NOAEL Studies Cosmetic Ingredient

1-Furfuryl-1H-Pyrrole NOAEL Studies

INCI: 1-FURFURYL-1H-PYRROLE

CAS: 1438-94-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 11.2 mg/kg bw/day rat oral 90 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =25 mg/kg bw/day Rat oral: feed 90 days subchronic EFSA CEF - 2015 - OutputID 2600 - haematology - hepatotoxicity - Scientific Opinion on Flavouring Group Evaluation 77, Revision 2 (FGE.77Rev2): Consideration of Pyridine, Pyrrole and Quinoline Derivatives evaluated by JECFA (63rd meeting) structurally related to Pyridine, Pyrrole, Indole and Quinoline Derivatives evaluated by EFSA in FGE.24Rev2 (2013) - doi:10.2903/j.efsa.2015.3997
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =25 mg/kg bw/day Rat oral: feed 90 days subchronic EFSA CEF - 2015 - OutputID 2600 - haematology - hepatotoxicity - Scientific Opinion on Flavouring Group Evaluation 77, Revision 2 (FGE.77Rev2): Consideration of Pyridine, Pyrrole and Quinoline Derivatives evaluated by JECFA (63rd meeting) structurally related to Pyridine, Pyrrole, Indole and Quinoline Derivatives evaluated by EFSA in FGE.24Rev2 (2013) - doi:10.2903/j.efsa.2015.3997
ToxValDB_EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA NOAEL =25 mg/kg bw/day Rat oral subchronic; 90 days subchronic LONG_REF=EFSA CEF (2015). Scientific Opinion on Flavouring Group Evaluation 77, Revision 2 (FGE.77Rev2): Consideration of Pyridine, Pyrrole and Quinoline Derivatives evaluated by JECFA (63rd meeting) structurally related to Pyridine, Pyrrole, Indole and Quinoline Derivatives evaluated by EFSA in FGE.24Rev2 (2013). doi:10.2903/j.efsa.2015.3997.; TITLE=Scientific Opinion on Flavouring Group Evaluation 77, Revision 2 (FGE.77Rev2): Consideration of Pyridine, Pyrrole and Quinoline Derivatives evaluated by JECFA (63rd meeting) structurally related to Pyridine, Pyrrole, Indole and Quinoline Derivatives evaluated by EFSA in FGE.24Rev2 (2013); AUTHOR=EFSA CEF; DOI=doi:10.2903/j.efsa.2015.3997; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2015; ORIGINAL_YEAR=2015; TOXICOLOGICAL_EFFECT=hematological; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=EFSA_dup_-_15621463_15621464:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9bf486b18d79686d1f80188f4b0ffc48
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 15HF30X204 UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H9NO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"15HF30X204"}
openFDA substances FDA UNII substance identifier 15HF30X204 UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H9NO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"15HF30X204"}
openFDA substances FDA UNII substance identifier 15HF30X204 UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H9NO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"15HF30X204"}
openFDA substances FDA UNII substance identifier 15HF30X204 UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H9NO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"15HF30X204"}