NOAEL Studies
Cosmetic Ingredient
Acetaminophen NOAEL Studies
INCI: ACETAMINOPHEN
CAS: 103-90-2
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
IARC Monographs 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 1998 | IARC Monographs | {"additional_info":"volume_publication_year=1999","evaluation_year":1998,"source_table":"iarc_classifications","volume":"50, 73"} |
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 1998 | IARC Monographs | {"additional_info":"volume_publication_year=1999","evaluation_year":1998,"source_table":"iarc_classifications","volume":"50, 73"} |
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 1998 | IARC Monographs | {"additional_info":"volume_publication_year=1999","evaluation_year":1998,"source_table":"iarc_classifications","volume":"50, 73"} |
NTP ICE acute oral 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =2400 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_341; row=3736; data_type=In Vivo; mixture=Chemical; chemical_name=Acetaminophen; preferred_name=Acetaminophen; dtxsid=DTXSID2020006; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020006; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2020006; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =1944 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM ChemIDplus TEST (undated); record_id=acute_oral_339; row=3737; data_type=In Vivo; mixture=Chemical; chemical_name=Acetaminophen; preferred_name=Acetaminophen; dtxsid=DTXSID2020006; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020006; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2020006; source_file=acute_oral.xlsx |
NTP ICE adme parameters 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE adme parameters | Clint | 0.3598 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=771; Record_ID=adme_parameters_241; Data_Type=Measured; DTXSID=DTXSID2020006; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=0.3598; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Paini 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020006; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2020006 |
| NTP ICE adme parameters | Clint | 15.83 | uL/min/10^6 cells | Rat | - | - | Measured; httk, Rat Hepatic Intrinsic Clearance | sheet=Data; excel_row=774; Record_ID=adme_parameters_241; Data_Type=Measured; DTXSID=DTXSID2020006; Assay=httk, Rat Hepatic Intrinsic Clearance; Endpoint=Clint; Response=15.83; Response_Unit=ul/min/10^6 cells; Species=Rat; Reference=httk2.3.1, Wood 2017; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020006; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2020006 |
| NTP ICE adme parameters | Fu | 0.9398 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=772; Record_ID=adme_parameters_241; Data_Type=Measured; DTXSID=DTXSID2020006; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.9398; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Paini 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020006; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2020006 |
| NTP ICE adme parameters | Fu | 0.82 | fraction | Rat | - | - | Measured; httk, Rat Plasma Fraction Unbound | sheet=Data; excel_row=773; Record_ID=adme_parameters_241; Data_Type=Measured; DTXSID=DTXSID2020006; Assay=httk, Rat Plasma Fraction Unbound; Endpoint=Fu; Response=0.82; Response_Unit=Unitless Fraction; Species=Rat; Reference=httk2.3.1, Naritomi 2003; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020006; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2020006 |
NTP ICE cancer 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE cancer | IARC group | 3 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=2210; Record_ID=cancer_1523; Data_Type=WOE; Formulation_Name=Acetaminophen; Mixture=Chemical; DTXSID=DTXSID2020006; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/68; http://publications.iarc.fr/91; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020006; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2020006 |
| NTP ICE cancer | POLY-3 lowest dose | 6000 | ppm | Rat | Dosed feed | - | In Vivo; Two year cancer bioassay | sheet=Data; excel_row=2201; Record_ID=cancer_1525; Data_Type=In Vivo; Formulation_Name=Acetaminophen (4-hydroxyacetanilide); Mixture=Chemical; DTXSID=DTXSID2020006; Assay=Two year cancer bioassay; Endpoint=POLY-3 lowest dose; Response=6000; Response_Unit=ppm; Species=Rat; Strain=F344/N; Sex=Female; Route=Dosed feed; Level_of_Evidence=Equivocal evidence; Tissue=Hematopoietic system; Lesion=Leukemia: lymphocytic, monocytic, mononuclear, or undifferentiated; Reference=TR-394; URL=https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr394/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020006; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2020006 |
| NTP ICE cancer | Top dose | 6000 | ppm | Rat | Dosed feed | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=2200; Record_ID=cancer_1525; Data_Type=In Vivo; Formulation_Name=Acetaminophen; Mixture=Chemical; DTXSID=DTXSID2020006; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=6000; Response_Unit=ppm; Species=Rat; Strain=F344/N; Sex=Female; Route=Dosed feed; Reference=TR-394; URL=https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr394/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020006; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2020006 |
NTP ICE endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=4530; RecordID=ARPathway2016_442; DatasetName=ARPathway2016; DTXSID=DTXSID2020006; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020006; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2020006 |
EPA ToxRefDB v3 17 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EPA ToxRefDB v3 | LEL | =625 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 14 day | SAC | study_id=5181; toxval_study_source_id=studyid5181_Adult_F0_F_systemic; toxval_effect_list=in life observation-food consumption-food consumption; dose_level=5; study_year=1993; study_citation=NTP_1993_Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_14 day study_Rats; dsstox_substance_id=DTXSID2020006; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =40 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 13 week | SUB | study_id=5183; toxval_study_source_id=studyid5183_Adult_F0_F_systemic; toxval_effect_list=organ weight-kidney-relative to body weight|organ weight-liver-relative to body weight|in life observation-body weight-body weight|in life observation-clinical signs-urine, discoloration|in life observation-clinical signs-reduced body size|in life observation-food consumption-food efficiency|pathology microscopic-liver-inflammation|pathology microscopic-ovary-atrophy|in life observation-mortality-mortality|pathology microscopic-uterus-atrophy|pathology microscopic-liver-necrosis|pathology microscopic-thymus-depletion lymphoid|pathology microscopic-kidney-casts|pathology microscopic-liver-pigmentation|pathology microscopic-liver-mineralization|pathology microscopic-liver-fibrosis|in life observation-food consumption-food consumption|pathology microscopic-liver-proliferation|pathology microscopic-lymph node-depletion lymphoid|pathology microscopic-kidney-regeneration|pathology microscopic-liver-cytomegaly; dose_level=1; study_year=1993; study_citation=NTP_1993_Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_13 week study_Rats; dsstox_substance_id=DTXSID2020006; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =930 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 13 week | SUB | study_id=5185; toxval_study_source_id=studyid5185_Adult_F0_F_systemic; toxval_effect_list=organ weight-kidney-relative to body weight|in life observation-food consumption-food consumption|pathology microscopic-liver-pigmentation|in life observation-food consumption-food efficiency|in life observation-body weight-body weight|pathology microscopic-liver-mineralization|pathology microscopic-liver-karyomegaly|pathology microscopic-liver-cytomegaly|pathology microscopic-liver-necrosis|in life observation-clinical signs-urine, discoloration|in life observation-mortality-mortality; dose_level=4; study_year=1993; study_citation=NTP_1993_Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_13 week study_Mice; dsstox_substance_id=DTXSID2020006; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =35 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 103 week | CHR | study_id=5187; toxval_study_source_id=studyid5187_Adult_F0_F_systemic; toxval_effect_list=pathology gross-full gross necropsy-leukemia mononuclear|pathology microscopic-kidney-nephropathy; dose_level=1; study_year=1993; study_citation=NTP_1993_Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_2 year study_Rats; dsstox_substance_id=DTXSID2020006; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =30 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 103 week | CHR | study_id=5187; toxval_study_source_id=studyid5187_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-kidney-hyperplasia|pathology microscopic-kidney-nephropathy|pathology microscopic-parathyroid gland-hyperplasia; dose_level=1; study_year=1993; study_citation=NTP_1993_Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_2 year study_Rats; dsstox_substance_id=DTXSID2020006; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =110 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 103 week | CHR | study_id=5189; toxval_study_source_id=studyid5189_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|pathology microscopic-thyroid gland-hyperplasia; dose_level=1; study_year=1993; study_citation=NTP_1993_Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_2 year study_Mice; dsstox_substance_id=DTXSID2020006; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =90 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 103 week | CHR | study_id=5189; toxval_study_source_id=studyid5189_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-thyroid gland-hyperplasia|in life observation-body weight-body weight; dose_level=1; study_year=1993; study_citation=NTP_1993_Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_2 year study_Mice; dsstox_substance_id=DTXSID2020006; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =625 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 13 week | SUB | study_id=5183; toxval_study_source_id=studyid5183_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight; dose_level=5; study_year=1993; study_citation=NTP_1993_Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_13 week study_Rats; dsstox_substance_id=DTXSID2020006; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =1875 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 13 week | SUB | study_id=5185; toxval_study_source_id=studyid5185_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-liver-pigmentation|in life observation-body weight-body weight|pathology microscopic-liver-mineralization; dose_level=5; study_year=1993; study_citation=NTP_1993_Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_13 week study_Mice; dsstox_substance_id=DTXSID2020006; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | >320 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 103 week | CHR | study_id=5187; toxval_study_source_id=studyid5187_Adult_F0_F_NA; dose_level=3; study_year=1993; study_citation=NTP_1993_Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_2 year study_Rats; dsstox_substance_id=DTXSID2020006; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | >1200 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 103 week | CHR | study_id=5189; toxval_study_source_id=studyid5189_Adult_F0_F_NA; dose_level=3; study_year=1993; study_citation=NTP_1993_Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_2 year study_Mice; dsstox_substance_id=DTXSID2020006; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =1000 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 103 week | CHR | study_id=5189; toxval_study_source_id=studyid5189_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight; dose_level=3; study_year=1993; study_citation=NTP_1993_Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_2 year study_Mice; dsstox_substance_id=DTXSID2020006; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =310 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 14 day | SAC | study_id=5181; toxval_study_source_id=studyid5181_Adult_F0_F_systemic; toxval_effect_list=in life observation-food consumption-food consumption; dose_level=4; study_year=1993; study_citation=NTP_1993_Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_14 day study_Rats; dsstox_substance_id=DTXSID2020006; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | >0 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 13 week | SUB | study_id=5183; toxval_study_source_id=studyid5183_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-liver-proliferation|pathology microscopic-liver-fibrosis|in life observation-food consumption-food consumption|pathology microscopic-lymph node-depletion lymphoid|organ weight-liver-relative to body weight|in life observation-clinical signs-reduced body size|pathology microscopic-kidney-regeneration|pathology microscopic-liver-cytomegaly|pathology microscopic-liver-inflammation|in life observation-body weight-body weight|in life observation-clinical signs-urine, discoloration|in life observation-food consumption-food efficiency|pathology microscopic-ovary-atrophy|in life observation-mortality-mortality|pathology microscopic-kidney-casts|pathology microscopic-thymus-depletion lymphoid|pathology microscopic-uterus-atrophy|pathology microscopic-liver-necrosis|pathology microscopic-liver-pigmentation|pathology microscopic-liver-mineralization|organ weight-kidney-relative to body weight; dose_level=0; study_year=1993; study_citation=NTP_1993_Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_13 week study_Rats; dsstox_substance_id=DTXSID2020006; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =480 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 13 week | SUB | study_id=5185; toxval_study_source_id=studyid5185_Adult_F0_F_systemic; toxval_effect_list=in life observation-food consumption-food efficiency|pathology microscopic-liver-mineralization|in life observation-mortality-mortality|in life observation-clinical signs-urine, discoloration|organ weight-kidney-relative to body weight|in life observation-body weight-body weight|pathology microscopic-liver-pigmentation|pathology microscopic-liver-necrosis|pathology microscopic-liver-cytomegaly|pathology microscopic-liver-karyomegaly|in life observation-food consumption-food consumption; dose_level=3; study_year=1993; study_citation=NTP_1993_Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_13 week study_Mice; dsstox_substance_id=DTXSID2020006; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NOAEL | =310 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 13 week | SUB | study_id=5183; toxval_study_source_id=studyid5183_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-liver-cytomegaly|pathology microscopic-kidney-regeneration|in life observation-clinical signs-reduced body size|pathology microscopic-lymph node-depletion lymphoid|organ weight-liver-relative to body weight|pathology microscopic-liver-fibrosis|in life observation-food consumption-food consumption|pathology microscopic-liver-proliferation|organ weight-kidney-relative to body weight|pathology microscopic-liver-pigmentation|pathology microscopic-liver-mineralization|pathology microscopic-uterus-atrophy|pathology microscopic-liver-necrosis|pathology microscopic-thymus-depletion lymphoid|pathology microscopic-kidney-casts|pathology microscopic-ovary-atrophy|in life observation-mortality-mortality|in life observation-food consumption-food efficiency|pathology microscopic-liver-inflammation|in life observation-body weight-body weight|in life observation-clinical signs-urine, discoloration; dose_level=4; study_year=1993; study_citation=NTP_1993_Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_13 week study_Rats; dsstox_substance_id=DTXSID2020006; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NOAEL | =450 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 103 week | CHR | study_id=5189; toxval_study_source_id=studyid5189_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight|pathology microscopic-thyroid gland-hyperplasia; dose_level=2; study_year=1993; study_citation=NTP_1993_Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_2 year study_Mice; dsstox_substance_id=DTXSID2020006; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ECHA 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEL | =111 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c7fbe4b0a7c65d215e6f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/21574/7/8?documentUUID=9aa0f04d-9ff6-43f7-aea1-51e99d4e5757; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=histopathology: neoplastic|histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=cancer|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15820052:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_92bfe1516b7ec620e9259e069259f366 |
| ECHA | LOAEL | =46.8 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c7fbe4b0a7c65d215e73; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/21574/7/8?documentUUID=9aa0f04d-9ff6-43f7-aea1-51e99d4e5757; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=histopathology: neoplastic|histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=cancer|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15820176:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3b782c8802da54f87bd23111735f0cc3 |
| ECHA | LOEL | =12500 | ppm | Rat | oral | short-term; 14 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c9f5e4b0a7c65d21f7cf; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/21574/7/6/2?documentUUID=9aa0f04d-9ff6-43f7-aea1-51e99d4e5757; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID:15835471:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b2313ff3d1897ab5ff4ab33cc255d1ad |
| ECHA | LOEL | =4925 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c9f5e4b0a7c65d21f7a6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/21574/7/6/2?documentUUID=9aa0f04d-9ff6-43f7-aea1-51e99d4e5757; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID:15850232:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_aa9a68d57f11398fe36a4319f16d4e80 |
| ECHA | LOEL | =1400 | mg/kg bw/day | Mouse | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c883e4b0a7c65d218eec; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/21574/7/9/2?documentUUID=9aa0f04d-9ff6-43f7-aea1-51e99d4e5757; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID:15861321:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_77a39008eeb5decd1dfaf974df0dcd9f |
| ECHA | NOAEL | =450 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c7fbe4b0a7c65d215e6b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/21574/7/8?documentUUID=9aa0f04d-9ff6-43f7-aea1-51e99d4e5757; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID:15820108:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2f0db477abd39460fda2201cd9a975bd |
| ECHA | NOAEL | =650 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c7fbe4b0a7c65d215e77; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/21574/7/8?documentUUID=9aa0f04d-9ff6-43f7-aea1-51e99d4e5757; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID:15820136:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ce7156912124c6c4439ff6703b24d7bd |
ToxValDB ECOTOX 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | LOEL | =300 | mg/kg bw/day | Mouse | injection | acute; 0.1667 days | acute | LONG_REF=Toxicology66(1): 81-91 Szymanska,J.A., E.A. Swietlicka, and J.K. Piotrowski Protective Effect of Zinc in the Hepatotoxicity of Bromobenzene and Acetaminophen 1991; TITLE=Protective Effect of Zinc in the Hepatotoxicity of Bromobenzene and Acetaminophen; AUTHOR=Szymanska,J.A., E.A. Swietlicka, and J.K. Piotrowski; DOI=10.1016/0300-483x(91)90180-9; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=85557; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=Biochemistry: Glutathione (reduced glutathione)|Biochemistry: Malondialdehyde|Biochemistry: Metallothionein|Enzyme(s): Alanine transaminase (ALT)|Enzyme(s): Sorbitol dehydrogenase; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|other; STUDY_GROUP=ECOTOX:15595095:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=3077e7a9583472cf5decf1c5262d2f2b |
| ToxValDB ECOTOX | NOEL | =3 | mmol/kg | Mouse | injection | short-term; 1.25 days | short-term | LONG_REF=Mutat. Res.66:33-43 King,M.T., H. Beikirch, K. Eckhardt, E. Gocke, and D. Wild Mutagenicity Studies with X-Ray Contrast Media, Analgesics, Antipyretics, Antirheumatics and Some Other Pharmaceutical Drugs in Bacterial, Drosophila and Mammalian Test Systems 1979; TITLE=Mutagenicity Studies with X-Ray Contrast Media, Analgesics, Antipyretics, Antirheumatics and Some Other Pharmaceutical Drugs in Bacterial, Drosophila and Mammalian Test Systems; AUTHOR=King,M.T., H. Beikirch, K. Eckhardt, E. Gocke, and D. Wild; DOI=10.1016/0165-1218(79)90005-3; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=181059; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=Genetics: Micronuclei; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15594852:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5bbda78ec2951ab6de3324172741be62 |
| ToxValDB ECOTOX | NOEL | =1000 | mg/kg bw/day | Rat | oral | acute; 1 days | acute | LONG_REF=J. Toxicol. Sci.31(1): 23-34 Kikkawa,R., M. Fujikawa, T. Yamamoto, Y. Hamada, H. Yamada, and I. Horii In Vivo Hepatotoxicity Study of Rats in Comparison with In Vitro Hepatotoxicity Screening System 2006; TITLE=In Vivo Hepatotoxicity Study of Rats in Comparison with In Vitro Hepatotoxicity Screening System; AUTHOR=Kikkawa,R., M. Fujikawa, T. Yamamoto, Y. Hamada, H. Yamada, and I. Horii; DOI=10.2131/jts.31.23; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=102380; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=Biochemistry: Albumin|Biochemistry: Albumin to globulin ratio|Biochemistry: Bilirubin, total|Biochemistry: Calcium content|Biochemistry: Chloride|Biochemistry: Cholesterol|Biochemistry: Creatinine|Biochemistry: Globulin|Biochemistry: Glucose|Biochemistry: Potassium content|Biochemistry: Protein, total|Biochemistry: Sodium content|Biochemistry: Triglycerides|Biochemistry: Urea nitrogen|Enzyme(s): (gamma) -glutamyl transferase|Enzyme(s): Alanine transaminase (ALT)|Enzyme(s): Alkaline phosphatase|Enzyme(s): Aspartate aminotransferase|Enzyme(s): Lactate dehydrogenase; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|enzyme activity|urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600860_15600861_15600862:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7015795e108472891648b5f8ef83566c |
| ToxValDB ECOTOX | NOEL | =300 | mg/kg bw/day | Rat | oral | acute; 1 days | acute | LONG_REF=J. Toxicol. Sci.31(1): 23-34 Kikkawa,R., M. Fujikawa, T. Yamamoto, Y. Hamada, H. Yamada, and I. Horii In Vivo Hepatotoxicity Study of Rats in Comparison with In Vitro Hepatotoxicity Screening System 2006; TITLE=In Vivo Hepatotoxicity Study of Rats in Comparison with In Vitro Hepatotoxicity Screening System; AUTHOR=Kikkawa,R., M. Fujikawa, T. Yamamoto, Y. Hamada, H. Yamada, and I. Horii; DOI=10.2131/jts.31.23; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=102380; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=Biochemistry: Cholesterol|Biochemistry: Globulin|Biochemistry: Protein, total|Biochemistry: Urea nitrogen; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600860_15600861_15600862:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f51b0b19b9eb5f6dd2704ab3ad14fb9f |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =12.006 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15629457:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5cb116feec66af34a26e6e6cf2d505db |
ToxValDB HESS 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB HESS | NOEL | <76.8 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0dfae4b0a676289dec23; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Relative Organ Weight: Liver increase, Right Kidney increase; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=HESS:15638358:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4e400e7fd5ec0b239d71b509bd772ab2 |
| ToxValDB HESS | NOEL | =20 | mg/kg bw/day | Rat | oral | short-term; 19 days | short-term | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0dd8e4b0a676289ddce0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Relative Organ Weight: Liver increase|Histopathology: Ileum-Intestinal epithelial cell vacuolation; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|organ weight; STUDY_GROUP=HESS:15639033:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_129a184876089bf3cede7856790036f5 |
ToxValDB MN MDH HHBW 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB MN MDH HHBW | NOAEL | =7.4 | mg/kg bw/day | Human | oral | epidemiologic | epidemiologic | LONG_REF=McNeil Consumer Healthcare. (2010). "TYLENOL Professional Product Information." from http://www.tylenolprofessional.com/assets/TYL_PPI.pdf.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c98af0e4b02565fc7d4dfb; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.health.state.mn.us/communities/environment/risk/guidance/gw/table.html; SUBSOURCE_URL=https://www.health.state.mn.us/communities/environment/risk/docs/guidance/dwec/sumacetamin.pdf; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=Hepatotoxicity in humans; STUDY_GROUP=MN MDH HHBW:15952704:-:-infant; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_68d8eec5334dc768ccafe34e1f72bbf5 |
ToxValDB ToxRefDB 16 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ToxRefDB | LEL | =625 | mg/kg bw/day | Rat | oral | short-term; 14 days | short-term | LONG_REF=NTP_1993_Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_14 day study_Rats; TITLE=Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_14 day study_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5181; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: in life observation-food consumption-food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15708739_15708740_15708741_15708742:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0bdf1e035ffdcd16e118ef7db0df781a |
| ToxValDB ToxRefDB | LEL | =40 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1993_Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_13 week study_Rats; TITLE=Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_13 week study_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5183; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: organ weight-kidney-relative to body weight|systemic: organ weight-liver-relative to body weight|systemic: in life observation-body weight-body weight|systemic: in life observation-clinical signs-urine, discoloration|systemic: in life observation-clinical signs-reduced body size|systemic: pathology microscopic-kidney-regeneration|systemic: pathology microscopic-liver-fibrosis|systemic: pathology microscopic-uterus-atrophy|systemic: in life observation-food consumption-food consumption|systemic: in life observation-food consumption-food efficiency|systemic: pathology microscopic-liver-necrosis|systemic: pathology microscopic-liver-inflammation|systemic: pathology microscopic-thymus-depletion lymphoid|systemic: pathology microscopic-kidney-casts|systemic: pathology microscopic-liver-proliferation|systemic: pathology microscopic-lymph node-depletion lymphoid|systemic: pathology microscopic-liver-cytomegaly|systemic: pathology microscopic-ovary-atrophy|systemic: pathology microscopic-liver-pigmentation|systemic: in life observation-mortality-mortality|systemic: pathology microscopic-liver-mineralization; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708747_15708748_15708749:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6cb3543e47a3f8b8994aa2039d1dd743 |
| ToxValDB ToxRefDB | LEL | =930 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1993_Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_13 week study_Mice; TITLE=Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_13 week study_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5185; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: organ weight-kidney-relative to body weight|systemic: in life observation-food consumption-food efficiency|systemic: pathology microscopic-liver-pigmentation|systemic: in life observation-body weight-body weight|systemic: in life observation-food consumption-food consumption|systemic: pathology microscopic-liver-mineralization|systemic: pathology microscopic-liver-karyomegaly|systemic: pathology microscopic-liver-cytomegaly|systemic: in life observation-clinical signs-urine, discoloration|systemic: pathology microscopic-liver-necrosis|systemic: in life observation-mortality-mortality; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708753_15708754_15708755_15708756:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_49ecf918dc34464671dbf2ef605bba90 |
| ToxValDB ToxRefDB | LEL | =35 | mg/kg bw/day | Rat | oral | chronic; 103 weeks | chronic | LONG_REF=NTP_1993_Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_2 year study_Rats; TITLE=Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_2 year study_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5187; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: pathology gross-full gross necropsy-leukemia mononuclear|systemic: pathology microscopic-kidney-nephropathy; TOXICOLOGICAL_EFFECT_CATEGORY=cancer|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15708761_15708762_15708763:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bfb64277cefd19d3e247e119ff1c9d43 |
| ToxValDB ToxRefDB | LEL | =30 | mg/kg bw/day | Rat | oral | chronic; 103 weeks | chronic | LONG_REF=NTP_1993_Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_2 year study_Rats; TITLE=Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_2 year study_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5187; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-parathyroid gland-hyperplasia|systemic: pathology microscopic-kidney-hyperplasia|systemic: pathology microscopic-kidney-nephropathy; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15708764_15708765:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c76ce25462940982074c38e2cb1ddec3 |
| ToxValDB ToxRefDB | LEL | =110 | mg/kg bw/day | Mouse | oral | chronic; 103 weeks | chronic | LONG_REF=NTP_1993_Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_2 year study_Mice; TITLE=Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_2 year study_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5189; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: pathology microscopic-thyroid gland-hyperplasia; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15708766_15708767_15708768:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8f7c582e103ba85f7a70c0d7225c3494 |
| ToxValDB ToxRefDB | LEL | =90 | mg/kg bw/day | Mouse | oral | chronic; 103 weeks | chronic | LONG_REF=NTP_1993_Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_2 year study_Mice; TITLE=Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_2 year study_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5189; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-thyroid gland-hyperplasia|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15708769_15708770_15708771:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4edbd7f54ab7b613f06acedd99b7791e |
| ToxValDB ToxRefDB | LOAEL | =625 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1993_Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_13 week study_Rats; TITLE=Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_13 week study_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5183; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15708747_15708748_15708749:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d417383bb28365bff3c06de03088acc2 |
| ToxValDB ToxRefDB | LOAEL | =1875 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1993_Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_13 week study_Mice; TITLE=Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_13 week study_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5185; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-liver-pigmentation|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-liver-mineralization; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15708753_15708754_15708755_15708756:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4df626f0617664fabf34a0f5af1ed079 |
| ToxValDB ToxRefDB | LOAEL | >320 | mg/kg bw/day | Rat | oral | chronic; 103 weeks | chronic | LONG_REF=NTP_1993_Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_2 year study_Rats; TITLE=Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_2 year study_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5187; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=ToxRefDB_dup_-_15708761_15708762_15708763:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9fb49b6a111dc768e008dc9f59fe787a |
| ToxValDB ToxRefDB | LOAEL | >1200 | mg/kg bw/day | Mouse | oral | chronic; 103 weeks | chronic | LONG_REF=NTP_1993_Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_2 year study_Mice; TITLE=Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_2 year study_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5189; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=ToxRefDB_dup_-_15708766_15708767_15708768:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3783ead60c2bc87f0c59b1a93f737435 |
| ToxValDB ToxRefDB | LOAEL | =1000 | mg/kg bw/day | Mouse | oral | chronic; 103 weeks | chronic | LONG_REF=NTP_1993_Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_2 year study_Mice; TITLE=Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_2 year study_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5189; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15708769_15708770_15708771:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9097081c86afc76678353059b1de7c50 |
| ToxValDB ToxRefDB | NEL | =310 | mg/kg bw/day | Rat | oral | short-term; 14 days | short-term | LONG_REF=NTP_1993_Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_14 day study_Rats; TITLE=Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_14 day study_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5181; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: in life observation-food consumption-food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15708739_15708740_15708741_15708742:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c07aac23ddb431d6fd376e50e8a0e0f4 |
| ToxValDB ToxRefDB | NEL | =480 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1993_Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_13 week study_Mice; TITLE=Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_13 week study_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5185; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-liver-cytomegaly|systemic: pathology microscopic-liver-karyomegaly|systemic: pathology microscopic-liver-pigmentation|systemic: in life observation-food consumption-food efficiency|systemic: pathology microscopic-liver-mineralization|systemic: in life observation-mortality-mortality|systemic: pathology microscopic-liver-necrosis|systemic: in life observation-clinical signs-urine, discoloration|systemic: organ weight-kidney-relative to body weight|systemic: in life observation-body weight-body weight|systemic: in life observation-food consumption-food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708753_15708754_15708755_15708756:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0344b0ff9d761c1207183fafb126dee8 |
| ToxValDB ToxRefDB | NOAEL | =310 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1993_Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_13 week study_Rats; TITLE=Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_13 week study_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5183; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-lymph node-depletion lymphoid|systemic: organ weight-kidney-relative to body weight|systemic: pathology microscopic-liver-cytomegaly|systemic: organ weight-liver-relative to body weight|systemic: pathology microscopic-liver-pigmentation|systemic: pathology microscopic-ovary-atrophy|systemic: in life observation-mortality-mortality|systemic: pathology microscopic-liver-mineralization|systemic: pathology microscopic-kidney-regeneration|systemic: pathology microscopic-liver-fibrosis|systemic: pathology microscopic-uterus-atrophy|systemic: in life observation-food consumption-food efficiency|systemic: pathology microscopic-liver-necrosis|systemic: in life observation-food consumption-food consumption|systemic: pathology microscopic-liver-inflammation|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-thymus-depletion lymphoid|systemic: pathology microscopic-kidney-casts|systemic: pathology microscopic-liver-proliferation|systemic: in life observation-clinical signs-reduced body size|systemic: in life observation-clinical signs-urine, discoloration; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708747_15708748_15708749:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_67998d90ac8bfd38310f39507d7d9693 |
| ToxValDB ToxRefDB | NOAEL | =450 | mg/kg bw/day | Mouse | oral | chronic; 103 weeks | chronic | LONG_REF=NTP_1993_Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_2 year study_Mice; TITLE=Toxicology and Carcinogenesis Studies of Acetaminophen (CAS No. 103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies)_2 year study_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5189; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: pathology microscopic-thyroid gland-hyperplasia; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15708769_15708770_15708771:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2588f8aebf9fdf42d92b6763b9b0dc62 |
openFDA substances 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 362O9ITL9D | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C8H9NO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"362O9ITL9D"} |
| openFDA substances | FDA UNII substance identifier | 362O9ITL9D | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C8H9NO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"362O9ITL9D"} |
| openFDA substances | FDA UNII substance identifier | 362O9ITL9D | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C8H9NO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"362O9ITL9D"} |
| openFDA substances | FDA UNII substance identifier | 362O9ITL9D | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C8H9NO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"362O9ITL9D"} |
| openFDA substances | FDA UNII substance identifier | 362O9ITL9D | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C8H9NO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"362O9ITL9D"} |
| openFDA substances | FDA UNII substance identifier | 362O9ITL9D | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C8H9NO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"362O9ITL9D"} |
| openFDA substances | FDA UNII substance identifier | 362O9ITL9D | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C8H9NO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"362O9ITL9D"} |
| openFDA substances | FDA UNII substance identifier | 362O9ITL9D | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C8H9NO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"362O9ITL9D"} |