What is the NOAEL for 4-Isopropylphenol?
4-Isopropylphenol has 8 NOAEL studies in the database. The lowest reported value is 37.1585717827295 uM. Source: NTP ICE endocrine.
NOAEL Data
REACH Registered
Cosmetic Ingredient
4-Isopropylphenol
Also known as: (p-Isopropylphenol), 4-06-00-03215, BRN 1363564, EINECS 202-798-8, 1-Hydroxy-4-isopropylbenzene (+1 more)
CAS 99-89-8
4-Isopropylphenol (CAS 99-89-8) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
4-Isopropylphenol is classified GHS Danger (H302, H312, H314, H332) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
8
SOURCE
Chemical inventory jurisdictions
Regulatory lists
3
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
12 fields
Name
4-Isopropylphenol
CAS Number
99-89-8
DTXSID
DTXSID5042299
Molecular Formula
C9H12O
InChI Key
YQUQWHNMBPIWGK-UHFFFAOYSA-N
Monoisotopic Mass
136.088815
Synonyms
(p-Isopropylphenol)4-06-00-03215BRN 1363564EINECS 202-798-81-Hydroxy-4-isopropylbenzeneUNII-9F59JOO816
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 48.9229407558269 | uM | AC50 | - | - | NTP ICE endocrine |
| 37.1585717827295 | uM | ACC | - | - | NTP ICE endocrine |
| 9F59JOO816 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9F59JOO816 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9F59JOO816 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9F59JOO816 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | unitless | Model Score | - | - | NTP ICE endocrine |
| 0.021 | unitless | Model Score | - | - | NTP ICE endocrine |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | p-isopropylphenol | 202-798-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
CHEMBL29966
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 4-Isopropylphenol?
4-Isopropylphenol appears on 3 regulatory/inventory lists including IFRA Transparency, Europe, Indirect additives food contact (10/2018). Source: EPA CPDat.
Is 4-Isopropylphenol used in cosmetics?
Yes, 4-Isopropylphenol is also indexed as a cosmetic ingredient under the name P-ISOPROPYLPHENOL. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 4-Isopropylphenol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does 4-Isopropylphenol have different safety status in cosmetics vs industrial chemicals?
4-Isopropylphenol is classified GHS Danger (H302, H312, H314, H332) in the chemicals database but is allowed in EU cosmetics.
Is 4-Isopropylphenol used outside industrial chemicals?
4-Isopropylphenol also appears in cosmetics, pharmaceutical, cannabis databases.