NOAEL Studies Cosmetic Ingredient

1,2-Butanediol NOAEL Studies

INCI: 1,2-BUTANEDIOL

CAS: 584-03-2

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =16000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_8017; row=10810; data_type=In Vivo; mixture=Chemical; chemical_name=1,2-Butanediol; preferred_name=1,2-Butanediol; dtxsid=DTXSID6040375; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6040375; source_file=acute_oral.xlsx
NTP_ICE_dart 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_dart LOEL 300 mg/kg bw/day Rat Oral - In Vivo; DART, Developmental malformation sheet=Data; excel_row=99990; Record_ID=dart_17754; Data_Type=In Vivo; DTXSID=DTXSID6040375; Assay=DART, Developmental malformation; Endpoint=LOEL; Response=300; Response_Unit=mg/kg/day; Species=Rat; Strain=Other; Sex=Male/Female; Life_Stage=Fetal; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0000768;CUI;Congenital Abnormality|UMLS;C0205394;CUI;Other; Reference=ToxRefDB v2 , ID = 3837; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6040375
ToxValDB_ECHA_IUCLID 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL >=1000 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac3ee4b0a7c65d1be1b5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17002/7/9/3?documentUUID=fd5e85d1-3e7c-478a-b839-de2467bcf308; YEAR=2016; ORIGINAL_YEAR=2016; STUDY_GROUP=ECHA IUCLID:15824959:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5a0ca5f73ebb8a6b91a199e145ce9573
ToxValDB_ECHA_IUCLID NOAEL =200 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab1ae4b0a7c65d1b8ce2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17002/7/9/2?documentUUID=f182768a-81b8-42eb-9168-5d399bb7fc06; YEAR=1999; ORIGINAL_YEAR=1999; STUDY_GROUP=ECHA IUCLID:15862872:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_aa60bfd12874ffcd08515ceb22ba08b6
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier RUN0H01QEU UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H10O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"RUN0H01QEU"}
openFDA substances FDA UNII substance identifier RUN0H01QEU UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H10O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"RUN0H01QEU"}
openFDA substances FDA UNII substance identifier RUN0H01QEU UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H10O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"RUN0H01QEU"}
openFDA substances FDA UNII substance identifier RUN0H01QEU UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H10O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"RUN0H01QEU"}