NOAEL Studies Cosmetic Ingredient

Acid Blue 1 NOAEL Studies

INCI: CI 42045

CAS: 129-17-9

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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IARC Monographs 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
IARC Monographs IARC carcinogenicity classification 3 IARC group - - 1987 IARC Monographs {"additional_info":"volume_publication_year=1987","evaluation_year":1987,"source_table":"iarc_classifications","volume":"16, Sup 7"}
IARC Monographs IARC carcinogenicity classification 3 IARC group - - 1987 IARC Monographs {"additional_info":"volume_publication_year=1987","evaluation_year":1987,"source_table":"iarc_classifications","volume":"16, Sup 7"}
IARC Monographs IARC carcinogenicity classification 3 IARC group - - 1987 IARC Monographs {"additional_info":"volume_publication_year=1987","evaluation_year":1987,"source_table":"iarc_classifications","volume":"16, Sup 7"}
NTP_ICE_cancer 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_cancer IARC group 3 unitless - - - WOE; IARC Carcinogenicity sheet=Data; excel_row=3944; Record_ID=cancer_6456; Data_Type=WOE; Formulation_Name=Sulfan blue; Mixture=Chemical; DTXSID=DTXSID3026065; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/34; http://publications.iarc.fr/139; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026065; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3026065
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Agonist sheet=Integrated_approaches; excel_row=5960; RecordID=ARPathway2016_766; DatasetName=ARPathway2016; DTXSID=DTXSID3026065; Assay=AR Pathway Model, Agonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026065; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3026065
ToxValDB_ECHA_IUCLID 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =500 mg/kg bw/day Mouse oral chronic; 23 months chronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf61e4b0a7c65d1cda74; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18846/7/6/2?documentUUID=484c0d50-648d-4d91-81c9-e253d7ff5598; YEAR=1973; ORIGINAL_YEAR=1973; STUDY_GROUP=ECHA IUCLID:15835744:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_76655a0e5c8f088cff6467c36731d174
ToxValDB_ECHA_IUCLID NOAEL =375 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf7ee4b0a7c65d1ce155; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17379/7/6/2?documentUUID=ac405efb-6e69-4506-b965-a0e056cda334; YEAR=2017; ORIGINAL_YEAR=2017; STUDY_GROUP=ECHA IUCLID:15846741:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6a5fb0709794be1483d73618e801b213
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =13.557 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632648:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d5eb6be955bcbe5c2ef677723e161245
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier FH1929ICIT UNII - - - chemical {"approval_status":null,"molecular_formula":"C27H31N2O6S2.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"FH1929ICIT"}
openFDA substances FDA UNII substance identifier FH1929ICIT UNII - - - chemical {"approval_status":null,"molecular_formula":"C27H31N2O6S2.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"FH1929ICIT"}
openFDA substances FDA UNII substance identifier FH1929ICIT UNII - - - chemical {"approval_status":null,"molecular_formula":"C27H31N2O6S2.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"FH1929ICIT"}
openFDA substances FDA UNII substance identifier FH1929ICIT UNII - - - chemical {"approval_status":null,"molecular_formula":"C27H31N2O6S2.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"FH1929ICIT"}