Is Acid Blue 9 Ammonium Salt safe in cosmetics?
Acid Blue 9 Ammonium Salt has a safety rating of "GOOD" in our database. EU status: permitted. US status: restricted.
Good
Cosmetic Ingredient
Acid Blue 9 Ammonium Salt
Also known as: A.F. Blue No. 1, C.I. Direct Brown 78, C.I. Direct Brown 78, Diammonium Salt, H.K. Formula No. K. 7117, Acid Blue 9 (+15 more)
INCI: ACID BLUE 9 AMMONIUM SALT
Acid Blue 9 Ammonium Salt (CAS 2650-18-2) is a cosmetic cosmetic ingredient functioning as Colorant. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 2650-18-2 →
Auto-generated CPSR Part A draft with source citations
Chemistry & Identifiers
IUPAC Name
diazanium;2-[[4-[ethyl-[(3-sulfonatophenyl)methyl]amino]phenyl]-[4-[ethyl-[(3-sulfonatophenyl)methyl]azaniumylidene]cyclohexa-2,5-dien-1-ylidene]methyl]benzenesulfonate
InChIKey
HMEKVHWROSNWPD-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
restricted
US Notes
Permanently listed as D&C Blue No. 4, certification required. Restricted to externally applied drugs and cosmetics only, not approved for ingestion or eye area.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Acid Blue 9 Ammonium Salt.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (2)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_hair_dye | 0.5 | Non-oxidative hair dye |
| CN | permitted_colorant | - | All cosmetics (Class 1) |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
Carcinogen Classification
3, not classifiable as to its carcinogenicity to humans. (L135)
Source: Toxin and Toxin Target Database (T3DB)
Evidence for Carcinogenicity
No data are available in humans. Limited evidence of carcinogenicity in animals. OVERALL EVALUATION: Group 3: The agent is not classifiable as to its carcinogenicity to humans.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Expert Verdict
Expert safety assessment and concern-level summary for Acid Blue 9 Ammonium Salt.
Regulatory Flags
colorant
Known Synonyms
A.F. Blue No. 1
C.I. Direct Brown 78
C.I. Direct Brown 78, Diammonium Salt
H.K. Formula No. K. 7117
Acid Blue 9
Acilan Turquoise Blue AE
AF Blue No. 1
Aizen Brilliant Blue FCF
Tortrazine C extra
Amacid Blue FG Conc
Bleu Brilliant FCF
Brilliant Blue Lake
Bucacid Azure Blue
Calcocid Blue 2G
Calcocid Blue EG
Caswell No. 007A
CI Acid Blue 9
CI Acid Blue 9, diammonium salt
CI Direct Brown 78
CI Direct Brown 78, diammonium salt
Chemical Function
Dye
Regulatory Lists
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
Europe; Personal care - hair coloring
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3188729
Frequently Asked Questions
Is Acid Blue 9 Ammonium Salt allowed in the EU?
Acid Blue 9 Ammonium Salt EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Acid Blue 9 Ammonium Salt do in cosmetics?
Acid Blue 9 Ammonium Salt functions as: Colorant. It is classified as a cosmetic ingredient in our database. CAS number: 2650-18-2.
Is Acid Blue 9 Ammonium Salt used outside cosmetics?
Acid Blue 9 Ammonium Salt also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Acid Blue 9 Ammonium Salt compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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