NOAEL Studies Cosmetic Ingredient

3-Propylidenephthalide NOAEL Studies

INCI: 3-PROPYLIDENEPHTHALIDE

CAS: 17369-59-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 6.55 mg/kg bw/day rat oral 90 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =5.42 mg/kg bw/day Rat oral: unspecified 90 days subchronic EFSA FEEDAP - 2012 - OutputID 152 - Scientific Opinion on the safety and efficacy of alicyclic and aromatic lactones (chemical group 11) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2622
NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =1650 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_3401; row=11990; data_type=In Vivo; mixture=Chemical; chemical_name=3-Propylidenephthalide; preferred_name=3-Propylidenephthalide; dtxsid=DTXSID7025972; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025972; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7025972; source_file=acute_oral.xlsx
NTP_ICE_skin_sensitization 25 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization CD54, EC200 55.6 ug/mL - Dermal - In Vitro; CE_hCLAT2018; h-CLAT sheet=Data_invitro; excel_row=1973; Record_ID=skin_sensitization_invitro_498; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID7025972; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=55.6; Reported_Response_Unit=ug/mL; Response=55.6; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025972; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025972
NTP_ICE_skin_sensitization CD86, EC150 31.2 ug/mL - Dermal - In Vitro; CE_hCLAT2018; h-CLAT sheet=Data_invitro; excel_row=1971; Record_ID=skin_sensitization_invitro_498; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID7025972; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=31.2; Reported_Response_Unit=ug/mL; Response=31.2; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025972; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025972
NTP_ICE_skin_sensitization CD86, EC150 >1219.393 ug/mL - Dermal - In Vitro; Urbisch_SkinSensitization2020; U-SENS sheet=Data_invitro; excel_row=8249; Record_ID=skin_sensitization_invitro_2272; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID7025972; Assay=U-SENS; Endpoint=CD86, EC150; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=7000; Reported_Response_Unit=uM; Conversion_Factor_Value=174.199; Conversion_Factor_Source=EPA Dashboard; Converted_Response_Modifier=>; Converted_Response=1219.393; Converted_Response_Unit=ug/mL; Response=1219.393; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025972; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025972
NTP_ICE_skin_sensitization CV75 113 ug/mL - Dermal - In Vitro; CE_hCLAT2018; h-CLAT sheet=Data_invitro; excel_row=1975; Record_ID=skin_sensitization_invitro_498; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID7025972; Assay=h-CLAT; Endpoint=CV75; Reported_Response=113; Reported_Response_Unit=ug/mL; Response=113; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025972; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025972
NTP_ICE_skin_sensitization CV75 112.9 ug/mL - Dermal - In Vitro; hCLAT2015; h-CLAT sheet=Data_invitro; excel_row=3625; Record_ID=skin_sensitization_invitro_829; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID7025972; Assay=h-CLAT; Endpoint=CV75; Reported_Response=112.9; Reported_Response_Unit=ug/mL; Response=112.9; Response_Unit=ug/mL; Reference=Ashikaga et al. 2010; 20822320; 10.1177/026119291003800403|Nukada et al. 2011; 21767275; 10.1111/j.1600-0536.2011.01952.x|Nukada et al. 2012; 22796097; 10.1016/j.tiv.2012.07.001|Nukada personal communication (undated)|Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025972; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025972
NTP_ICE_skin_sensitization Concentration, 5% incidence of positive responses 1.667 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=5762; Record_ID=skin_sensitization_invivo_1330; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7025972; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=1.667; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1975: report to RIFM|Opdyke personal communication 1975|Anonymous 1978; Not available; 10.1016/S0015-6264(78)80148-5|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Api et al. 2017; 28691948; 10.1097/der.0000000000000304; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025972; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025972
NTP_ICE_skin_sensitization Concentration, one positive response 1.333 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=5758; Record_ID=skin_sensitization_invivo_1330; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7025972; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=1.333; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1975: report to RIFM|Opdyke personal communication 1975|Anonymous 1978; Not available; 10.1016/S0015-6264(78)80148-5|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Api et al. 2017; 28691948; 10.1097/der.0000000000000304; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025972; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025972
NTP_ICE_skin_sensitization Depletion Cys -5.6 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1321; Record_ID=skin_sensitization_invitro_354; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7025972; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=-5.6; Reported_Response_Unit=%; Response=-5.6; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025972; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025972
NTP_ICE_skin_sensitization Depletion Cys 14.3 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1328; Record_ID=skin_sensitization_invitro_356; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7025972; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=14.3; Reported_Response_Unit=%; Response=14.3; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025972; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025972
NTP_ICE_skin_sensitization Depletion Lys 12.6 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1319; Record_ID=skin_sensitization_invitro_354; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7025972; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=12.6; Reported_Response_Unit=%; Response=12.6; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025972; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025972
NTP_ICE_skin_sensitization Depletion Lys 30.6 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1327; Record_ID=skin_sensitization_invitro_356; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7025972; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=30.6; Reported_Response_Unit=%; Response=30.6; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025972; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025972
NTP_ICE_skin_sensitization Depletion Lys + Cys 6.3 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1323; Record_ID=skin_sensitization_invitro_354; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7025972; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=6.3; Reported_Response_Unit=%; Response=6.3; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025972; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025972
NTP_ICE_skin_sensitization Depletion Lys + Cys 22.45 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1330; Record_ID=skin_sensitization_invitro_356; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7025972; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=22.45; Reported_Response_Unit=%; Response=22.45; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025972; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025972
NTP_ICE_skin_sensitization EC1.5 >2000 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=5452; Record_ID=skin_sensitization_invitro_1278; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID7025972; Assay=KeratinoSens; Endpoint=EC1.5; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2000; Reported_Response_Unit=uM; Response=2000; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025972; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025972
NTP_ICE_skin_sensitization EC3 3.7 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13586; Record_ID=skin_sensitization_invivo_3811; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7025972; Assay=LLNA; Endpoint=EC3; Response=3.7; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025972; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025972
NTP_ICE_skin_sensitization EC3 3.7 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13586; Record_ID=skin_sensitization_invivo_3811; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7025972; Assay=LLNA; Endpoint=EC3; Response=3.7; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025972; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025972
NTP_ICE_skin_sensitization EC3 3.7 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13586; Record_ID=skin_sensitization_invivo_3811; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7025972; Assay=LLNA; Endpoint=EC3; Response=3.7; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025972; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025972
NTP_ICE_skin_sensitization EC3 3.7 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13586; Record_ID=skin_sensitization_invivo_3811; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7025972; Assay=LLNA; Endpoint=EC3; Response=3.7; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025972; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025972
NTP_ICE_skin_sensitization IC50 717.4 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=5454; Record_ID=skin_sensitization_invitro_1278; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID7025972; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=717.4; Reported_Response_Unit=uM; Response=717.4; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025972; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025972
NTP_ICE_skin_sensitization Imax 1.1 ratio - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=5455; Record_ID=skin_sensitization_invitro_1278; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID7025972; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.1000000000000001; Reported_Response_Unit=Unitless; Response=1.1; Response_Unit=Ratio; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025972; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025972
NTP_ICE_skin_sensitization Incidence of positive responses 12 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=5754; Record_ID=skin_sensitization_invivo_1330; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7025972; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=12; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1975: report to RIFM|Opdyke personal communication 1975|Anonymous 1978; Not available; 10.1016/S0015-6264(78)80148-5|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Api et al. 2017; 28691948; 10.1097/der.0000000000000304; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025972; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025972
NTP_ICE_skin_sensitization Induction dose per skin area 2700 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=5752; Record_ID=skin_sensitization_invivo_1330; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7025972; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=2700; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1975: report to RIFM|Opdyke personal communication 1975|Anonymous 1978; Not available; 10.1016/S0015-6264(78)80148-5|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Api et al. 2017; 28691948; 10.1097/der.0000000000000304; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025972; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025972
NTP_ICE_skin_sensitization Induction dose per skin area, 5% incidence of positive responses 1125 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=5764; Record_ID=skin_sensitization_invivo_1330; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7025972; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=1125; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1975: report to RIFM|Opdyke personal communication 1975|Anonymous 1978; Not available; 10.1016/S0015-6264(78)80148-5|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Api et al. 2017; 28691948; 10.1097/der.0000000000000304; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025972; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025972
NTP_ICE_skin_sensitization Induction dose per skin area, one positive response 900 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=5760; Record_ID=skin_sensitization_invivo_1330; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7025972; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=900; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1975: report to RIFM|Opdyke personal communication 1975|Anonymous 1978; Not available; 10.1016/S0015-6264(78)80148-5|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Api et al. 2017; 28691948; 10.1097/der.0000000000000304; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025972; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025972
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=5766; Record_ID=skin_sensitization_invivo_1330; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7025972; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1975: report to RIFM|Opdyke personal communication 1975|Anonymous 1978; Not available; 10.1016/S0015-6264(78)80148-5|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Api et al. 2017; 28691948; 10.1097/der.0000000000000304; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025972; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025972
ToxValDB_EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA NOAEL =5.42 mg/kg bw/day Rat oral subchronic; 90 days subchronic LONG_REF=EFSA FEEDAP (2012). Scientific Opinion on the safety and efficacy of alicyclic and aromatic lactones (chemical group 11) when used as flavourings for all animal species. doi:10.2903/j.efsa.2012.2622.; TITLE=Scientific Opinion on the safety and efficacy of alicyclic and aromatic lactones (chemical group 11) when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2012.2622; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=EFSA:15614070:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_642f62e9e243c1def3eca6872629bf65
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier WHD8YJ226P UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"WHD8YJ226P"}
openFDA substances FDA UNII substance identifier WHD8YJ226P UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"WHD8YJ226P"}
openFDA substances FDA UNII substance identifier WHD8YJ226P UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"WHD8YJ226P"}
openFDA substances FDA UNII substance identifier WHD8YJ226P UNII - - - mixture {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"WHD8YJ226P"}