NOAEL Data REACH Registered Cosmetic Ingredient

4-{[4,6-Bis(octylsulfanyl)-1,3,5-triazin-2-yl]amino}-2,6-di-tert-butylphenol

Also known as: 2,4-Bis(octylthio)-6-(4-hydroxy-3,5-di-tert-butylanilino)-1,3,5-triazine, EINECS 213-590-1, Irganox 565, Irganox RA 565, NSC 328455 (+1 more)

CAS 991-84-4

4-{[4,6-Bis(octylsulfanyl)-1,3,5-triazin-2-yl]amino}-2,6-di-tert-butylphenol (CAS 991-84-4) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Di-t-Butyl Hydroxyphenylamino Bisoctylthiotriazine →

SOURCE noael studies public
NOAEL studies
11
SOURCE chemical inventory jurisdictions
Regulatory lists
3
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 12 fields
Name
4-{[4,6-Bis(octylsulfanyl)-1,3,5-triazin-2-yl]amino}-2,6-di-tert-butylphenol
CAS Number
991-84-4
DTXSID
DTXSID1052662
Molecular Formula
C33H56N4OS2
InChI Key
QRLSTWVLSWCGBT-UHFFFAOYSA-N
Monoisotopic Mass
588.389555
Synonyms
2,4-Bis(octylthio)-6-(4-hydroxy-3,5-di-tert-butylanilino)-1,3,5-triazineEINECS 213-590-1Irganox 565Irganox RA 565NSC 328455UNII-O1Q826IX7H

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 10 records
AntioxidantHeat stabilizer

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 3 records
ListKeywordSource
drinking_water; Europe; manufacturing; plastic_additiveBelgaquaCPCat
CEDIFDAUnited States Food and Drug Administration (FDA)
Indirect additives food contact (10/2018)FDAUnited States Food and Drug Administration (FDA)

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 11 of 11 studies
ValueUnitEndpointRouteSpeciesSource
=3mg/m3DNEL localinhalationHumanToxValDB_GESTIS_DNEL
O1Q826IX7HUNIIFDA UNII substance identifier--openFDA substances
O1Q826IX7HUNIIFDA UNII substance identifier--openFDA substances
O1Q826IX7HUNIIFDA UNII substance identifier--openFDA substances
O1Q826IX7HUNIIFDA UNII substance identifier--openFDA substances
=200mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
=818mg/kg bw/dayNOAELoralDogToxValDB_ECHA_IUCLID
=1297.3mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
=3000mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
=987mg/kg bw/dayNOELoralRatToxValDB_ECHA_IUCLID
=1010mg/kg bw/dayNOELoralRatToxValDB_ECHA_IUCLID

Showing 11 of 11 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
Registered2,6-di-tert-butyl-4-(4,6-bis(octylthio)-1,3,5-triazin-2-ylamino)phenol213-590-1ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Antioxidant
View full cosmetic safety profile →

Frequently Asked Questions

What is the NOAEL for 4-{[4,6-Bis(octylsulfanyl)-1,3,5-triazin-2-yl]amino}-2,6-di-tert-butylphenol?

4-{[4,6-Bis(octylsulfanyl)-1,3,5-triazin-2-yl]amino}-2,6-di-tert-butylphenol has 11 NOAEL studies in the database. The lowest reported value is 3 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include 4-{[4,6-Bis(octylsulfanyl)-1,3,5-triazin-2-yl]amino}-2,6-di-tert-butylphenol?

4-{[4,6-Bis(octylsulfanyl)-1,3,5-triazin-2-yl]amino}-2,6-di-tert-butylphenol appears on 3 regulatory/inventory lists including drinking_water; Europe; manufacturing; plastic_additive, CEDI, Indirect additives food contact (10/2018). Source: EPA CPDat.

Is 4-{[4,6-Bis(octylsulfanyl)-1,3,5-triazin-2-yl]amino}-2,6-di-tert-butylphenol used in cosmetics?

Yes, 4-{[4,6-Bis(octylsulfanyl)-1,3,5-triazin-2-yl]amino}-2,6-di-tert-butylphenol is also indexed as a cosmetic ingredient under the name Di-t-Butyl Hydroxyphenylamino Bisoctylthiotriazine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 4-{[4,6-Bis(octylsulfanyl)-1,3,5-triazin-2-yl]amino}-2,6-di-tert-butylphenol come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Is 4-{[4,6-Bis(octylsulfanyl)-1,3,5-triazin-2-yl]amino}-2,6-di-tert-butylphenol used outside industrial chemicals?

4-{[4,6-Bis(octylsulfanyl)-1,3,5-triazin-2-yl]amino}-2,6-di-tert-butylphenol also appears in cosmetics databases.