-term; 9 days short-term LONG_REF=J. Toxicol. Environ. Health10:267-276 Mankes,R.F., I. Rosenblum, K.F. Benitz, R. LeFevre, and R. Abraham Teratogenic and Reproductive Effects of Ethanol in Long-Evans Rats 1982; TITLE=Teratogenic and Reproductive Effects of Ethanol in Long-Evans Rats; AUTHOR=Mankes,R.F., I. Rosenblum, K.F. Benitz, R. LeFevre, and R. Abraham; DOI=10.1080/15287398209530249; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112708; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=Reproduction: Pregnant, Paris or Gravid; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598579_15601507_15601508:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=ed2f9e6ebccce2fd63cd03a3872ef825
ToxValDB_ECOTOX NOEL =8 % v/v Rat oral subchronic; 56 days subchronic LONG_REF=Pharmacol. Toxicol.76(2): 107-111 Nylen,P., M. Hagman, and A.C. Johnson Function of the Auditory System, the Visual System, and Peripheral Nerve and Long-Term Combined Exposure to Toluene and Ethanol in Rats 1995; TITLE=Function of the Auditory System, the Visual System, and Peripheral Nerve and Long-Term Combined Exposure to Toluene and Ethanol in Rats; AUTHOR=Nylen,P., M. Hagman, and A.C. Johnson; DOI=10.1111/j.1600-0773.1995.tb00113.x; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=52765; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Feeding behavior: Water consumption|Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598646_15609028:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=157d160f1cd8ef6c8ae521064678c035
ToxValDB_ECOTOX NOEL =5 % Rat oral short-term; 18 days developmental LONG_REF=Exp. Pathol. (Jena)25(4): 205-213 Jones,W.L., and D.B. Stewart Effects of Orally-Administered Ethanol on Mammary Gland Morphology and Functional Efficiency in Lactating Rats 1984; TITLE=Effects of Orally-Administered Ethanol on Mammary Gland Morphology and Functional Efficiency in Lactating Rats; AUTHOR=Jones,W.L., and D.B. Stewart; DOI=10.1016/s0232-1513(84)80022-5; QUALITY=Control type: Baseline control; EXTERNAL_SOURCE_ID=113117; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Development: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX:15598778:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=0f0d95951138dd91ced58a9c06b3e611
ToxValDB_ECOTOX NOEL =4000 mg/L Rat oral subchronic; 56 days subchronic LONG_REF=Alcohol16(2): 135-138 Cagiano,R., M. Tattoli, M. Persichella, M. Mazzoccoli, S. Govoni, and V. Cuomo Effects of Chronic Low-Dose Ethanol Intake on Sexual Behavior in Rats 1998; TITLE=Effects of Chronic Low-Dose Ethanol Intake on Sexual Behavior in Rats; AUTHOR=Cagiano,R., M. Tattoli, M. Persichella, M. Mazzoccoli, S. Govoni, and V. Cuomo; DOI=10.1016/s0741-8329(97)00182-1; QUALITY=Control type: Control outside of primary exposure system; EXTERNAL_SOURCE_ID=116873; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX:15599673:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=826d40ad7ebd2efe6062cc3090a29a93
ToxValDB_ECOTOX NOEL =8500 mg Mouse oral short-term; 28 days short-term LONG_REF=Alcohol Alcohol.32(5): 563-572 Cebral,E., A. Lasserre, V. Rettori, and M.A.F. De Gimeno Impaired Mouse Fertilization by Low Chronic Alcohol Treatment 1997; TITLE=Impaired Mouse Fertilization by Low Chronic Alcohol Treatment; AUTHOR=Cebral,E., A. Lasserre, V. Rettori, and M.A.F. De Gimeno; DOI=10.1093/oxfordjournals.alcalc.a008297; QUALITY=Control type: Control outside of primary exposure system; EXTERNAL_SOURCE_ID=116874; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Growth: Weight|Reproduction: Fertilization; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595538_15598190_15600014:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=62ebd015aba801d32909bf7b58d2e1ad
ToxValDB_ECOTOX NOEL =1250 mg/kg bw/day Rat oral short-term; 4.5 days short-term LONG_REF=Alcohol Alcohol.35(5): 439-445 Brzoska,M.M., J. Moniuszko-Jakoniuk, M. Jurczuk, M. Galazyn-Sidorczuk, and J. Rogalska Effect of Short-Term Ethanol Administration on Cadmium Retention and Bioelement Metabolism in Rats Continuously Exposed to Cadmium 2000; TITLE=Effect of Short-Term Ethanol Administration on Cadmium Retention and Bioelement Metabolism in Rats Continuously Exposed to Cadmium; AUTHOR=Brzoska,M.M., J. Moniuszko-Jakoniuk, M. Jurczuk, M. Galazyn-Sidorczuk, and J. Rogalska; DOI=10.1093/alcalc/35.5.439; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=85532; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Feeding behavior: Water consumption|Growth: Weight gain|Physiology: Excretion rate; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600252_15604207:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=94f3f8ecded6a41a9701c8d2ab4b81e3
ToxValDB_ECOTOX NOEL =2000 ppm Rat oral short-term; 5 days short-term LONG_REF=Biochem. Pharmacol.34(22): 3979-3982 Eriksson,C.J.P. Endogenous Acetaldehyde in Rats. Effects of Exogenous Ethanol, Pyrazole, Cyanamide and Disulfiram 1985; TITLE=Endogenous Acetaldehyde in Rats. Effects of Exogenous Ethanol, Pyrazole, Cyanamide and Disulfiram; AUTHOR=Eriksson,C.J.P.; DOI=10.1016/0006-2952(85)90375-2; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=99133; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=Biochemistry: Acetaldehyde|Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601244_15604577:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=746669d72c1094a43b0ee7b007a74e03
ToxValDB_ECOTOX NOEL =1240 mg/kg bw/day Mouse oral short-term; 5 days short-term LONG_REF=Steroids23(6): 921-928 Badr,F.M., and A. Bartke Effect of Ethyl Alcohol on Plasma Testosterone Level in Mice 1974; TITLE=Effect of Ethyl Alcohol on Plasma Testosterone Level in Mice; AUTHOR=Badr,F.M., and A. Bartke; DOI=10.1016/0039-128x(74)90064-6; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112967; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1974; ORIGINAL_YEAR=1974; TOXICOLOGICAL_EFFECT=Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601680_15602688_15602689:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4bf509f949d4ba14ceddf79e779d452b
ToxValDB_ECOTOX NOEL =2000 mg/kg bw/day Dog oral acute; 0.25 days acute LONG_REF=Toxicol. Appl. Pharmacol.18(3): 660-664 Reves,J.G., and W.H. Newman Blood Volume Following Acute Ethyl Alcohol Ingestion in Dogs 1971; TITLE=Blood Volume Following Acute Ethyl Alcohol Ingestion in Dogs; AUTHOR=Reves,J.G., and W.H. Newman; DOI=10.1016/s0041-008x(71)80020-0; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=113099; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1971; ORIGINAL_YEAR=1971; TOXICOLOGICAL_EFFECT=Biochemistry: Hematocrit (anemia)|Physiology: Volume; TOXICOLOGICAL_EFFECT_CATEGORY=hematology|other; STUDY_GROUP=ECOTOX:15601788:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=edf86fbd349134d814e490e8c42f7310
ToxValDB_ECOTOX NOEL =0.5 % Rat environmental short-term; 2 days short-term LONG_REF=Toxicology30(1): 45-57 Kitchin,K.T., and M.T. Ebron Further Development of Rodent Whole Embryo Culture: Solvent Toxicity and Water Insoluble Compound Delivery System 1984; TITLE=Further Development of Rodent Whole Embryo Culture: Solvent Toxicity and Water Insoluble Compound Delivery System; AUTHOR=Kitchin,K.T., and M.T. Ebron; DOI=10.1016/0300-483x(84)90061-1; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=115431; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Biochemistry: Protein content; TOXICOLOGICAL_EFFECT_CATEGORY=urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15602437_15602438:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=3f0b680b8e5a0d0acfeb3c5ad51839aa
ToxValDB_ECOTOX NOEL =155 mg/kg bw/day Mouse oral short-term; 5 days short-term LONG_REF=Steroids23(6): 921-928 Badr,F.M., and A. Bartke Effect of Ethyl Alcohol on Plasma Testosterone Level in Mice 1974; TITLE=Effect of Ethyl Alcohol on Plasma Testosterone Level in Mice; AUTHOR=Badr,F.M., and A. Bartke; DOI=10.1016/0039-128x(74)90064-6; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112967; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1974; ORIGINAL_YEAR=1974; TOXICOLOGICAL_EFFECT=Hormone(s): Testosterone; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601680_15602688_15602689:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8f74191dfc6498e439242773213b4c37
ToxValDB_ECOTOX NOEL =9504 mg/kg bw/day Dog injection acute; 0.125 days acute LONG_REF=Am. J. Physiol.267(5, Pt. 2): R1280 - R1287 Molina,P.E., K. Jabbour, P. Williams, and N.N. Abumrad Effect of Acute Ethanol Intoxication on Glucoregulation During Prolonged Insulin-Induced Hypoglycemia 1994; TITLE=Effect of Acute Ethanol Intoxication on Glucoregulation During Prolonged Insulin-Induced Hypoglycemia; AUTHOR=Molina,P.E., K. Jabbour, P. Williams, and N.N. Abumrad; DOI=10.1152/ajpregu.1994.267.5.R1280; QUALITY=Control type: Baseline control; EXTERNAL_SOURCE_ID=112704; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Biochemistry: Glucose|Hormone(s): Cortisol; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX:15603496:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=3e3f970bca0ef69fe118baf8c470bc0f
ToxValDB_ECOTOX NOEL =0.1 % v/v Mouse environmental short-term; 8 days developmental LONG_REF=J. Reprod. Fertil.80(1): 49-57 Wiebold,J.L., and W.C. Becker In-Vivo and In-Vitro Effects of Ethanol on Mouse Preimplantation Embryos 1987; TITLE=In-Vivo and In-Vitro Effects of Ethanol on Mouse Preimplantation Embryos; AUTHOR=Wiebold,J.L., and W.C. Becker; DOI=10.1530/jrf.0.0800049; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113118; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Development: Blastocyst stage; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX:15603581:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=98831727c27d1c97cb3ac3ac55b17832
ToxValDB_ECOTOX NOEL =3000 mg/kg bw/day Rat oral short-term; 7.2917 days short-term LONG_REF=Braz. J. Med. Biol. Res.26(11): 1241-1244 Guedes,R.C.A., and S.F. Frade Effect of Ethanol on Cortical Spreading Depression 1993; TITLE=Effect of Ethanol on Cortical Spreading Depression; AUTHOR=Guedes,R.C.A., and S.F. Frade; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=115287; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Physiology: Nerve conduction velocity; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX:15603685:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=718e306e65d6c3bf291f21423824cd33
ToxValDB_ECOTOX NOEL =2.5 % Mouse oral short-term; 28 days short-term LONG_REF=Alcohol Alcohol.32(5): 563-572 Cebral,E., A. Lasserre, V. Rettori, and M.A.F. De Gimeno Impaired Mouse Fertilization by Low Chronic Alcohol Treatment 1997; TITLE=Impaired Mouse Fertilization by Low Chronic Alcohol Treatment; AUTHOR=Cebral,E., A. Lasserre, V. Rettori, and M.A.F. De Gimeno; DOI=10.1093/oxfordjournals.alcalc.a008297; QUALITY=Control type: Control outside of primary exposure system; EXTERNAL_SOURCE_ID=116874; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Reproduction: Fertilization; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15603004_15603970:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=a1a6d599b5ee3de1aded85394e98e565
ToxValDB_ECOTOX NOEL =40 mg/kg bw/day Dog injection acute; 0.0042 days acute LONG_REF=Alcohol. Clin. Exp. Res.5(1): 56-63 Stratton,R., K.J. Dormer, and A.R. Zeiner The Cardiovascular Effects of Ethanol and Acetaldehyde in Exercising Dogs 1981; TITLE=The Cardiovascular Effects of Ethanol and Acetaldehyde in Exercising Dogs; AUTHOR=Stratton,R., K.J. Dormer, and A.R. Zeiner; DOI=10.1111/j.1530-0277.1981.tb04865.x; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=112741; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1981; ORIGINAL_YEAR=1981; TOXICOLOGICAL_EFFECT=Physiology: Heart rate; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX_dup_EPA ORD_15604075_15604076:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7de78534f409346eba8946244b4eccd7
ToxValDB_ECOTOX NOEL =3.6 % w/v Mouse oral short-term; 15 days reproduction developmental LONG_REF=J. Pharmacol. Exp. Ther.222(2): 294-300 Daniel,M.A., and M.A. Evans Quantitative Comparison of Maternal Ethanol and Maternal Tertiary Butanol Diet on Postnatal Development 1982; TITLE=Quantitative Comparison of Maternal Ethanol and Maternal Tertiary Butanol Diet on Postnatal Development; AUTHOR=Daniel,M.A., and M.A. Evans; QUALITY=Control type: Control outside of primary exposure system; EXTERNAL_SOURCE_ID=112707; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX:15604388:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=a22cedfb7c4ed6469744ff59680bd0a0
ToxValDB_ECOTOX NOEL =20928 mg/kg bw/day Rat oral subchronic; 49 days subchronic LONG_REF=Biosci. Biotechnol. Biochem.56(12): 2037-2040 Mochizuki,S., Y. Watanabe, K. Kato, and A. Yoshida Effects of Ethanol and Polychlorinated Biphenyls in Combination on Ascorbic Acid Metabolism, Liver Drug-Metabolizing Enzymes, and Lipid Metabolism in Rats 1992; TITLE=Effects of Ethanol and Polychlorinated Biphenyls in Combination on Ascorbic Acid Metabolism, Liver Drug-Metabolizing Enzymes, and Lipid Metabolism in Rats; AUTHOR=Mochizuki,S., Y. Watanabe, K. Kato, and A. Yoshida; DOI=10.1271/bbb.56.576; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=74769; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Feeding behavior: Food consumption|Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECOTOX_dup_EPA ORD_15604464_15605798:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d961b642257c534de8056766d29691d2
ToxValDB_ECOTOX NOEL =1500 mg/kg bw/day Rat injection acute; 0.0174 days acute LONG_REF=Neurotoxicol. Teratol.21(5): 551-557 Virgolini,M.B., L.M. Cancela, and S. Fulginiti Behavioral Responses to Ethanol in Rats Perinatally Exposed to Low Lead Levels 1999; TITLE=Behavioral Responses to Ethanol in Rats Perinatally Exposed to Low Lead Levels; AUTHOR=Virgolini,M.B., L.M. Cancela, and S. Fulginiti; DOI=10.1016/s0892-0362(99)00020-3; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=113348; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=Behavior: Activity, general; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX_dup_EPA ORD_15605082_15605083:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4c95e20f5bfb1a879606bfdbcd3974a1
ToxValDB_ECOTOX NOEL =65.4 mL Rat oral short-term; 19 days reproduction developmental LONG_REF=Alcohol33(2): 83-89 Peres,W.A.F., M.G.T. Carmo, S. Zucoloto, A.C. Iglesias, and V.B. Braulio Ethanol Intake Inhibits Growth of the Epithelium in the Intestine of Pregnant Rats 2004; TITLE=Ethanol Intake Inhibits Growth of the Epithelium in the Intestine of Pregnant Rats; AUTHOR=Peres,W.A.F., M.G.T. Carmo, S. Zucoloto, A.C. Iglesias, and V.B. Braulio; DOI=10.1016/j.alcohol.2004.05.001; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113181; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Growth: Weight gain|Physiology: Digestion|Reproduction: Progeny counts/numbers; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|reproduction; STUDY_GROUP=ECOTOX:15605214:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7d8e0120949824aee6734a7d42f14caa
ToxValDB_ECOTOX NOEL =800 mg/100 mL Mouse environmental short-term; 3 days developmental LONG_REF=Experientia45(5): 484-487 Kalmus,G.W., and C.C. Buckenmaier III Effects of Ethanol and Acetaldehyde on Cultured Pre-Implantation Mouse Embryos 1989; TITLE=Effects of Ethanol and Acetaldehyde on Cultured Pre-Implantation Mouse Embryos; AUTHOR=Kalmus,G.W., and C.C. Buckenmaier III; DOI=10.1007/BF01952040; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112963; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Development: Stage; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX:15605635:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=a7829ad2e9a6d183779fd5d0b8a2844d
ToxValDB_ECOTOX NOEL =5 mL/kg bw Mouse oral acute; 1 days acute LONG_REF=J. Toxicol. Environ. Health18(4): 575-587 Lin,S.C., H. Saito, T. Yohro, and J. Shiga Acute Hepatotoxicity Induced by Hepatotoxins in Suncus murinus 1986; TITLE=Acute Hepatotoxicity Induced by Hepatotoxins in Suncus murinus; AUTHOR=Lin,S.C., H. Saito, T. Yohro, and J. Shiga; DOI=10.1080/15287398609530895; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=112721; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=Enzyme(s): Alanine transaminase (ALT); TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX_dup_EPA ORD_15606994_15606995_15606996:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=929bb90355eccf0a97d7d71f87d05bbb
ToxValDB_ECOTOX NOEL =2 % w/v Mouse oral short-term; 18 days developmental LONG_REF=Toxicology242(1-3): 109-122 Huang,L.H., N.H. Shiao, Y.D. Hsuuw, and W.H. Chan Protective Effects of Resveratrol on Ethanol-Induced Apoptosis in Embryonic Stem Cells and Disruption of Embryonic Development in Mouse Blastocysts 2007; TITLE=Protective Effects of Resveratrol on Ethanol-Induced Apoptosis in Embryonic Stem Cells and Disruption of Embryonic Development in Mouse Blastocysts; AUTHOR=Huang,L.H., N.H. Shiao, Y.D. Hsuuw, and W.H. Chan; DOI=10.1016/j.tox.2007.09.015; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=107979; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=Development: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX:15607035:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=de7ed87d87d0783fea15430e88953eea
ToxValDB_ECOTOX NOEL =500 mg/kg bw/day Dog injection acute; 0.0208 days acute LONG_REF=Anesth. Analg.96(3): 665-672 Weber,T.P., M.A.G. Hartlage, N. Rolf, M. Booke, E. Berendes, H. Van Aken, and A. Meissner Short-Term Administration of Ethanol does Not Affect Functional Recovery from Myocardial Stunning in Awake Dogs 2003; TITLE=Short-Term Administration of Ethanol does Not Affect Functional Recovery from Myocardial Stunning in Awake Dogs; AUTHOR=Weber,T.P., M.A.G. Hartlage, N. Rolf, M. Booke, E. Berendes, H. Van Aken, and A. Meissner; DOI=10.1213/01.ANE.0000048712.95074.CD; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=113175; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=Physiology: Blood pressure; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX:15607241:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e333ba8b772232856bde13a43b6aeedf
ToxValDB_ECOTOX NOEL =4.8 g/L Mouse environmental short-term; 2 days developmental LONG_REF=Neurotoxicol. Teratol.17(4): 497-506 Van Maele-Fabry,G., F. Gofflot, F. Clotman, and J.J. Picard Alterations of Mouse Embryonic Branchial Nerves and Ganglia Induced by Ethanol 1995; TITLE=Alterations of Mouse Embryonic Branchial Nerves and Ganglia Induced by Ethanol; AUTHOR=Van Maele-Fabry,G., F. Gofflot, F. Clotman, and J.J. Picard; DOI=10.1016/0892-0362(95)00009-g; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=55098; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Development: Organ/tissue formation; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX:15607265:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=86c49e053ca5623c17b54a2e1e95bf0c
ToxValDB_ECOTOX NOEL =200 mg/100 mL Rat environmental short-term; 2 days short-term LONG_REF=Biochem. Pharmacol.31(22): 3641-3643 Priscott,P.K. The Effects of Ethanol on Rat Embryos Developing In Vitro 1982; TITLE=The Effects of Ethanol on Rat Embryos Developing In Vitro; AUTHOR=Priscott,P.K.; DOI=10.1016/0006-2952(82)90588-3; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112969; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=Morphology: Length; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15607345_15607346:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=93c085a774a0ca2b75d3d4066ee41ea4
ToxValDB_ECOTOX NOEL =390 mg/100 mL Rat environmental short-term; 2 days developmental LONG_REF=Biochem. Pharmacol.31(22): 3641-3643 Priscott,P.K. The Effects of Ethanol on Rat Embryos Developing In Vitro 1982; TITLE=The Effects of Ethanol on Rat Embryos Developing In Vitro; AUTHOR=Priscott,P.K.; DOI=10.1016/0006-2952(82)90588-3; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112969; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=Development: Stage; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX_dup_EPA ORD_15608138_15608139:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1c151691308d8909e58eafa7547e5af9
ToxValDB_ECOTOX NOEL =5000 mg/kg bw/day Mouse oral short-term; 3 days short-term LONG_REF=Toxicol. Appl. Pharmacol.74(2): 230-236 Waalkes,M.P., J.J. Hjelle, and C.D. Klaassen Transient Induction of Hepatic Metallothionein Following Oral Ethanol Administration 1984; TITLE=Transient Induction of Hepatic Metallothionein Following Oral Ethanol Administration; AUTHOR=Waalkes,M.P., J.J. Hjelle, and C.D. Klaassen; DOI=10.1016/0041-008x(84)90147-9; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=87717; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15608653:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=80c61be7bf575c338e8889f1c020406c
ToxValDB_ECOTOX NOEL =5.5 mL/kg bw Mouse oral short-term; 8 days developmental LONG_REF=Dev. Pharmacol. Ther.11(4): 237-242 Kennedy,L.A., S. Mukerji, and B. Bhaumick Mouse Placental Receptor for Basic Somatomedin Following Maternal Ethanol Administration 1988; TITLE=Mouse Placental Receptor for Basic Somatomedin Following Maternal Ethanol Administration; AUTHOR=Kennedy,L.A., S. Mukerji, and B. Bhaumick; DOI=10.1159/000457694; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112739; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=Development: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX_dup_EPA ORD_15610158_15610159:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=64a5a3d9b4400e23443378d9d2556c79
ToxValDB_ECOTOX NOEL =4 mg/mL Mouse environmental short-term; 2 days short-term LONG_REF=Toxicol. In Vitro18(5): 601-607 Jing,H., and Y. Li Effects of Ethanol on Mouse Embryonic Brain Development and Heat Shock Protein 73 Expression 2004; TITLE=Effects of Ethanol on Mouse Embryonic Brain Development and Heat Shock Protein 73 Expression; AUTHOR=Jing,H., and Y. Li; DOI=10.1016/j.tiv.2004.02.004; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=116709; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Biochemistry: Heat shock protein 70; STUDY_GROUP=ECOTOX:15610249:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f1fc0786e10a495ef2eb593e6dd36ad1
ToxValDB_ECOTOX NOEL =1 % Mouse oral subchronic; 70 days subchronic LONG_REF=Toxicol. Appl. Pharmacol.220(3): 302-310 Wahl,E.C., J. Aronson, L. Liu, Z. Liu, D.S. Perrien, R.A. Skinner, T.M. Badger, M.J.J. Ronis, and C.K.,Jr. Lumpkin Chronic Ethanol Exposure Inhibits Distraction Osteogenesis in a Mouse Model: Role of the TNF Signaling Axis 2007; TITLE=Chronic Ethanol Exposure Inhibits Distraction Osteogenesis in a Mouse Model: Role of the TNF Signaling Axis; AUTHOR=Wahl,E.C., J. Aronson, L. Liu, Z. Liu, D.S. Perrien, R.A. Skinner, T.M. Badger, M.J.J. Ronis, and C.K.,Jr. Lumpkin; DOI=10.1016/j.taap.2007.02.011; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113160; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15610815_15610967:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=0fa022030b5981bd5e7ce175d2a88649
ToxValDB_ECOTOX NOEL =2.97 g/org-day Rat oral short-term; 28 days reproduction developmental LONG_REF=J. Pharmacobio-Dyn.6(12): 913-921 Terada,N., T. Nakai, M. Yamaguchi, A. Hatta, K. Arizono, and T. Ariyoshi Influences of Maternal Ethanol Intake on Maternal and Perinatal Hepatic Heme and Drug Metabolizing Enzymes in Rats 1983; TITLE=Influences of Maternal Ethanol Intake on Maternal and Perinatal Hepatic Heme and Drug Metabolizing Enzymes in Rats; AUTHOR=Terada,N., T. Nakai, M. Yamaguchi, A. Hatta, K. Arizono, and T. Ariyoshi; DOI=10.1248/bpb1978.6.913; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113098; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=Enzyme(s): Cytochrome P-450|Growth: Weight|Morphology: Organ weight in relationship to body weight|Reproduction: Progeny counts/numbers; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|enzyme activity|organ weight|reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15610849_15610990_15611092:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8c2568334bb7d66cfecd9cfd007ce841
ToxValDB_ECOTOX NOEL =12 % Rat oral subchronic; 34 days subchronic LONG_REF=Arch. Toxicol.55(4): 258-264 Elves,R.G., T.H. Ueng, and A.P. Alvares Comparative Effects of Ethanol Administration on Hepatic Monooxygenases in Rats and Mice 1984; TITLE=Comparative Effects of Ethanol Administration on Hepatic Monooxygenases in Rats and Mice; AUTHOR=Elves,R.G., T.H. Ueng, and A.P. Alvares; DOI=10.1007/BF00341022; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=105811; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Biochemistry: Microsomal proteins|Enzyme(s): Cytochrome P-450|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity|organ weight|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15610859_15610888:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=44df1eb75bf9435a9496e32c14edf737
ToxValDB_ECOTOX NOEL =25000 mg/kg bw/day Mouse oral subchronic; 45 days subchronic LONG_REF=Biochem. Pharmacol.36(13): 2157-2167 Anderson,R.A.,Jr., B.R. Willis, J.F. Phillips, C. Oswald, and L.J.D. Zaneveld Delayed Pubertal Development of the Male Reproductive Tract Associated with Chronic Ethanol Ingestion 1987; TITLE=Delayed Pubertal Development of the Male Reproductive Tract Associated with Chronic Ethanol Ingestion; AUTHOR=Anderson,R.A.,Jr., B.R. Willis, J.F. Phillips, C. Oswald, and L.J.D. Zaneveld; DOI=10.1016/0006-2952(87)90145-6; QUALITY=Control type: Control outside of primary exposure system; EXTERNAL_SOURCE_ID=116882; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Biochemistry: Fructose|Cell(s): Number of cells|Enzyme(s): Acid phosphatase|Reproduction: Fertility; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity|nonneoplastic histopathology|other|reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15610861_15610884:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=309984ed8a7faad05481acac9d5317cf
ToxValDB_ECOTOX NOEL =2 % v/v Rat oral short-term (developmental); 20 days developmental LONG_REF=Pediatr. Res.19(1): 12-14 Inselman,L.S., S.E. Fisher, H. Spencer, and M. Atkinson Effect of Intrauterine Ethanol Exposure on Fetal Lung Growth 1985; TITLE=Effect of Intrauterine Ethanol Exposure on Fetal Lung Growth; AUTHOR=Inselman,L.S., S.E. Fisher, H. Spencer, and M. Atkinson; DOI=10.1203/00006450-198501000-00004; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113116; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=Growth: Weight gain|Reproduction: Viability; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15610877_15610937:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=81cbdfd4576428f07192a9be7d037e99
ToxValDB_ECOTOX NOEL =4 % Mouse oral short-term; 29 days reproduction developmental LONG_REF=Behav. Brain Funct.1(5): 1-10 Sluyter,F., L. Jamot, J.Y. Bertholet, and W.E. Crusio Prenatal Exposure to Alcohol does not Affect Radial Maze Learning and Hippocampal Mossy Fiber Sizes in Three Inbred Strains of Mouse 2005; TITLE=Prenatal Exposure to Alcohol does not Affect Radial Maze Learning and Hippocampal Mossy Fiber Sizes in Three Inbred Strains of Mouse; AUTHOR=Sluyter,F., L. Jamot, J.Y. Bertholet, and W.E. Crusio; DOI=10.1186/1744-9081-1-5; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=113168; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Reproduction: Reproductive success (general); TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15610898_15611094:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5465d8f8ca85bd741890d4c9a301c19a
ToxValDB_ECOTOX NOEL =2.4 % v/v Mouse oral subchronic; 37 days reproduction developmental LONG_REF=Alcohol. Clin. Exp. Res.30(10): 1791-1798 Parnell,S.E., D.B. Dehart, T.A. Wills, S.Y. Chen, C.W. Hodge, J. Besheer, H.G. Waage-Baudet, M.E. Charness, and K.K. Su Maternal Oral Intake Mouse Model for Fetal Alcohol Spectrum Disorders: Ocular Defects as a Measure of Effect 2006; TITLE=Maternal Oral Intake Mouse Model for Fetal Alcohol Spectrum Disorders: Ocular Defects as a Measure of Effect; AUTHOR=Parnell,S.E., D.B. Dehart, T.A. Wills, S.Y. Chen, C.W. Hodge, J. Besheer, H.G. Waage-Baudet, M.E. Charness, and K.K. Su; DOI=10.1111/j.1530-0277.2006.00212.x; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=113183; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=Reproduction: Resorbed embryos; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECOTOX:15610964:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d1a51f7602a1d14ca87cfb0cf6ffefbd
ToxValDB_ECOTOX NOEL =2.8 g/org-day Rat oral short-term; 28 days reproduction developmental LONG_REF=J. Pharmacobio-Dyn.6(12): 913-921 Terada,N., T. Nakai, M. Yamaguchi, A. Hatta, K. Arizono, and T. Ariyoshi Influences of Maternal Ethanol Intake on Maternal and Perinatal Hepatic Heme and Drug Metabolizing Enzymes in Rats 1983; TITLE=Influences of Maternal Ethanol Intake on Maternal and Perinatal Hepatic Heme and Drug Metabolizing Enzymes in Rats; AUTHOR=Terada,N., T. Nakai, M. Yamaguchi, A. Hatta, K. Arizono, and T. Ariyoshi; DOI=10.1248/bpb1978.6.913; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113098; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=Enzyme(s): Cytochrome P-450|Growth: Weight|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|enzyme activity|organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15610849_15610990_15611092:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=0b9006a39cc4b8013785b2a6549139dd
ToxValDB_ECOTOX NOEL =2.5 % w/v Rat oral subchronic; 55 days subchronic LONG_REF=Anat. Rec.202:255-260 Bo,W.J., W.A. Krueger, P.K. Rudeen, and S.K. Symmes Ethanol-Induced Alterations in the Morphology and Function of the Rat Ovary 1982; TITLE=Ethanol-Induced Alterations in the Morphology and Function of the Rat Ovary; AUTHOR=Bo,W.J., W.A. Krueger, P.K. Rudeen, and S.K. Symmes; DOI=10.1002/ar.1092020210; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=112426; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=Growth: Weight|Morphology: Organ weight in relationship to body weight|Reproduction: Vaginal opening; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|organ weight|reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15611236_15611237:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7bdbb42a9f24c3f33c199dee3be5d753
ToxValDB_ECOTOX NOEL =6000 ppm Rat oral chronic; 97 days reproduction developmental LONG_REF=Alcohol Alcohol.37(1): 30-37 Ren,J., L.E. Wold, M. Natavio, B.H. Ren, J.H. Hannigan, and R.A. Brown Influence of Prenatal Alcohol Exposure on Myocardial Contractile Function in Adult Rat Hearts: Role of Intracellular Calcium and Apoptosis 2002; TITLE=Influence of Prenatal Alcohol Exposure on Myocardial Contractile Function in Adult Rat Hearts: Role of Intracellular Calcium and Apoptosis; AUTHOR=Ren,J., L.E. Wold, M. Natavio, B.H. Ren, J.H. Hannigan, and R.A. Brown; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112952; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Cell(s): Length|Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15611316_15611352:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=71750935ad2afedda90b3f232ba1289a
ToxValDB_ECOTOX NOEL =10000 mg/kg bw/day Rat oral chronic; 8 months chronic LONG_REF=- | Toxicol. Lett.32(1-2): 9-18 Opacka,J., B. Opalska, J. Kolakowski, and T. Wronska-Nofer Neurotoxic Effects of the Combined Exposure to Carbon Disulphide and Ethanol in Rats 1986; TITLE=Neurotoxic Effects of the Combined Exposure to Carbon Disulphide and Ethanol in Rats; AUTHOR=Opacka,J., B. Opalska, J. Kolakowski, and T. Wronska-Nofer; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98049; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=Biochemistry: Protein content|Enzyme(s): beta-Glucuronidase | body weight changes, cerebtal cortex and hippocampus weight changes | morphological changes; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity|gross pathology|multiple|urinalysis; STUDY_GROUP=ECOTOX:15613600:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=8d55828b2c219e719d8a8be30d780d9d
ToxValDB_EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA NOAEL =1730 mg/kg bw/day Rat oral subchronic; 90 days subchronic LONG_REF=EFSA FEEDAP (2013). Scientific Opinion on the safety and efficacy of straight-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing saturated alcohols and acetals containing saturated aldehydes (chemical group 1) when used as flavourings for all animal species. doi:10.2903/j.efsa.2013.3169.; TITLE=Scientific Opinion on the safety and efficacy of straight-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing saturated alcohols and acetals containing saturated aldehydes (chemical group 1) when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2013.3169; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=organ weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=EFSA:15614461:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_76496917e94830382939ce57e1d2ae9f
ToxValDB_GESTIS_DNEL 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =950 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15631874_15631875:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7de786ce8b8e31db3d78e4150cce7985
ToxValDB_GESTIS_DNEL DNEL systemic =380 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15631874_15631875:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e3350f95f32fc5ebfa7c2355230e7780
ToxValDB_HPVIS 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_HPVIS LOAEL =3600 mg/kg bw/day Mouse oral - reproduction developmental LONG_REF=Wier, P., Lewis, S., and Traul, K. (1987). A comparison of developmental toxicity evident at term to postnatal growth and survival using ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, and ethanol. Teratogen. Carcinogen. Mutagen. 7:55-64.; TITLE=A comparison of developmental toxicity evident at term to postnatal growth and survival using ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, and ethanol; AUTHOR=Wier, P., Lewis, S., and Traul, K; EXTERNAL_SOURCE_ID=57816; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1987; ORIGINAL_YEAR=1987; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Devtox_15642265_15642628:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a1e0a9e793b996cc001cdd0916176a47
ToxValDB_HPVIS LOAEL =37684.4 mg/m3 Rat inhalation short-term; 19 days reproduction developmental LONG_REF=Nelson, B., Brightwell, W., MacKenzie, D., et al. (1985). Teratological assessment of methanol and ethanol at high inhalation levels in rats. Fundam. Appl. Toxicol. 5:727-736.; TITLE=Teratological assessment of methanol and ethanol at high inhalation levels in rats; AUTHOR=Nelson, B., Brightwell, W., MacKenzie, D., et al; EXTERNAL_SOURCE_ID=59772; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Devtox_15642737_15642855:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_58c009f9b3b1f70d24675bdb9d8bca22
ToxValDB_HPVIS LOAEL >15 % diet Mouse oral chronic; 105 days reproduction developmental LONG_REF=George, J., Myers, C., Reel, J., et al. (1985). Ethanol: Reproduction and fertility assessment in CD-2 mice when administered in the drinking water. National Toxicology Program. PB86144979An abstract of the ethanol is presented by Lamb, J., George, J., Reel, J.. et al. (1997). Environ. 1 health Perspect. 105 Suppl. 1 :309-310. Results of all 48 chemical tests, and a review of the continuous breeding protocol, are published by Morrissey, R., Lamb, J., Morris, R., et al.(1989). Fundam. Appl. Toxicol. 13:747-777.; EXTERNAL_SOURCE_ID=65445; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480598; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Reprotox_15643236_15643374:-:F2offspring; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f4cb9c5931d17e56f62d569c51a39ba2
ToxValDB_HPVIS NOAEL =2 % diet Rat oral subchronic; 90 days subchronic LONG_REF=Holmberg, B., Kronevi, T., and Ekner, A. (1986). Subchronic toxicity investigation of ethyl alcohol: a test for lowest effective dose (led) to be used in a long-term bioassay for carcinogenicity. National Board of Occupational Safety and Health, Solna, Sweden.; TITLE=Subchronic toxicity investigation of ethyl alcohol: a test for lowest effective dose (led) to be used in a long-term bioassay for carcinogenicity; AUTHOR=Holmberg, B., Kronevi, T., and Ekner, A; EXTERNAL_SOURCE_ID=60570; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639621_15639701_15639926_15640027:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_31958733c916f48bb47716f67de10c72
ToxValDB_HPVIS NOAEL >=6400 mg/kg bw/day Mouse oral - developmental LONG_REF=Wier, P., Lewis, S., and Traul, K. (1987). A comparison of developmental toxicity evident at term to postnatal growth and survival using ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, and ethanol. Teratogen. Carcinogen. Mutagen. 7:55-64.; TITLE=A comparison of developmental toxicity evident at term to postnatal growth and survival using ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, and ethanol; AUTHOR=Wier, P., Lewis, S., and Traul, K; EXTERNAL_SOURCE_ID=58567; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1987; ORIGINAL_YEAR=1987; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Devtox_15642494_15642495:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1bf8ff9420ecef81ec2ca7a757d84604
ToxValDB_HPVIS NOAEL =2200 mg/kg bw/day Mouse oral - reproduction developmental LONG_REF=Wier, P., Lewis, S., and Traul, K. (1987). A comparison of developmental toxicity evident at term to postnatal growth and survival using ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, and ethanol. Teratogen. Carcinogen. Mutagen. 7:55-64.; TITLE=A comparison of developmental toxicity evident at term to postnatal growth and survival using ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, and ethanol; AUTHOR=Wier, P., Lewis, S., and Traul, K; EXTERNAL_SOURCE_ID=58965; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1987; ORIGINAL_YEAR=1987; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Devtox_15642265_15642628:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_20da063a520b4a7b4b8efdaacc693861
openFDA substances 20 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 7528N5H79B UNII - - - specifiedSubstanceG1 {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"specifiedSubstanceG1","unii_code":"7528N5H79B"}
openFDA substances FDA UNII substance identifier 3K9958V90M UNII - - - chemical {"approval_status":null,"molecular_formula":"C2H6O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3K9958V90M"}
openFDA substances FDA UNII substance identifier 3K9958V90M UNII - - - chemical {"approval_status":null,"molecular_formula":"C2H6O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3K9958V90M"}
openFDA substances FDA UNII substance identifier 3K9958V90M UNII - - - chemical {"approval_status":null,"molecular_formula":"C2H6O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3K9958V90M"}
openFDA substances FDA UNII substance identifier concept identifier - - - concept {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"concept","unii_code":null}
openFDA substances FDA UNII substance identifier 7528N5H79B UNII - - - specifiedSubstanceG1 {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"specifiedSubstanceG1","unii_code":"7528N5H79B"}
openFDA substances FDA UNII substance identifier 7528N5H79B UNII - - - specifiedSubstanceG1 {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"specifiedSubstanceG1","unii_code":"7528N5H79B"}
openFDA substances FDA UNII substance identifier 3K9958V90M UNII - - - chemical {"approval_status":null,"molecular_formula":"C2H6O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3K9958V90M"}
openFDA substances FDA UNII substance identifier 3K9958V90M UNII - - - chemical {"approval_status":null,"molecular_formula":"C2H6O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3K9958V90M"}
openFDA substances FDA UNII substance identifier 3K9958V90M UNII - - - chemical {"approval_status":null,"molecular_formula":"C2H6O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3K9958V90M"}
openFDA substances FDA UNII substance identifier 3K9958V90M UNII - - - chemical {"approval_status":null,"molecular_formula":"C2H6O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3K9958V90M"}
openFDA substances FDA UNII substance identifier 3K9958V90M UNII - - - chemical {"approval_status":null,"molecular_formula":"C2H6O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3K9958V90M"}
openFDA substances FDA UNII substance identifier 3K9958V90M UNII - - - chemical {"approval_status":null,"molecular_formula":"C2H6O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3K9958V90M"}
openFDA substances FDA UNII substance identifier 7528N5H79B UNII - - - specifiedSubstanceG1 {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"specifiedSubstanceG1","unii_code":"7528N5H79B"}
openFDA substances FDA UNII substance identifier 3K9958V90M UNII - - - chemical {"approval_status":null,"molecular_formula":"C2H6O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3K9958V90M"}
openFDA substances FDA UNII substance identifier 3K9958V90M UNII - - - chemical {"approval_status":null,"molecular_formula":"C2H6O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3K9958V90M"}
openFDA substances FDA UNII substance identifier 3K9958V90M UNII - - - chemical {"approval_status":null,"molecular_formula":"C2H6O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3K9958V90M"}
openFDA substances FDA UNII substance identifier concept identifier - - - concept {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"concept","unii_code":null}
openFDA substances FDA UNII substance identifier concept identifier - - - concept {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"concept","unii_code":null}
openFDA substances FDA UNII substance identifier concept identifier - - - concept {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"concept","unii_code":null}