NOAEL Studies Cosmetic Ingredient

4-T-Butylcyclohexanol NOAEL Studies

INCI: 4-T-BUTYLCYCLOHEXANOL

CAS: 98-52-2

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =10 mg/kg bw/day Rat - - acute toxicity EFSA - 2010 - OutputID 1237 - neurology - neurotoxicity - Conclusion on the peer review of the pesticide risk assessment of the active substance spiroxamine. - doi:10.2903/j.efsa.2010.1719
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =2.5 mg/kg bw/day Dog oral: unspecified 365 days chronic/long term toxicity EFSA - 2010 - OutputID 1237 - histopathology non neoplastic - hepatotoxicity - Conclusion on the peer review of the pesticide risk assessment of the active substance spiroxamine. - doi:10.2903/j.efsa.2010.1719
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =31.5 mg/kg bw/day Rat - - reproduction toxicity EFSA - 2021 - OutputID 3927 - clinical signs - systemic - Peer review of the pesticide risk assessment for the active substance spiroxamine in light of confirmatory data submitted - doi:10.2903/j.efsa.2021.6385
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =30 mg/kg bw/day Rat - 28 days subchronic EFSA - 2021 - OutputID 3927 - clinical signs - neurotoxicity - Peer review of the pesticide risk assessment for the active substance spiroxamine in light of confirmatory data submitted - doi:10.2903/j.efsa.2021.6385
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOEL =9.19 mg/kg bw/day Rat - - chronic/long term toxicity EFSA - 2010 - OutputID 1237 - Conclusion on the peer review of the pesticide risk assessment of the active substance spiroxamine. - doi:10.2903/j.efsa.2010.1719
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOEL =22.2 mg/kg bw/day Rat - - chronic/long term toxicity EFSA - 2010 - OutputID 1237 - Conclusion on the peer review of the pesticide risk assessment of the active substance spiroxamine. - doi:10.2903/j.efsa.2010.1719
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOEL =2.02 mg/kg bw/day Bobwhite quail - - reproduction toxicity EFSA - 2010 - OutputID 1237 - Conclusion on the peer review of the pesticide risk assessment of the active substance spiroxamine. - doi:10.2903/j.efsa.2010.1719
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOEL =10.6 mg/kg bw/day Mallard duck - - reproduction toxicity EFSA - 2010 - OutputID 1237 - Conclusion on the peer review of the pesticide risk assessment of the active substance spiroxamine. - doi:10.2903/j.efsa.2010.1719
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ADI =0.025 mg/kg bw/day Consumers - - ADI EFSA - 2010 - OutputID 1237 - Consumers - Conclusion on the peer review of the pesticide risk assessment of the active substance spiroxamine. - doi:10.2903/j.efsa.2010.1719
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ADI =0.03 mg/kg bw/day Consumers - - ADI EFSA - 2021 - OutputID 3927 - Consumers - Peer review of the pesticide risk assessment for the active substance spiroxamine in light of confirmatory data submitted - doi:10.2903/j.efsa.2021.6385
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ADI =0.025 mg/kg bw/day Consumers - - ADI EFSA - 2010 - OutputID 1237 - Consumers - Conclusion on the peer review of the pesticide risk assessment of the active substance spiroxamine. - doi:10.2903/j.efsa.2010.1719
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ADI =0.03 mg/kg bw/day Consumers - - ADI EFSA - 2021 - OutputID 3927 - Consumers - Peer review of the pesticide risk assessment for the active substance spiroxamine in light of confirmatory data submitted - doi:10.2903/j.efsa.2021.6385
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ARfD =0.1 mg/kg bw Consumers - - ARfD EFSA - 2010 - OutputID 1237 - Consumers - Conclusion on the peer review of the pesticide risk assessment of the active substance spiroxamine. - doi:10.2903/j.efsa.2010.1719
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ARfD =0.1 mg/kg bw/day Consumers - - ARfD EFSA - 2021 - OutputID 3927 - Consumers - Peer review of the pesticide risk assessment for the active substance spiroxamine in light of confirmatory data submitted - doi:10.2903/j.efsa.2021.6385
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ARfD =0.1 mg/kg bw Consumers - - ARfD EFSA - 2010 - OutputID 1237 - Consumers - Conclusion on the peer review of the pesticide risk assessment of the active substance spiroxamine. - doi:10.2903/j.efsa.2010.1719
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ARfD =0.1 mg/kg bw/day Consumers - - ARfD EFSA - 2021 - OutputID 3927 - Consumers - Peer review of the pesticide risk assessment for the active substance spiroxamine in light of confirmatory data submitted - doi:10.2903/j.efsa.2021.6385
NTP_ICE_acute_oral 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 >2000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_11906; row=8923; data_type=In Vivo; mixture=Chemical; chemical_name=4-tert-Butylcyclohexanol; preferred_name=4-tert-Butylcyclohexanol; dtxsid=DTXSID5026623; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5026623; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =4200 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_11907; row=8924; data_type=In Vivo; mixture=Chemical; chemical_name=4-tert-Butylcyclohexanol; preferred_name=4-tert-Butylcyclohexanol; dtxsid=DTXSID5026623; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5026623; source_file=acute_oral.xlsx
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=4192; RecordID=ARPathway2016_1800; DatasetName=ARPathway2016; DTXSID=DTXSID5026623; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5026623
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=11500; Record_ID=skin_sensitization_invivo_2498; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5026623; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1973: report to RlFM|Opdyke 1974; Not available; 10.1016/0015-6264(74)90141-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5026623
NTP_ICE_skin_sensitization Induction dose per skin area 2592 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=11498; Record_ID=skin_sensitization_invivo_2498; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5026623; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=2592; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1973: report to RlFM|Opdyke 1974; Not available; 10.1016/0015-6264(74)90141-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5026623
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=11504; Record_ID=skin_sensitization_invivo_2498; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5026623; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1973: report to RlFM|Opdyke 1974; Not available; 10.1016/0015-6264(74)90141-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5026623
ToxValDB_ECHA_IUCLID 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LOAEL =300 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf8fe4b0a7c65d1ce813; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13464/7/6/2?documentUUID=29f2fd75-a496-45d9-99e9-44563f27619a; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837798_15844833_15850065_15850066:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b5c5c83cf5ea89d5e0c8e63464127594
ToxValDB_ECHA_IUCLID NOAEL =150 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf8fe4b0a7c65d1ce81c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13464/7/6/2?documentUUID=341f03c9-2697-4a75-b830-b55fb7de2def; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837798_15844833_15850065_15850066:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b0525974ee01091e1ac1ab35a0aa695a
ToxValDB_EFSA 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA NOAEL =31.5 mg/kg bw/day Rat oral - reproduction developmental LONG_REF=EFSA (2021). Peer review of the pesticide risk assessment for the active substance spiroxamine in light of confirmatory data submitted. doi:10.2903/j.efsa.2021.6385.; TITLE=Peer review of the pesticide risk assessment for the active substance spiroxamine in light of confirmatory data submitted; AUTHOR=EFSA; DOI=doi:10.2903/j.efsa.2021.6385; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2021; ORIGINAL_YEAR=2021; TOXICOLOGICAL_EFFECT=clinical signs; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=EFSA:15625574:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5d8a91f3a86b216d1ca564bae308b837
ToxValDB_EFSA NOAEL =30 mg/kg bw/day Rat oral short-term; 28 days short-term LONG_REF=EFSA (2021). Peer review of the pesticide risk assessment for the active substance spiroxamine in light of confirmatory data submitted. doi:10.2903/j.efsa.2021.6385.; TITLE=Peer review of the pesticide risk assessment for the active substance spiroxamine in light of confirmatory data submitted; AUTHOR=EFSA; DOI=doi:10.2903/j.efsa.2021.6385; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2021; ORIGINAL_YEAR=2021; TOXICOLOGICAL_EFFECT=clinical signs; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=EFSA:15625575:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_37b6b1bd3535638c10111f698cc267a2
ToxValDB_GESTIS_DNEL 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =1.76 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15630416_15630417:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_139c1a6ea540ee5bf2d46f39512bb671
ToxValDB_GESTIS_DNEL DNEL systemic =4.93 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15630416_15630417:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f3c95a870897f4ea19354666888d2edf
ToxValDB_HPVIS 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_HPVIS NOAEL =50 mg/kg bw/day Rat oral short-term; 28 days short-term LONG_REF=Degussa AG (1999) Unpublished report. Report No. 98-0184-DGT.Posting dates of the documents from the HPV Challenge Program website from which data have been entered into the HPVIS: Jan. 30, 2007.; QUALITY=1; EXTERNAL_SOURCE_ID=62749; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1998; ORIGINAL_YEAR=1998; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639823_15639934:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8c29a1e858d3d81e2ebe7d2f1356b3e6
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier K0H1405S9C UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"K0H1405S9C"}
openFDA substances FDA UNII substance identifier K0H1405S9C UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"K0H1405S9C"}
openFDA substances FDA UNII substance identifier K0H1405S9C UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"K0H1405S9C"}
openFDA substances FDA UNII substance identifier K0H1405S9C UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"K0H1405S9C"}