NOAEL Studies Cosmetic Ingredient

Adipic Acid NOAEL Studies

INCI: ADIPIC ACID

CAS: 124-04-9

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 9 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 500 mg/kg bw/day rat oral 730 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 440 mg/kg bw/day rat oral 28 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 8000 mg/kg bw/day rat oral 231 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 3400 mg/kg bw/day rat oral 28 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 2400 mg/kg bw/day rat oral 28 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 263 mg/kg bw/day mouse oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 288 mg/kg bw/day rat oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 205 mg/kg bw/day hamster oral 5 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 250 mg/kg bw/day rabbit oral 13 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 >11000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_1901; row=11690; data_type=In Vivo; mixture=Chemical; chemical_name=Hexanedioic acid; preferred_name=Hexanedioic acid; dtxsid=DTXSID7021605; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021605; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7021605; source_file=acute_oral.xlsx
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=10334; RecordID=ARPathway2016_728; DatasetName=ARPathway2016; DTXSID=DTXSID7021605; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021605; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7021605
ToxValDB_ECHA_IUCLID 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL >3750 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9d8e4b0a7c65d1b30c5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15464/7/8?documentUUID=3b03eedd-9bf0-4895-b2ae-a1728402f8b9; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816831_15817788:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_cd788b84832127ede9b90f9f043414d3
ToxValDB_ECHA_IUCLID NOAEL >750 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9d8e4b0a7c65d1b30c5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15464/7/8?documentUUID=3b03eedd-9bf0-4895-b2ae-a1728402f8b9; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816832_15817789:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f854f20a7da80d95b045f96cf2671eb1
ToxValDB_ECHA_IUCLID NOAEL >=250 mg/kg bw/day Rabbit oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabd2e4b0a7c65d1bbec8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15464/7/9/3?documentUUID=3b03eedd-9bf0-4895-b2ae-a1728402f8b9; STUDY_GROUP=ECHA IUCLID:15820915:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_47dc15ddc3b543b7e6eea7889c9b1b99
ToxValDB_ECHA_IUCLID NOAEL >=288 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabd2e4b0a7c65d1bbed2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15464/7/9/3?documentUUID=3b03eedd-9bf0-4895-b2ae-a1728402f8b9; STUDY_GROUP=ECHA IUCLID:15821164:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_860aa409e2cc3eeb71e09dc82fce4700
ToxValDB_ECHA_IUCLID NOAEL >=263 mg/kg bw/day Mouse oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabd2e4b0a7c65d1bbed4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15464/7/9/3?documentUUID=3b03eedd-9bf0-4895-b2ae-a1728402f8b9; STUDY_GROUP=ECHA IUCLID:15821228:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c3c70b7c2bfa15d86087c20ccdec48cd
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =74.1 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15629504:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1bc0b65f0bcd278ae9582b20a2099b9b
ToxValDB_PPRTV_(CPHEA) 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_PPRTV_(CPHEA) NOAEL =470 mg/kg bw/day Rat oral chronic; 2 years chronic LONG_REF=Horn et al. 1957; AUTHOR=Horn et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754d6e4b08a6b3934b7e5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1767; TOXICOLOGICAL_EFFECT=reduced body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=PPRTV (CPHEA):15654090:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b9dc0e30f830829749fef20e2534c76f
ToxValDB_PPRTV_(CPHEA) RfD (provisional) =2 mg/kg bw/day Human oral - Toxicity Value LONG_REF=Horn et al. 1957; AUTHOR=Horn et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754d6e4b08a6b3934b7e5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1767; TOXICOLOGICAL_EFFECT=Decreased body weight in male/female rats; STUDY_GROUP=PPRTV (CPHEA)_dup_PPRTV Summary_15653811_15653812:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7f77f1e9a875a73ce215af2906c317ca
ToxValDB_WHO_JECFA_ADI 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_WHO_JECFA_ADI ADI <=5 mg/kg Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650af6c3e4b0d99f5a875ad9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/194; YEAR=1999; ORIGINAL_YEAR=1999; STUDY_GROUP=WHO JECFA ADI:15715265:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2596eae0ed7babc60ddc8ad5d52f8230
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 76A0JE0FKJ UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H10O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"76A0JE0FKJ"}
openFDA substances FDA UNII substance identifier 76A0JE0FKJ UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H10O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"76A0JE0FKJ"}
openFDA substances FDA UNII substance identifier 76A0JE0FKJ UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H10O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"76A0JE0FKJ"}
openFDA substances FDA UNII substance identifier 76A0JE0FKJ UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H10O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"76A0JE0FKJ"}