Is Acrylamidopropyltrimonium Chloride safe in cosmetics?
Acrylamidopropyltrimonium Chloride has a safety rating of "GOOD" in our database. EU status: prohibited. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Acrylamidopropyltrimonium Chloride
Also known as: (3-Acrylamidopropyl)trimethylammonium Chloride
INCI: ACRYLAMIDOPROPYLTRIMONIUM CHLORIDE
Acrylamidopropyltrimonium Chloride (CAS 45021-77-0) is a cosmetic cosmetic ingredient functioning as Antistatic, hair fixing. NOAEL 200 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 45021-77-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Acrylamidopropyltrimonium Chloride is prohibited in EU cosmetics but has active industrial GHS classifications (H412).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Antistatic, hair fixing
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
trimethyl-[3-(prop-2-enoylamino)propyl]azanium chloride
InChIKey
OEIXGLMQZVLOQX-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Permitted; CIR-reviewed — safe as used with acrylamide monomer ≤5 ppm
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Acrylamidopropyltrimonium Chloride.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Acrylamidopropyltrimonium Chloride. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =1000 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =3000 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Acrylamidopropyltrimonium Chloride across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
No specific technical function
Expert Verdict
Expert safety assessment and concern-level summary for Acrylamidopropyltrimonium Chloride.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Acrylamidopropyltrimonium Chloride by CAS number or substance name.
Studies
2
Lowest NOAEL
1000 mg/kg bw/day
Highest NOAEL
3000 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
(3-Acrylamidopropyl)trimethylammonium Chloride
Chemical Function
No specific technical function
Frequently Asked Questions
Is Acrylamidopropyltrimonium Chloride allowed in the EU?
Acrylamidopropyltrimonium Chloride EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Acrylamidopropyltrimonium Chloride do in cosmetics?
Acrylamidopropyltrimonium Chloride functions as: Antistatic, hair fixing. It is classified as a cosmetic ingredient in our database. CAS number: 45021-77-0.
What is the NOAEL for Acrylamidopropyltrimonium Chloride?
The NOAEL (No Observed Adverse Effect Level) for Acrylamidopropyltrimonium Chloride is =1000 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Acrylamidopropyltrimonium Chloride used outside cosmetics?
Acrylamidopropyltrimonium Chloride also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Acrylamidopropyltrimonium Chloride have different safety status in cosmetics vs industrial chemicals?
Acrylamidopropyltrimonium Chloride is prohibited in EU cosmetics but has active industrial GHS classifications (H412).
Compliance Tools
Check Acrylamidopropyltrimonium Chloride compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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