NOAEL Data Cosmetic Ingredient

Alpha-Phellandrene

Also known as: 3-05-00-00342, BRN 1280394, EINECS 202-792-5, FEMA No. 2856, 1-Isopropyl-4-methyl-2,4-cyclohexadiene (+11 more)

CAS 99-83-2

Alpha-Phellandrene (CAS 99-83-2) is a chemical substance. Key regulatory status: 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.

View cosmetic safety profile for Alpha-Phellandrene →

Cross-Vertical Regulatory Divergence

Alpha-Phellandrene is classified GHS Danger (H304, H317, H226) in the chemicals database but is allowed in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 22 fields

Name

Alpha-Phellandrene

CAS Number

99-83-2

DTXSID

DTXSID4047593

Molecular Formula

C10H16

InChI Key

OGLDWXZKYODSOB-UHFFFAOYSA-N

Monoisotopic Mass

136.125201

Synonyms

3-05-00-00342BRN 1280394EINECS 202-792-5FEMA No. 28561-Isopropyl-4-methyl-2,4-cyclohexadiene4-Isopropyl-1-methyl-1,5-cyclohexadiene(-)-2-Methyl-5-(1-methylethyl)-1,3-cyclohexadieneUNII-49JV13XE391-methyl-4-isopropyl-1,5-cyclohexadiene2-methyl-5-isopropyl-1,3-cyclohexadiene5-isopropyl-2-methylcyclohexa-1,3-dieneFEMA 2856

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 9 records

FragranceFlavouring and nutrient

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 6 records

List	Keyword	Source
air; Cleaning products and household care - laundry and fabric treatment; detected; emissions	Elsevier	CPCat
air; Cleaning products and household care; detected; emissions	Elsevier	CPCat
IFRA Transparency	IFRA	IFRA
Europe	European Commission	Fl@vis
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
consumer_product	P&G	Proctor & Gamble

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 15 of 15 studies

Value	Unit	Endpoint	Route	Species	Source
5	%	Concentration, 5% incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
5.4	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
5.4	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
5.4	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
5.4	%	EC3	Dermal	Mouse	NTP_ICE_skin_sensitization
49JV13XE39	UNII	FDA UNII substance identifier	-	-	openFDA substances
49JV13XE39	UNII	FDA UNII substance identifier	-	-	openFDA substances
49JV13XE39	UNII	FDA UNII substance identifier	-	-	openFDA substances
49JV13XE39	UNII	FDA UNII substance identifier	-	-	openFDA substances
-	%	Incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
4	%	Incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
2592	ug/cm2	Induction dose per skin area	Dermal	Human	NTP_ICE_skin_sensitization
5184	ug/cm2	Induction dose per skin area	Dermal	Human	NTP_ICE_skin_sensitization
3240	ug/cm2	Induction dose per skin area, 5% incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
3	unitless	Relative reliability score	Dermal	Human	NTP_ICE_skin_sensitization

Showing 15 of 15 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL3188459

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Alpha-Phellandrene?

Alpha-Phellandrene has 15 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP_ICE_skin_sensitization.

What regulatory lists include Alpha-Phellandrene?

Alpha-Phellandrene appears on 6 regulatory/inventory lists including air; Cleaning products and household care - laundry and fabric treatment; detected; emissions, air; Cleaning products and household care; detected; emissions, IFRA Transparency, and 3 more. Source: EPA CPDat.

Is Alpha-Phellandrene used in cosmetics?

Yes, Alpha-Phellandrene is also indexed as a cosmetic ingredient under the name Alpha-Phellandrene. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Alpha-Phellandrene come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Alpha-Phellandrene have different safety status in cosmetics vs industrial chemicals?

Alpha-Phellandrene is classified GHS Danger (H304, H317, H226) in the chemicals database but is allowed in EU cosmetics.

Is Alpha-Phellandrene used outside industrial chemicals?

Alpha-Phellandrene also appears in cosmetics, pharmaceutical, food safety, cannabis databases.