NOAEL Studies
Active Ingredient
Acetic Acid — Deep Research Profile NOAEL Studies
INCI: ACETIC ACID
CAS: 64-19-7
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS DB 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | NOAEL | 390 | mg/kg bw/day | rat | oral | 120 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 400 | mg/kg bw/day | rabbit | oral | 150 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 700 | mg/kg bw/day | rabbit | oral | 390 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
EFSA 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA | NOAEL | =16 | mg/kg bw/day | Rabbit | oral: unspecified | - | reproduction toxicity | EFSA - 2013 - OutputID 1362 - mortality - systemic - Conclusion on the peer review of the pesticide risk assessment of the active substance acetic acid - doi:10.2903/j.efsa.2013.3060 |
| EFSA | NOAEC | =10 | mg/m3 | Human | inhalation | short-term; 15 days | clinical | LONG_REF=EFSA (2013). Conclusion on the peer review of the pesticide risk assessment of the active substance acetic acid. doi:10.2903/j.efsa.2013.3060.; TITLE=Conclusion on the peer review of the pesticide risk assessment of the active substance acetic acid; AUTHOR=EFSA; DOI=doi:10.2903/j.efsa.2013.3060; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=clinical signs; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=EFSA:15614152:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dcc7d16caa198bb886ba9bf7eeb664c6 |
| EFSA | NOAEL | =16 | mg/kg bw/day | Rabbit | oral | - | reproduction developmental | LONG_REF=EFSA (2013). Conclusion on the peer review of the pesticide risk assessment of the active substance acetic acid. doi:10.2903/j.efsa.2013.3060.; TITLE=Conclusion on the peer review of the pesticide risk assessment of the active substance acetic acid; AUTHOR=EFSA; DOI=doi:10.2903/j.efsa.2013.3060; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=EFSA:15614150:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d0fe37a224751dfb05d5147d7c239987 |
NTP ICE acute inhalation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | LC50 | 11 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2887; Record_ID=acute_inhalation_3558; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID5024394; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=11; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5024394; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5024394 |
NTP ICE endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=4546; RecordID=ARPathway2016_1436; DatasetName=ARPathway2016; DTXSID=DTXSID5024394; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5024394; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5024394 |
NTP ICE eye irritation 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE eye irritation | Draize rabbit irritation score | 68 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=1564; Record_ID=eye_irritation_211; Data_Type=In Vivo; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5024394; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=68; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5024394; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5024394 |
| NTP ICE eye irritation | GHS Classification | 1 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=1562; Record_ID=eye_irritation_211; Data_Type=In Vivo; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5024394; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=1; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5024394; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5024394 |
| NTP ICE eye irritation | Intensity | 0 | %/sec | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=1563; Record_ID=eye_irritation_1317; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5024394; Assay=Vitrigel; Endpoint=Intensity; Response=0; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5024394; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5024394 |
| NTP ICE eye irritation | Lag time | >180 | s | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=1565; Record_ID=eye_irritation_1317; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5024394; Assay=Vitrigel; Endpoint=Lag time; Response_Modifier=>; Response=180; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5024394; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5024394 |
| NTP ICE eye irritation | Plateau level | 51 | % | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=1570; Record_ID=eye_irritation_1317; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5024394; Assay=Vitrigel; Endpoint=Plateau level; Response=51; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5024394; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5024394 |
NTP ICE skin irritation 17 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin irritation | Breakthrough Time | 21.7 | min | - | Dermal | - | In Vitro; Corrositex | sheet=Data_invitro; excel_row=3611; Record_ID=skin_irritation_invitro_15; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5024394; Assay=Corrositex; Endpoint=Breakthrough Time; Response=21.7; Response_Unit=min; Reference=Botham et al. 1995; Not available; 10.1177/026119299502300207; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5024394; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5024394 |
| NTP ICE skin irritation | Breakthrough Time | 28.5 | min | - | Dermal | - | In Vitro; Corrositex | sheet=Data_invitro; excel_row=3609; Record_ID=skin_irritation_invitro_18; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5024394; Assay=Corrositex; Endpoint=Breakthrough Time; Response=28.5; Response_Unit=min; Reference=Botham et al. 1995; Not available; 10.1177/026119299502300207; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5024394; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5024394 |
| NTP ICE skin irritation | Breakthrough Time | 35 | min | - | Dermal | - | In Vitro; Corrositex | sheet=Data_invitro; excel_row=3607; Record_ID=skin_irritation_invitro_21; Data_Type=In Vitro; Concentration=99; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5024394; Assay=Corrositex; Endpoint=Breakthrough Time; Response=35; Response_Unit=min; Reference=Gordon et al. 1994; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5024394; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5024394 |
| NTP ICE skin irritation | GHS classification | 1 | unitless | Rabbit | Dermal | - | In Vivo; Draize Skin Irritation/Corrosion Test | sheet=Data_invivo; excel_row=1043; Record_ID=skin_irritation_invivo_122; Data_Type=In Vivo; Concentration=>99; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5024394; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=GHS classification; Response=1B; Response_Unit=Unitless; Species=Rabbit; Reference=ICCVAM 2002; Not available; https://ntp.niehs.nih.gov/iccvam/docs/dermal_docs/cwgfinal02/cwgfinal.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5024394; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5024394 |
| NTP ICE skin irritation | Positive reaction | 9.5 | % | Human | Dermal | - | In Vivo; Four-hour Human Patch Test | sheet=Data_invivo; excel_row=1041; Record_ID=skin_irritation_invivo_1; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5024394; Assay=Four-hour Human Patch Test; Endpoint=Positive reaction; Response=9.5; Response_Unit=%; Species=Human; Reference=Basketter et al. 2004; 15291823; 10.1111/j.0105-1873.2004.00385.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5024394; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5024394 |
| NTP ICE skin irritation | Positive reaction | 32.6 | % | Human | Dermal | - | In Vivo; Four-hour Human Patch Test | sheet=Data_invivo; excel_row=1040; Record_ID=skin_irritation_invivo_3; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5024394; Assay=Four-hour Human Patch Test; Endpoint=Positive reaction; Response=32.6; Response_Unit=%; Species=Human; Reference=Robinson et al. 2001; 11422260; 10.1034/j.1600-0536.2001.045001001.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5024394; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5024394 |
| NTP ICE skin irritation | TER | 1.3 | kiloohms | - | Dermal | - | In Vitro; TER Corrosion | sheet=Data_invitro; excel_row=3603; Record_ID=skin_irritation_invitro_2465; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5024394; Assay=TER Corrosion; Endpoint=TER; Response=1.3; Response_Unit=kiloohms; Reference=Botham et al. 1995; Not available; 10.1177/026119299502300207; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5024394; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5024394 |
| NTP ICE skin irritation | TER | 1.5 | kiloohms | - | Dermal | - | In Vitro; TER Corrosion | sheet=Data_invitro; excel_row=3604; Record_ID=skin_irritation_invitro_2466; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5024394; Assay=TER Corrosion; Endpoint=TER; Response=1.5; Response_Unit=kiloohms; Reference=Botham et al. 1995; Not available; 10.1177/026119299502300207; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5024394; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5024394 |
| NTP ICE skin irritation | Viability (240 minutes) | 2.6 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=3596; Record_ID=skin_irritation_invitro_1843; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5024394; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=2.6; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5024394; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5024394 |
| NTP ICE skin irritation | Viability (240 minutes) | 2.8 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=3595; Record_ID=skin_irritation_invitro_1842; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5024394; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=2.8; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5024394; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5024394 |
| NTP ICE skin irritation | Viability (240 minutes) | 3 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=3594; Record_ID=skin_irritation_invitro_1841; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5024394; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=3; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5024394; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5024394 |
| NTP ICE skin irritation | Viability (3 minutes) | 2.4 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=3597; Record_ID=skin_irritation_invitro_1841; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5024394; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=2.4; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5024394; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5024394 |
| NTP ICE skin irritation | Viability (3 minutes) | 2.9 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=3601; Record_ID=skin_irritation_invitro_1843; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5024394; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=2.9; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5024394; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5024394 |
| NTP ICE skin irritation | Viability (3 minutes) | 4.5 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=3593; Record_ID=skin_irritation_invitro_1842; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5024394; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=4.5; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5024394; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5024394 |
| NTP ICE skin irritation | Viability (60 minutes) | 4.1 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=3612; Record_ID=skin_irritation_invitro_1843; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5024394; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=4.10; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5024394; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5024394 |
| NTP ICE skin irritation | Viability (60 minutes) | 4.7 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=3591; Record_ID=skin_irritation_invitro_1842; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5024394; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=4.7; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5024394; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5024394 |
| NTP ICE skin irritation | Viability (60 minutes) | 5.6 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=3592; Record_ID=skin_irritation_invitro_1841; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5024394; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=5.6; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5024394; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5024394 |
ToxValDB DOE Protective Action Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB DOE Protective Action Criteria | LEL | =98245.1 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2008; ORIGINAL_YEAR=2008; STUDY_GROUP=DOE Protective Action Criteria:15511759:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_946aa36edf809c52cc74e3175225ca65 |
ECHA 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | NOAEL | >=1600 | mg/kg bw/day | Rabbit | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac26e4b0a7c65d1bda50; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14400/7/9/3?documentUUID=688ac347-3f66-4697-a477-810a7fdadd00; YEAR=2004; ORIGINAL_YEAR=2004; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820631_15820656:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_28af2b492f0ffbcc3b0281981ec9a4a8 |
ToxValDB ECOTOX 17 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | LOEL | =0.00001 | mM | European Rabbit | environmental | short-term; 5 days | developmental | LONG_REF=Biol. Reprod.20(2): 323-332 Kane,M.T. Fatty Acids as Energy Sources for Culture of One-Cell Rabbit Ova to Viable Morulae 1979; TITLE=Fatty Acids as Energy Sources for Culture of One-Cell Rabbit Ova to Viable Morulae; AUTHOR=Kane,M.T.; DOI=10.1095/biolreprod20.2.323; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=101665; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=Development: Blastocyst stage; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX:15601035:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4e5e258f79afae2b0ddd25a252c846e1 |
| ToxValDB ECOTOX | LOEL | =0.1 | % | Rat | injection | acute; 0.25 days | acute | LONG_REF=Brain Res.967(1-2): 81-88 Mitsui,T., H. Kakizaki, S. Matsuura, H. Tanaka, M. Yoshioka, and T. Koyanagi Chemical Bladder Irritation Provokes c-fos Expression in the Midbrain Periaqueductal Gray Matter of the Rat 2003; TITLE=Chemical Bladder Irritation Provokes c-fos Expression in the Midbrain Periaqueductal Gray Matter of the Rat; AUTHOR=Mitsui,T., H. Kakizaki, S. Matsuura, H. Tanaka, M. Yoshioka, and T. Koyanagi; DOI=10.1016/s0006-8993(02)04226-9; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=102859; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=Genetics: Gene expression; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15594547:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8dfb6bff11482cab6360f44d98d694d3 |
| ToxValDB ECOTOX | LOEL | =0.667 | mmol | Mouse | dermal | chronic; 210 days | chronic | LONG_REF=Cancer Lett.42(1/2): 87-90 Rotstein,J.B., and T.J. Slaga Acetic Acid, a Potent Agent of Tumor Progression in the Multistage Mouse Skin Model for Chemical Carcinogenesis 1988; TITLE=Acetic Acid, a Potent Agent of Tumor Progression in the Multistage Mouse Skin Model for Chemical Carcinogenesis; AUTHOR=Rotstein,J.B., and T.J. Slaga; DOI=10.1016/0304-3835(88)90243-1; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=103294; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=Injury: Tumor induction; TOXICOLOGICAL_EFFECT_CATEGORY=cancer; STUDY_GROUP=ECOTOX:15603243:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c777540cdbd3d113b240e990277ca9bf |
| ToxValDB ECOTOX | LOEL | =2 | mL/kg | Rat | injection | acute; 0.0208 days | acute | LONG_REF=Life Sci.29(16): 1669-1674 Mueller,G.P. Beta-Endorphin Immunoreactivity in Rat Plasma: Variations in Response to Different Physical Stimuli 1981; TITLE=Beta-Endorphin Immunoreactivity in Rat Plasma: Variations in Response to Different Physical Stimuli; AUTHOR=Mueller,G.P.; DOI=10.1016/0024-3205(81)90069-2; QUALITY=Control type: Control outside of primary exposure system; EXTERNAL_SOURCE_ID=107840; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1981; ORIGINAL_YEAR=1981; TOXICOLOGICAL_EFFECT=Biochemistry: General biochemical effect; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15602020:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2555f47c7bdf83ef0fac77279ef55627 |
| ToxValDB ECOTOX | LOEL | =3 | % | Rat | environmental | acute; 1 days | acute | LONG_REF=Toxicol. Appl. Pharmacol.205(1): 43-52 Mahgoub,A., A. El-Medany, A. Mustafa, M. Arafah, and M. Moursi Azithromycin and Erythromycin Ameliorate the Extent of Colonic Damage Induced by Acetic Acid in Rats 2005; TITLE=Azithromycin and Erythromycin Ameliorate the Extent of Colonic Damage Induced by Acetic Acid in Rats; AUTHOR=Mahgoub,A., A. El-Medany, A. Mustafa, M. Arafah, and M. Moursi; DOI=10.1016/j.taap.2004.09.012; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=80297; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Biochemistry: Tumor necrosis factor-alpha|Enzyme(s): Enzyme activity; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|enzyme activity; STUDY_GROUP=ECOTOX:15597448:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8e2cc5bdca48611e1803e1780d4faf5c |
| ToxValDB ECOTOX | LOEL | =3 | % w/v | European Rabbit | dermal | acute; 1 days | acute | LONG_REF=Toxicol. Pathol.28(5): 668-678 Jester,J.V., A. Molai, W.M. Petroll, R.D. Parker, G.J. Carr, H.D. Cavanagh, and J.K. Maurer Quantitative Characterization of Acid- and Alkali-Induced Corneal Injury in the Low-Volume Eye Test 2000; TITLE=Quantitative Characterization of Acid- and Alkali-Induced Corneal Injury in the Low-Volume Eye Test; AUTHOR=Jester,J.V., A. Molai, W.M. Petroll, R.D. Parker, G.J. Carr, H.D. Cavanagh, and J.K. Maurer; DOI=10.1177/019262330002800506; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=151823; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Cell(s): Height; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15599640_15607051:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2fe2aa91ba60ca78fa498a956db17043 |
| ToxValDB ECOTOX | LOEL | =5 | % | Rat | injection | acute; 1 days | acute | LONG_REF=Brain Res.672(1-2): 77-82 Burton,M.B., and G.F. Gebhart Effects of Intracolonic Acetic Acid on Responses to Colorectal Distension in the Rat 1995; TITLE=Effects of Intracolonic Acetic Acid on Responses to Colorectal Distension in the Rat; AUTHOR=Burton,M.B., and G.F. Gebhart; DOI=10.1016/0006-8993(94)01382-r; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=102857; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Cell(s): Leukocytes; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=ECOTOX:15603473:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=92f40273ed407cd6a745e0589df3420d |
| ToxValDB ECOTOX | LOEL | =10 | % | Rat | dermal | acute; 0.0417 days | acute | LONG_REF=Dig. Dis. Sci.36(6): 727-732 Leung,F.W., and A. Koo Mucosal Vascular Stasis Precedes loss of Viability of Endothelial Cells in Rat Acetic Acid Colitis 1991; TITLE=Mucosal Vascular Stasis Precedes loss of Viability of Endothelial Cells in Rat Acetic Acid Colitis; AUTHOR=Leung,F.W., and A. Koo; DOI=10.1007/BF01311228; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=102828; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=Physiology: Iodine uptake; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15594968:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=9b1fd4b943cefe29bbfea3bfe15e98f1 |
| ToxValDB ECOTOX | LOEL | =10 | mL/kg | Rat | injection | acute; 0.0035 days | acute | LONG_REF=Dig. Dis. Sci.40(9): 1913-1921 Julia,V., T. Mezzasalma, and L. Bueno Influence of Bradykinin in Gastrointestinal Disorders and Visceral Pain Induced by Acute or Chronic Inflammation in Rats 1995; TITLE=Influence of Bradykinin in Gastrointestinal Disorders and Visceral Pain Induced by Acute or Chronic Inflammation in Rats; AUTHOR=Julia,V., T. Mezzasalma, and L. Bueno; DOI=10.1007/BF02208656; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=102827; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Physiology: Contraction rate; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15599785:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=da59f05d80b56003b74099f162637a35 |
| ToxValDB ECOTOX | LOEL | =10 | % w/v | European Rabbit | dermal | short-term; 3 days | short-term | LONG_REF=Toxicol. Pathol.28(5): 668-678 Jester,J.V., A. Molai, W.M. Petroll, R.D. Parker, G.J. Carr, H.D. Cavanagh, and J.K. Maurer Quantitative Characterization of Acid- and Alkali-Induced Corneal Injury in the Low-Volume Eye Test 2000; TITLE=Quantitative Characterization of Acid- and Alkali-Induced Corneal Injury in the Low-Volume Eye Test; AUTHOR=Jester,J.V., A. Molai, W.M. Petroll, R.D. Parker, G.J. Carr, H.D. Cavanagh, and J.K. Maurer; DOI=10.1177/019262330002800506; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=151823; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Cell(s): Size; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15606157_15606158:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=29923b9d97686ce072b657e3726697ef |
| ToxValDB ECOTOX | LOEL | =40 | mg | Mouse | dermal | short-term; 2 days | short-term | LONG_REF=Cancer Res.47(23): 6388-6392 Pence,B.C., and J.J.,Jr. Reiners Murine Epidermal Xanthine Oxidase Activity: Correlation with Degree of Hyperplasia Induced by Tumor Promoters 1987; TITLE=Murine Epidermal Xanthine Oxidase Activity: Correlation with Degree of Hyperplasia Induced by Tumor Promoters; AUTHOR=Pence,B.C., and J.J.,Jr. Reiners; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=102860; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Enzyme(s): Xanthine oxidase, XOD; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX_dup_EPA ORD_15599703_15599704:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=26233f5fbef60364edf23e283c115b06 |
| ToxValDB ECOTOX | LOEL | =75 | uL | Rat | dermal | subchronic; 42 days | subchronic | LONG_REF=J. Physiol. Pharmacol.59(Suppl. 2): 179-189 Zurowski,D., L. Dobrek, A. Bugajski, and P.J. Thor The Role of Sensory C-Fibers in Response of Vagal Afferent Stimulation by Gastric Distension in Rats with Experimental Chronic Gastric Ulcer 2008; TITLE=The Role of Sensory C-Fibers in Response of Vagal Afferent Stimulation by Gastric Distension in Rats with Experimental Chronic Gastric Ulcer; AUTHOR=Zurowski,D., L. Dobrek, A. Bugajski, and P.J. Thor; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=151795; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=Physiology: Neuroresponse; STUDY_GROUP=ECOTOX:15611174:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7482efbb1a0ed7a47f07749c1db22181 |
| ToxValDB ECOTOX | LOEL | =100 | % | Rat | dermal | acute; 1 days | acute | LONG_REF=Aliment. Pharmacol. Ther.16(suppl. 2): 10-19 Kazumori,H., S. Ishihara, R. Fukuda, and Y. Kinoshita Time-Course Changes of ECL Cell Markers in Acetic Acid-Induced Gastric Ulcers in Rats 2002; TITLE=Time-Course Changes of ECL Cell Markers in Acetic Acid-Induced Gastric Ulcers in Rats; AUTHOR=Kazumori,H., S. Ishihara, R. Fukuda, and Y. Kinoshita; DOI=10.1046/j.1365-2036.16.s2.10.x; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=103295; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Biochemistry: Acid produced|Hormone(s): Gastrin; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15599329:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=25a4a56edc9058fc3e297185c51d13f4 |
| ToxValDB ECOTOX | NOEL | =0.3 | mL/L | Rat | oral | short-term; 18 days | short-term | LONG_REF=Neurobehav. Toxicol. Teratol.4(1): 105-108 Barrett,J., and P.J. Livesey The Acetic Acid Component of Lead Acetate: Its Effect on Rat Weight and Activity 1982; TITLE=The Acetic Acid Component of Lead Acetate: Its Effect on Rat Weight and Activity; AUTHOR=Barrett,J., and P.J. Livesey; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=65398; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=Feeding behavior: Water consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ECOTOX:15601473:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=fc33b0bab6c196c092692b0ffdb82710 |
| ToxValDB ECOTOX | NOEL | =3 | % w/v | European Rabbit | dermal | short-term; 3 days | short-term | LONG_REF=Toxicol. Pathol.28(5): 668-678 Jester,J.V., A. Molai, W.M. Petroll, R.D. Parker, G.J. Carr, H.D. Cavanagh, and J.K. Maurer Quantitative Characterization of Acid- and Alkali-Induced Corneal Injury in the Low-Volume Eye Test 2000; TITLE=Quantitative Characterization of Acid- and Alkali-Induced Corneal Injury in the Low-Volume Eye Test; AUTHOR=Jester,J.V., A. Molai, W.M. Petroll, R.D. Parker, G.J. Carr, H.D. Cavanagh, and J.K. Maurer; DOI=10.1177/019262330002800506; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=151823; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Cell(s): Size; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15606157_15606158:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=16fca581bd70d4766c3f36cc74cfab9a |
| ToxValDB ECOTOX | NOEL | =10 | % w/v | European Rabbit | dermal | subchronic; 35 days | subchronic | LONG_REF=Toxicol. Pathol.28(5): 668-678 Jester,J.V., A. Molai, W.M. Petroll, R.D. Parker, G.J. Carr, H.D. Cavanagh, and J.K. Maurer Quantitative Characterization of Acid- and Alkali-Induced Corneal Injury in the Low-Volume Eye Test 2000; TITLE=Quantitative Characterization of Acid- and Alkali-Induced Corneal Injury in the Low-Volume Eye Test; AUTHOR=Jester,J.V., A. Molai, W.M. Petroll, R.D. Parker, G.J. Carr, H.D. Cavanagh, and J.K. Maurer; DOI=10.1177/019262330002800506; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=151823; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Injury: Injury, general|Morphology: Thickness; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15596623:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=57797fa4bbad094c99bfdda00a70194b |
| ToxValDB ECOTOX | NOEL | =20 | mg | Mouse | dermal | short-term; 2 days | short-term | LONG_REF=Cancer Res.47(23): 6388-6392 Pence,B.C., and J.J.,Jr. Reiners Murine Epidermal Xanthine Oxidase Activity: Correlation with Degree of Hyperplasia Induced by Tumor Promoters 1987; TITLE=Murine Epidermal Xanthine Oxidase Activity: Correlation with Degree of Hyperplasia Induced by Tumor Promoters; AUTHOR=Pence,B.C., and J.J.,Jr. Reiners; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=102860; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Enzyme(s): Xanthine oxidase, XOD; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX_dup_EPA ORD_15599703_15599704:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1909e27c6b01da01e9d746c3493c5c7d |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL local | =25 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15629460:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7fa80e30813603e9192a7515f6db6616 |
ToxValDB NIOSH IDLH 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB NIOSH IDLH | LOEL | =122.806 | mg/m3 | Human | inhalation | acute | occupational | LONG_REF=AIHA [1972]. Acetic acid. In: Hygienic guide series. Am Ind Hyg Assoc J 33:624-627.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c9b377e4b02565fc7d6e4a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.cdc.gov/niosh/idlh/; SUBSOURCE_URL=https://www.cdc.gov/niosh/idlh/64197.html; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=intolerable to most persons due to intense lacrimation and irritation of the eyes, nose, and throat; STUDY_GROUP=NIOSH IDLH:15952974:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6f8d25fbe834eac257458f011d0a736e |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | Q40Q9N063P | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C2H4O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"Q40Q9N063P"} |
| openFDA substances | FDA UNII substance identifier | Q40Q9N063P | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C2H4O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"Q40Q9N063P"} |
| openFDA substances | FDA UNII substance identifier | Q40Q9N063P | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C2H4O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"Q40Q9N063P"} |
| openFDA substances | FDA UNII substance identifier | Q40Q9N063P | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C2H4O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"Q40Q9N063P"} |