Is 2,7-Naphthalenediol safe in cosmetics?
2,7-Naphthalenediol has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
2,7-Naphthalenediol
Also known as: 4-06-00-06570, BRN 2042383, EINECS 209-478-7, Naphthalenediol-2,7, UNII-0TO8E448UD
INCI: 2,7-NAPHTHALENEDIOL
2,7-Naphthalenediol (CAS 582-17-2) is a cosmetic cosmetic ingredient functioning as Hair Dyeing (oxidative and non-oxidative). Reported NOAEL =0.04 mg/kg bw/d in rat (SCCS_vision_codex); EU Regulation 1223/2009 status: prohibited, max 1.0%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 582-17-2 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
2,7-Naphthalenediol is prohibited in EU cosmetics at max 1.0% but has active industrial GHS classifications (H302, H315, H317, H318, H319, H335, H411).
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Hair Dyeing (oxidative and non-oxidative)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
naphthalene-2,7-diol
InChIKey
DFQICHCWIIJABH-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
EU Max Conc.
1.0%
US US Status
permitted
US Notes
Permitted for hair dye use under the coal tar hair dye exemption (FD&C Act §601(a))
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 2,7-Naphthalenediol.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for 2,7-Naphthalenediol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.04 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.04 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.04 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.04 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.06 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.06 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.06 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.06 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =60 mg/kg/day | oral | rat | NOAEL study | SCCS_vision_codex |
| NOAEL | =60 mg/kg/day | oral | rat | NOAEL study | SCCS_vision_codex |
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
6.5%
DPRA Lys %
57.5%
KeratinoSens IC50
320.792 µM
hCLAT CV75
97.5 µg/mL
LLNA EC3
2.8%
NESIL
700 µg/cm²
LLNA: Moderate (1B)
GHS: 1B
Source: LLNA: CosmEur database; DPRA: Cosmetics Europe; KS: Cosmetics Europe; hCLAT: Cosmetics Europe
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
KR Korea MFDS Annex 2 (Restricted)
Category: Restricted. Max: 1.0%. 기타제품에는 사용금지
SA Saudi SFDA (III - Restricted)
Product type: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non- oxidative hair dye products. Max: (b) 1,0 %.
BRIN Brazil/India Cosmetics
India: Restricted · max (b) 1,0 %
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| KR | prohibited | - | - |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
hair_dye
{"cas_number": "582-17-2", "ingredient_class": "oxidative_dye_coupler", "chemical_class": "naphtol", "molecular_weight_Da": "160.17", "color_result_on_hair": "Yellow-orange modifier", "shade_range": "blonde", "primary_function": "coupler", "oxidative_dye_type": "coupler", "requires_developer": "yes", "permanence": "permanent", "oxidation_mechanism": "coupling", "hair_penetration_depth": "cortex", …
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (1)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for 2,7-Naphthalenediol.
Regulatory Flags
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to 2,7-Naphthalenediol by CAS number or substance name.
Studies
28
Lowest NOAEL
0.04
Highest NOAEL
585
Units vary across source rows: mg/kg/day, mg/kg bw/day, mg/kg bw/d
SCCS_vision_codex
Known Synonyms
4-06-00-06570
BRN 2042383
EINECS 209-478-7
Naphthalenediol-2,7
UNII-0TO8E448UD
Chemical Function
Dye
Regulatory Lists
Europe; Personal care - hair coloring
Europe; Personal care; restricted
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL205165
Frequently Asked Questions
Is 2,7-Naphthalenediol allowed in the EU?
2,7-Naphthalenediol EU regulatory status: prohibited. Maximum allowed concentration: 1.0%. This is based on EU Regulation 1223/2009 and its amendments.
What does 2,7-Naphthalenediol do in cosmetics?
2,7-Naphthalenediol functions as: Hair Dyeing (oxidative and non-oxidative). It is classified as a cosmetic ingredient in our database. CAS number: 582-17-2.
What is the NOAEL for 2,7-Naphthalenediol?
The NOAEL (No Observed Adverse Effect Level) for 2,7-Naphthalenediol is =0.04 mg/kg bw/d based on a dermal absorption study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
Is 2,7-Naphthalenediol used outside cosmetics?
2,7-Naphthalenediol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 2,7-Naphthalenediol have different safety status in cosmetics vs industrial chemicals?
2,7-Naphthalenediol is prohibited in EU cosmetics at max 1.0% but has active industrial GHS classifications (H302, H315, H317, H318, H319, H335, H411).
Compliance Tools
Check 2,7-Naphthalenediol compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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