Is Acetyl Tripeptide-30 Citrulline safe in cosmetics?
Acetyl Tripeptide-30 Citrulline has a safety rating of "GOOD" in our database. EU status: restricted. US status: restricted.
Good
Cosmetic Ingredient
Acetyl Tripeptide-30 Citrulline
Also known as: UNII-6KRO2N7539, L-Arg-L-Ala, RA, Arg-Ala
INCI: ACETYL TRIPEPTIDE-30 CITRULLINE
Acetyl Tripeptide-30 Citrulline (CAS 40968-45-4) is a cosmetic cosmetic ingredient functioning as Skin Conditioning (anti-aging peptide; MMP inhibitor that prevents ECM. EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 40968-45-4 →
Auto-generated CPSR Part A draft with source citations
Function
Skin Conditioning (anti-aging peptide; MMP inhibitor that prevents ECM degradation; firming/lifting)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(2S)-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]propanoic acid
InChIKey
WVRUNFYJIHNFKD-WDSKDSINSA-N
Regulatory Status
EU EU Status
restricted
US US Status
restricted
US Notes
Not specifically restricted; permitted for cosmetic use under general FDA cosmetic regulations. No CIR monograph specific to this peptide
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Acetyl Tripeptide-30 Citrulline.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for Acetyl Tripeptide-30 Citrulline.
Known Synonyms
UNII-6KRO2N7539
L-Arg-L-Ala
RA
Arg-Ala
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL328471
Frequently Asked Questions
Is Acetyl Tripeptide-30 Citrulline allowed in the EU?
Acetyl Tripeptide-30 Citrulline EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Acetyl Tripeptide-30 Citrulline do in cosmetics?
Acetyl Tripeptide-30 Citrulline functions as: Skin Conditioning (anti-aging peptide; MMP inhibitor that prevents ECM degradation; firming/lifting). It is classified as a cosmetic ingredient in our database. CAS number: 40968-45-4.
Is Acetyl Tripeptide-30 Citrulline used outside cosmetics?
Acetyl Tripeptide-30 Citrulline also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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(APPLE/CITRUS JUNOS/LENTIL/PEAR/PUMPKIN/STRAWBERRY/TOMATO FRUIT)/CORN KERNEL/(ARCTIUM LAPPA/BRASSICA OLERACEA ACEPHALA/CABBAGE/CAMELLIA SINENSIS/MORINGA OLEIFERA/RADISH/SPINACH LEAF)/(SORGHUM BICOLOR LEAF/STEM)/OAT MEAL/POTATO PULP/(CARROT/NELUMBO NUCIFERA/RADISH/WILD YAM ROOT)/(AMARANTHUS HYPOCHONDRIACUS/CASHEW/CICER ARIETINUM/COIX LACRYMA-JOBI MA-YUEN /MACADAMIA TERNIFOLIA/PHASEOLUS ANGULARIS/PISTACIA VERA/RHYNCHOSIA NULUBILIS/RICE/SESAME/SETARIA ITALICA/SOYBEAN/SWEET ALMOND/WHEAT SEED)/HORDEUM VULGARE SPROUT/CYPERUS ESCULENTUS TUBER/ARTEMISIA PRINCEPS/BROCCOLI/CHENOPODIUM QUINOA/ENTEROMORPHA COMPRESSA/HORDEUM VULGARE/IPOMOEA BATATAS/LAMINARIA JAPONICA/LENTINUS EDODES/PLEUROTUS OSTREATUS/PORPHYRA TENERA/UNDARIA PINNATIFIDA EXTRACT
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Chemical family
Skin Conditioning / Skin Repairing
ACETALDEHYDE
Moderate
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Fragrance
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