NOAEL Studies Cosmetic Ingredient

2,4-Xylenol NOAEL Studies

INCI: 2,4-XYLENOL (2,4-DIMETHYLPHENOL)

CAS: 105-67-9

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =67 mg/kg bw/day Rat oral: unspecified 90 days subchronic EFSA FEEDAP - 2012 - OutputID 201 - food consumption - systemic - Scientific Opinion on the safety and efficacy of Scansmoke SEF7525 (smoke flavourings) for cats and dogs - doi:10.2903/j.efsa.2012.2729
EPA_IRIS_iris_rfd_systems.csv 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EPA_IRIS_iris_rfd_systems.csv NOAEL =50 mg/kg/day - oral chronic IRIS chronic oral RfD system PoD row_hash=7f2122072f0e0d38; file=iris_rfd_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=NOAEL : 5.0e1 mg/kg-day; system=Nervous, Hematologic; basis=Clinical signs (lethargy, prostration, and ataxia) and hematological changes; point_of_departure=NOAEL : 5.0e1 mg/kg-day; composite_uf=3000; confidence=Low; dtxsid=DTXSID2021864; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=466; rfd_last_updated=11/01/1990; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0466_summary.pdf
EPA_IRIS_iris_rfd_systems.csv RfD =0.02 mg/kg/day - oral chronic IRIS chronic oral RfD system row_hash=57b3debd1cbb5a8a; file=iris_rfd_systems.csv; kind=reference_value; raw_column=rfd_mg_per_kg_day; raw_value=2e-2; system=Nervous, Hematologic; basis=Clinical signs (lethargy, prostration, and ataxia) and hematological changes; point_of_departure=NOAEL : 5.0e1 mg/kg-day; composite_uf=3000; confidence=Low; dtxsid=DTXSID2021864; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=466; rfd_last_updated=11/01/1990; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0466_summary.pdf
NTP_ICE_acute_oral 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =2300 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_486; row=3994; data_type=In Vivo; mixture=Chemical; chemical_name=2,4-Dimethylphenol; preferred_name=2,4-Dimethylphenol; dtxsid=DTXSID2021864; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021864; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021864; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =3200 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_488; row=3995; data_type=In Vivo; mixture=Chemical; chemical_name=2,4-Dimethylphenol; preferred_name=2,4-Dimethylphenol; dtxsid=DTXSID2021864; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021864; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021864; source_file=acute_oral.xlsx
NTP_ICE_adme_parameters 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_adme_parameters Clint 38 uL/min/10^6 cells Rat - - Measured; httk, Rat Hepatic Intrinsic Clearance sheet=Data; excel_row=844; Record_ID=adme_parameters_1356; Data_Type=Measured; DTXSID=DTXSID2021864; Assay=httk, Rat Hepatic Intrinsic Clearance; Endpoint=Clint; Response=38.0; Response_Unit=ul/min/10^6 cells; Species=Rat; Reference=httk2.3.1, Honda 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021864; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021864
NTP_ICE_adme_parameters Fu 0.228 fraction Rat - - Measured; httk, Rat Plasma Fraction Unbound sheet=Data; excel_row=843; Record_ID=adme_parameters_1356; Data_Type=Measured; DTXSID=DTXSID2021864; Assay=httk, Rat Plasma Fraction Unbound; Endpoint=Fu; Response=0.228; Response_Unit=Unitless Fraction; Species=Rat; Reference=httk2.3.1, Honda 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021864; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021864
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=1906; RecordID=ARPathway2016_461; DatasetName=ARPathway2016; DTXSID=DTXSID2021864; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021864; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021864
ToxValDB_Alaska_DEC 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_Alaska_DEC RfD =0.01 mg/kg bw/day Human dermal - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445733:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=29909d179ad1fe48b4bc6806a947f4f4
ToxValDB_Alaska_DEC RfD =0.02 mg/kg bw/day Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445734:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=6c2d6c6cdaaf7b7be336780306601334
ToxValDB_Alaska_DEC RfD =0.01 mg/kg bw/day Human dermal - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445733:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=29909d179ad1fe48b4bc6806a947f4f4
ToxValDB_Alaska_DEC RfD =0.02 mg/kg bw/day Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445734:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=6c2d6c6cdaaf7b7be336780306601334
ToxValDB_ECOTOX 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECOTOX LOEL =540 mg/kg bw/day Rat oral subchronic; 90 days subchronic LONG_REF=Drug Chem. Toxicol.16(4): 351-368 Daniel,F.B., M. Robinson, G.R. Olson, R.G. York, and L.W. Condie Ten and Ninety-Day Toxicity Studies of 2,4-Dimethylphenol in Sprague-Dawley Rats 1993; TITLE=Ten and Ninety-Day Toxicity Studies of 2,4-Dimethylphenol in Sprague-Dawley Rats; AUTHOR=Daniel,F.B., M. Robinson, G.R. Olson, R.G. York, and L.W. Condie; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=117835; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Biochemistry: Creatinine|Enzyme(s): Aspartate aminotransferase|Growth: Weight|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|other; STUDY_GROUP=ECOTOX:15611634:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=0ae96f96e11ce107246bf81162af51e6
ToxValDB_ECOTOX NOEL =1000 mM Mouse dermal short-term; 8 days short-term LONG_REF=Toxicology232(1-2): 132-137 Yamano,T., M. Ichihara, M. Shimizu, T. Noda, and Y. Tsujimoto Immunomodulatory Effects of Mono-, di-, and Trimethylphenols in Mice 2007; TITLE=Immunomodulatory Effects of Mono-, di-, and Trimethylphenols in Mice; AUTHOR=Yamano,T., M. Ichihara, M. Shimizu, T. Noda, and Y. Tsujimoto; DOI=10.1016/j.tox.2006.12.021; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=115071; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=Cell(s): Lymphocyte|Hormone(s): Cytokinin; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15604839_15605260:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=bd796eddbdc8ecfcff3d85fce0055cb1
ToxValDB_HPVIS 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_HPVIS NOAEL =50 mg/kg bw/day Mouse oral subchronic; 90 days subchronic LONG_REF=US EPA Ninety-day gavage study in albino mice using 2,4-dimethylphenol. Study number 410-2831, 1989.Posting dates of the documents from the HPV Challenge Program website from which data have been entered into the HPVIS: June 11, 2002 and July 21, 2006 (first and second revisions).; QUALITY=1; EXTERNAL_SOURCE_ID=62044; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=HPVIS:15639833:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a270361f94d5940b8bacb1d2725b2f4a
ToxValDB_IRIS 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_IRIS LOAEL =250 mg/kg bw/day Mouse oral subchronic; 90 days subchronic LONG_REF=U.S. EPA. 1989. Ninety-day gavage study in Albino mice using 2,4- dimethylphenol. Study No. 410-2831, prepared by Dynamac Corporation, Rockville, MD, for the Office of Solid Waste and Emergency Response, Washington, DC.; TITLE=Ninety-day gavage study in Albino mice using 2,4- dimethylphenol; AUTHOR=U.S. EPA; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5b03; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=466; TOXICOLOGICAL_EFFECT=clinical signs (lethargy, prostration, and ataxia and hematological changes; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=IRIS_dup_IRIS Summary_15645264_15645265:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_56f5cee5c709960815f9ea007f7ee579
ToxValDB_PPRTV_(CPHEA) 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_PPRTV_(CPHEA) RfD (provisional) =0.05 mg/kg bw/day Human oral - Toxicity Value LONG_REF=US EPA 1989; AUTHOR=US EPA; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754a4e4b08a6b3934aedf; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1715; TOXICOLOGICAL_EFFECT=Squinting, lethargy, prostration, and ataxia in male/female mice; STUDY_GROUP=PPRTV (CPHEA):15653561:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e17c8dbedfd29ad409a4d8fad20194ce
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 5OD803C081 UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"5OD803C081"}
openFDA substances FDA UNII substance identifier 5OD803C081 UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"5OD803C081"}
openFDA substances FDA UNII substance identifier 5OD803C081 UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"5OD803C081"}
openFDA substances FDA UNII substance identifier 5OD803C081 UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"5OD803C081"}