NOAEL Studies Cosmetic Ingredient

Acid Blue 74 NOAEL Studies

INCI: ACID BLUE 74

CAS: 860-22-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 250 mg/kg bw/day rat oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 500 mg/kg bw/day dog oral 730 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 1000 mg/kg bw/day rat oral 900 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 1350 mg/kg bw/day swine oral 90 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 2400 mg/kg bw/day mouse oral 588 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 2500 mg/kg bw/day rat oral 730 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 7500 mg/kg bw/day mouse oral 701 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =500 mg/kg bw/day Rat oral: feed 730 days chronic/long term toxicity EFSA ANS - 2014 - OutputID 2522 - growth - systemic - Scientific Opinion on the re-evaluation of Indigo Carmine (E 132) as a food additive - doi:10.2903/j.efsa.2014.3768
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =500 mg/kg bw/day Rat oral: feed 730 days chronic/long term toxicity EFSA ANS - 2014 - OutputID 2522 - growth - systemic - Scientific Opinion on the re-evaluation of Indigo Carmine (E 132) as a food additive - doi:10.2903/j.efsa.2014.3768
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ADI =5 mg/kg bw/day Consumers - - ADI EFSA ANS - 2014 - OutputID 2522 - Consumers - Scientific Opinion on the re-evaluation of Indigo Carmine (E 132) as a food additive - doi:10.2903/j.efsa.2014.3768
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ADI =5 mg/kg bw/day Consumers - - ADI EFSA ANS - 2014 - OutputID 2522 - Consumers - Scientific Opinion on the re-evaluation of Indigo Carmine (E 132) as a food additive - doi:10.2903/j.efsa.2014.3768
NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =2000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_10961; row=1997; data_type=In Vivo; mixture=Chemical; chemical_name=C.I. Acid Blue 74; preferred_name=C.I. Acid Blue 74; dtxsid=DTXSID1020190; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020190; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1020190; source_file=acute_oral.xlsx
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=5976; RecordID=ARPathway2016_1650; DatasetName=ARPathway2016; DTXSID=DTXSID1020190; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020190; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020190
ToxValDB_ECHA_IUCLID 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =250 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac86e4b0a7c65d1bf804; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17362/7/9/3?documentUUID=3baccaf5-9f89-435a-ad9d-e66292487d45; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID:15823787:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1c84b18b29b7e6915e0f8fd436545bc4
ToxValDB_ECHA_IUCLID NOAEL =1282 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab77e4b0a7c65d1ba62e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17362/7/9/2?documentUUID=3baccaf5-9f89-435a-ad9d-e66292487d45; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855768_15861479_15861758:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ee1b3cb0aa2c1a8f07d131612ca113a4
ToxValDB_ECHA_IUCLID NOAEL =1592 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab77e4b0a7c65d1ba62e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17362/7/9/2?documentUUID=3baccaf5-9f89-435a-ad9d-e66292487d45; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15856525_15861429_15861710:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_029ed99d755f4c383f4db7f4a02da0e0
ToxValDB_ECHA_IUCLID NOAEL =8259 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab77e4b0a7c65d1ba62a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17362/7/9/2?documentUUID=3baccaf5-9f89-435a-ad9d-e66292487d45; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855768_15861479_15861758:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5f9d97e30426928c4641672d80b0fa09
ToxValDB_ECHA_IUCLID NOAEL =9456 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab77e4b0a7c65d1ba62a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17362/7/9/2?documentUUID=3baccaf5-9f89-435a-ad9d-e66292487d45; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15856525_15861429_15861710:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_dd38ea3659157537fb6b6ae08d08dfc0
ToxValDB_ECOTOX 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECOTOX NOEL =2000 mg/kg bw/day Mouse oral acute; 1 days acute LONG_REF=Mutat. Res.519(1/2): 103-119 Sasaki,Y.F., S. Kawaguchi, A. Kamaya, M. Ohshita, K. Kabasawa, K. Iwama, K. Taniguchi, and S. Tsuda The Comet Assay with 8 Mouse Organs: Results with 39 Currently Used Food Additives 2002; TITLE=The Comet Assay with 8 Mouse Organs: Results with 39 Currently Used Food Additives; AUTHOR=Sasaki,Y.F., S. Kawaguchi, A. Kamaya, M. Ohshita, K. Kabasawa, K. Iwama, K. Taniguchi, and S. Tsuda; DOI=10.1016/s1383-5718(02)00128-6; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75840; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Genetics: Damage; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15595767:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=3b7dd64d307f0c201d2ffda611f7ff6b
ToxValDB_EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA NOAEL =500 mg/kg bw/day Rat oral chronic; 2 years chronic LONG_REF=EFSA ANS (2014). Scientific Opinion on the re-evaluation of Indigo Carmine (E 132) as a food additive. doi:10.2903/j.efsa.2014.3768.; TITLE=Scientific Opinion on the re-evaluation of Indigo Carmine (E 132) as a food additive; AUTHOR=EFSA ANS; DOI=doi:10.2903/j.efsa.2014.3768; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2014; ORIGINAL_YEAR=2014; TOXICOLOGICAL_EFFECT=growth; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=EFSA_dup_-_15622709_15622710:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_04e12ba2d328d7aec83b64b6b0597be3
ToxValDB_WHO_JECFA_ADI 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_WHO_JECFA_ADI ADI <=5 mg/kg Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650afc3fe4b0d99f5a87bf95; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/2814; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=WHO JECFA ADI:15715420:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a0fabe008dd07b7e63a1553663e9fa79
openFDA substances 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier D3741U8K7L UNII - - - chemical {"approval_status":null,"molecular_formula":"C16H8N2O8S2.2Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"D3741U8K7L"}
openFDA substances FDA UNII substance identifier D3741U8K7L UNII - - - chemical {"approval_status":null,"molecular_formula":"C16H8N2O8S2.2Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"D3741U8K7L"}
openFDA substances FDA UNII substance identifier D3741U8K7L UNII - - - chemical {"approval_status":null,"molecular_formula":"C16H8N2O8S2.2Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"D3741U8K7L"}
openFDA substances FDA UNII substance identifier D3741U8K7L UNII - - - chemical {"approval_status":null,"molecular_formula":"C16H8N2O8S2.2Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"D3741U8K7L"}
openFDA substances FDA UNII substance identifier L06K8R7DQK UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"L06K8R7DQK"}
openFDA substances FDA UNII substance identifier L06K8R7DQK UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"L06K8R7DQK"}
openFDA substances FDA UNII substance identifier L06K8R7DQK UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"L06K8R7DQK"}
openFDA substances FDA UNII substance identifier L06K8R7DQK UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"L06K8R7DQK"}