NOAEL Studies Cosmetic Ingredient

4-Ethylphenol NOAEL Studies

INCI: 4-ETHYLPHENOL

CAS: 123-07-9

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 342 mg/kg bw/day rat oral 90 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 300 mg/kg bw/day rat oral 21 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
NTP_ICE_endocrine 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine AC50 54.0425139317328 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=3868; RecordID=ERPathway2016_464; DatasetName=ERPathway2016; DTXSID=DTXSID4021977; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=54.0425139317328; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021977
NTP_ICE_endocrine AC50/EC50/IC50 428000 nM - - - In Vitro; AR Binding sheet=Data_invitro; excel_row=99; Record_ID=endocrine_invitro_93; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID4021977; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=428000; Reported_Response_Unit=nM; Response=428000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Fang et al. 2003; 14565775; 10.1021/tx030011g; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021977
NTP_ICE_endocrine ACC 44.6362455584907 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=3869; RecordID=ERPathway2016_464; DatasetName=ERPathway2016; DTXSID=DTXSID4021977; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=44.6362455584907; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021977
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=3864; RecordID=ARPathway2016_711; DatasetName=ARPathway2016; DTXSID=DTXSID4021977; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021977
NTP_ICE_endocrine Model Score 0.00352 unitless - - - ERPathway2016; ER Pathway Model, Agonist sheet=Integrated_approaches; excel_row=3870; RecordID=ERPathway2016_464; DatasetName=ERPathway2016; DTXSID=DTXSID4021977; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.00352; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021977
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =8.167 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632079:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e993721be863f4cae88d107f3ddf985d
openFDA substances 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier AGG7E6G0ZC UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"AGG7E6G0ZC"}
openFDA substances FDA UNII substance identifier AGG7E6G0ZC UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"AGG7E6G0ZC"}
openFDA substances FDA UNII substance identifier AGG7E6G0ZC UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"AGG7E6G0ZC"}