NOAEL Studies
Cosmetic Ingredient
Adipic Acid Dihydrazide NOAEL Studies
INCI: ADIPIC ACID DIHYDRAZIDE
CAS: 1071-93-8
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP ICE acute oral 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | >2000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_672; row=1415; data_type=In Vivo; mixture=Chemical; chemical_name=Hexanedihydrazide; preferred_name=Hexanedihydrazide; dtxsid=DTXSID0044361; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0044361; source_file=acute_oral.xlsx |
NTP ICE adme parameters 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE adme parameters | Clint | 0.6018 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=325; Record_ID=adme_parameters_1122; Data_Type=Measured; DTXSID=DTXSID0044361; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=0.6018; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Paini 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0044361 |
| NTP ICE adme parameters | Fu | 0.9601 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=326; Record_ID=adme_parameters_1122; Data_Type=Measured; DTXSID=DTXSID0044361; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.9601; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Paini 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0044361 |
ECHA 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | NOAEL | =100 | mg/kg bw/day | Rat | oral | - | developmental | GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabb9e4b0a7c65d1bb6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13483/7/9/3?documentUUID=75ce9621-bca4-447f-af1a-16301182e55c; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=fetus: fetal/pup body weight changes; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15821878:M:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e5a3f017e12fb7de50ba9dbe173835b0 |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =17.5 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15629505:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_295dad86e31213a70fb7060fd3fdf7b2 |
ToxValDB HESS 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB HESS | NOEL | =85 | mg/kg bw/day | Rat | oral | - | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0de5e4b0a676289de499; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Clinical Observation: Emaciation R Incontinence of urine R Diarrhea R Loose stool R |Relative Organ Weight: Thymus increase, Kidney increase; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|organ weight; STUDY_GROUP=HESS:15638549:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_06286b86efa596b62b77f2fe25adb62c |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | VK98I9YW5M | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H14N4O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"VK98I9YW5M"} |
| openFDA substances | FDA UNII substance identifier | VK98I9YW5M | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H14N4O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"VK98I9YW5M"} |
| openFDA substances | FDA UNII substance identifier | VK98I9YW5M | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H14N4O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"VK98I9YW5M"} |
| openFDA substances | FDA UNII substance identifier | VK98I9YW5M | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H14N4O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"VK98I9YW5M"} |