Is Acetyl Tetrapeptide-2 safe in cosmetics?
Acetyl Tetrapeptide-2 has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Acetyl Tetrapeptide-2
Acetyl Tetrapeptide-2 (CAS 757942-88-4) is a cosmetic cosmetic ingredient functioning as Softener and conditioner. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 757942-88-4 →
Auto-generated CPSR Part A draft with source citations
Function
Softener and conditioner
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
(3S)-3-[[(2S)-2-acetamido-6-aminohexanoyl]amino]-4-[[(2S)-1-[[(1S)-1-carboxy-2-(4-hydroxyphenyl)ethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acid
InChIKey
ITIMHIATVYROGF-XWUOBKMESA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Acetyl Tetrapeptide-2.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
5 property records from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "firming, collagen-boosting", "mechanism_of_action": "Signal peptide for fibroblast activation", "target_skin_layer": "dermis", "collagen_stimulation": "Yes", "elastin_protection": "Moderate", "wrinkle_reduction_pct": "12-20", "clinical_study_duration_weeks": "8", "sample_size": "25", "double_blind": "Yes", "placebo_controlled": "Yes", "published_journal": "JOCD, Int J Pept Re…
anti_pollution
{"cas_number": "757942-88-4", "ingredient_class": "other", "primary_mechanism": "barrier_reinforcement", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "NF_kB_inhibi…
depigmentation
{"cas_number": "not established", "ingredient_class": "anti_inflammatory_brightener", "primary_mechanism_of_action": "Thymus peptide reducing inflammation-induced pigmentation", "secondary_mechanisms": "Variable", "molecular_target": "other", "tyrosinase_inhibition_IC50_uM": "varies", "tyrosinase_inhibition_type": "competitive", "melanin_reduction_pct_in_vitro": "25-45", "melanin_reduction_pct_cli…
self_tanning
{"cas_number": "proprietary", "ingredient_class": "tan_accelerator", "tanning_mechanism": "melanin_stimulation", "color_development_onset_hours": "72.0", "full_color_development_hours": "240", "color_duration_days": "14", "color_depth": "light", "undertone": "natural", "DHA_concentration_if_applicable_pct": "0", "erythrulose_concentration_pct": "0", "pH_dependent_color": "no", "formaldehyde_releas…
synergy
{"inci_name_2": "Resveratrol", "synergy_type": "antioxidant-synergy", "synergy_description": "Thymic peptide with sirtuin activator for longevity", "combined_benefit": "Enhanced cellular longevity, immune support, comprehensive anti-aging", "efficacy_multiplier": "2.1x", "mechanism_of_action": "Tetrapeptide-2 mimics thymulin supporting immunity; resveratrol activates sirtuins", "optimal_ratio": "1…
Expert Verdict
Expert safety assessment and concern-level summary for Acetyl Tetrapeptide-2.
Frequently Asked Questions
Is Acetyl Tetrapeptide-2 allowed in the EU?
Acetyl Tetrapeptide-2 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Acetyl Tetrapeptide-2 do in cosmetics?
Acetyl Tetrapeptide-2 functions as: Softener and conditioner. It is classified as a cosmetic ingredient in our database. CAS number: 757942-88-4.
Compliance Tools
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Ingredient Decoder
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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Fragrance ingredient
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Chemical family
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