Warning GHS02GHS08GHS07 NOAEL Data REACH Registered Cosmetic Ingredient

2-Hydroxyethyl picramic acid

Also known as: UNII-KZ27KOJ0GZ, 2-((2-Hydroxyethyl)amino)-4,6-dinitrophenol, Phenol, 2-((2-hydroxyethyl)amino)-4,6-dinitro-

CAS 99610-72-7

2-Hydroxyethyl picramic acid (CAS 99610-72-7) is a chemical substance with GHS signal word Warning; key hazard signal: H228; H361f ***; H302. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for 2-Hydroxyethyl Picramic Acid →

SOURCE noael studies public
NOAEL studies
72
SOURCE chemical inventory jurisdictions
Regulatory lists
6
SOURCE eu clp annex vi
GHS signal
Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 9 fields
Name
2-Hydroxyethyl picramic acid
CAS Number
99610-72-7
DTXSID
DTXSID40244163
Molecular Formula
C8H9N3O6
InChI Key
OABRBVCUJIJMOB-UHFFFAOYSA-N
Monoisotopic Mass
243.049135
Synonyms
UNII-KZ27KOJ0GZ2-((2-Hydroxyethyl)amino)-4,6-dinitrophenolPhenol, 2-((2-hydroxyethyl)amino)-4,6-dinitro-

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Flam. Sol. 2; Repr. 2; Acute Tox. 4 *H228; H361f ***; H302GHS02; GHS08; GHS07Warning

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records
Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 6 records
ListKeywordSource
Europe; Personal care; restrictedEuropean CommissionCosIng
Canada; Personal care; Substances in PCP - Canada (4/2014)Government of CanadaCPCat
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 72 studies
ValueUnitEndpointRouteSpeciesSource
20mg/kg bw--ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
20mg/kg bw--ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
50mg/kg bw/day--humanUnifiedCodex:SCCS_SHADOW:beta.noael_studies
50mg/kg bw/day--humanUnifiedCodex:SCCS_SHADOW:beta.noael_studies
50mg/kg bw/day--humanUnifiedCodex:SCCS_SHADOW:beta.noael_studies
50mg/kg bw/day--humanUnifiedCodex:SCCS_SHADOW:beta.noael_studies
KZ27KOJ0GZUNIIFDA UNII substance identifier--openFDA substances
KZ27KOJ0GZUNIIFDA UNII substance identifier--openFDA substances
KZ27KOJ0GZUNIIFDA UNII substance identifier--openFDA substances
KZ27KOJ0GZUNIIFDA UNII substance identifier--openFDA substances
20mg/kg bw/dayLOAELoralratCOSMOS_DB
=0.13mg/kg bwNOAELoralratSCCS_vision_codex
=0.13mg/kg bwNOAELoralratSCCS_vision_codex
=0.13mg/kg bwNOAELoralratSCCS_vision_codex
=0.13mg/kg bwNOAELoralratSCCS_vision_codex
=0.16mg/kg bwNOAELoralratSCCS_vision_codex
=0.16mg/kg bwNOAELoralratSCCS_vision_codex
=0.16mg/kg bwNOAELoralratSCCS_vision_codex
=0.16mg/kg bwNOAELoralratSCCS_vision_codex
=15mg/kg bwNOAEL-ratSCCS_vision_codex
=15mg/kg bwNOAEL-ratSCCS_vision_codex
=15mg/kg bwNOAEL-ratSCCS_vision_codex
=15mg/kg bwNOAEL-ratSCCS_vision_codex
=20mg/kg bwNOAEL-ratSCCS_vision_codex
=20mg/kg bw/dayNOAEL-ratSCCS_vision_codex
=20mg/kg bwNOAEL-ratSCCS_vision_codex
=20mg/kg bw/dayNOAEL-ratSCCS_vision_codex
=20mg/kg bwNOAEL-ratSCCS_vision_codex
=20mg/kg bw/dayNOAEL-ratSCCS_vision_codex
=20mg/kg bwNOAEL-ratSCCS_vision_codex
=20mg/kg bw/dayNOAEL-ratSCCS_vision_codex
=50mg/kg bwNOAELoral-SCCS_vision_codex
=50mg/kg bw/dayNOAEL-humanSCCS_vision_codex
=50mg/kg bwNOAELoral-SCCS_vision_codex
=50mg/kg bw/dayNOAEL-humanSCCS_vision_codex
=50mg/kg bwNOAELoral-SCCS_vision_codex
=50mg/kg bw/dayNOAEL-humanSCCS_vision_codex
=50mg/kg bwNOAELoral-SCCS_vision_codex
=50mg/kg bw/dayNOAEL-humanSCCS_vision_codex
=60mg/kg bwNOAEL-ratSCCS_vision_codex
=60mg/kg bwNOAEL-ratSCCS_vision_codex
=60mg/kg bwNOAEL-ratSCCS_vision_codex
=60mg/kg bwNOAEL-ratSCCS_vision_codex
=120mg/kg bw/dayNOAELoralratSCCS_vision_codex
=120mg/kg bwNOAELdermalrabbitSCCS_vision_codex
=120mg/kg bw/dayNOAELoralratSCCS_vision_codex
=120mg/kg bwNOAELdermalrabbitSCCS_vision_codex
=120mg/kg bw/dayNOAELoralratSCCS_vision_codex
=120mg/kg bwNOAELdermalrabbitSCCS_vision_codex
=120mg/kg bw/dayNOAELoralratSCCS_vision_codex

Showing 50 of 72 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
Registered2-(2-hydroxy-3,5-dinitroanilino)ethanol412-520-9ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Colorant
View full cosmetic safety profile →

Frequently Asked Questions

What is the GHS hazard classification for 2-Hydroxyethyl picramic acid?

2-Hydroxyethyl picramic acid (CAS 99610-72-7) is classified under EU CLP Annex VI as Flam. Sol. 2; Repr. 2; Acute Tox. 4 * with signal word Warning. Hazard statements: H228; H361f ***; H302. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 2-Hydroxyethyl picramic acid?

2-Hydroxyethyl picramic acid has 72 NOAEL studies in the database. The lowest reported value is 0.13 mg/kg bw via oral in rat. Source: SCCS_vision_codex.

What regulatory lists include 2-Hydroxyethyl picramic acid?

2-Hydroxyethyl picramic acid appears on 3 regulatory/inventory lists including Europe; Personal care; restricted, Canada; Personal care; Substances in PCP - Canada (4/2014), Europe; Personal care - hair coloring. Source: EPA CPDat.

Is 2-Hydroxyethyl picramic acid used in cosmetics?

Yes, 2-Hydroxyethyl picramic acid is also indexed as a cosmetic ingredient under the name 2-Hydroxyethyl Picramic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-Hydroxyethyl picramic acid come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does 2-Hydroxyethyl picramic acid have different safety status in cosmetics vs industrial chemicals?

2-Hydroxyethyl picramic acid is classified GHS CMR hazard (H228, H361f, H302) in the chemicals database but is restricted in EU cosmetics.

Is 2-Hydroxyethyl picramic acid used outside industrial chemicals?

2-Hydroxyethyl picramic acid also appears in cosmetics databases.