Also known as: UNII-S409QAZ004, 1H,5H-Pyrazolo(1,2-a)pyrazol-1-one, 2,3-diamino-6,7-dihydro-, dimethanesulfonate, Imexine OBH
INCI: 2,3-DIAMINODIHYDROPYRAZOLO PYRAZOLONE DIMETHOSULFONATE
2,3-Diaminodihydropyrazolo Pyrazolone Dimethosulfonate (CAS 857035-95-1) is a cosmetic cosmetic ingredient functioning as Hair dyeing - oxidative hair dye precursor/coupler. NOAEL 300 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 857035-95-1 →
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for 2,3-Diaminodihydropyrazolo Pyrazolone Dimethosulfonate.
Calculate MoS for your specific formulation with the MoS Calculator.
10 study endpoints found for 2,3-Diaminodihydropyrazolo Pyrazolone Dimethosulfonate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.03 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.03 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.03 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.03 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =300 mg/kg bw/day | - | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =300 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =300 mg/kg bw/day | - | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =300 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =300 mg/kg bw/day | - | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =300 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
Pre-calculated NOAEL → SED → MoS audit trail for 2,3-Diaminodihydropyrazolo Pyrazolone Dimethosulfonate across SCCS product categories, with measured dermal absorption where available.
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured_sccs_opinion | 0.39% | - | - | SCCS/1470/12 |
| measured_sccs_opinion | 0.39% | - | - | SCCS/1470/12 |
Expert safety assessment and concern-level summary for 2,3-Diaminodihydropyrazolo Pyrazolone Dimethosulfonate.
Public NOAEL study rows linked to 2,3-Diaminodihydropyrazolo Pyrazolone Dimethosulfonate by CAS number or substance name.
Units vary across source rows: mg/kg bw/day, mg/kg bw/d
| Absorption % | Method | Vehicle |
|---|---|---|
| 0.39% | SCCS opinion extraction | - |
| 0.39% | SCCS opinion extraction | - |
2,3-Diaminodihydropyrazolo Pyrazolone Dimethosulfonate has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
2,3-Diaminodihydropyrazolo Pyrazolone Dimethosulfonate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
2,3-Diaminodihydropyrazolo Pyrazolone Dimethosulfonate functions as: Hair dyeing - oxidative hair dye precursor/coupler. It is classified as a cosmetic ingredient in our database. CAS number: 857035-95-1.
The NOAEL (No Observed Adverse Effect Level) for 2,3-Diaminodihydropyrazolo Pyrazolone Dimethosulfonate is =0.03 mg/kg bw/d based on a dermal absorption study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
2,3-Diaminodihydropyrazolo Pyrazolone Dimethosulfonate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
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