NOAEL Studies Cosmetic Ingredient

1,4-Butanediol NOAEL Studies

INCI: 1,4-BUTANEDIOL

CAS: 110-63-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ADI >=0.1 mg/kg bw/day Consumers - - ADI EFSA CONTAM - 2011 - OutputID 586 - Consumers - Scientific Opinion on the evaluation of the substances currently on the list in the Annex to Commission Directive 96/3/EC as acceptable previous cargoes for edible fats and oils - Part I of III - doi:10.2903/j.efsa.2011.2482
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ADI >=0.1 mg/kg bw/day Consumers - - ADI EFSA CONTAM - 2011 - OutputID 586 - Consumers - Scientific Opinion on the evaluation of the substances currently on the list in the Annex to Commission Directive 96/3/EC as acceptable previous cargoes for edible fats and oils - Part I of III - doi:10.2903/j.efsa.2011.2482
NTP_ICE_acute_inhalation 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_inhalation LC50 >15 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=1453; Record_ID=acute_inhalation_2535; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID2024666; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=15; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15496/7/3/3/?documentUUID=0083f99e-84be-45f7-9492-ce732e9a6686; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2024666; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2024666
NTP_ICE_acute_inhalation LC50 >5.1 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=1454; Record_ID=acute_inhalation_2537; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID2024666; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=5.1; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15496/7/3/3/?documentUUID=46c3ade0-13d7-4de9-bdb7-bf42762eba04; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2024666; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2024666
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=796; RecordID=ARPathway2016_548; DatasetName=ARPathway2016; DTXSID=DTXSID2024666; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2024666; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2024666
ToxValDB_DOE_Protective_Action_Criteria 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_DOE_Protective_Action_Criteria LEL =71876.8 mg/m3 Human inhalation - acute LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2014; ORIGINAL_YEAR=2014; STUDY_GROUP=DOE Protective Action Criteria:15512947:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f531a98f133b1988c08a25c3bca3169b
ToxValDB_ECHA_IUCLID 11 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LEL =4600 mg/m3 Rat inhalation - acute QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15496/7/3/3?documentUUID=7d399c28-1295-47b3-9ce9-420bb90611f5; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Inhalation_15797082_15797084:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c8a8863dc30fd1a6d99dc8676562d9c3
ToxValDB_ECHA_IUCLID LOAEL =500 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacd7e4b0a7c65d1c11bf; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15496/7/6/2?documentUUID=7d399c28-1295-47b3-9ce9-420bb90611f5; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=liver: clinical biochemistry|histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15850387:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_dc08c77d202ed825ace20196524a3699
ToxValDB_ECHA_IUCLID LOEC =5000 mg/m3 Rat inhalation short-term; 2 weeks short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61fa0e4b096bca877e314; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15496/7/6/3?documentUUID=7d399c28-1295-47b3-9ce9-420bb90611f5; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15826940_15826941_15829164_15829165:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_123bb81bda7a81eb197b3ea1421a583d
ToxValDB_ECHA_IUCLID LOEC =5200 mg/m3 Rat inhalation short-term; 2 weeks short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15496/7/6/3?documentUUID=7d399c28-1295-47b3-9ce9-420bb90611f5; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15826940_15826941_15829164_15829165:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_113ebe33d6b55d1781ffb168b1fa9e80
ToxValDB_ECHA_IUCLID NOAEL =400 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabb9e4b0a7c65d1bb777; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15496/7/9/3?documentUUID=7d399c28-1295-47b3-9ce9-420bb90611f5; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=fetus: fetal/pup body weight changes; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15823990:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_22edd7d1961fd138d9ac098745d060e6
ToxValDB_ECHA_IUCLID NOAEL =50 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacd7e4b0a7c65d1c11bf; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15496/7/6/2?documentUUID=7d399c28-1295-47b3-9ce9-420bb90611f5; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=liver: body weight and weight gain|clinical biochemistry|clinical signs|food consumption and compound intake|histopathology: non-neoplastic|mortality; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|clinical signs|food and/or water consumption|mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID:15850386:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2b81d161af0bfe36aad8a6767ed6ccec
ToxValDB_ECHA_IUCLID NOAEL =800 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa57e4b0a7c65d1b5675; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15496/7/9/2?documentUUID=7d399c28-1295-47b3-9ce9-420bb90611f5; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=P0: reproductive performance; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15856391_15862531:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_94e991725f64004bfa96a48ffc0ac38d
ToxValDB_ECHA_IUCLID NOEC =1000 mg/m3 Rat inhalation short-term; 2 weeks short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61fa0e4b096bca877e314; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15496/7/6/3?documentUUID=7d399c28-1295-47b3-9ce9-420bb90611f5; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15826940_15826941_15829164_15829165:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_786916dc8ec8da4783cf5373fd60acd8
ToxValDB_ECHA_IUCLID NOEC =1100 mg/m3 Rat inhalation short-term; 2 weeks short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15496/7/6/3?documentUUID=7d399c28-1295-47b3-9ce9-420bb90611f5; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15826940_15826941_15829164_15829165:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_28fec1fe0062c19ffad1d5db0d41d836
ToxValDB_ECHA_IUCLID NOEL <200 mg/kg bw/day Rat oral subchronic (developmental); 42 days reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacd7e4b0a7c65d1c11c1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15496/7/6/2?documentUUID=7d399c28-1295-47b3-9ce9-420bb90611f5; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15836025_15847605:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_972706b607002d1897dbec9b9d5abb7f
ToxValDB_ECHA_IUCLID NOEL =400 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa57e4b0a7c65d1b5675; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15496/7/9/2?documentUUID=7d399c28-1295-47b3-9ce9-420bb90611f5; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15856391_15862531:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_346e9e7742f0bdfa9f0e3f3e2fa0c6a7
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =136 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630350:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_952033bc11852114a7cde9c8d6f43909
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 7XOO2LE6G3 UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H10O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"7XOO2LE6G3"}
openFDA substances FDA UNII substance identifier 7XOO2LE6G3 UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H10O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"7XOO2LE6G3"}
openFDA substances FDA UNII substance identifier 7XOO2LE6G3 UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H10O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"7XOO2LE6G3"}
openFDA substances FDA UNII substance identifier 7XOO2LE6G3 UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H10O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"7XOO2LE6G3"}