NOAEL Studies Cosmetic Ingredient

4-Tert-Butyltoluene NOAEL Studies

INCI: 4-TERT-BUTYLTOLUENE

CAS: 98-51-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP ICE acute inhalation 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute inhalation LC50 0.9998 mg/L - Inhalation Duration=8 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=1017; Record_ID=acute_inhalation_2676; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1024704; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.9998; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024704; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024704
NTP ICE acute oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 =1555 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_11905; row=2630; data_type=In Vivo; mixture=Chemical; chemical_name=4-tert-Butyltoluene; preferred_name=4-tert-Butyltoluene; dtxsid=DTXSID1024704; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024704; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1024704; source_file=acute_oral.xlsx
NTP ICE endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=4218; RecordID=ARPathway2016_1799; DatasetName=ARPathway2016; DTXSID=DTXSID1024704; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1024704; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1024704
ECHA 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA LOAEL =50 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab95e4b0a7c65d1baf06; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22796/7/9/2?documentUUID=7d93d4b0-bbf6-41ba-8851-5ce6e3b5e66d; YEAR=2004; ORIGINAL_YEAR=2004; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15856438_15857006_15861966:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a09a359b402a4530d294c5b204351202
ECHA NOAEC <150 mg/m3 Rat inhalation chronic; 26 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22796/7/6/3?documentUUID=7d93d4b0-bbf6-41ba-8851-5ce6e3b5e66d; YEAR=2004; ORIGINAL_YEAR=2004; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15828775_15828776:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c3cc68664aa981cb8d58242090d25567
ECHA NOAEL =25 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab95e4b0a7c65d1baf06; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22796/7/9/2?documentUUID=7d93d4b0-bbf6-41ba-8851-5ce6e3b5e66d; YEAR=2004; ORIGINAL_YEAR=2004; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15856438_15857006_15861966:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c031f5d73be66ad042dd88d515d24e7f
ECHA NOAEL <100 mg/kg bw/day Guinea Pig oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c977e4b0a7c65d21d058; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22796/7/9/2?documentUUID=7d93d4b0-bbf6-41ba-8851-5ce6e3b5e66d; YEAR=2004; ORIGINAL_YEAR=2004; STUDY_GROUP=ECHA IUCLID:15857508:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0d30868c2c9ab278b2a091aca82cfd55
ECHA NOAEL <200 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c977e4b0a7c65d21d04f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22796/7/9/2?documentUUID=7d93d4b0-bbf6-41ba-8851-5ce6e3b5e66d; YEAR=2004; ORIGINAL_YEAR=2004; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15856438_15857006_15861966:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3f7063d13832144b98a02b1ce2acfa2e
ECHA NOEL =1.5 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf8fe4b0a7c65d1ce810; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22796/7/6/2?documentUUID=7d93d4b0-bbf6-41ba-8851-5ce6e3b5e66d; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=clinical biochemistry|haematology|histopathology: non-neoplastic|organ weights and organ / body weight ratios|urinalysis; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|hematology|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=ECHA IUCLID:15850063:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a8fe1db03c4dac8a4790c87e65c8a5b5
ECHA NOEL =5 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf8fe4b0a7c65d1ce810; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22796/7/6/2?documentUUID=7d93d4b0-bbf6-41ba-8851-5ce6e3b5e66d; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=clinical biochemistry|haematology|histopathology: non-neoplastic|organ weights and organ / body weight ratios|urinalysis; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|hematology|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=ECHA IUCLID:15850064:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1f4edce2045234ada29e3af9e90a5c69
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 589519D43L UNII - - - chemical {"approval_status":null,"molecular_formula":"C11H16","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"589519D43L"}
openFDA substances FDA UNII substance identifier 589519D43L UNII - - - chemical {"approval_status":null,"molecular_formula":"C11H16","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"589519D43L"}
openFDA substances FDA UNII substance identifier 589519D43L UNII - - - chemical {"approval_status":null,"molecular_formula":"C11H16","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"589519D43L"}
openFDA substances FDA UNII substance identifier 589519D43L UNII - - - chemical {"approval_status":null,"molecular_formula":"C11H16","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"589519D43L"}