NOAEL Studies
Cosmetic Ingredient
2-Isobutylquinoline NOAEL Studies
INCI: 2-ISOBUTYLQUINOLINE
CAS: 4439-24-1
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP_ICE_acute_oral 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | =400 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM ChemIDplus TEST (undated); record_id=acute_oral_6530; row=6465; data_type=In Vivo; mixture=Chemical; chemical_name=Ethylene glycol monoisobutyl ether; preferred_name=Ethylene glycol monoisobutyl ether; dtxsid=DTXSID3063469; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3063469; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =1020 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM ChemIDplus TEST (undated); record_id=acute_oral_11553; row=9455; data_type=In Vivo; mixture=Chemical; chemical_name=2-(2-Methylpropyl)quinoline; preferred_name=2-Isobutylquinoline; dtxsid=DTXSID5052622; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5052622; source_file=acute_oral.xlsx |
NTP_ICE_skin_sensitization 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=11131; Record_ID=skin_sensitization_invivo_2435; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5052622; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1973: report to RlFM|Opdyke 1976; Not available; 10.1016/S0015-6264(76)80297-0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5052622 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 1296 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=11130; Record_ID=skin_sensitization_invivo_2435; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5052622; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=1296; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1973: report to RlFM|Opdyke 1976; Not available; 10.1016/S0015-6264(76)80297-0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5052622 |
| NTP_ICE_skin_sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=11133; Record_ID=skin_sensitization_invivo_2435; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5052622; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1973: report to RlFM|Opdyke 1976; Not available; 10.1016/S0015-6264(76)80297-0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5052622 |
ToxValDB_ECHA_IUCLID 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | NOAEL | ~15 | mg/kg bw/day | Rat | oral | subchronic; 47 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae42e4b0a7c65d1c8538; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24901/7/6/2?documentUUID=e2534827-9a2a-488d-b1c0-9911c8563790; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=hematological; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15831340_15831341:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_abde2b151dc770d741c592c2c25da4ce |
| ToxValDB_ECHA_IUCLID | NOAEL | =150 | mg/kg bw/day | Rat | oral | subchronic; 47 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae42e4b0a7c65d1c8538; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24901/7/6/2?documentUUID=e2534827-9a2a-488d-b1c0-9911c8563790; YEAR=2013; ORIGINAL_YEAR=2013; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15831340_15831341:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c89acb8eee52e5853227750571a1740b |