NOAEL Studies Cosmetic Ingredient

4-Terpineol (Terpinen-4-ol) NOAEL Studies

INCI: TERPINEN-4-OL

CAS: 562-74-3

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA NOAEL =250 mg/kg bw/day Rat oral: gavage 35 days reproduction toxicity EFSA FEEDAP - 2012 - OutputID 2155 - reproduction - reproductive - Scientific Opinion on the safety and efficacy of aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols and esters with esters containing tertiary alcohols ethers (chemical group 6) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2966
NTP ICE skin sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=8201; Record_ID=skin_sensitization_invivo_1853; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID4044824; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Epstein 1977: report to RIFM|RIFM 1977; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Anonymous 1982; Not available; 10.1016/S0015-6264(82)80217-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4044824
NTP ICE skin sensitization Induction dose per skin area 3375 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=8199; Record_ID=skin_sensitization_invivo_1853; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID4044824; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=3375; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Epstein 1977: report to RIFM|RIFM 1977; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Anonymous 1982; Not available; 10.1016/S0015-6264(82)80217-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4044824
NTP ICE skin sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=8205; Record_ID=skin_sensitization_invivo_1853; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID4044824; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Epstein 1977: report to RIFM|RIFM 1977; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Anonymous 1982; Not available; 10.1016/S0015-6264(82)80217-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4044824
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier L65MV77ZG6 UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H18O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"L65MV77ZG6"}
openFDA substances FDA UNII substance identifier L65MV77ZG6 UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H18O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"L65MV77ZG6"}
openFDA substances FDA UNII substance identifier L65MV77ZG6 UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H18O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"L65MV77ZG6"}
openFDA substances FDA UNII substance identifier L65MV77ZG6 UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H18O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"L65MV77ZG6"}